Forkhead box O1 (FOXO1) in pregnant human myometrial cells: A role as a pro-inflammatory mediator in human parturition

Journal of Reproductive Immunology

Volumn 99, Issue 1-2, 2013, Pages 24-32

  Lappas, Martha ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MERCY HOSPITAL FOR WOMEN   (Australia)

Author keywords

Cytokines; FOXO1; Inflammation; Labour; Myometrium; Prostaglandins

Indexed keywords

GELATINASE B; INTERLEUKIN 1BETA; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; TRANSCRIPTION FACTOR FKHR;

ARTICLE; BIRTH; CONTROLLED STUDY; CYTOKINE RESPONSE; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; LABOR; MYOMETRIUM; PREGNANT WOMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION;

CYTOKINES; FOXO1; INFLAMMATION; LABOUR; MYOMETRIUM; PROSTAGLANDINS;

CELLS, CULTURED; CYCLOOXYGENASE 2; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MATRIX METALLOPROTEINASE 9; MYOMETRIUM; PARTURITION; PREGNANCY; PREMATURE BIRTH; PROSTAGLANDINS; RNA, SMALL INTERFERING;

EID: 84883558806     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2013.04.005     Document Type: Article

References (51)

1. Alblowi J., et al. High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing. Am. J. Pathol. 2009, 175:1574-1585.
2. Allport V.C., et al. Human labour is associated with nuclear factor-kappab activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'. Mol. Hum. Reprod. 2001, 7:581-586.
3. Barros F.C., et al. Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions. BMC Pregnancy Childbirth 2010, 10(Suppl. 1):S3.
4. Behl Y., et al. Foxo1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes 2009, 58:917-925.
5. Bowen J.M., et al. Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. Placenta 2002, 23:257-273.
6. Chevillard G., et al. Identification of interleukin-1beta regulated genes in uterine smooth muscle cells. Reproduction 2007, 134:811-822.
7. Choi S.J., et al. Changes of nuclear factor kappa b (nf-κb), cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) in human myometrium before and during term labor. Eur. J. Obstet. Gynecol. Reprod. Biol. 2007, 132:182-188.
8. Christiaens I., et al. Inflammatory processes in preterm and term parturition. J. Reprod. Immunol. 2008, 79:50-57.
9. Chwalisz K., et al. Cervical ripening with the cytokines interleukin 8, interleukin 1 beta and tumour necrosis factor alpha in guinea-pigs. Hum. Reprod. 1994, 9:2173-2181.
10. Crankshaw D.J., Dyal R. Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contractility of the human lower uterine segment in vitro. Can. J. Physiol. Pharmacol. 1994, 72:870-874.
11. El Maradny E., et al. Biochemical changes in the cervical tissue of rabbit induced by interleukin-8, interleukin-1beta, dehydroepiandrosterone sulphate and prostaglandin e2: A comparative study. Hum. Reprod. 1996, 11:1099-1104.
12. Fan W., et al. Foxo1 regulates tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010, 29:4223-4236.
13. Fata J.E., et al. Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors. Cell. Mol. Life Sci. 2000, 57:77-95.
14. Feng X., et al. Cdc25a regulates matrix metalloprotease 1 through foxo1 and mediates metastasis of breast cancer cells. Mol. Cell. Biol. 2011, 31:3457-3471.
15. Ferdous A., et al. Forkhead factor foxo1 is essential for placental morphogenesis in the developing embryo. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:16307-16312.
16. Hosaka T., et al. Disruption of forkhead transcription factor (foxo) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:2975-2980.
17. Hua R., et al. Stretch and inflammatory cytokines drive myometrial chemokine expression via nf-kappab activation. Endocrinology 2012, 153:481-491.
18. Ito Y., et al. Foxo1 increases pro-inflammatory gene expression by inducing c/ebp beta in tnf-alpha-treated adipocytes. Biochem. Biophys. Res. Commun. 2009, 378:290-295.
19. Keelan J.A., et al. Cytokines, prostaglandins and parturition - a review. Placenta 2003, 24(Suppl. A):S33-S46.
20. Kovacs K.A., et al. Involvement of fkhr (foxo1) transcription factor in human uterus leiomyoma growth. Fertil. Steril. 2010, 94:1491-1495.
