Electrocardiographic and blood pressure alterations caused by intravenous injection of ropivacaine - A study in piglets

Paediatric Anaesthesia

Volumn 23, Issue 2, 2013, Pages 144-148

  Mauch, Jacqueline Y ^a,b   Weiss, Markus ^a   Spielmann, Nelly ^a   Ringer, Simone K ^c  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b CANTONAL HOSPITAL AARAU   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

anesthetics local; epinephrine; heart conduction; heart rate; local anesthetics; ropivacaine; toxicity

Indexed keywords

ADRENALIN; ROPIVACAIN; ROPIVACAINE; SEVOFLURANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE FLUCTUATION; CONTINUOUS INFUSION; DRUG DOSE TITRATION; ELECTROCARDIOGRAPHY; FEMALE; HEART ARREST; HEMODYNAMIC PARAMETERS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PIGLET; PRIORITY JOURNAL; T WAVE; TACHYCARDIA;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; ARTERIAL PRESSURE; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; ENDPOINT DETERMINATION; EPINEPHRINE; FEMALE; HEART RATE; INJECTIONS, INTRAVENOUS; MALE; SWINE; VASOCONSTRICTOR AGENTS;

EID: 84872053611     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/pan.12059     Document Type: Article

References (15)

1. Polaner DM, Suresh S, Coté CJ,. Regional Anesthesia. In:, Coté CJ, Lerman J, Todres ID, eds. A practice of Anesthesia for Infants and Children. Philadelphia: Saunders Elsevier, 2009; 867.
2. Freid EB, Bailey AG, Valley RD,. Electrocardiographic and hemodynamic changes associated with unintentional intravascular injection of bupivacaine with epinephrine in infants. Anesthesiology 1993; 79: 394-398.
3. Fisher QA, Shaffner DH, Yaster M,. Detection of intravascular injection of regional anaesthetics in children. Can J Anaesth 1997; 44: 592-598.
4. Tobias JD,. Caudal epidural block: a review of test dosing and recognition of systemic injection in children. Anesth Analg 2001; 93: 1156-1161.
5. Mauch JY, Spielmann N, Hartnack S, et al,. Electrocardiographic and haemodynamic alterations caused by three different test solutions of local anaesthetics to detect accidental intravascular injection in children. Br J Anaesth 2012; 108: 283-289.
6. Mauch J, Kutter AP, Madjdpour C, et al,. Electrocardiographic alterations during intravascular application of three different test doses of bupivacaine and epinephrine: experimental study in neonatal pigs. Br J Anaesth 2010; 104: 94-97.
7. Mauch J, Kutter APN, Madjdpour C, et al,. Electrocardiographic changes during continuous intravenous application of bupivacaine in neonatal pigs. Br J Anaesth 2010; 105: 437-441.
8. Ogasawara K, Tanaka M, Nishikawa T,. Choice of electrocardiography lead does not affect the usefulness of the T-wave criterion for detecting intravascular injection of an epinephrine test dose in anesthetized children. Anesth Analg 2003; 97: 372-376.
9. Tanaka M, Nishikawa T,. Evaluating T-wave amplitude as guide for detecting intravascular injection of a test dose in anesthetized children. Anesth Analg 1999; 88: 754-758.
10. Ecoffey C, Lacroix F, Giaufré E, et al,. Epidemiology and morbidity of regional anaesthesia in children: a follow-up one-year prospective survey of the French-Language Society of Paediatric Anaesthesiologists (ADARPEF). Pediatr Anesth 2010; 20: 1061-1069.
11. Dobereiner EFA, Cox RG, Ewen A, et al,. Evidence-based clinical update: which local anesthetic drug for pediatric caudal block provides optimal efficacy with the fewest side effects? Can J Anaesth 2010; 57: 1102-1110.
12. Morrison SG, Dominguez JJ, Frascarolo P, et al,. A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine, and ropivacaine in anesthetized swine. Anesth Analg 2000; 90: 1308-1314.
13. Santos AC, DeArmas PI,. Systemic toxicity of levobupivacaine, bupivacaine, and ropivacaine during continuous intravenous infusion to nonpregnant and pregnant ewes. Anesthesiology 2001; 95: 1256-1264.
14. Udelsmann A, Silva WA, Moraes AC, et al,. Hemodynamic effects of ropivacaine and levobupivacaine intravenous injection in swines. Acta Cir Bras 2009; 24: 296-302.
15. Neal JM, Bernards CM, Butterworth JF, et al,. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med 2010; 35: 152-161.