메뉴 건너뛰기




Volumn 16, Issue 9, 1998, Pages 3179-3190

Design and interpretation of clinical trials that evaluate agents that may offer protection from the toxic effects of cancer chemotherapy

Author keywords

[No Author keywords available]

Indexed keywords

AMIFOSTINE; BLEOMYCIN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; ERYTHROPOIETIN; ETOPOSIDE; FLUOROURACIL; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; MITOXANTRONE; PREDNISONE; PROTECTIVE AGENT; RAZOXANE; VINCRISTINE;

EID: 0031698016     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.9.3179     Document Type: Review
Times cited : (45)

References (87)
  • 1
    • 0025615002 scopus 로고
    • Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting
    • DeMulder PHM, Seynaeve C, Vermorken JB, et al: Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting. Ann Intern Med 113:834-840, 1990
    • (1990) Ann Intern Med , vol.113 , pp. 834-840
    • DeMulder, P.H.M.1    Seynaeve, C.2    Vermorken, J.B.3
  • 2
    • 0026071703 scopus 로고
    • Prevention of cisplatin-induced emesis: A double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone
    • Roila F, Tonato M, Cognetti F, et al: Prevention of cisplatin-induced emesis: A double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone. J Clin Oncol 9:675-678, 1991
    • (1991) J Clin Oncol , vol.9 , pp. 675-678
    • Roila, F.1    Tonato, M.2    Cognetti, F.3
  • 3
    • 0024496307 scopus 로고
    • Phase II trials of the serotonin antagonist GR38032F for the control of vomiting caused by cisplatin
    • Kris MG, Gralla RJ, Clark RA, et al: Phase II trials of the serotonin antagonist GR38032F for the control of vomiting caused by cisplatin. J Natl Cancer Inst 81:42-46, 1989
    • (1989) J Natl Cancer Inst , vol.81 , pp. 42-46
    • Kris, M.G.1    Gralla, R.J.2    Clark, R.A.3
  • 4
    • 0027178307 scopus 로고
    • Randomized double-blind comparison of three dose levels of intravenous ondansetron in the prevention of cisplatin-induced emesis
    • Grunberg SM, Lane M, Lester EP, et al: Randomized double-blind comparison of three dose levels of intravenous ondansetron in the prevention of cisplatin-induced emesis. Cancer Chemother Pharmacol 32:268-272, 1993
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 268-272
    • Grunberg, S.M.1    Lane, M.2    Lester, E.P.3
  • 5
    • 0029362078 scopus 로고
    • Guidelines for the optimal management of chemotherapy-induced nausea and vomiting: A consensus
    • Osoba D, Warr DG, Fitch MI, et al: Guidelines for the optimal management of chemotherapy-induced nausea and vomiting: A consensus. Can J Oncol 5:381-400, 1995
    • (1995) Can J Oncol , vol.5 , pp. 381-400
    • Osoba, D.1    Warr, D.G.2    Fitch, M.I.3
  • 6
    • 0018716636 scopus 로고
    • Risk factors for doxorubicin-induced congestive heart failure
    • Von Hoff DD, Layard M, Basa P, et al: Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 91:710-717, 1979
    • (1979) Ann Intern Med , vol.91 , pp. 710-717
    • Von Hoff, D.D.1    Layard, M.2    Basa, P.3
  • 7
    • 0025155529 scopus 로고
    • Epirubicin cardiotoxicity: A study of 135 patients with advanced breast cancer
    • Nielsen D, Jensen JB, Dombernowsky P, et al: Epirubicin cardiotoxicity: A study of 135 patients with advanced breast cancer. J Clin Oncol 8:1806-1810, 1990
    • (1990) J Clin Oncol , vol.8 , pp. 1806-1810
    • Nielsen, D.1    Jensen, J.B.2    Dombernowsky, P.3
  • 8
    • 0015849162 scopus 로고
    • A clinicopathologic analysis of Adriamycin cardiotoxicity
    • Lefrak EA, Pitha J, Rosenheim S, et al: A clinicopathologic analysis of Adriamycin cardiotoxicity. Cancer 32:302-314, 1973
    • (1973) Cancer , vol.32 , pp. 302-314
    • Lefrak, E.A.1    Pitha, J.2    Rosenheim, S.3
  • 9
    • 0016797157 scopus 로고
    • Adriamycin (NSC-123127) cardiomyopathy - An overview with determination of risk factors
    • Minow RA, Benjamin RA, Gottleib JA: Adriamycin (NSC-123127) cardiomyopathy - An overview with determination of risk factors. Cancer Chemother Rep 6:195-201, 1975
    • (1975) Cancer Chemother Rep , vol.6 , pp. 195-201
    • Minow, R.A.1    Benjamin, R.A.2    Gottleib, J.A.3
  • 11
    • 0021687876 scopus 로고
    • Cardiac effects of anthracyclines used in the treatment of childhood acute lymphoblastic leukemia: A 10 year experience
    • Sallen SE, Clavell LA: Cardiac effects of anthracyclines used in the treatment of childhood acute lymphoblastic leukemia: A 10 year experience. Semin Oncol 11:19-21, 1984 (suppl 3)
    • (1984) Semin Oncol , vol.11 , Issue.3 SUPPL. , pp. 19-21
