Stimulated human peripheral T cells produce high amounts of IL-35 protein in a proliferation-dependent manner

Cytokine

Volumn 64, Issue 1, 2013, Pages 46-50

  Guttek, Karina ^a   Reinhold, Dirk ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Cyclosporine A; Dexamethasone; ELISA; IL 35; Stimulated human T cells

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; INTERLEUKIN 12P35; INTERLEUKIN 35; RAPAMYCIN;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ CD25- T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T CELL CULTURE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

HUMAN HERPESVIRUS 4;

CYCLOSPORINE A; DEXAMETHASONE; EBI3; ELISA; EPSTEIN-BARR VIRUS-INDUCED GENE 3; FORKHEAD BOX P3; FOXP3; IL; IL-35; INTERLEUKIN; PBMC; PERIPHERAL BLOOD MONONUCLEAR CELLS; STIMULATED HUMAN T CELLS; TGF-SS; TRANSFORMING GROWTH FACOR-BETA;

ANTIGENS, CD28; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYCLOSPORINE; DEXAMETHASONE; HUMANS; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKINS; LYMPHOCYTE ACTIVATION; SIROLIMUS;

EID: 84883559578     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2013.04.037     Document Type: Article

References (14)

1. Niedbala W., Wei X.Q., Cai B., Hueber A.J., Leung B.P., McInnes I.B., et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol 2007, 37:3021-3029.
2. Collison L.W., Workman C.J., Kuo T.T., Boyd K., Wang Y., Vignali K.M., et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007, 450:566-569.
3. Bettini M., Vignali D.A. Regulatory T cells and inhibitory cytokines in autoimmunity. Curr Opin Immunol 2009, 21:612-618.
4. Collison L.W., Chaturvedi V., Henderson A.L., Giacomin P.R., Guy C., Bankoti J., et al. IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 2010, 11:1093-1101.
5. Chaturvedi V., Collison L.W., Guy C.S., Workman C.J., Vignali D.A. Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol 2011, 186:6661-6666.
6. Bardel E., Larousserie F., Charlot-Rabiega P., Coulomb-L'Herminé A., Devergne O. Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35. J Immunol 2008, 181:6898-6905.
7. Allan S.E., Song-Zhao G.X., Abraham T., McMurchy A.N., Levings M.K. Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. Eur J Immunol 2008, 38:3282-3289.
8. Gillis S., Crabtree G.R., Smith K.A. Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. J Immunol 1979, 123(4):1624-1631.
9. Ho S., Clipstone N., Timmermann L., Northrop J., Graef I., Fiorentino D., et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol 1996, 80(3 Pt 2):S40-S45.
10. Abraham R.T., Wiederrecht G.J. Immunopharmacology of rapamycin. Annu Rev Immunol 1996, 14:483-510.
11. Li X., Mai J., Virtue A., Yin Y., Gong R., Sha X., et al. IL-35 is a novel responsive anti-inflammatory cytokine - a new system of categorizing anti-inflammatory cytokines. PLoS ONE 2012, 7:e33628.
12. Liu F., Tong F., He Y., Liu H. Detectable expression of IL-35 in CD4+ T cells from peripheral blood of chronic hepatitis B patients. Clin Immunol 2011, 139:1-5.
13. Langhans B., Braunschweiger I., Arndt S., Schulte W., Satoguina J., Layland L.E., et al. Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C. Clin Sci 2010, 119:97-109.
14. Seyerl M., Kirchberger S., Majdic O., Seipelt J., Jindra C., Schrauf C., et al. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol 2010, 40:321-329.