21. Kyo S., et al. Forkhead transcription factor foxo1 is a direct target of progestin to inhibit endometrial epithelial cell growth. Clin. Cancer Res. 2011, 17:525-537.
22. 2 isozymes in pregnancy and parturition. Prostaglandins Leukot. Essent. Fatty Acids 2004, 70:87-100.
23. Lappas M., et al. Nuclear factor kappa b regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol. Reprod. 2002, 67:668-673.
24. Lappas M., et al. N-acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappab deoxyribonucleic acid-binding activity in human fetal membranes in vitro. J. Clin. Endocrinol. Metab. 2003, 88:1723-1729.
25. Lappas M., et al. Regulation of phospholipase isozymes by nuclear factor-kappab in human gestational tissues in vitro. J. Clin. Endocrinol. Metab. 2004, 89:2365-2372.
26. Lappas M., et al. 15-deoxy-delta(12,14)-prostaglandin j(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues. Placenta 2006, 27:1060-1072.
27. Lappas M., et al. Localisation and expression of foxo1 proteins in human gestational tissues. Placenta 2009, 30:256-262.
28. Lappas M., et al. Increased expression of ac-foxo1 protein in prelabor fetal membranes overlying the cervix: possible role in human fetal membrane rupture. Reprod. Sci. 2009, 16:635-641.
29. Lappas M., et al. Expression and localisation of foxo3 and foxo4 in human placenta and fetal membranes. Placenta 2010, 31:1043-1050.
30. Lim R., et al. Human labour is associated with decreased cytoplasmic foxo4. Placenta 2012, 33:52-59.
31. Lirussi F., et al. Sar150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis. Br. J. Pharmacol. 2010, 159:1354-1366.
32. Manase K., et al. Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Reprod. Biol. Endocrinol. 2006, 4:32.
33. Miao H.M., et al. Foxo1 increases ccl20 to promote nf-kappa b-dependent lymphocyte chemotaxis. Mol. Endocrinol. 2012, 26:423-437.
34. Monga M., Sanborn B.M. Uterine contractile activity introduction. Semin. Perinatol. 1995, 19:1-2.
35. Olson D.M. The role of prostaglandins in the initiation of parturition. Best Pract. Res. Clin. Obstet. Gynaecol. 2003, 17:717-730.
36. Osman I., et al. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol. Hum. Reprod. 2003, 9:41-45.
37. Paik J.H., et al. Foxos are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007, 128:309-323.
38. Potente M., et al. Involvement of foxo transcription factors in angiogenesis and postnatal neovascularization. J. Clin. Invest. 2005, 115:2382-2392.
39. Rauk P.N., et al. Interleukin-6 up-regulates the oxytocin receptor in cultured uterine smooth muscle cells. Am. J. Reprod. Immunol. 2001, 45:148-153.
40. Rice G.E. Cytokines and the initiation of parturition. Front. Horm. Res. 2001, 27:113-146.
41. Roh C.R., et al. Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells. Mol. Hum. Reprod. 2000, 6:96-102.
42. Romero R., et al. Inflammation in preterm and term labour and delivery. Semin. Fetal Neonatal Med. 2006, 11:317-326.
43. Romero R., et al. The role of inflammation and infection in preterm birth. Semin. Reprod. Med. 2007, 25:21-39.
44. Sennstrom M.B., et al. Human cervical ripening, an inflammatory process mediated by cytokines. Mol. Hum. Reprod. 2000, 6:375-381.
45. Siqueira M.F., et al. Impaired wound healing in mouse models of diabetes is mediated by tnf-alpha dysregulation and associated with enhanced activation of forkhead box o1 (foxo1). Diabetologia 2010, 53:378-388.
46. Sooranna S.R., et al. Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells. Mol. Hum. Reprod. 2004, 10:109-113.
47. Sooranna S.R., et al. The mitogen-activated protein kinase dependent expression of prostaglandin h synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: The differential effect of stretch and interleukin-1{beta}. J. Clin. Endocrinol. Metab. 2005, 90:3517-3527.
48. Su D., et al. Foxo1 links insulin resistance to proinflammatory cytokine il-1β production in macrophages. Diabetes 2009, 58:2624-2633.
49. Tattersall M., et al. Pro-labour myometrial gene expression: are preterm labour and term labour the same?. Reproduction 2008, 135:569-579.
50. Thomson A.J., et al. Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Hum. Reprod. 1999, 14:229-236.
51. Tothova Z., et al. Foxos are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007, 128:325-339.