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Volumn 8, Issue 9, 2013, Pages

Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; GLUCOSE; INSULIN RECEPTOR; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; RNA;

EID: 84883615750     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073011     Document Type: Article
Times cited : (50)

References (37)
  • 1
    • 77957376253 scopus 로고    scopus 로고
    • Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
    • doi: 10.1210/me.2010-0142
    • Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, et al. (2010) Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol 24: 2050-2064. doi:10.1210/me.2010-0142. PubMed: 20667984.
    • (2010) Mol Endocrinol , vol.24 , pp. 2050-2064
    • Fon Tacer, K.1    Bookout, A.L.2    Ding, X.3    Kurosu, H.4    John, G.B.5
  • 3
    • 33846418834 scopus 로고    scopus 로고
    • The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    • doi: 17068132
    • Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, et al. (2007) The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 148: 774-781. PubMed: 17068132.
    • (2007) Endocrinology , vol.148 , pp. 774-781
    • Kharitonenkov, A.1    Wroblewski, V.J.2    Koester, A.3    Chen, Y.F.4    Clutinger, C.K.5
  • 4
    • 84865442538 scopus 로고    scopus 로고
    • Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
    • doi: 10.1210/en.2012-1211
    • Véniant MM, Komorowski R, Chen P, Stanislaus S, Winters K, et al. (2012) Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys. Endocrinology 153: 4192-4203. doi:10.1210/en.2012-1211. PubMed: 22798348.
    • (2012) Endocrinology , vol.153 , pp. 4192-4203
    • Véniant, M.M.1    Komorowski, R.2    Chen, P.3    Stanislaus, S.4    Winters, K.5
  • 5
    • 84863011453 scopus 로고    scopus 로고
    • FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
    • doi: 10.2337/db11-0838
    • Mu J, Pinkstaff J, Li Z, Skidmore L, Li N, et al. (2012) FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes 61: 505-512. doi:10.2337/db11-0838. PubMed: 22210323.
    • (2012) Diabetes , vol.61 , pp. 505-512
    • Mu, J.1    Pinkstaff, J.2    Li, Z.3    Skidmore, L.4    Li, N.5
  • 6
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • doi: 10.1016/j.cmet.2007.05.002
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, et al. (2007) Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5: 426-437. doi:10.1016/j.cmet.2007.05.002. PubMed: 17550778.
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5
  • 7
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • doi: 10.1016/j.cmet.2007.05.003
    • Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, et al. (2007) Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 5: 415-425. doi:10.1016/j.cmet.2007.05.003. PubMed: 17550777.
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3    Ding, X.4    Gautron, L.5
  • 8
    • 47949111205 scopus 로고    scopus 로고
    • Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states
    • doi: 10.1124/mol.108.044826
    • Muise ES, Azzolina B, Kuo DW, El-Sherbeini M, Tan Y, et al. (2008) Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Mol Pharmacol 74: 403-412. doi:10.1124/mol.108.044826. PubMed: 18467542.
    • (2008) Mol Pharmacol , vol.74 , pp. 403-412
    • Muise, E.S.1    Azzolina, B.2    Kuo, D.W.3    El-Sherbeini, M.4    Tan, Y.5
  • 9
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
    • doi: 10.1016/j.cell.2011.11.062
    • Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, et al. (2012) Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones. Cell 148: 556-567. doi:10.1016/j.cell.2011.11.062. PubMed: 22304921.
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5
  • 10
    • 34848869695 scopus 로고    scopus 로고
    • Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    • doi: 10.1074/jbc.M704165200
    • Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, et al. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem 282: 26687-26695. doi:10.1074/jbc.M704165200. PubMed: 17623664.
    • (2007) J Biol Chem , vol.282 , pp. 26687-26695
    • Kurosu, H.1    Choi, M.2    Ogawa, Y.3    Dickson, A.S.4    Goetz, R.5
  • 11
    • 70350455732 scopus 로고    scopus 로고
    • Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects
    • doi: 10.1152/ajpendo.00348.2009
    • Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, et al. (2009) Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab 297: E1105-E1114. doi:10.1152/ajpendo.00348.2009. PubMed: 19706786.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Xu, J.1    Stanislaus, S.2    Chinookoswong, N.3    Lau, Y.Y.4    Hager, T.5
  • 12
    • 57349098220 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 corrects obesity in mice
    • doi: 10.1210/en.2008-0816
    • Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, et al. (2008) Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149: 6018-6027. doi:10.1210/en.2008-0816. PubMed: 18687777.
