The small-molecule TNF-α inhibitor, UTL-5g, delays deaths and increases survival rates for mice treated with high doses of cisplatin

Cancer Chemotherapy and Pharmacology

Volumn 72, Issue 3, 2013, Pages 703-707

  Shaw, Jiajiu ^a   Media, Joseph ^b   Chen, Ben ^a   Valeriote, Fredrick ^b  

^a 21st Century Therapeutics   (United States)

^b HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

Animal death survival; Body weight; Cisplatin; Maximum tolerated dose; Toxicity; UTL 5g

Indexed keywords

CISPLATIN; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; UTL 5G;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TOXICITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; DRUG TOLERABILITY; EXPERIMENTAL MOUSE; FEMALE; LIVER TOXICITY; MAXIMUM TOLERATED DOSE; MOUSE; NEPHROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SURVIVAL RATE; SURVIVAL TIME; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BODY WEIGHT; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, INTRAPERITONEAL; ISOXAZOLES; MAXIMUM TOLERATED DOSE; MICE; SURVIVAL RATE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 84883487779     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2236-4     Document Type: Article

References (15)

1. Madias NE, Harrington JT (1978) Platinum nephrotoxicity. Am J Med 65(2):307-314
2. Cavalli F, Tschopp L, Sonntag RW, Zimmermann A (1978) A case of liver toxicity following cis-dichlorodiammineplatinum(II) treatment. Cancer Treat Rep 62(12):2125-2126
3. Cersosimo RJ (1993) Hepatotoxicity associated with cisplatin chemotherapy. Ann Pharmacother 27(4):438-441
4. Pollera CF, Ameglio F, Nardi M, Vitelli G, Marolla P (1987) Cisplatin-induced hepatic toxicity. J Clin Oncol 5(2):318-319
5. Subbiah U, Raghunathan M (2008) Chemoprotective action of resveratrol and genistein from apoptosis induced in human peripheral blood lymphocytes. J Biomol Struct Dyn 25(4):425-434
6. Li R, Bianchet MA, Talalay P, Amzel LM (1995) The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction. Proc Natl Acad Sci USA 92(19):8846-8850
7. Psotova J, Chlopcikova S, Miketova P, Hrbac J, Simanek V (2004) Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin. Phytother Res 18(7):516-521. doi: 10.1002/ptr.1462
8. Markman M (1998) Amifostine in reducing cisplatin toxicity. Semin Oncol 25(5):522-524
9. Phillips KA, Tannock IF (1998) Design and interpretation of clinical trials that evaluate agents that may offer protection from the toxic effects of cancer chemotherapy. J Clin Oncol 16(9):3179-3190
10. Korst AE, Gall HE, Vermorken JB, van der Vijgh WJ (1996) Pharmacokinetics of amifostine and its metabolites in the plasma and ascites of a cancer patient. Cancer Chemother Pharmacol 39(1-2):162-166
11. Culy CR, Spencer CM (2001) Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome. Drugs 61(5):641-684
12. Volckova E, Dudones LP, Bose RN (2002) HPLC determination of binding of cisplatin to DNA in the presence of biological thiols: implications of dominant platinum-thiol binding to its anticancer action. Pharm Res 19(2):124-131. doi: 10.1023/A:1014268729658
13. Sadowitz PD, Hubbard BA, Dabrowiak JC, Goodisman J, Tacka KA, Aktas MK, Cunningham MJ, Dubowy RL, Souid AK (2002) Kinetics of cisplatin binding to cellular DNA and modulations by thiol-blocking agents and thiol drugs. Drug Metab Dispos 30(2):183-190
14. Shaw J, Chen B, Huang W-H, Lee A-R, Media J, Valeriote F (2011) The small-molecule TNF-A modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo. J Exp Ther Oncol 9(2):129-137
15. Leite EA, Lana AM, Junior AD, Coelho LG, De Oliveira MC (2012) Acute toxicity study of cisplatin loaded long-circulating and pH-sensitive liposomes administered in mice. J Biomed Nanotechnol 8(2):229-239