    • Sallen, S.E.1    Clavell, L.A.2
  • 12
    • 0017656527 scopus 로고
    • Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response
    • Myers CE, McGuire WP, Liss RH, et al: Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response. Science 197:165-167, 1977
    • (1977) Science , vol.197 , pp. 165-167
    • Myers, C.E.1    McGuire, W.P.2    Liss, R.H.3
  • 13
    • 0026551924 scopus 로고
    • In vitro evidence for direct complexation of ADR-529/ICRF-187 [(+)-1,2bis-(3,5-dioxopiperazinyl-1-yl)propane] onto an existing ferric-anthracycline complex
    • Sobol MM, Amiet RG, Green MD: In vitro evidence for direct complexation of ADR-529/ICRF-187 [(+)-1,2bis-(3,5-dioxopiperazinyl-1-yl)propane] onto an existing ferric-anthracycline complex. Mol Pharmacol 41:8-16, 1991
    • (1991) Mol Pharmacol , vol.41 , pp. 8-16
    • Sobol, M.M.1    Amiet, R.G.2    Green, M.D.3
  • 14
    • 0024573486 scopus 로고
    • The interaction of the cardioprotective agent ICRF-187 ((+)-1,2bis-(3,5-dioxopiperazinyl-1-yl)propane); Its hydrolysis product (ICRF-198) and other chelating agents with the Fe(III) and Cu(II) complexes of Adriamycin
    • Hasinoff BB: The interaction of the cardioprotective agent ICRF-187 ((+)-1,2bis-(3,5-dioxopiperazinyl-1-yl)propane); Its hydrolysis product (ICRF-198) and other chelating agents with the Fe(III) and Cu(II) complexes of Adriamycin. Agents Act 26:378-385, 1989
    • (1989) Agents Act , vol.26 , pp. 378-385
    • Hasinoff, B.B.1
  • 15
    • 0023693833 scopus 로고
    • Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer
    • Speyer JL, Green MD, Kramer E, et al: Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer. N Engl J Med 319:745-752, 1988
    • (1988) N Engl J Med , vol.319 , pp. 745-752
    • Speyer, J.L.1    Green, M.D.2    Kramer, E.3
  • 16
    • 0025681671 scopus 로고
    • A prospective randomized trial of ICRF-187 for prevention of cumulative doxorubicin-induced cardiac toxicity in women with breast cancer
    • Speyer JL, Green MD, Sanger J, et al: A prospective randomized trial of ICRF-187 for prevention of cumulative doxorubicin-induced cardiac toxicity in women with breast cancer. Cancer Treat Rev 17:161-163, 1990
    • (1990) Cancer Treat Rev , vol.17 , pp. 161-163
    • Speyer, J.L.1    Green, M.D.2    Sanger, J.3
  • 17
    • 0026585672 scopus 로고
    • ICRF-187 permits longer treatment with doxorubicin in women with breast cancer
    • Speyer JL, Green MD, Zeleniuch-Jacquotte A, et al: ICRF-187 permits longer treatment with doxorubicin in women with breast cancer. J Clin Oncol 10:117-127, 1992
    • (1992) J Clin Oncol , vol.10 , pp. 117-127
    • Speyer, J.L.1    Green, M.D.2    Zeleniuch-Jacquotte, A.3
  • 18
    • 10544231456 scopus 로고    scopus 로고
    • Multicenter randomized controlled clinical trial to evaluate cardioprotection of dexrazoxane versus no cardioprotection in women receiving epirubicin chemotherapy for advanced breast cancer
    • Venturini M, Michelotti A, Del Mastro L, et al: Multicenter randomized controlled clinical trial to evaluate cardioprotection of dexrazoxane versus no cardioprotection in women receiving epirubicin chemotherapy for advanced breast cancer. J Clin Oncol 14:3112-3120, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 3112-3120
    • Venturini, M.1    Michelotti, A.2    Del Mastro, L.3
  • 19
    • 9044233260 scopus 로고    scopus 로고
    • Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin
    • Wexler LH, Andrich MP, Venzon D, et al: Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin. J Clin Oncol 14:362-372, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 362-372
    • Wexler, L.H.1    Andrich, M.P.2    Venzon, D.3
  • 20
    • 0030991044 scopus 로고    scopus 로고
    • Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy
    • Swain SM, Whaley FS, Gerber MC, et al: Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy. J Clin Oncol 15:1333-1340, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 1333-1340
    • Swain, S.M.1    Whaley, F.S.2    Gerber, M.C.3
  • 21
    • 0030904096 scopus 로고    scopus 로고
    • Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer
    • Swain SM, Whaley FS, Gerber MC, et al: Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer. J Clin Oncol 15:1318-1332, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 1318-1332
    • Swain, S.M.1    Whaley, F.S.2    Gerber, M.C.3
  • 22
    • 0031983153 scopus 로고    scopus 로고
    • Randomized prospective clinical trial of high-dose epirubicin and dexrazoxane in patients with advanced breast cancer and soft tissue sarcomas
