메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages

Impaired Hypothalamic mTOR Activation in the Adult Rat Offspring Born to Mothers Fed a Low-Protein Diet

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE;

EID: 84883610723     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074990     Document Type: Article
Times cited : (10)

References (48)
  • 1
    • 0027529974 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
    • Barker D, Hales C, Fall C, Osmond C, Phipps K, et al. (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36: 62-67.
    • (1993) Diabetologia , vol.36 , pp. 62-67
    • Barker, D.1    Hales, C.2    Fall, C.3    Osmond, C.4    Phipps, K.5
  • 2
    • 33750597519 scopus 로고    scopus 로고
    • The Importance of Catch-up Growth after Early Malnutrition for the Programming of Obesity in Male Rat[ast]
    • Bieswal F, Ahn M-T, Reusens B, Holvoet P, Raes M, et al. (2006) The Importance of Catch-up Growth after Early Malnutrition for the Programming of Obesity in Male Rat[ast]. Obesity 14: 1330-1343.
    • (2006) Obesity , vol.14 , pp. 1330-1343
    • Bieswal, F.1    Ahn, M.-T.2    Reusens, B.3    Holvoet, P.4    Raes, M.5
  • 3
    • 33645282282 scopus 로고    scopus 로고
    • A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat
    • Zambrano E, Bautista CJ, Deás M, Martínez-Samayoa PM, González-Zamorano M, et al. (2006) A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. The Journal of Physiology 571: 221-230.
    • (2006) The Journal of Physiology , vol.571 , pp. 221-230
    • Zambrano, E.1    Bautista, C.J.2    Deás, M.3    Martínez-Samayoa, P.M.4    González-Zamorano, M.5
  • 4
    • 33646799773 scopus 로고    scopus 로고
    • Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity
    • Krechowec SO, Vickers M, Gertler A, Breier BH, (2006) Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity. Journal of Endocrinology 189: 355-363.
    • (2006) Journal of Endocrinology , vol.189 , pp. 355-363
    • Krechowec, S.O.1    Vickers, M.2    Gertler, A.3    Breier, B.H.4
  • 5
    • 34648813967 scopus 로고    scopus 로고
    • Programmed Hyperphagia Due to Reduced Anorexigenic Mechanisms in Intrauterine Growth-Restricted Offspring
    • Desai M, Gayle D, Han G, Ross MG, (2007) Programmed Hyperphagia Due to Reduced Anorexigenic Mechanisms in Intrauterine Growth-Restricted Offspring. Reproductive Sciences 14: 329-337.
    • (2007) Reproductive Sciences , vol.14 , pp. 329-337
    • Desai, M.1    Gayle, D.2    Han, G.3    Ross, M.G.4
  • 7
    • 26844482535 scopus 로고    scopus 로고
    • Influence of maternal pre-pregnancy body composition and diet during early?mid pregnancy on cardiovascular function and nephron number in juvenile sheep
    • Gopalakrishnan GS, Gardner DS, Dandrea J, Langley-Evans SC, Pearce S, et al. (2005) Influence of maternal pre-pregnancy body composition and diet during early?mid pregnancy on cardiovascular function and nephron number in juvenile sheep. British Journal of Nutrition 94: 938-947.
    • (2005) British Journal of Nutrition , vol.94 , pp. 938-947
    • Gopalakrishnan, G.S.1    Gardner, D.S.2    Dandrea, J.3    Langley-Evans, S.C.4    Pearce, S.5
  • 8
    • 11144285411 scopus 로고    scopus 로고
    • Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms
    • McMullen S, Langley-Evans SC, (2005) Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms. Am J Physiol Regul Integr Comp Physiol 288: R85-90.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288
    • McMullen, S.1    Langley-Evans, S.C.2
  • 10
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
    • Hales C, Barker D, (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35: 595-601.
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.1    Barker, D.2
  • 12
    • 2442693049 scopus 로고    scopus 로고
    • Effect of maternal low-protein diet and taurine on the vulnerability of adult Wistar rat islets to cytokines
    • Merezak S, Reusens B, Renard A, Goosse K, Kalbe L, et al. (2004) Effect of maternal low-protein diet and taurine on the vulnerability of adult Wistar rat islets to cytokines. Diabetologia 47: 669-675.
    • (2004) Diabetologia , vol.47 , pp. 669-675
    • Merezak, S.1    Reusens, B.2    Renard, A.3    Goosse, K.4    Kalbe, L.5
  • 13
    • 0035173379 scopus 로고    scopus 로고
    • Prenatal programming of adult hypertension in the rat
    • Vehaskari VM, Aviles DH, Manning J, (2001) Prenatal programming of adult hypertension in the rat. Kidney Int 59: 238-245.
    • (2001) Kidney Int , vol.59 , pp. 238-245
    • Vehaskari, V.M.1    Aviles, D.H.2    Manning, J.3
  • 15
    • 65649099098 scopus 로고    scopus 로고
    • Hormones as epigenetic signals in developmental programming
    • Fowden AL, Forhead AJ, (2009) Hormones as epigenetic signals in developmental programming. Experimental Physiology 94: 607-625.
