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Volumn 39, Issue 1-2, 1996, Pages 162-166

Pharmacokinetics of amifostine and its metabolites in the plasma and ascites of a cancer patient

Author keywords

Amifostine; Ascites; Disulfides; Pharmacokinetics; WR 1065

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; AMIFOSTINE; CARBOPLATIN; DEXAMETHASONE; DRUG METABOLITE; ONDANSETRON; THIETHYLPERAZINE MALEATE;

EID: 0029822506     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050553     Document Type: Article
Times cited : (25)

References (12)
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    • Calabro-Jones PM, Fahey RC, Smoluk GD, Ward JF (1985) Alkaline phosphatase promotes radioprotection and accumulation of WR 1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol 47: 23-27
    • (1985) Int J Radiat Biol , vol.47 , pp. 23-27
    • Calabro-Jones, P.M.1    Fahey, R.C.2    Smoluk, G.D.3    Ward, J.F.4
  • 2
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    • Fleckenstein L, Swynnerton NF, Ludden TM, Mangold DJ (1988) Bioavailability and newer methods of delivery of phosphorothioate radioprotectors. Pharmacol Ther 39: 203-212
    • (1988) Pharmacol Ther , vol.39 , pp. 203-212
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  • 7
    • 0028127149 scopus 로고
    • Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse
    • Shaw LM, Bonner HS, Brown DQ (1994) Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse. Drug Metab Dispos 22: 895-902
    • (1994) Drug Metab Dispos , vol.22 , pp. 895-902
    • Shaw, L.M.1    Bonner, H.S.2    Brown, D.Q.3
  • 8
    • 0002416765 scopus 로고
    • Clinical experiences with a chemical radioprotector in tumor radiotherapy: WR-2721
    • Sugahara T (ed) Academic Press, Tokyo
    • Tanaka Y (1984) Clinical experiences with a chemical radioprotector in tumor radiotherapy: WR-2721. In: Sugahara T (ed) Modification of radio sensitivity in cancer treatment. Academic Press, Tokyo, pp 61-81
    • (1984) Modification of Radio Sensitivity in Cancer Treatment , pp. 61-81
    • Tanaka, Y.1
  • 9
    • 0026505855 scopus 로고
    • Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethylcarbamate
    • Treskes M, Nijtmans LG, Fichtinger-Schepman AMJ, et al (1992) Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethylcarbamate. Biochem Pharmacol 43: 1013-1019
    • (1992) Biochem Pharmacol , vol.43 , pp. 1013-1019
    • Treskes, M.1    Nijtmans, L.G.2    Fichtinger-Schepman, A.M.J.3
  • 10
    • 0028323126 scopus 로고
    • Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice
    • Treskes M, Boven E, Van de Loosdrecht AA, et al (1994) Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice. Eur J Cancer 30A: 183-187
    • (1994) Eur J Cancer , vol.30 A , pp. 183-187
    • Treskes, M.1    Boven, E.2    Van De Loosdrecht, A.A.3
  • 11
    • 0021168541 scopus 로고
    • Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721
    • Utley JF, Seaver N, Newton GL, Fahey RC (1984) Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721. Int J Radiat Oncol Biol Phys 10: 1525-1528
    • (1984) Int J Radiat Oncol Biol Phys , vol.10 , pp. 1525-1528
    • Utley, J.F.1    Seaver, N.2    Newton, G.L.3    Fahey, R.C.4
  • 12
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    • Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)ethylphosphorothioic acid
    • Yuhas JM (1980) Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)ethylphosphorothioic acid. Cancer Res 40: 1519-1524
    • (1980) Cancer Res , vol.40 , pp. 1519-1524
    • Yuhas, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.