    • Lopez M, Vici P, Di Lauro L, et al: Randomized prospective clinical trial of high-dose epirubicin and dexrazoxane in patients with advanced breast cancer and soft tissue sarcomas. J Clin Oncol 16:86-92, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 86-92
    • Lopez, M.1    Vici, P.2    Di Lauro, L.3
  • 23
    • 0027974088 scopus 로고
    • A decade of breast cancer clinical investigation: Results as reported in the Program/Proceedings of the American Society of Clinical Oncology
    • Chlebowski RT, Lillington LM: A decade of breast cancer clinical investigation: Results as reported in the Program/Proceedings of the American Society of Clinical Oncology. J Clin Oncol 12:1789-1795, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 1789-1795
    • Chlebowski, R.T.1    Lillington, L.M.2
  • 24
    • 0024443146 scopus 로고
    • Hematopoietic growth factors: Biology and clinical applications
    • Groopman JE, Molina JM, Scadden DT: Hematopoietic growth factors: Biology and clinical applications. N Engl J Med 321:1449-1459, 1989
    • (1989) N Engl J Med , vol.321 , pp. 1449-1459
    • Groopman, J.E.1    Molina, J.M.2    Scadden, D.T.3
  • 25
    • 0004759622 scopus 로고
    • Colony-stimulating factors: General biology
    • DeVita VT, Hellman S, Rosenberg SA (eds): Philadelphia, PA, Lippincott
    • Metcalf D, Morstyn G: Colony-stimulating factors: General biology, in DeVita VT, Hellman S, Rosenberg SA (eds): Biologic Therapy of Cancer. Philadelphia, PA, Lippincott, 1991, pp 417-444
    • (1991) Biologic Therapy of Cancer , pp. 417-444
    • Metcalf, D.1    Morstyn, G.2
  • 26
    • 0005497545 scopus 로고
    • Phase I study of KRN8601 (rhG-CSF) in normal healthy volunteers: Safety and pharmacokinetics in single subcutaneous administration
    • Azuma J, Kurimoto T, Awata S, et al: Phase I study of KRN8601 (rhG-CSF) in normal healthy volunteers: Safety and pharmacokinetics in single subcutaneous administration. Rinsho Iyaku 5:2231-2252, 1989
    • (1989) Rinsho Iyaku , vol.5 , pp. 2231-2252
    • Azuma, J.1    Kurimoto, T.2    Awata, S.3
  • 27
    • 0023585071 scopus 로고
    • Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer
    • Bronchud MH, Scarffe JH, Thatcher N, et al: Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 56:809-813, 1987
    • (1987) Br J Cancer , vol.56 , pp. 809-813
    • Bronchud, M.H.1    Scarffe, J.H.2    Thatcher, N.3
  • 28
    • 0023682969 scopus 로고
    • Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression
    • Antman KS, Griffin JD, Elias E, et al: Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 319:593-598, 1988
    • (1988) N Engl J Med , vol.319 , pp. 593-598
    • Antman, K.S.1    Griffin, J.D.2    Elias, E.3
  • 29
    • 0023945042 scopus 로고
    • Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium
    • Gabrilove JL, Jakubowski A, Scher H, et al: Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 318:1414-1422, 1988
    • (1988) N Engl J Med , vol.318 , pp. 1414-1422
    • Gabrilove, J.L.1    Jakubowski, A.2    Scher, H.3
  • 30
    • 0023905962 scopus 로고
    • Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation
    • Brandt SJ, Peters WP, Atwater SK, et al: Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. N Engl J Med 318:869-876, 1988
    • (1988) N Engl J Med , vol.318 , pp. 869-876
    • Brandt, S.J.1    Peters, W.P.2    Atwater, S.K.3
  • 31
    • 0025187881 scopus 로고
    • Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia
    • Ohno R, Tomonaga M, Kobayashi T, et al: Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia. N Engl J Med 323:871-877, 1990
    • (1990) N Engl J Med , vol.323 , pp. 871-877
    • Ohno, R.1    Tomonaga, M.2    Kobayashi, T.3
  • 32
    • 0028256428 scopus 로고
    • A double-blind controlled study of granulocyte colony-stimulating factor started two days before induction chemotherapy in refractory acute myeloid leukemia
    • Ohno R, Naoe T, Kanamura A, et al: A double-blind controlled study of granulocyte colony-stimulating factor started two days before induction chemotherapy in refractory acute myeloid leukemia. Blood 83:2086-2092, 1994
    • (1994) Blood , vol.83 , pp. 2086-2092
    • Ohno, R.1    Naoe, T.2    Kanamura, A.3
  • 33
    • 0029174762 scopus 로고
    • Design and conduct of a double-blind, placebo-controlled trial of daunorubicin and cytarabine with or without granulocyte colony-stimulating factor in elderly patients with acute myeloid leukemia: A Southwest Oncology Group study