    • (2009) Experimental Physiology , vol.94 , pp. 607-625
    • Fowden, A.L.1    Forhead, A.J.2
  • 16
    • 84864910025 scopus 로고    scopus 로고
    • Alteration of mitochondrial function in adult rat offspring of malnourished dams
    • Reusens B, Theys N, Remacle C, (2011) Alteration of mitochondrial function in adult rat offspring of malnourished dams. World J Diabetes 15: 149-157.
    • (2011) World J Diabetes , vol.15 , pp. 149-157
    • Reusens, B.1    Theys, N.2    Remacle, C.3
  • 19
    • 26844503967 scopus 로고    scopus 로고
    • Fetal programming of appetite by exposure to a maternal low-protein diet in the rat
    • Bellinger L, Langley-Evans SC, (2005) Fetal programming of appetite by exposure to a maternal low-protein diet in the rat. Clin Sci 109: 413-420.
    • (2005) Clin Sci , vol.109 , pp. 413-420
    • Bellinger, L.1    Langley-Evans, S.C.2
  • 20
    • 78651326777 scopus 로고    scopus 로고
    • Epigenetic changes in early life and future risk of obesity
    • Lillycrop KA, Burdge GC, (2011) Epigenetic changes in early life and future risk of obesity. Int J Obes 35: 72-83.
    • (2011) Int J Obes , vol.35 , pp. 72-83
    • Lillycrop, K.A.1    Burdge, G.C.2
  • 21
    • 70350674919 scopus 로고    scopus 로고
    • Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome
    • Plagemann A, Harder T, Brunn M, Harder A, Roepke K, et al. (2009) Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. The Journal of Physiology 587: 4963-4976.
    • (2009) The Journal of Physiology , vol.587 , pp. 4963-4976
    • Plagemann, A.1    Harder, T.2    Brunn, M.3    Harder, A.4    Roepke, K.5
  • 22
    • 74949087038 scopus 로고    scopus 로고
    • Nutritional Programming Affects Hypothalamic Organization and Early Response to Leptin
    • Coupé B, Amarger V, Grit I, Benani A, Parnet P, (2010) Nutritional Programming Affects Hypothalamic Organization and Early Response to Leptin. Endocrinology 151: 702-713.
    • (2010) Endocrinology , vol.151 , pp. 702-713
    • Coupé, B.1    Amarger, V.2    Grit, I.3    Benani, A.4    Parnet, P.5
  • 24
    • 38549152262 scopus 로고    scopus 로고
    • Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance
    • Samuelsson A-M, Matthews PA, Argenton M, Christie MR, McConnell JM, et al. (2008) Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance. Hypertension 51: 383-392.
    • (2008) Hypertension , vol.51 , pp. 383-392
    • Samuelsson, A.-M.1    Matthews, P.A.2    Argenton, M.3    Christie, M.R.4    McConnell, J.M.5
  • 25
    • 83155175110 scopus 로고    scopus 로고
    • A common cause for a common phenotype: The gatekeeper hypothesis in fetal programming
    • McMullen S, Langley-Evans SC, Gambling L, Lang C, Swali A, et al. (2012) A common cause for a common phenotype: The gatekeeper hypothesis in fetal programming. Medical Hypotheses 78: 88-94.
    • (2012) Medical Hypotheses , vol.78 , pp. 88-94
    • McMullen, S.1    Langley-Evans, S.C.2    Gambling, L.3    Lang, C.4    Swali, A.5
  • 26
    • 78149440714 scopus 로고    scopus 로고
    • Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus
    • Orozco-Solís R, Matos RJB, Guzmán-Quevedo O, Lopes de Souza S, Bihouée A, et al. (2010) Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus. PLoS ONE 5: e13537.
    • (2010) PLoS ONE , vol.5
    • Orozco-Solís, R.1    Matos, R.J.B.2    Guzmán-Quevedo, O.3    Lopes de Souza, S.4    Bihouée, A.5
  • 27
    • 50949092240 scopus 로고    scopus 로고
    • Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR
    • Woods SC, Seeley RJ, Cota D, (2008) Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR. Annual Review of Nutrition 28: 295-311.
    • (2008) Annual Review of Nutrition , vol.28 , pp. 295-311
    • Woods, S.C.1    Seeley, R.J.2    Cota, D.3
  • 29
    • 0030912476 scopus 로고    scopus 로고
    • Components of the AIN-93 Diets as Improvements in the AIN-76A Diet
    • Reeves PG, (1997) Components of the AIN-93 Diets as Improvements in the AIN-76A Diet. The Journal of Nutrition 127: 838S-841S.
    • (1997) The Journal of Nutrition , vol.127
    • Reeves, P.G.1
  • 30
    • 38749132867 scopus 로고    scopus 로고
    • Effect of a low-protein diet during pregnancy on skeletal muscle mechanical properties of offspring rats
    • Toscano AE, Manhães-de-Castro R, Canon F, (2008) Effect of a low-protein diet during pregnancy on skeletal muscle mechanical properties of offspring rats. Nutrition 24: 270-278.
