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Volumn 686, Issue , 2011, Pages 313-336

Molecular and Functional Characterization of P-Glycoprotein In Vitro

Author keywords

Astrocytes; ATP binding cassette membrane transporter; Blood brain barrier; Brain microvessel endothelial cells; Cell culture; Drug accumulation studies; Immunoblotting; P glycoprotein; Polymerase chain reaction (PCR); Transepithelial flux; Transport activity

Indexed keywords

GLYCOPROTEIN P;

EID: 79957714550     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-60761-938-3_15     Document Type: Chapter
Times cited : (9)

References (27)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Rönnbäck L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7:41–53
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 2
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins BT, Davis TP (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57(2):173–185
    • (2005) Pharmacol Rev , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 3
    • 34250177984 scopus 로고    scopus 로고
    • The blood-brain barrier and cancer: Transporters, treatment, and trojan horses
    • Deeken JF, Löscher W (2007) The blood-brain barrier and cancer: transporters, treatment, and trojan horses. Clin Cancer Res 13(6):1663–1674.
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1663-1674
    • Deeken, J.F.1    Löscher, W.2
  • 5
    • 33748949567 scopus 로고    scopus 로고
    • In situ localization of P-glycoprotein (ABCB1) in human and rat brain
    • Bendayan R, Ronaldson PT, Gingras D, Bendayan M (2006) In situ localization of P-glycoprotein (ABCB1) in human and rat brain. J Histochem Cytochem 54(10):1159–1167
    • (2006) J Histochem Cytochem , vol.54 , Issue.10 , pp. 1159-1167
    • Bendayan, R.1    Ronaldson, P.T.2    Gingras, D.3    Bendayan, M.4
  • 6
    • 85130974466 scopus 로고    scopus 로고
    • Drug transporters: Molecular characterization and role in drug disposition
    • You G. and Morris M.E., Wiley, New Jersey
    • Ronaldson PT, Babakhanian K, Bendayan R (2007) Drug transporters: molecular characterization and role in drug disposition. In: You G. and Morris M.E.(eds) Chapter 14. Drug transport in the brain, pg 411–461. Wiley, New Jersey
    • (2007) Chapter 14. Drug Transport in the Brain, Pg , pp. 411-461
    • Ronaldson, P.T.1    Babakhanian, K.2    Bendayan, R.3
  • 8
    • 0036605677 scopus 로고    scopus 로고
    • Functional expression and localization of P-glycoprotein at the blood brain barrier
    • Bendayan R, Lee G, Bendayan M (2002) Functional expression and localization of P-glycoprotein at the blood brain barrier. Microsc Res Tech 57:365–380
    • (2002) Microsc Res Tech , vol.57 , pp. 365-380
    • Bendayan, R.1    Lee, G.2    Bendayan, M.3
  • 9
    • 33646754516 scopus 로고    scopus 로고
    • Multidrug resistance-associated proteins: Expression and function in the central nervous system
    • Dallas S, Miller DS, Bendayan R (2006) Multidrug resistance-associated proteins: Expression and function in the central nervous system. Pharmacol Rev 58: 140–161
    • (2006) Pharmacol Rev , vol.58 , pp. 140-161
    • Dallas, S.1    Miller, D.S.2    Bendayan, R.3
  • 10
    • 0035253135 scopus 로고    scopus 로고
    • Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1)
    • Kusuhara H, Sugiyama Y (2001) Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1). Drug Discov Today 6(3):150–156
    • (2001) Drug Discov Today , vol.6 , Issue.3 , pp. 150-156
    • Kusuhara, H.1    Sugiyama, Y.2
  • 11
    • 4344561089 scopus 로고    scopus 로고
    • Functional expression and localization of P-glycoprotein in the central nervous system: Relevance to the pathogenesis and treatment of neurological disorders
    • Lee G, Bendayan R (2004) Functional expression and localization of P-glycoprotein in the central nervous system: Relevance to the pathogenesis and treatment of neurological disorders. Pharm Res 21(8):1313–1330
    • (2004) Pharm Res , vol.21 , Issue.8 , pp. 1313-1330
    • Lee, G.1    Bendayan, R.2
  • 12
    • 0035254189 scopus 로고    scopus 로고
    • Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2)
    • Kusuhara H, Sugiyama Y (2001) Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2). Drug Discov Today 6(4):206–212
    • (2001) Drug Discov Today , vol.6 , Issue.4 , pp. 206-212
    • Kusuhara, H.1    Sugiyama, Y.2
  • 13
    • 33745831231 scopus 로고    scopus 로고
    • Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters
    • Choudhuri S and Klaassen C (2006) Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol 25(4):231–259
    • (2006) Int J Toxicol , vol.25 , Issue.4 , pp. 231-259
    • Choudhuri, S.1    Klaassen, C.2
  • 14
    • 38549096764 scopus 로고    scopus 로고
    • Immortalized human brain endothelial cells and flow-based vascular modeling: A marriage of convenience for rational neurovascular studies