    • (2008) Endocrinology , vol.149 , pp. 6018-6027
    • Coskun, T.1    Bina, H.A.2    Schneider, M.A.3    Dunbar, J.D.4    Hu, C.C.5
  • 13
    • 33845407972 scopus 로고    scopus 로고
    • Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling
    • doi: 10.1002/jcp.20847
    • Moyers JS, Shiyanova TL, Mehrbod F, Dunbar JD, Noblitt TW, et al. (2007) Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling. J Cell Physiol 210: 1-6. doi:10.1002/jcp.20847. PubMed: 17063460.
    • (2007) J Cell Physiol , vol.210 , pp. 1-6
    • Moyers, J.S.1    Shiyanova, T.L.2    Mehrbod, F.3    Dunbar, J.D.4    Noblitt, T.W.5
  • 14
    • 84865741904 scopus 로고    scopus 로고
    • betaKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
    • doi: 10.1016/j.cmet.2012.08.002
    • Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, et al. (2012) betaKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism. Cell Metab 16: 387-393. doi:10.1016/j.cmet.2012.08.002. PubMed: 22958921.
    • (2012) Cell Metab , vol.16 , pp. 387-393
    • Ding, X.1    Boney-Montoya, J.2    Owen, B.M.3    Bookout, A.L.4    Coate, K.C.5
  • 15
    • 84905679771 scopus 로고    scopus 로고
    • The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
    • doi: 10.1016/j.molmet.2012.08.007
    • Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, et al. (2013) The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Molecular Metabolism 2: 31-37. doi:10.1016/j.molmet.2012.08.007.
    • (2013) Molecular Metabolism , vol.2 , pp. 31-37
    • Adams, A.C.1    Yang, C.2    Coskun, T.3    Cheng, C.C.4    Gimeno, R.E.5
  • 16
    • 84863637593 scopus 로고    scopus 로고
    • FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
    • doi: 10.1371/journal.pone.0040164
    • Véniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, et al. (2012) FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLOS ONE 7: e40164. doi:10.1371/journal.pone.0040164. PubMed: 22792234.
    • (2012) PLOS ONE , vol.7
    • Véniant, M.M.1    Hale, C.2    Helmering, J.3    Chen, M.M.4    Stanislaus, S.5
  • 17
    • 84877272187 scopus 로고    scopus 로고
    • An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
    • doi: 10.1016/j.cmet.2013.03.019
    • Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, et al. (2013) An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab 17: 790-797. doi:10.1016/j.cmet.2013.03.019. PubMed: 23663742.
    • (2013) Cell Metab , vol.17 , pp. 790-797
    • Holland, W.L.1    Adams, A.C.2    Brozinick, J.T.3    Bui, H.H.4    Miyauchi, Y.5
  • 18
    • 84877260638 scopus 로고    scopus 로고
    • Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
    • doi: 10.1016/j.cmet.2013.04.005
    • Lin Z, Tian H, Lam KS, Lin S, Hoo RC, et al. (2013) Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab 17: 779-789. doi:10.1016/j.cmet.2013.04.005. PubMed: 23663741.
    • (2013) Cell Metab , vol.17 , pp. 779-789
    • Lin, Z.1    Tian, H.2    Lam, K.S.3    Lin, S.4    Hoo, R.C.5
  • 19
    • 84879149663 scopus 로고    scopus 로고
    • Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity
    • Murphy M, Samms R, Warner A, Bolborea M, Barrett P, et al. (2012) Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity. J Neuroendocrinol.
    • (2012) J Neuroendocrinol
    • Murphy, M.1    Samms, R.2    Warner, A.3    Bolborea, M.4    Barrett, P.5
  • 20
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • doi: 10.1101/gad.177857.111
    • Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, et al. (2012) FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26: 271-281. doi:10.1101/gad.177857.111. PubMed: 22302939.
