HPLC determination of binding of cisplatin to DNA in the presence of biological thiols: Implications of dominant platinum-thiol binding to its anticancer action

Pharmaceutical Research

Volumn 19, Issue 2, 2002, Pages 124-131

  Volckova, E ^a   Dudones, L P ^b   Bose, R N ^a  

^a KENT STATE UNIVERSITY   (United States)

^b Ricerca Inc   (United States)

Author keywords

Cis diamminedichloroplatinum(II) (cisplatin); Platinum DNA binding; Platinum glutathione

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYSTEINE; DNA; GLUTATHIONE; PLATINUM; THIOL;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DNA BINDING; INCUBATION TIME; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CISPLATIN; CYSTEINE; DNA, SINGLE-STRANDED; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; PLATINUM; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFHYDRYL COMPOUNDS;

EID: 0036176697     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014268729658     Document Type: Article

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