The bZIP Protein MeaB Mediates Virulence Attributes in Aspergillus flavus

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Amaike, Saori ^a,b   Affeldt, Katharyn J ^a   Yin, Wen Bing ^a,c   Franke, Stephen ^a   Choithani, Anjali ^a   Keller, Nancy P ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; TRIACYLGLYCEROL LIPASE;

ARTICLE; ASPERGILLUS FLAVUS; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL COLONIZATION; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SILENCING; MEAB GENE; MICROARRAY ANALYSIS; NITROGEN UTILIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN DEPLETION; REGULATOR GENE; UPREGULATION; WILD TYPE;

AFLATOXINS; ASPERGILLUS FLAVUS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; FUNGAL PROTEINS; GENE DELETION; GENE KNOCKDOWN TECHNIQUES; MUTATION; NITRATES; NITROGEN; VIRULENCE;

EID: 84883621869     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074030     Document Type: Article

References (47)

1. Klich MA, (2007) Aspergillus flavus: the major producer of aflatoxin. Mol Plant Pathol 8: 713-722.
2. Yu J, Cleveland TE, Nierman WC, Bennett JW, (2005) Aspergillus flavus genomics: gateway to human and animal health, food safety, and crop resistance to diseases. Rev Iberoam Micol 22: 194-202.
3. Amaike S, Keller NP, (2011) Aspergillus flavus. Ann Rev Phytopathol 49: 107-133.
4. Amaike S, Keller NP, (2009) Distinct role for veA and laeA in development and pathogenesis of Aspergillus flavus. Eukary Cell 8: 1051-1060.
5. Duran RM, Cary JW, Calvo AM, (2007) Production of cyclopiazonic acid, aflatrem, and aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotia formation. Appl Microbiol Biotechnol 73: 1158-1168.
6. Kale SP, Milde L, Trapp MK, Frisvad JC, Keller NP, et al. (2008) Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus. Fungal Genet Biol 45: 1422-1429.
7. Bok JW, Balajee SA, Marr KA, Andes D, Nielsen KF, et al. (2005) LaeA, a regulator of morphogenetic fungal virulence factors. Eukary Cell 4: 1574-1582.
8. Wiemann P, Brown DW, Kleigrewe K, Bok JW, Keller NP, et al. (2010) FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence. Mol Microbiol 77: 972-994.
9. Xing W, Deng C, Hu CH, (2010) Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum. Biotechnol Lett 32: 1733-1737.
10. Wu D, Oide S, Zhang N, Choi MY, Turgeon BG, (2012) ChLae1 and ChVel1 regulate T-toxin production, virulence, oxidative stress response, and development of the maize pathogen Cochliobolus heterostrophus. PLoS Pathog 8: e1002542.
11. Bayrum O, Krappmann S, Ni M, Bok JW, Helmstaedt K, et al. (2008) The VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320: 1504-1506.
12. Calvo AM, (2008) The VeA regulatory system and its role in morphological and chemical development in fungi. Fungal Genet Biol 45: 1053-1061.
13. Merhej J, Urban M, Dufresne M, Hammond-Kosack KE, Richard-Forget F, et al. (2012) The velvet gene, FgVe1, affects fungal development and positively regulates trichothecene biosynthesis and pathogenicity in Fusarium graminearum. Mol Plant Pathol 13: 363-374.
14. Bok JW, Hoffmeister D, Maggio-Hall LA, Murillo R, Glasner JD, et al. (2006) Genomic mining for Aspergillus natural products. Chem Biol 13: 31-37.
15. Georgianna DR, Fedorova ND, Burroughs JL, Dolezal AL, Bok JW, et al. (2010) Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters. Mol Plant Pathol 11: 213-226.
16. Shaaban MI, Bok JW, Lauer C, Keller NP, (2010) Suppressor mutagenesis identifies a velvet complex remediator of Aspergillus nidulans secondary metabolism. Eukary Cell 9: 1816-1824.
17. Yin WB, Amaike S, Wohlbach DJ, Gasch A, Chiang YM, et al. (2012) Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Mol Microbiol 83: 1024-1034.
18. Fernandez L, Rodrigues-Pousada C, Struhl K, (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17: 6982-6993.
19. Schretti M, Beckmann N, Heinekamp T, Jacobsen ID, Jöchi C, et al. (2010) HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog 6: e1001124.
20. Roze LV, Chanda A, Wee J, Awad D, Linz JE, (2011) Stress-related transcription factor atfB integrates secondary metabolism with the oxidative stress response in Aspergilli. J Biol Chem 286: 35137-35148.
21. Reverberi M, Zjalic S, Punelli F, Ricelli A, Fabbri A, et al. (2007) Apyap1 affects aflatoxin biosynthesis during Aspergillus parasiticus growth in maize seeds. Food Addit Contam 24: 1070-1075.
