SAR150640, a selective β 3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis

British Journal of Pharmacology

Volumn 159, Issue 6, 2010, Pages 1354-1366

  Lirussi, F ^a,b,c,d   O'Brien, M ^e   Wendremaire, M ^b,c,d   Goirand, F ^a,b,c,d   Sagot, P ^b,c   Dumas, M ^b,c,d   Morrison, J J ^e   Bardou, M ^a,b,c,d  

^a INSERM   (France)

^b DIJON UNIVERSITY HOSPITAL   (France)

^c Laboratoire de Biochimie Médicale   (France)

^d UNIVERSITÉ DE BOURGOGNE   (France)

^e UNIVERSITY HOSPITAL GALWAY   (Ireland)

Author keywords

3 adrenoceptor; Bacterial infection; Chorioamnionitis; Human myometrium; Inflammation; Lipopolysaccharide; Matrix metalloproteinase (MMP); Pregnancy

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; COLLAGEN; GELATINASE A; GELATINASE B; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; SAR 150640; UNCLASSIFIED DRUG; BENZOIC ACID DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR; ETHYL 4 (4 ((2 HYDROXY 3 (4 HYDROXY 3 ((METHYLSULFONYL)AMINO)PHENOXY)PROPYL)AMINO)CYCLOHEXYL)BENZOATE; ETHYL 4-(4-((2-HYDROXY-3-(4-HYDROXY-3-((METHYLSULFONYL)AMINO)PHENOXY)PROPYL)AMINO)CYCLOHEXYL)BENZOATE; LIPOPOLYSACCHARIDE, E COLI O55 B5; LIPOPOLYSACCHARIDE, E COLI O55-B5; PROPRANOLOL; SULFONAMIDE;

ARTICLE; CHORIOAMNIONITIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; ESCHERICHIA COLI; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INCUBATION TIME; INFLAMMATION; MYOMETRIUM; PREMATURE LABOR; PRIORITY JOURNAL; STAINING; BIOLOGICAL MODEL; BIOSYNTHESIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; PATHOLOGY; PREGNANCY; WESTERN BLOTTING;

BENZOATES; BLOTTING, WESTERN; CHORIOAMNIONITIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASES; MODELS, BIOLOGICAL; MYOMETRIUM; PREGNANCY; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA-3; SULFONAMIDES;

EID: 77949367463     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00616.x     Document Type: Article