    • (2008) Nutrition , vol.24 , pp. 270-278
    • Toscano, A.E.1    Manhães-de-Castro, R.2    Canon, F.3
  • 32
    • 34247337735 scopus 로고    scopus 로고
    • Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression
    • Ikenasio-Thorpe BA, Breier BH, Vickers MH, Fraser M, (2007) Prenatal influences on susceptibility to diet-induced obesity are mediated by altered neuroendocrine gene expression. Journal of Endocrinology 193: 31-37.
    • (2007) Journal of Endocrinology , vol.193 , pp. 31-37
    • Ikenasio-Thorpe, B.A.1    Breier, B.H.2    Vickers, M.H.3    Fraser, M.4
  • 33
    • 33750631389 scopus 로고    scopus 로고
    • Gender difference in the effect of intrauterine malnutrition on the central anorexigenic action of insulin in adult rats
    • Sardinha FLC, Telles MM, Albuquerque KT, Oyama LM, Guimarães PAMP, et al. (2006) Gender difference in the effect of intrauterine malnutrition on the central anorexigenic action of insulin in adult rats. Nutrition 22: 1152-1161.
    • (2006) Nutrition , vol.22 , pp. 1152-1161
    • Sardinha, F.L.C.1    Telles, M.M.2    Albuquerque, K.T.3    Oyama, L.M.4    Guimarães, P.A.M.P.5
  • 34
    • 84856084746 scopus 로고    scopus 로고
    • Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis
    • Coupé B, Grit I, Hulin P, Randuineau G, Parnet P, (2012) Postnatal Growth after Intrauterine Growth Restriction Alters Central Leptin Signal and Energy Homeostasis. PLoS ONE 7: e30616.
    • (2012) PLoS ONE , vol.7
    • Coupé, B.1    Grit, I.2    Hulin, P.3    Randuineau, G.4    Parnet, P.5
  • 36
    • 49049114337 scopus 로고    scopus 로고
    • The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity
    • Cota D, Matter EK, Woods SC, Seeley RJ, (2008) The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity. The Journal of Neuroscience 28: 7202-7208.
    • (2008) The Journal of Neuroscience , vol.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 37
    • 70349315117 scopus 로고    scopus 로고
    • Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status
    • Villanueva EC, Münzberg H, Cota D, Leshan RL, Kopp K, et al. (2009) Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status. Endocrinology 150: 4541-4551.
    • (2009) Endocrinology , vol.150 , pp. 4541-4551
    • Villanueva, E.C.1    Münzberg, H.2    Cota, D.3    Leshan, R.L.4    Kopp, K.5
  • 38
    • 56449115916 scopus 로고    scopus 로고
    • Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
    • Blouet C, Ono H, Schwartz GJ, (2008) Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis. Cell Metabolism 8: 459-467.
    • (2008) Cell Metabolism , vol.8 , pp. 459-467
    • Blouet, C.1    Ono, H.2    Schwartz, G.J.3
  • 39
    • 63449109316 scopus 로고    scopus 로고
    • Critical Role for Hypothalamic mTOR Activity in Energy Balance
    • Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, et al. (2009) Critical Role for Hypothalamic mTOR Activity in Energy Balance. Cell Metabolism 9: 362-374.
    • (2009) Cell Metabolism , vol.9 , pp. 362-374
    • Mori, H.1    Inoki, K.2    Münzberg, H.3    Opland, D.4    Faouzi, M.5
  • 40
    • 67749120742 scopus 로고    scopus 로고
    • Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation
    • Cripps RL, Martin-Gronert MS, Archer ZA, Hales CN, Mercer JG, et al. (2009) Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation. Clinical Science 117: 85-93.
    • (2009) Clinical Science , vol.117 , pp. 85-93
    • Cripps, R.L.1    Martin-Gronert, M.S.2    Archer, Z.A.3    Hales, C.N.4    Mercer, J.G.5
  • 44
    • 63449111277 scopus 로고    scopus 로고
    • Maternal Protein Restriction Affects Postnatal Growth and the Expression of Key Proteins Involved in Lifespan Regulation in Mice
    • Chen J-H, Martin-Gronert MS, Tarry-Adkins J, Ozanne SE, (2009) Maternal Protein Restriction Affects Postnatal Growth and the Expression of Key Proteins Involved in Lifespan Regulation in Mice. PLoS ONE 4: e4950.
    • (2009) PLoS ONE , vol.4
    • Chen, J.-H.1    Martin-Gronert, M.S.2    Tarry-Adkins, J.3    Ozanne, S.E.4
  • 45
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, et al. (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431: 200-205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3    Picard, F.4    Joaquin, M.5
  • 46
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome
    • Zhang BB, Zhou G, Li C, (2009) AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome. Cell Metabolism 9: 407-416.
    • (2009) Cell Metabolism , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.