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3    Fox, E.C.4    Mepani, R.J.5
  • 21
    • 84885484874 scopus 로고    scopus 로고
    • PEGylated FGF21 Rapidly Normalizes Insulin-Stimulated Glucose Utilization in Diet-Induced Insulin Resistant Mice
    • (. (2013)), 23831019
    • Camacho RC, (2013) PEGylated FGF21 Rapidly Normalizes Insulin-Stimulated Glucose Utilization in Diet-Induced Insulin Resistant Mice. Eur J Pharmacol (. (2013)) PubMed: 23831019.
    • (2013) Eur J Pharmacol
    • Camacho, R.C.1
  • 22
    • 77956253088 scopus 로고    scopus 로고
    • Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters
    • doi: 10.1124/mol.110.064980
    • Zhao W, Fong O, Muise ES, Thompson JR, Weingarth D, et al. (2010) Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters. Mol Pharmacol 78: 350-359. doi:10.1124/mol.110.064980. PubMed: 20530130.
    • (2010) Mol Pharmacol , vol.78 , pp. 350-359
    • Zhao, W.1    Fong, O.2    Muise, E.S.3    Thompson, J.R.4    Weingarth, D.5
  • 23
    • 0032544690 scopus 로고    scopus 로고
    • Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes
    • doi: 10.1074/jbc.273.38.24665
    • Souza SC, de Vargas LM, Yamamoto MT, Lien P, Franciosa MD, et al. (1998) Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J Biol Chem 273: 24665-24669. doi:10.1074/jbc.273.38.24665. PubMed: 9733764.
    • (1998) J Biol Chem , vol.273 , pp. 24665-24669
    • Souza, S.C.1    de Vargas, L.M.2    Yamamoto, M.T.3    Lien, P.4    Franciosa, M.D.5
  • 24
    • 0036583926 scopus 로고    scopus 로고
    • Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
    • doi: 10.1074/mcp.M200025-MCP200
    • Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, et al. (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1: 376-386. doi:10.1074/mcp.M200025-MCP200. PubMed: 12118079.
    • (2002) Mol Cell Proteomics , vol.1 , pp. 376-386
    • Ong, S.E.1    Blagoev, B.2    Kratchmarova, I.3    Kristensen, D.B.4    Steen, H.5
  • 25
    • 0030458404 scopus 로고    scopus 로고
    • Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha
    • doi: 10.1210/me.10.11.1457
    • Zhang B, Berger J, Hu E, Szalkowski D, White-Carrington S, et al. (1996) Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol 10: 1457-1466. doi:10.1210/me.10.11.1457. PubMed: 8923470.
    • (1996) Mol Endocrinol , vol.10 , pp. 1457-1466
    • Zhang, B.1    Berger, J.2    Hu, E.3    Szalkowski, D.4    White-Carrington, S.5
  • 26
    • 0029918680 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
    • doi: 10.1074/jbc.271.11.6497
    • Chu Y, Solski PA, Khosravi-Far R, Der CJ, Kelly K, (1996) The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem 271: 6497-6501. doi:10.1074/jbc.271.11.6497. PubMed: 8626452.
    • (1996) J Biol Chem , vol.271 , pp. 6497-6501
    • Chu, Y.1    Solski, P.A.2    Khosravi-Far, R.3    Der, C.J.4    Kelly, K.5
  • 27
    • 58149359604 scopus 로고    scopus 로고
    • Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis
    • doi: 10.1165/rcmb.2008-0147OC
    • Minowada G, Miller YE, (2009) Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol 40: 31-37. doi:10.1165/rcmb.2008-0147OC. PubMed: 18635814.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 31-37
    • Minowada, G.1    Miller, Y.E.2
  • 28
    • 33748657539 scopus 로고    scopus 로고
    • Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs
    • doi: 10.1096/fj.06-6042com
    • Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE, (2006) Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J 20: 1855-1864. doi:10.1096/fj.06-6042com. PubMed: 16940157.
    • (2006) FASEB J , vol.20 , pp. 1855-1864
    • Hunt, M.C.1    Rautanen, A.2    Westin, M.A.3    Svensson, L.T.4    Alexson, S.E.5
  • 29
    • 0037315168 scopus 로고    scopus 로고
    • Role of the fatty acid binding protein mal1 in obesity and insulin resistance
    • doi: 12540600
    • Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, et al. (2003) Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes 52: 300-307. PubMed: 12540600.