References (55)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2): S1-S209.
2. Ananth CV, Misra DP, Demissie K, Smulian JC (2001). Rates of preterm delivery among black women and white women in the United States over two decades: an age-period-cohort analysis. Am J Epidemiol 154: 657-665.
3. Bardou M, Loustalot C, Cortijo J, Simon B, Naline E, Dumas M et al. (2000). Functional, biochemical and molecular biological evidence for a possible beta(3)-adrenoceptor in human near-term myometrium. Br J Pharmacol 130: 1960-1966.
4. Borges LF, Gutierrez PS, Marana HR, Taboga SR (2007). Picrosirius-polarization staining method as an efficient histopathological tool for collagenolysis detection in vesical prolapse lesions. Micron 38: 580-583.
5. Christiaens I, Zaragoza DB, Guilbert L, Robertson SA, Mitchell BF, Olson DM (2008). Inflammatory processes in preterm and term parturition. J Reprod Immunol 79: 50-57.
6. Croci T, Cecchi R, Marini P, Rouget C, Viviani N, Germain G et al. (2007). In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-ph enoxy]propyl) amino]cyclohexyl-]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor. J Pharmacol Exp Ther 321: 1118-1126.
7. Dennedy MC, Houlihan DD, McMillan H, Morrison JJ (2002). Beta2- and beta3-adrenoreceptor agonists: human myometrial selectivity and effects on umbilical artery tone. Am J Obstet Gynecol 187: 641-647.
8. Edwards RK (2005). Chorioamnionitis and labor. Obstet Gynecol Clin North Am 32: 287-296.
9. Ekelund CK, Vogel I, Skogstrand K, Thorsen P, Hougaard DM, Langhoff-Roos J et al. (2008). Interleukin-18 and interleukin-12 in maternal serum and spontaneous preterm delivery. J Reprod Immunol 77: 179-185.
10. Fata JE, Ho AT, Leco KJ, Moorehead RA, Khokha R (2000). Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors. Cell Mol Life Sci 57: 77-95.
11. Fortunato SJ, Menon R, Swan KF, Lyden TW (1994). Organ culture of amniochorionic membrane in vitro. Am J Reprod Immunol 32: 184-187.
12. Goldenberg RL, Rouse DJ (1998). Prevention of premature birth. N Engl J Med 339: 313-320.
13. Goldenberg RL, Culhane JF, Iams JD, Romero R (2008). Epidemiology and causes of preterm birth. Lancet 371: 75-84.
14. Hoffmann C, Leitz MR, Oberdorf-Maass S, Lohse MJ, Klotz KN (2004). Comparative pharmacology of human beta-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol 369: 151-159.
15. Junqueira LC, Bignolas G, Brentani RR (1979). Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11: 447-455.
16. Labied S, Galant C, Nisolle M, Ravet S, Munaut C, Marbaix E et al. (2009). Differential elevation of matrix metalloproteinase expression in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time. Hum Reprod 24: 113-121.
17. Larroque B, Ancel PY, Marret S, Marchand L, Andre M, Arnaud C et al. (2008). Neurodevelopmental disabilities and special care of 5-yearold children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Lancet 371: 813-820.
18. Leroy MJ, Cedrin I, Breuiller M, Giovagrandi Y, Ferre F (1989). Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term. Biochem Pharmacol 38: 9-15.
19. Lindstrom TM, Bennett PR (2005). The role of nuclear factor kappa B in human labour. Reproduction 130: 569-581.
20. Lirussi F, Rakotoniaina Z, Madani S, Goirand F, Breuiller-Fouche M, Leroy MJ et al. (2008). ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis. Biol Reprod 78: 497-505.
21. Manase K, Endo T, Chida M, Nagasawa K, Honnma H, Yamazaki K et al. (2006). Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Reprod Biol Endocrinol 4: 32.
22. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S (2006). Births: final data for 2004. Natl Vital Stat Rep 55: 1-101.
23. Martin-Chouly CA, Astier A, Jacob C, Pruniaux MP, Bertrand C, Lagente V (2004). Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors. Life Sci 75: 823-840.
24. Maymon E, Romero R, Pacora P, Gomez R, Mazor M, Edwin S et al. (2001). A role for the 72 kDa gelatinase (MMP-2) and its inhibitor (TIMP-2) in human parturition, premature rupture of membranes and intraamniotic infection. J Perinat Med 29: 308-316.
25. Monga M, Sanborn BM (1995). Uterine contractile activity. Introduction. Semin Perinatol 19: 1-2.
26. O'Brien M, O'Shaughnessy D, Ahamide E, Morrison JJ, Smith TJ (2007). Differential expression of the metalloproteinase MMP3 and the {alpha}5 integrin subunit in human myometrium at labour. Mol Hum Reprod 13: 655-661.
27. Oger S, Mehats C, Dallot E, Cabrol D, Leroy MJ (2005). Evidence for a role of phosphodiesterase 4 in lipopolysaccharide-stimulated prostaglandin E2 production and matrix metalloproteinase-9 activity in human amniochorionic membranes. J Immunol 174: 8082-8289.