    • Godwin J: Design and conduct of a double-blind, placebo-controlled trial of daunorubicin and cytarabine with or without granulocyte colony-stimulating factor in elderly patients with acute myeloid leukemia: A Southwest Oncology Group study. J Natl Cancer Inst 19:31-35, 1995
    • (1995) J Natl Cancer Inst , vol.19 , pp. 31-35
    • Godwin, J.1
  • 34
    • 0029015209 scopus 로고
    • A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: A study of the Eastern Cooperative Oncology Group
    • Rowe JM, Anderson JW, Mazza JJ, et al: A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: A study of the Eastern Cooperative Oncology Group. Blood 86:457-462, 1995
    • (1995) Blood , vol.86 , pp. 457-462
    • Rowe, J.M.1    Anderson, J.W.2    Mazza, J.J.3
  • 35
    • 0029068452 scopus 로고
    • A controlled study of recombinant human granulocyte colony-stimulating factor in elderly patients after treatment for acute myelogenous leukemia
    • Dombret H, Chastang C, Fenaux P, et al: A controlled study of recombinant human granulocyte colony-stimulating factor in elderly patients after treatment for acute myelogenous leukemia. N Engl J Med 332:1678-1683, 1995
    • (1995) N Engl J Med , vol.332 , pp. 1678-1683
    • Dombret, H.1    Chastang, C.2    Fenaux, P.3
  • 36
    • 0029033064 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia
    • Stone RM, Berg DT, George SL, et al: Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia. N Engl J Med 332:1671-1677, 1995
    • (1995) N Engl J Med , vol.332 , pp. 1671-1677
    • Stone, R.M.1    Berg, D.T.2    George, S.L.3
  • 37
    • 0028959505 scopus 로고
    • GM-CSF in a double-blind randomized, placebo controlled trial in therapy of adult patients with de novo Acute Myeloid Leukemia (AML)
    • Heil G, Chadid L, Hoezler D, et al: GM-CSF in a double-blind randomized, placebo controlled trial in therapy of adult patients with de novo acute myeloid leukemia (AML). Leukemia 9:3-9, 1995
    • (1995) Leukemia , vol.9 , pp. 3-9
    • Heil, G.1    Chadid, L.2    Hoezler, D.3
  • 38
    • 8944234342 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor associated with induction treatment of acute myelogenous leukemia: A randomized trial by the European Organization for Research and Treatment of Cancer Leukemia Cooperative Group
    • Zittoun R, Suciu S, Mandelli F, et al: Granulocyte-macrophage colony-stimulating factor associated with induction treatment of acute myelogenous leukemia: A randomized trial by the European Organization for Research and Treatment of Cancer Leukemia Cooperative Group. J Clin Oncol 14:2150-2159, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2150-2159
    • Zittoun, R.1    Suciu, S.2    Mandelli, F.3
  • 39
    • 6844251615 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia
    • Heil G, Hoelzer D, Sanz MA, et al: A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia. Blood 90:4710-4718, 1997
    • (1997) Blood , vol.90 , pp. 4710-4718
    • Heil, G.1    Hoelzer, D.2    Sanz, M.A.3
  • 40
    • 0030811665 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor as an adjunct to induction chemotherapy for adult acute lymphoblastic leukemia - A randomized phase-III study
    • Geissler K, Koller K, Hubman E, et al: Granulocyte colony-stimulating factor as an adjunct to induction chemotherapy for adult acute lymphoblastic leukemia - A randomized phase-III study. Blood 90:590-596, 1997
    • (1997) Blood , vol.90 , pp. 590-596
    • Geissler, K.1    Koller, K.2    Hubman, E.3
  • 41
    • 0344405536 scopus 로고    scopus 로고
    • ASCO: Update of recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based clinical practice guidelines
    • ASCO: Update of recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based clinical practice guidelines. J Clin Oncol 14:1957-1960, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 1957-1960
  • 42
    • 0025800331 scopus 로고
    • Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer
    • Crawford J, Ozer H, Stoller R, et al: Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 325:164-170, 1991
    • (1991) N Engl J Med , vol.325 , pp. 164-170
    • Crawford, J.1    Ozer, H.2    Stoller, R.3
  • 43
    • 0026667676 scopus 로고
    • Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: A randomized controlled trial
    • Pettengell R, Gurney H, Radford JA, et al: Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: A randomized controlled trial. Blood 80:1430-1436, 1992
    • (1992) Blood , vol.80 , pp. 1430-1436
    • Pettengell, R.1    Gurney, H.2    Radford, J.A.3
  • 44
    • 0027366241 scopus 로고
    • Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) after chemotherapy in patients with non-Hodgkin's lymphoma: A placebo-controlled double blind phase III trial
    • Kaku K, Takahashi M, Moriyama Y, et al: Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) after chemotherapy in patients with non-Hodgkin's lymphoma: A placebo-controlled double blind phase III trial. Leuk Lymphoma 11:229-238, 1993
    • (1993) Leuk Lymphoma , vol.11 , pp. 229-238
    • Kaku, K.1    Takahashi, M.2    Moriyama, Y.3
  • 45
    • 0027517297 scopus 로고
    • Randomized, double-blind, placebo-controlled, phase III study of recombinant human granulocyte-macrophage colony-stimulating factor as an adjunct to induction treatment of high-grade malignant non-Hodgkin's lymphomas
    • Gerhartz HH, Engelhard M, Meusers P, et al: Randomized, double-blind, placebo-controlled, phase III study of recombinant human granulocyte-macrophage colony-stimulating factor as an adjunct to induction treatment of high-grade malignant non-Hodgkin's lymphomas. Blood 82:2329-2339, 1993
    • (1993) Blood , vol.82 , pp. 2329-2339
    • Gerhartz, H.H.1    Engelhard, M.2    Meusers, P.3
  • 46
    • 0027957443 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (GM-CSF) allows acceleration and dose intensity increase of CEF chemotherapy: A randomized study in patients with advanced breast cancer
    • Ardizzoni A, Venturini M, Sertoli MR, et al: Granulocyte-macrophage colony-stimulating factor (GM-CSF) allows acceleration and dose intensity increase of CEF chemotherapy: A randomized study in patients with advanced breast cancer. Br J Cancer 69:385-391, 1994
    • (1994) Br J Cancer , vol.69 , pp. 385-391
    • Ardizzoni, A.1    Venturini, M.2    Sertoli, M.R.3
  • 47
    • 0028982821 scopus 로고
    • Chemoradiotherapy with or without granulocyte-macrophage colony-stimulating factor in the treatment of limited-stage small-cell lung cancer: A prospective phase III randomized study of the Southwest Oncology Group
    • Bunn PA, Crowley J, Kelly K, et al: Chemoradiotherapy with or without granulocyte-macrophage colony-stimulating factor in the treatment of limited-stage small-cell lung cancer: A prospective phase III randomized study of the Southwest Oncology Group. J Clin Oncol 13:1632-1641, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 1632-1641
    • Bunn, P.A.1    Crowley, J.2    Kelly, K.3
  • 48
    • 0029063262 scopus 로고
    • Lenograstim prevents morbidity from intensive induction chemotherapy in the treatment of inflammatory breast cancer
    • Chevallier B, Chollet P, Merrouche Y, et al: Lenograstim prevents morbidity from intensive induction chemotherapy in the treatment of inflammatory breast cancer. J Clin Oncol 13:1564-1571, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 1564-1571
    • Chevallier, B.1    Chollet, P.2    Merrouche, Y.3
  • 49
    • 10344242915 scopus 로고    scopus 로고
    • Randomized double-blind prospective trial to evaluate the effects of sargramostim versus placebo in a moderate-dose fluorouracil, doxorubicin and cyclophosphamide adjuvant chemotherapy program for stage II and III breast cancer
    • Jones SE, Schottstaedt MW, Duncan LA, et al: Randomized double-blind prospective trial to evaluate the effects of sargramostim versus placebo in a moderate-dose fluorouracil, doxorubicin and cyclophosphamide adjuvant chemotherapy program for stage II and III breast cancer. J Clin Oncol 14:2976-2983, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2976-2983
    • Jones, S.E.1    Schottstaedt, M.W.2    Duncan, L.A.3
  • 50
    • 8244221002 scopus 로고    scopus 로고
    • Placebo-controlled phase III study of lenograstim (glycosylated recombinant human granulocyte colony-stimulating factor) in aggressive non-Hodgkin's lymphoma: Factors influencing chemotherapy administration
    • Gisselbrecht C, Haioun C, Lepage E, et al: Placebo-controlled phase III study of lenograstim (glycosylated recombinant human granulocyte colony-stimulating factor) in aggressive non-Hodgkin's lymphoma: Factors influencing chemotherapy administration. Leuk Lymphoma 25:289-300, 1997
    • (1997) Leuk Lymphoma , vol.25 , pp. 289-300
    • Gisselbrecht, C.1    Haioun, C.2    Lepage, E.3
  • 51
    • 0030738678 scopus 로고    scopus 로고
    • Dose-intense chemotherapy in extensive-stage small-cell lung cancer
    • Negoro S, Masuda N, Furuse K, et al: Dose-intense chemotherapy in extensive-stage small-cell lung cancer. Cancer Chemother Pharmacol 40:S70-73, 1997 (suppl)
    • (1997) Cancer Chemother Pharmacol , vol.40 , Issue.SUPPL.