    • (2003) Diabetes , vol.52 , pp. 300-307
    • Maeda, K.1    Uysal, K.T.2    Makowski, L.3    Görgün, C.Z.4    Atsumi, G.5
  • 30
    • 78751489992 scopus 로고    scopus 로고
    • Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
    • doi: 10.1194/jlr.M011205
    • Basantani MK, Sitnick MT, Cai L, Brenner DS, Gardner NP, et al. (2011) Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res 52: 318-329. doi:10.1194/jlr.M011205. PubMed: 21068004.
    • (2011) J Lipid Res , vol.52 , pp. 318-329
    • Basantani, M.K.1    Sitnick, M.T.2    Cai, L.3    Brenner, D.S.4    Gardner, N.P.5
  • 31
    • 0034717015 scopus 로고    scopus 로고
    • Energy metabolism in uncoupling protein 3 gene knockout mice
    • doi: 10.1074/jbc.M910179199
    • Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, et al. (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem 275: 16258-16266. doi:10.1074/jbc.M910179199. PubMed: 10748196.
    • (2000) J Biol Chem , vol.275 , pp. 16258-16266
    • Vidal-Puig, A.J.1    Grujic, D.2    Zhang, C.Y.3    Hagen, T.4    Boss, O.5
  • 32
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization
    • doi: 10.1210/en.143.3.998
    • Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, et al. (2002) Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 143: 998-1007. doi:10.1210/en.143.3.998. PubMed: 11861525.
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1    Wagner, J.A.2    Berger, J.3    Doebber, T.4    Wang, W.J.5
  • 33
    • 77954844177 scopus 로고    scopus 로고
    • Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
    • doi: 10.1126/science.1188280
    • Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, et al. (2010) Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329: 454-457. doi:10.1126/science.1188280. PubMed: 20558665.
    • (2010) Science , vol.329 , pp. 454-457
    • Ouchi, N.1    Higuchi, A.2    Ohashi, K.3    Oshima, Y.4    Gokce, N.5
  • 34
    • 84872076992 scopus 로고    scopus 로고
    • Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans
    • doi: 10.1210/jc.2012-2466
    • Hu W, Li L, Yang M, Luo X, Ran W, et al. (2013) Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans. J Clin Endocrinol Metab 98: 290-298. doi:10.1210/jc.2012-2466. PubMed: 23185036.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 290-298
    • Hu, W.1    Li, L.2    Yang, M.3    Luo, X.4    Ran, W.5
  • 35
    • 84874818457 scopus 로고    scopus 로고
    • Characterization of the Wnt inhibitors secreted frizzled-related proteins (SFRPs) in human adipose tissue
    • doi: 10.1210/jc.2012-3416
    • Ehrlund A, Mejhert N, Lorente-Cebrián S, Aström G, Dahlman I, et al. (2013) Characterization of the Wnt inhibitors secreted frizzled-related proteins (SFRPs) in human adipose tissue. J Clin Endocrinol Metab 98: E503-E508. doi:10.1210/jc.2012-3416. PubMed: 23393180.
    • (2013) J Clin Endocrinol Metab , vol.98
    • Ehrlund, A.1    Mejhert, N.2    Lorente-Cebrián, S.3    Aström, G.4    Dahlman, I.5
  • 36
    • 84863116228 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma
    • doi: 10.1073/pnas.1200797109
    • Wei W, Dutchak PA, Wang X, Ding X, Wang X, et al. (2012) Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci U S A 109: 3143-3148. doi:10.1073/pnas.1200797109. PubMed: 22315431.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3143-3148
    • Wei, W.1    Dutchak, P.A.2    Wang, X.3    Ding, X.4    Wang, X.5
  • 37
    • 37549052177 scopus 로고    scopus 로고
    • Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
    • doi: 10.1128/MCB.00992-07
    • Wang H, Qiang L, Farmer SR, (2008) Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Mol Cell Biol 28: 188-200. doi:10.1128/MCB.00992-07. PubMed: 17954559.
    • (2008) Mol Cell Biol , vol.28 , pp. 188-200
    • Wang, H.1    Qiang, L.2    Farmer, S.R.3


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