22. Reverberi M, Gazzetti K, Punelli F, Scarpari M, Zjalic S, et al. (2012) Aoyap1 regulates OTA synthesis by controlling cell redox balance in Aspergillus ochraceus. Appl Microbiol Biotechnol. 95: 1293-304.
23. Wagner D, Schmeinck A, Mos M, Morozov IY, Caddick MX, et al. (2010) The bZIP transcription factor MeaB mediates nitrogen metabolite repression at specific loci. Eukary Cell 9: 1588-1601.
24. López-Berges MS, Rispall N, Prados-Rosales RC, Pietro A, (2010) A nitrogen response pathway regulates virulence functions in Fusarium oxysporum via the protein kinase tor and the bZIP protein MeaB. Plant Cell 22: 2459-2475.
25. Ehrlich KC, Cotty PJ, (2002) Variability in nitrogen regulation of aflatoxin production by Aspergillus flavus strains. Appl Microbiol Biotechnol 60: 174-178.
26. Chang PK, Ehrlich KC, Yu J, Bhatnagar D, Cleveland TE, (1995) Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl Environ Microbiol 61: 2372-2377.
27. Kachholz T, Demain AL, (1983) Nitrate repression of averufin and aflatoxin biosynthesis J Natural Products. 46: 499-506.
28. Feng GH, Leonard TJ, (1998) Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans. Appl Environ Microbiol 64: 2275-2277.
29. Mateles RI, Adye JC, (1965) Production of aflatoxins in submerged culture. Appl Microbiol. 13: 208-11.
30. Wong KH, Hynes MJ, Todd RB, Davis MA, (2007) Transcriptional control of nmrA by the bZIP transcriptional factor MeaB reveals a new level of nitrogen regulation in Aspergillus nidulans. Mol Microbiol 66: 534-551.
31. Polly SD, Caddick MX, (1996) Molecular characterization of meaB, a novel gene affecting nitrogen metabolite repression in Aspergillus nidulans. FEMS Lett 338: 200-205.
32. Andrianopoulos A, Kourambas S, Sharp JA, Davis MA, MJ H, (1998) Characterization of the Aspergillus nidulans nmrA gene involved in nitrogen metabolite repression. J Bacteriol 180: 1973-1977.
33. Caddick MX, Arst HNJ, Taylor LH, Johnson RI, Brownlee AG, (1986) Cloning of the regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. EMBO J 5: 1087-1090.
34. Morita H, Hatamonoto O, Masuda T, Sato T, Takeuchi M, (2007) Function analysis of steA homolog in Aspergillus oryzae. Fungal Genet Biol 44: 330-338.
35. Vallim MA, Millerm KY, Miller BL, (2000) Aspergillus SteA (sterile12-like) is a homodomain- C2/H2-Zn+2 finger transcription factor required for sexual reproduction. Mol Microbiol 36: 290-301.
36. Robellet X, Oestreicher N, Guitton A, Velot C, (2010) Gene silencing of transgenes inserted in the Aspergillus nidulans alcM and/or alcS loci. 56: 341-348.
37. Palmer JM, Mallaredy S, Perry DW, Sanchez JF, Theisen JM, et al. (2010) Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans. Microbiology. 156: 3522-3531.
38. Shaffer PM, Arst HN Jr, (1984) Regulation of pyrimidine salvage in Aspergillus nidulans: a role for the major regulatory gene areA mediating nitrogen metabolite repression. Mol Gen Genet. 198: 139-145.
39. Soukup AA, Farnoodian M, Berthier E, Keller NP, (2012) NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion. Fungal Genet Biol. 49: 857-65.
40. Shimizu K, Keller NP, (2001) Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating molphological and chemical transitions in Aspergillus nidulans. Genetics 157: 591-600.
41. Szewczyk E, Nayal T, Oakley CE, Edgerton H, Yi X, et al. (2007) Fusion PCR and gene targeting in Aspergillus nidulans. Nature Protocol 1: 3111-3120.
42. Bok J, Keller NP, (2012) Fast and easy method for construction of plasmid vectors using modified Quick-change mutagenesis. Methods Mol Biol. 944: 163-174.
43. Tsitsigiannis DI, Bok JW, Andes D, Nielsen KF, Frisvad JC, et al. (2005) Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect Immun 73: 4548-4559.
44. Miller BL, Miller KY, Timberlake WE, (1985) Direct and indirect gene replacements in Aspergillus nidulans. Mol Cell Biol 5: 1714-1721.
45. He ZM, Price MS, O'Brian G, Georgianna DR, Payne GA, (2007) Improved protocols for functional analysis in pathogenic fungus Aspergillus flavus. BMC Microbiology 7: 104.
46. Calvo AM, Bok J, Brooks W, Keller NP, (2004) veA is required for toxin and sclerotial production in Aspergillus parasiticus. Appl Environ Microbiol 70: 4733-4739.
47. McDonald T, Brown D, Keller NP, Hammond TM, (2005) RNA silencing of mycotoxin production in Aspergillus and Fusarium species. Mol Plant-Microbe Inter 18: 539-545.