    • Negoro, S.1    Masuda, N.2    Furuse, K.3
  • 52
    • 0023610106 scopus 로고
    • A randomized comparison of high dose versus conventional dose cyclophosphamide, doxorubicin and vincristine for extensive stage small cell lung cancer: A phase III trial of the Southeastern Cancer Study Group
    • Johnson DH, Einhorn LH, Birch R, et al: A randomized comparison of high dose versus conventional dose cyclophosphamide, doxorubicin and vincristine for extensive stage small cell lung cancer: A phase III trial of the Southeastern Cancer Study Group. J Clin Oncol 5:1731-1738, 1987
    • (1987) J Clin Oncol , vol.5 , pp. 1731-1738
    • Johnson, D.H.1    Einhorn, L.H.2    Birch, R.3
  • 53
    • 0022971415 scopus 로고
    • Initial therapy with cisplatin plus VP-16 in small cell lung cancer
    • Einhorn L: Initial therapy with cisplatin plus VP-16 in small cell lung cancer. Semin Oncol 13:5-9, 1986
    • (1986) Semin Oncol , vol.13 , pp. 5-9
    • Einhorn, L.1
  • 54
    • 0028238352 scopus 로고
    • Incidence of neutropenic fever in patients treated with standard-dose combination chemotherapy for small-cell lung cancer and the cost impact of treatment with granulocyte colony-stimulating factor
    • Nichols CR, Fox EP, Roth BJ, et al: Incidence of neutropenic fever in patients treated with standard-dose combination chemotherapy for small-cell lung cancer and the cost impact of treatment with granulocyte colony-stimulating factor. J Clin Oncol 12:1245-1250, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 1245-1250
    • Nichols, C.R.1    Fox, E.P.2    Roth, B.J.3
  • 55
    • 0027140280 scopus 로고
    • Persistent high hopes held for colony stimulating factors
    • Vanchieri C: Persistent high hopes held for colony stimulating factors. J Natl Cancer Inst 85:1982-1983, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1982-1983
    • Vanchieri, C.1
  • 56
    • 0026428924 scopus 로고
    • Biotech industry flourishes with cancer research advances
    • Vanchieri C: Biotech industry flourishes with cancer research advances. J Natl Cancer Inst 83:1608-1611, 1991
    • (1991) J Natl Cancer Inst , vol.83 , pp. 1608-1611
    • Vanchieri, C.1
  • 57
    • 0025971726 scopus 로고
    • Prospective multicenter trial for the response-adapted treatment of high-grade malignant non-Hodgkin's lymphomas: Updated results of the COP-BLAM/IMVP-16 protocol with randomized adjuvant radiotherapy
    • Engelhard M, Meusers P, Brittinger G, et al: Prospective multicenter trial for the response-adapted treatment of high-grade malignant non-Hodgkin's lymphomas: Updated results of the COP-BLAM/IMVP-16 protocol with randomized adjuvant radiotherapy. Ann Oncol 2:177-180, 1992
    • (1992) Ann Oncol , vol.2 , pp. 177-180
    • Engelhard, M.1    Meusers, P.2    Brittinger, G.3
  • 58
    • 0027394689 scopus 로고
    • Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma
    • Fisher RI, Gaaynor ER, Dahlberg S, et al: Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med 328:1002-1006, 1993
    • (1993) N Engl J Med , vol.328 , pp. 1002-1006
    • Fisher, R.I.1    Gaaynor, E.R.2    Dahlberg, S.3
  • 59
    • 0028034967 scopus 로고
    • Treatment of aggressive non-Hodgkin's lymphomas: Lessons from the past 10 years
    • Fisher RI: Treatment of aggressive non-Hodgkin's lymphomas: Lessons from the past 10 years. Cancer 74:2657-2661, 1994
    • (1994) Cancer , vol.74 , pp. 2657-2661
    • Fisher, R.I.1
  • 60
    • 0030755761 scopus 로고    scopus 로고
    • Clinical impact of chemotherapy dose escalation in patients with hematologic malignancies and solid tumors
    • Savarese DMF, Hsieh CC, Stewart FM: Clinical impact of chemotherapy dose escalation in patients with hematologic malignancies and solid tumors. J Clin Oncol 15:2891-2895, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 2891-2895
    • Savarese, D.M.F.1    Hsieh, C.C.2    Stewart, F.M.3
  • 61
    • 0030857202 scopus 로고    scopus 로고
    • Chemotherapy dose escalation: Case unproven
    • editorial
    • Siu LL, Tannock IF: Chemotherapy dose escalation: Case unproven. J Clin Oncol 15:2765-2768, 1997 (editorial)
    • (1997) J Clin Oncol , vol.15 , pp. 2765-2768
    • Siu, L.L.1    Tannock, I.F.2
  • 62
    • 0027250028 scopus 로고
    • Erythropoietin for the prevention of anemia in neoplastic patients treated with cisplatin
    • Gamucci T, Thorel MF, Frasca AM, et al: Erythropoietin for the prevention of anemia in neoplastic patients treated with cisplatin. Eur J Cancer 29A:S13-S14, 1993 (suppl 2)
    • (1993) Eur J Cancer , vol.29 , Issue.2 SUPPL.
    • Gamucci, T.1    Thorel, M.F.2    Frasca, A.M.3
  • 63
    • 0027220373 scopus 로고
    • Erythropoietin for anemia in cancer patients
    • Abels R: Erythropoietin for anemia in cancer patients. Eur J Cancer 29A:S2-S8, 1993 (suppl 2)
    • (1993) Eur J Cancer , vol.29 A , Issue.2 SUPPL.
