Epinephrine improves 24-hour survival in a swine model of prolonged ventricular fibrillation demonstrating that early intraosseous is superior to delayed intravenous administration

Anesthesia and Analgesia

Volumn 112, Issue 4, 2011, Pages 884-890

  Zuercher, Mathias ^a,b   Kern, Karl B ^a,c   Indik, Julia H ^a,c   Loedl, Michael ^d   Hilwig, Ronald W ^a   Ummenhofer, Wolfgang ^b   Berg, Robert A ^a,c   Ewy, Gordon A ^a,c  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; EXPERIMENTAL PIG; FEMALE; HEART ARREST; HEART VENTRICLE FIBRILLATION; INJECTION SITE; MALE; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SURVIVAL; TREATMENT OUTCOME;

EID: 79953196835     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31820dc9ec     Document Type: Article

References (40)

1. American Heart Association. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2005;112:1-203
2. Ewy GA. Cardiocerebral resuscitation: the new cardiopulmonary resuscitation. Circulation 2005;111:2134-42 (Pubitemid 40577910)
3. Kern KB, Valenzuela TD, Clark LL, Berg RA, Hilwig RW, Berg MD, Otto CW, Newburn D, Ewy GA. An alternative approach to advancing resuscitation science. Resuscitation 2005;64:261-8 (Pubitemid 40298779)
4. Michael JR, Guerci AD, Koehler RC, Shi AY, Tsitlik J, Chandra N, Niedermeyer E, Rogers MC, Traystman RJ, Weisfeldt ML. Mechanisms by which epinephrine augments cerebral and myocardial perfusion during cardiopulmonary resuscitation in dogs. Circulation 1984;69:822-35 (Pubitemid 14125664)
5. Paradis NA, Martin GB, Rivers EP, Goetting MG, Appleton TJ, Feingold M, Nowak RM. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation. JAMA 1990;263:1106-13 (Pubitemid 20047444)
6. Brown CG, Martin DR, Pepe PE, Stueven H, Cummins RO, Gonzalez E, Jastremski M. A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. The Multicenter High-Dose Epinephrine Study group. N Engl J Med 1992;327:1051-5
7. Gueugniaud PY, Mols P, Goldstein P, Pham E, Dubien PY, Deweerdt C, Vergnion M, Petit P, Carli P. A comparison of repeated high doses and repeated standard doses of epinephrine for cardiac arrest outside the hospital. European Epinephrine Study group. N Engl J Med 1998;339:1595-601 (Pubitemid 28536134)
8. Gueugniaud PY, David JS, Chanzy E, Hubert H, Dubien PY, Mauriaucourt P, Braganca C, Billeres X, Clotteau-Lambert MP, Fuster P, Thiercelin D, Debaty G, Ricard-Hibon A, Roux P, Espesson C, Querellou E, Ducros L, Ecollan P, Halbout L, Savary D, Guillaumee F, Maupoint R, Capelle P, Bracq C, Dreyfus P, Nouguier P, Gache A, Meurisse C, Boulanger B, Lae C, Metzger J, Raphael V, Beruben A, Wenzel V, Guinhouya C, Vilhelm C, Marret E. Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation. N Engl J Med 2008;359:21-30 (Pubitemid 351931093)
9. Wenzel V, Krismer AC, Arntz HR, Sitter H, Stadlbauer KH, Lindner KH. A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation. N Engl J Med 2004;350:105-13 (Pubitemid 38056221)
10. Ong ME, Tan EH, Ng FS, Panchalingham A, Lim SH, Manning PG, Ong VY, Lim SH, Yap S, Tham LP, Ng KS, Venkataraman A. Survival outcomes with the introduction of intravenous epinephrine in the management of out-of-hospital cardiac arrest. Ann Emerg Med 2007;50:635-42 (Pubitemid 350110492)
11. Olasveengen TM, Sunde K, Brunborg C, Thowsen J,Steen PA, Wik L. Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA 2009;302:2222-9
12. Reynolds JC, Rittenberger JC, Menegazzi JJ. Drug administration in animal studies of cardiac arrest does not reflect human clinical experience. Resuscitation 2007;74:13-26 (Pubitemid 46891663)
13. McNamara RM, Spivey WH, Sussman C. Pediatric resuscitation without an intravenous line. Am J Emerg Med 1986;4:31-3 (Pubitemid 16179769)
14. Smith RJ, Keseg DP, Manley LK, Standeford T. Intraosseous infusions by prehospital personnel in critically ill pediatric patients. Ann Emerg Med 1988;17:491-5
15. Zaritsky A. Selected concepts and controversies in pediatric cardiopulmonary resuscitation. Crit Care Clin 1988;4:735-54
16. Risk of infection during CPR training and rescue: supplemental guidelines. The Emergency Cardiac Care Committee of the American Heart Association. JAMA 1989;262:2714-5
17. Niermeyer S, Kattwinkel J, Van Reempts P, Nadkarni V, Phillips B, Zideman D, Azzopardi D, Berg R, Boyle D, Boyle R, Burchfield D, Carlo W, Chameides L, Denson S, Fallat M, Gerardi M, Gunn A, Hazinski MF, Keenan W, Knaebel S, Milner A, Perlman J, Saugstad OD, Schleien C, Solimano A, Speer M, Toce S, Wiswell T, Zaritsky A. International Guidelines for Neonatal Resuscitation: an excerpt from the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: International Consensus on Science. Contributors and Reviewers for the Neonatal Resuscitation Guidelines. Pediatrics 2000;106:E29
