Whole-body scanning PCR; A highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides

Nucleic Acids Research

Volumn 41, Issue 15, 2013, Pages

  Boos, Julien A ^a   Kirk, David W ^a   Piccolotto, Mari Luz ^a   Zuercher, Werner ^a   Gfeller, Sandro ^a   Neuner, Philippe ^a   Dattler, Andre ^a   Wishart, William L ^a   Von Arx, Fabian ^a   Beverly, Michael ^b   Christensen, Jesper ^a   Litherland, Karine ^a   Van De Kerkhof, Esther ^a   Swart, Pieter J ^a   Faller, Thomas ^a   Beyerbach, Armin ^a   Morrissey, David ^b   Hunziker, Juerg ^a   Beuvink, Iwan ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Protein Sciences and Design   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE DERIVATIVE; 5' O BIPHENYLSULPHONYL 2' DEOXYNUCLEOSIDE DERIVATIVE; 5' O BIPHENYLSULPHONYL 2' DEOXYNUCLEOSIDE PHOSPHORAMIDITE DERIVATIVE; 5' O BIPHENYLSULPHONYL OLIGODEOXYNUCLEOTIDE DERIVATIVE; ANTAGOMIR; DEOXYRIBONUCLEOTIDE; DNA 18S; GENOMIC DNA; MESSENGER RNA; MICRORNA 16; OLIGODEOXYNUCLEOTIDE DERIVATIVE; OLIGONUCLEOTIDE; RIBOSOME RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA ANALYSIS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; VALIDATION STUDY; WHOLE BODY IMAGING;

ANIMALS; HCT116 CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MICE; OLIGONUCLEOTIDES; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA, UNTRANSLATED; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; WHOLE BODY IMAGING;

EID: 84883474528     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt515     Document Type: Article

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