    • Abels, R.1
  • 64
    • 0027299160 scopus 로고
    • Recombinant human erythropoietin therapy for anemic cancer patients on combination chemotherapy
    • Case DC, Bukowski RM, Carey RW, et al: Recombinant human erythropoietin therapy for anemic cancer patients on combination chemotherapy. J Natl Cancer Inst 85:801-806, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 801-806
    • Case, D.C.1    Bukowski, R.M.2    Carey, R.W.3
  • 65
    • 0028295942 scopus 로고
    • Recombinant human erythropoietin treatment in cisplatin-associated anemia: A randomized, double-blind trial with placebo
    • Cascinu S, Fedeli A, Del Ferro E, et al: Recombinant human erythropoietin treatment in cisplatin-associated anemia: A randomized, double-blind trial with placebo. J Clin Oncol 12:1058-1062, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 1058-1062
    • Cascinu, S.1    Fedeli, A.2    Del Ferro, E.3
  • 66
    • 17144459940 scopus 로고    scopus 로고
    • Randomized phase III trial evaluating the role of erythropoietin in the prevention of chemotherapy-induced anemia
    • Del Mastro L, Venturini M, Lionetto R, et al: Randomized phase III trial evaluating the role of erythropoietin in the prevention of chemotherapy-induced anemia. J Clin Oncol 15:2715-2721, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 2715-2721
    • Del Mastro, L.1    Venturini, M.2    Lionetto, R.3
  • 67
    • 0028343099 scopus 로고
    • Identification and cloning of a megacaryocyte growth and development factor that is a ligand for the cytokine receptor mpl
    • Bartley TD, Bogenberger J, Hunt P, et al: Identification and cloning of a megacaryocyte growth and development factor that is a ligand for the cytokine receptor mpl. Cell 77:1117-1124, 1994
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 68
    • 0028332474 scopus 로고
    • Promotion of a megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
    • Kaushansky K, Lok S, Holly RD, et al: Promotion of a megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568-571, 1994
    • (1994) Nature , vol.369 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 69
    • 0028114123 scopus 로고
    • In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells
    • Zeigler FC, deSauvage F, Widmer HR, et al: In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045-4052, 1994
    • (1994) Blood , vol.84 , pp. 4045-4052
    • Zeigler, F.C.1    DeSauvage, F.2    Widmer, H.R.3
  • 70
    • 0028985594 scopus 로고
    • Thrombopoietin, the Mpl-ligand, is essential for full megakaryocyte development
    • abstr
    • Kaushansky K, Broudy VC, Lin N, et al: Thrombopoietin, the Mpl-ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92:3234, 1995 (abstr)
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3234
    • Kaushansky, K.1    Broudy, V.C.2    Lin, N.3
  • 71
    • 0028803099 scopus 로고
    • Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
    • Hokom MM, Lacey D, Kinstler OB, et al: Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486-4492, 1995
    • (1995) Blood , vol.86 , pp. 4486-4492
    • Hokom, M.M.1    Lacey, D.2    Kinstler, O.B.3
  • 72
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucci M, Glaspy J, Crawford J, et al: Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 336:404-409, 1997
    • (1997) N Engl J Med , vol.336 , pp. 404-409
    • Fanucci, M.1    Glaspy, J.2    Crawford, J.3
  • 73
    • 0026584467 scopus 로고
    • Interleukin-11 enhances human megakaryocytopoiesis in vitro
    • Teramura M, Kobayashi S, Hoshino S, et al: Interleukin-11 enhances human megakaryocytopoiesis in vitro. Blood 79:327-331, 1992
    • (1992) Blood , vol.79 , pp. 327-331
    • Teramura, M.1    Kobayashi, S.2    Hoshino, S.3
  • 74
    • 0030666621 scopus 로고    scopus 로고
    • Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin
    • Isaacs C, Robert NJ, Bailey A, et al: Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin. J Clin Oncol 15:3368-3377, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 3368-3377
    • Isaacs, C.1    Robert, N.J.2    Bailey, A.3
  • 75
    • 0029745368 scopus 로고    scopus 로고
    • Amifostine: The preclinical basis for broadspectrum selective cytoprotection of normal tissues from cytotoxic therapies
    • Capezzi RL. Amifostine: The preclinical basis for broadspectrum selective cytoprotection of normal tissues from cytotoxic therapies. Semin Oncol 23:2-17, 1996 (suppl 6)
    • (1996) Semin Oncol , vol.23 , Issue.6 SUPPL. , pp. 2-17
    • Capezzi, R.L.1
  • 76
    • 0023815322 scopus 로고
    • Influence of WR-2721 on DNA cross-linking by nitrogen mustard in normal mouse bone marrow and leukemia cells in vivo
    • DeNeve WJ, Everett CK, Suminski JE, et al: Influence of WR-2721 on DNA cross-linking by nitrogen mustard in normal mouse bone marrow and leukemia cells in vivo. Cancer Res 48:6002-6005, 1988