18. Spivey WH, Crespo SG, Fuhs LR, Schoffstall JM. Plasma catecholamine levels after intraosseous epinephrine administration in a cardiac arrest model. Ann Emerg Med 1992;21: 127-31
19. Wenzel V, Lindner KH, Augenstein S, Voelckel W, Strohmenger HU, Prengel AW, Steinbach G. Intraosseous vasopressin improves coronary perfusion pressure rapidly during cardiopulmonary resuscitation in pigs. Crit Care Med 1999;27:1565-9 (Pubitemid 29406948)
20. Calkins MD, Fitzgerald G, Bentley TB, Burris D. Intraosseous infusion devices: a comparison for potential use in special operations. J Trauma 2000;48:1068-74 (Pubitemid 30436822)
21. Spriggs NM, White LJ, Martin SW, Brawley D, Chambers RM. Comparison of two intraosseous infusion techniques in an EMT training program. Acad Emerg Med 2000;7:1168
22. Hubble MW, Trigg DC. Training prehospital personnel in saphenous vein cutdown and adult intraosseous access techniques. Prehosp Emerg Care 2001;5:181-9 (Pubitemid 32322119)
23. Olsen D, Packer BE, Perrett J, Balentine H, Andrews GA. Evaluation of the bone injection gun as a method for intraosseous cannula placement for fluid therapy in adult dogs. Vet Surg 2002;31:533-40
24. Ben-Abraham R, Gur I, Vater Y, Weinbroum AA. Intraosseous emergency access by physicians wearing full protective gear. Acad Emerg Med 2003;10:1407-10 (Pubitemid 37531866)
25. Curran A, Sen A. Best evidence topic report. Bone injection gun placement of intraosseous needles. Emerg Med J 2005;22:366 (Pubitemid 40667656)
26. Lamhaut L, Dagron C, Apriotesei R, Gouvernaire J, Elie C, Marx JS, Telion C, Vivien B, Carli P. Comparison of intravenous and intraosseous access by pre-hospital medical emergency personnel with and without CBRN protective equipment. Resuscitation; 81:65-8
27. Lindner KH, Ahnefeld FW, Bowdler IM. The effect of epinephrine on hemodynamics, acid-base status and potassium during spontaneous circulation and cardiopulmonary resuscitation. Resuscitation 1988;16:251-61 (Pubitemid 18265098)
28. Lindner KH, Strohmenger HU, Prengel AW, Ensinger H, Goertz A, Weichel T. Hemodynamic and metabolic effects of epinephrine during cardiopulmonary resuscitation in a pig model. Crit Care Med 1992;20:1020-6
29. Berg RA, Kern KB, Sanders AB, Otto CW, Hilwig RW, Ewy GA. Bystander cardiopulmonary resuscitation. Is ventilation necessary? Circulation 1993;88:1907-15 (Pubitemid 23296938)
30. Berg RA, Wilcoxson D, Hilwig RW, Kern KB, Sanders AB, Otto CW, Eklund DK, Ewy GA. The need for ventilatory support during bystander CPR. Ann Emerg Med 1995;26:342-50
31. Berg RA, Kern KB, Hilwig RW, Berg MD, Sanders AB, Otto CW, Ewy GA. Assisted ventilation does not improve outcome in a porcine model of single-rescuer bystander cardiopulmonary resuscitation. Circulation 1997;95:1635-41 (Pubitemid 27142824)
32. Frascone RJ, Jensen JP, Kaye K, Salzman JG. Consecutive field trials using two different intraosseous devices. Prehosp Emerg Care 2007;11:164-71 (Pubitemid 46514903)
33. Shoor PM, Berryhill RE, Benumof JL. Intraosseous infusion: pressure-flow relationship and pharmacokinetics. J Trauma 1979;19:772-4 (Pubitemid 10196532)
34. Orlowski JP, Porembka DT, Gallagher JM, Lockrem JD, Van- Lente F. Comparison study of intraosseous, central intravenous, and peripheral intravenous infusions of emergency drugs. Am J Dis Child 1990;144:112-7 (Pubitemid 20026428)
35. Kern KB, Elchisak MA, Sanders AB, Badylak SF, Tacker WA, Ewy GA. Plasma catecholamines and resuscitation from prolonged cardiac arrest. Crit Care Med 1989;17:786-91 (Pubitemid 19199509)
36. Kern KB, Ewy GA, Voorhees WD, Babbs CF, Tacker WA. Myocardial perfusion pressure: a predictor of 24-hour survival during prolonged cardiac arrest in dogs. Resuscitation 1988;16:241-50 (Pubitemid 18265097)
37. Rittenberger JC, Bost JE, Menegazzi JJ. Time to give the first medication during resuscitation in out-of-hospital cardiac arrest. Resuscitation 2006;70:201-6 (Pubitemid 44188999)
38. Mader TJ, Kellogg AR, Walterscheid JK, Lodding CC, Sherman LD. A randomized comparison of cardiocerebral and cardiopulmonary resuscitation using a swine model of prolonged ventricular fibrillation. Resuscitation 2010;81:596-602
39. Angelos MG, Butke RL, Panchal AR, Torres CA, Blumberg A, Schneider JE, Aune SE. Cardiovascular response to epinephrine varies with increasing duration of cardiac arrest. Resuscitation 2008;77:101-10
40. Brown CG, Taylor RB, Werman HA, Luu T, Ashton J, Hamlin RL. Myocardial oxygen delivery/consumption during cardiopulmonary resuscitation: a comparison of epinephrine and phenylephrine. Ann Emerg Med 1988;17:302-8