28. Oner C, Schatz F, Kizilay G, Murk W, Buchwalder LF, Kayisli UA et al. (2008). Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery. J Clin Endocrinol Metab 93: 252-259.
29. Park KH, Chaiworapongsa T, Kim YM, Espinoza J, Yoshimatsu J, Edwin S et al. (2003). Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity. J Perinat Med 31: 12-22.
30. Poon LC, Nekrasova E, Anastassopoulos P, Livanos P, Nicolaides KH (2009). First-trimester maternal serum matrix metalloproteinase-9 (MMP-9) and adverse pregnancy outcome. Prenat Diagn 29: 553-559.
31. Redline RW, Faye-Petersen O, Heller D, Qureshi F, Savell V, Vogler C (2003). Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 6: 435-448.
32. Redline RW, Heller D, Keating S, Kingdom J (2005). Placental diagnostic criteria and clinical correlation - a workshop report. Placenta 26 (Suppl. A): S114-S117.
33. Roberts SJ, Russell FD, Molenaar P, Summers RJ (1995). Characterization and localization of atypical beta-adrenoceptors in rat ileum. Br J Pharmacol 116: 2549-2556.
34. Roh CR, Oh WJ, Yoon BK, Lee JH (2000). Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells. Mol Hum Reprod 6: 96-102.
35. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel LA, Nien JK (2006). Inflammation in preterm and term labour and delivery. Semin Fetal Neonatal Med 11: 317-326.
36. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel L, Hassan S (2007). The role of inflammation and infection in preterm birth. Semin Reprod Med 25: 21-39.
37. Rouget C, Breuiller-Fouche M, Mercier FJ, Leroy MJ, Loustalot C, Naline E et al. (2004). The human near-term myometrial beta3-adrenoceptor but not the beta2-adrenoceptor is resistant to desensitisation after sustained agonist stimulation. Br J Pharmacol 141: 831-841.
38. Rouget C, Bardou M, Breuiller-Fouche M, Loustalot C, Qi H, Naline E et al. (2005). Beta3-adrenoceptor is the predominant beta-adrenoceptor subtype in human myometrium and its expression is up-regulated in pregnancy. J Clin Endocrinol Metab 90: 1644-1650.
39. Sabbah HN (2004). Biologic rationale for the use of beta-blockers in the treatment of heart failure. Heart Fail Rev 9: 91-97.
40. Schwalm H, Dubrauszky V (1966). The structure of the musculature of the human uterus - muscles and connective tissue. Am J Obstet Gynecol 94: 391-404.
41. Shimizu K, Maekawa K (1983). Collagen degradation in the mouse uterus during postpartum involution: extracellular pathway. Acta Anat (Basel) 117: 257-260.
42. Shynlova O, Mitchell JA, Tsampalieros A, Langille BL, Lye SJ (2004). Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium. Biol Reprod 70: 986-992.
43. Simon C, Einspanier A (2009). The hormonal induction of cervical remodeling in the common marmoset monkey (Callithrix jacchus). Reproduction 137: 517-525.
44. Smith R (2007). Parturition. N Engl J Med 356: 271-283.
45. Steel JH, Malatos S, Kennea N, Edwards AD, Miles L, Duggan P et al. (2005). Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor. Pediatr Res 57: 404-411.
46. Steinle JJ, Zamora DO, Rosenbaum JT, Granger HJ (2005). Beta 3-adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation. Exp Eye Res 80: 83-91.
47. Stygar D, Wang H, Vladic YS, Ekman G, Eriksson H, Sahlin L (2002). Increased level of matrix metalloproteinases 2 and 9 in the ripening process of the human cervix. Biol Reprod 67: 889-894.
48. Sweet DG, Huggett MT, Warner JA, Moss TJ, Kloosterboer N, Halliday HL et al. (2008). Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheep. Neonatology 94: 79-86.
49. Vadillo-Ortega F, Estrada-Gutierrez G (2005). Role of matrix metalloproteinases in preterm labour. BJOG 112 (Suppl. 1): 19-22.
50. Visse R, Nagase H (2003). Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92: 827-839.
51. Weiss A, Goldman S, Shalev E (2007). The matrix metalloproteinases (MMPS) in the decidua and fetal membranes. Front Biosci 12: 649-659.
52. Wieslander CK, Marinis SI, Drewes PG, Keller PW, Acevedo JF, Word RA (2008). Regulation of elastolytic proteases in the mouse vagina during pregnancy, parturition, and puerperium. Biol Reprod 78: 521-528.
53. Yonemoto H, Young CB, Ross JT, Guilbert LL, Fairclough RJ, Olson DM (2006). Changes in matrix metalloproteinase (MMP)-2 and MMP-9 in the fetal amnion and chorion during gestation and at term and preterm labor. Placenta 27: 669-677.
54. Zhang H, Sun L, Wang W Ma X (2006). Quantitative analysis of fibrosis formation on the microcapsule surface with the use of picro-sirius red staining, polarized light microscopy, and digital image analysis. J Biomed Mater Res A 76: 120-125.
55. Zhu XM, Han T, Sargent IL, Wang YL, Yao YQ (2009). Conditioned medium from human decidual stromal cells has a concentration-dependent effect on trophoblast cell invasion. Placenta 30: 74-78.