    • (1988) Cancer Res , vol.48 , pp. 6002-6005
    • DeNeve, W.J.1    Everett, C.K.2    Suminski, J.E.3
  • 77
    • 0026505855 scopus 로고
    • Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethylthiocarbamate
    • Treskes M, Nijtmans LG, Schepman AMJ, et al: Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethylthiocarbamate. Biochem Pharmacol 43:1013-1019, 1992
    • (1992) Biochem Pharmacol , vol.43 , pp. 1013-1019
    • Treskes, M.1    Nijtmans, L.G.2    Schepman, A.M.J.3
  • 78
    • 0000577297 scopus 로고
    • Biochemical determinants of the cytoprotective effect of amifostine
    • abstr 1725
    • Yang YL, Fernandes DJ, Speicher L, et al: Biochemical determinants of the cytoprotective effect of amifostine. Proc Am Assoc Cancer Res 36:290, 1995 (abstr 1725)
    • (1995) Proc am Assoc Cancer Res , vol.36 , pp. 290
    • Yang, Y.L.1    Fernandes, D.J.2    Speicher, L.3
  • 79
    • 0023679159 scopus 로고
    • Uptake of the WR-2721 derivatives by cells in culture: Identification of the transported form of the drug
    • Calabro-Jones PM, Aguilera JA, Ward JF, et al: Uptake of the WR-2721 derivatives by cells in culture: Identification of the transported form of the drug. Cancer Res 48:3634-3640, 1988
    • (1988) Cancer Res , vol.48 , pp. 3634-3640
    • Calabro-Jones, P.M.1    Aguilera, J.A.2    Ward, J.F.3
  • 80
    • 0029902007 scopus 로고    scopus 로고
    • Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: Results of a randomized control trial in patients with advanced ovarian cancer
    • Kemp G, Rose P, Lurain J, et al: Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: Results of a randomized control trial in patients with advanced ovarian cancer. J Clin Oncol 14:2101-2112, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2101-2112
    • Kemp, G.1    Rose, P.2    Lurain, J.3
  • 81
    • 0029065797 scopus 로고
    • An assessment of dose intense therapy in suboptimally debulked ovarian cancer: A Gynaecologic Oncology Group study
    • McGuire WP, Hoskins WJ, Brady MF, et al: An assessment of dose intense therapy in suboptimally debulked ovarian cancer: A Gynaecologic Oncology Group study. J Clin Oncol 13:1589-1599, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 1589-1599
    • McGuire, W.P.1    Hoskins, W.J.2    Brady, M.F.3
  • 82
    • 8944243551 scopus 로고    scopus 로고
    • Mature results of a randomized trial of two doses of cisplatin for the treatment of ovarian cancer
    • Kaye SB, Cassidy JPJ, Lewis CR, et al: Mature results of a randomized trial of two doses of cisplatin for the treatment of ovarian cancer. J Clin Oncol 14:2113-2119, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2113-2119
    • Kaye, S.B.1    Cassidy, J.P.J.2    Lewis, C.R.3
  • 83
    • 0028118692 scopus 로고
    • Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer
    • Poplin EA, LoRusso P, Lokich JJ, et al: Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer. Cancer Chemother Pharmacol 33:415-419, 1994
    • (1994) Cancer Chemother Pharmacol , vol.33 , pp. 415-419
    • Poplin, E.A.1    LoRusso, P.2    Lokich, J.J.3
  • 84
    • 24244467995 scopus 로고    scopus 로고
    • A phase III randomized study of carboplatin and amifostine versus carboplatin and G-CSF in patients with inoperable non-small cell lung cancer (NSCLC)
    • abstr 1708
    • Mercer V, Anderson H, Habboubi N, et al: A phase III randomized study of carboplatin and amifostine versus carboplatin and G-CSF in patients with inoperable non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 16:474a, 1997 (abstr 1708)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Mercer, V.1    Anderson, H.2    Habboubi, N.3
  • 85
    • 0029002997 scopus 로고
    • Perceptions of cancer patients and their physicians involved in phase I trials
    • Daugherty C, Ratain MJ, Grochowski E. et al: Perceptions of cancer patients and their physicians involved in phase I trials. J Clin Oncol 13:1062-1072, 1995
    • (1995) J Clin Oncol , vol.13 , pp. 1062-1072
    • Daugherty, C.1    Ratain, M.J.2    Grochowski, E.3
  • 86
    • 0014115513 scopus 로고
    • Explanatory and pragmatic attitudes in therapeutic trials
    • Schwartz D, Lellouch J: Explanatory and pragmatic attitudes in therapeutic trials. J Chronic Dis 20:637-648, 1967
    • (1967) J Chronic Dis , vol.20 , pp. 637-648
    • Schwartz, D.1    Lellouch, J.2
  • 87
    • 0030268577 scopus 로고    scopus 로고
    • Surrogate endpoints in clinical trials: Are we being misled?
    • Fleming T, DeMets DL: Surrogate endpoints in clinical trials: Are we being misled? Ann Intern Med 125:605-613, 1996
    • (1996) Ann Intern Med , vol.125 , pp. 605-613
    • Fleming, T.1    DeMets, D.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.