Intravenous versus intramuscular epinephrine administration during cardiopulmonary resuscitation - A pilot study in piglets

Paediatric Anaesthesia

Volumn 23, Issue 10, 2013, Pages 906-912

  Mauch, Jacqueline ^a,b   Ringer, Simone K ^c   Spielmann, Nelly ^a   Weiss, Markus ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b Kantonsspital Aarau ^*  (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Anesthetics; Cardiopulmonary resuscitation; Epinephrine; Heart arrest; Local; Ropivacaine

Indexed keywords

ADRENALIN; ROPIVACAINE; SEVOFLURANE;

ANIMAL TISSUE; ARTICLE; COMPRESSION; CONTROLLED STUDY; ELECTRIC ACTIVITY; HEART ARREST; HEART RHYTHM; INTERMETHOD COMPARISON; LUNG VENTILATION; NONHUMAN; PIGLET; PILOT STUDY; PRIORITY JOURNAL; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SWINE; TREATMENT OUTCOME;

ANESTHETICS; CARDIOPULMONARY RESUSCITATION; EPINEPHRINE; HEART ARREST; LOCAL; ROPIVACAINE;

AMIDES; ANESTHESIA; ANESTHETICS, LOCAL; ANIMALS; ARTERIAL PRESSURE; CARDIOPULMONARY RESUSCITATION; EPINEPHRINE; FEMALE; HEART ARREST; HEART RATE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; MALE; PILOT PROJECTS; SURVIVAL; SWINE; VASOCONSTRICTOR AGENTS;

EID: 84883536687     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/pan.12149     Document Type: Article

References (17)

1. Neumar RW, Otto CW, Link MS, et al,. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010; 122: 729-767.
2. Otto CW, Yakaitis RW,. The role of epinephrine in CPR: a reappraisal. Ann Emerg Med 1984; 13: 840-843.
3. Mader TJ, Kellogg AR, Walterscheid JK, et al,. A randomized comparison of cardiocerebral and cardiopulmonary resuscitation using a swine model of prolonged ventricular fibrillation. Resuscitation 2010; 81: 596-602.
4. Zuercher M, Kern KB, Indik JH, et al,. Epinephrine improves 24-hour survival in a swine model of prolonged ventricular fibrillation demonstrating that early intraosseous is superior to delayed intravenous administration. Anesth Analg 2011; 112: 884-890.
5. Nordseth T, Olasveengen TM, Kvaløy JT, et al,. Dynamic effects of adrenaline (epinephrine) in out-of-hospital cardiac arrest with initial pulseless electrical activity (PEA). Resuscitation 2012; 83: 946-952.
6. Ewy GA, Kern KB,. Recent advances in cardiopulmonary resuscitation: cardiocerebral resuscitation. J Am Coll Cardiol 2009; 53: 149-157.
7. Berg RA, Sanders AB, Kern KB, et al,. Adverse hemodynamic effects of interrupting chest compressions for rescue breathing during cardiopulmonary resuscitation for ventricular fibrillation cardiac arrest. Circulation 2001; 104: 2465-2470.
8. Jacobs IG, Finn JC, Jelinek GA, et al,. Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomised double-blind placebo-controlled trial. Resuscitation 2011; 82: 1138-1143.
9. Olasveengen TM, Sunde K, Brunborg C, et al,. Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA 2009; 302: 2222-2229.
10. Rittenberger JC, Menegazzi JJ, Callaway CW,. Association of delay to first intervention with return of spontaneous circulation in a swine model of cardiac arrest. Resuscitation 2007; 73: 154-160.
11. Reynolds JC, Rittenberger JC, Menegazzi JJ,. Drug administration in animal studies of cardiac arrest does not reflect human clinical experience. Resuscitation 2007; 74: 13-26.
12. Rittenberger JC, Bost JE, Menegazzi JJ,. Time to give the first medication during resuscitation in out-of-hospital cardiac arrest. Resuscitation 2006; 70: 201-206.
13. Walker DM,. Update on epinephrine (adrenaline) for pediatric emergencies. Curr Opin Pediatr 2009; 21: 313-319.
14. Simons FE, Gu X, Simons KJ,. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol 2001; 108: 871-873.
15. Difficult Airway Society Extubation Guidelines Group, Popat M, Mitchell V, Dravid R, et al,. Difficult Airway Society Guidelines for the management of tracheal extubation. Anaesthesia 2012; 67: 318-340.
16. Gavel G, Walker R,. Extubation guidelines: management of laryngospasm. Anaesthesia 2012; 67: 920-921.
17. Mauch JY, Weiss M, Spielmann N, et al,. Electrocardiographic and blood pressure alterations caused by intravenous injection of ropivacaine-A study in piglets. Pediatr Anesth 2013; 23: 144-148.