    • Cucullo L, Couraud P, Weksler B, Romero IA, Hossain M, Rapp E, Janigro D (2008) Immortalized human brain endothelial cells and flow-based vascular modeling: A marriage of convenience for rational neurovascular studies. J Cereb Blood Flow Metab 28:312–328
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 312-328
    • Cucullo, L.1    Couraud, P.2    Weksler, B.3    Romero, I.A.4    Hossain, M.5    Rapp, E.6    Janigro, D.7
  • 16
    • 0028024646 scopus 로고
    • Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells
    • Roux F, Durieu-Trautmann O, Chaverot N, Claire M, Mailly P, Bourre J, Strosberg AD, Couraud P (1994) Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J Cell Physiol 159:101–113
    • (1994) J Cell Physiol , vol.159 , pp. 101-113
    • Roux, F.1    Durieu-Trautmann, O.2    Chaverot, N.3    Claire, M.4    Mailly, P.5    Bourre, J.6    Strosberg, A.D.7    Couraud, P.8
  • 17
    • 0033868095 scopus 로고    scopus 로고
    • Controversy surrounding the existence of discrete functional classes of astrocytes in adult gray matter
    • Walz W (2000) Controversy surrounding the existence of discrete functional classes of astrocytes in adult gray matter. Glia 31:95–103
    • (2000) Glia , vol.31 , pp. 95-103
    • Walz, W.1
  • 18
    • 48249151774 scopus 로고    scopus 로고
    • HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells
    • Ronaldson PT, Bendayan R (2008) HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells. J Neurochem 106(3):1298–1313
    • (2008) J Neurochem , vol.106 , Issue.3 , pp. 1298-1313
    • Ronaldson, P.T.1    Bendayan, R.2
  • 19
    • 33747604377 scopus 로고    scopus 로고
    • HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein
    • Ronaldson PT, Bendayan R (2006) HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein. Mol Pharmacol 70(3):1087–1098
    • (2006) Mol Pharmacol , vol.70 , Issue.3 , pp. 1087-1098
    • Ronaldson, P.T.1    Bendayan, R.2
  • 20
    • 2042451616 scopus 로고    scopus 로고
    • Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures
    • Ronaldson PT, Bendayan M, Gingras D, Piquette-Miller M, R Bendayan (2004) Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures. J Neurochem 89:788–800
    • (2004) J Neurochem , vol.89 , pp. 788-800
    • Ronaldson, P.T.1    Bendayan, M.2    Gingras, D.3    Piquette-Miller, M.4    Bendayan, R.5
  • 21
    • 2442673340 scopus 로고    scopus 로고
    • Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines
    • Ronaldson PT, Lee G, Dallas S, Bendayan R (2004) Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines. Pharm Res 21:811–818
    • (2004) Pharm Res , vol.21 , pp. 811-818
    • Ronaldson, P.T.1    Lee, G.2    Dallas, S.3    Bendayan, R.4
  • 22
    • 39149144011 scopus 로고    scopus 로고
    • Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function
    • Colgan OC, Collins NT, Ferguson G, Murphy RP, Birney YA, Cahill PA, Cummins PM (2008) Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function. Brain Res 1193:84–92
    • (2008) Brain Res , vol.1193 , pp. 84-92
    • Colgan, O.C.1    Collins, N.T.2    Ferguson, G.3    Murphy, R.P.4    Birney, Y.A.5    Cahill, P.A.6    Cummins, P.M.7
  • 24
    • 34547500470 scopus 로고    scopus 로고
    • Localization of P-glycoprotein at the nuclear envelope of rat brain cells
    • Babakhanian K, Bendayan M, Bendayan R (2007) Localization of P-glycoprotein at the nuclear envelope of rat brain cells. Biochem Biophys Res Commun 361(2):301–306
    • (2007) Biochem Biophys Res Commun , vol.361 , Issue.2 , pp. 301-306
    • Babakhanian, K.1    Bendayan, M.2    Bendayan, R.3
  • 25
    • 0023786746 scopus 로고
    • Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells
    • Richert ND, Aldwin L, Nitecki D, Gottesman MM, Pastan I (1988) Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry 27:7607–7613
    • (1988) Biochemistry , vol.27 , pp. 7607-7613
    • Richert, N.D.1    Aldwin, L.2    Nitecki, D.3    Gottesman, M.M.4    Pastan, I.5
  • 26
    • 0242599280 scopus 로고    scopus 로고
    • Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: What they are and what they do
    • Kiernan JA (2000) Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: What they are and what they do. Micros Today 00-1:8–12
    • (2000) Micros Today , pp. 00-01
    • Kiernan, J.A.1
  • 27
    • 34249879813 scopus 로고    scopus 로고
    • Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems
    • Lee G, Babakhanian K, Ramaswamy M, Prat A, Wosik K, Bendayan R (2007) Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems. Pharm Res 24(7):1262–1274
    • (2007) Pharm Res , vol.24 , Issue.7 , pp. 1262-1274
    • Lee, G.1    Babakhanian, K.2    Ramaswamy, M.3    Prat, A.4    Wosik, K.5    Bendayan, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.