Morphological restriction of human coronary artery endothelial cells substantially impacts global gene expression patterns

FEBS Journal

Volumn 280, Issue 18, 2013, Pages 4474-4494

  Stiles, Jessica M ^a   Pham, Robert ^b   Rowntree, Rebecca K ^a   Amaya, Clarissa ^a   Battiste, James ^c   Boucheron, Laura E ^b   Mitchell, Dianne C ^a   Bryan, Brad A ^a  

^a Texas Tech University Health Sciences Center El Paso   (United States)

^b Horeshoe Cir Jett Hall   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

actin; cell morphology; coronary artery; cytoskeleton; endothelial cell; genomics; image recognition; microarray; micropatterning

Indexed keywords

FOCAL ADHESION KINASE; MESSENGER RNA; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; WNT PROTEIN;

ALGORITHM; ARTERIOSCLEROSIS; ARTICLE; CELL ADHESION; CELL CONTACT; CELL CYCLE REGULATION; CELL ELONGATION; CELL GROWTH; CELL POLARITY; CELL PROLIFERATION; CELL SHAPE; CELL SIZE; CELL SPREADING; CELL STRUCTURE; CELL TYPE; CORONARY ARTERY; DISEASE COURSE; DOWN REGULATION; ENDOTHELIUM CELL; GENE; GENE EXPRESSION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPRODUCIBILITY; SMAD6 GENE; SMAD7 GENE; TGFB2 GENE; UPREGULATION;

ACTIN; CELL MORPHOLOGY; CORONARY ARTERY; CYTOSKELETON; ENDOTHELIAL CELL; GENOMICS; IMAGE RECOGNITION; MICROARRAY; MICROPATTERNING;

ACTIN CYTOSKELETON; ALGORITHMS; CELL ADHESION; CELL POLARITY; CELL SHAPE; CORONARY VESSELS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MECHANOTRANSDUCTION, CELLULAR; MICROFILAMENT PROTEINS; MICROSCOPY, CONFOCAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRIMARY CELL CULTURE;

EID: 84883465615     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12410     Document Type: Article

References (32)

1. Nieves BJ, D'Amore PA, &, Bryan BA, (2009) The function of vascular endothelial growth factor. BioFactors 35, 332-337.
2. Ingber DE, (2008) Tensegrity and mechanotransduction. J Bodyw Mov Ther 12, 198-200.
3. Ingber DE, (2008) Tensegrity-based mechanosensing from macro to micro. Prog Biophys Mol Biol 97, 163-179.
4. Klein-Nulend J, Bacabac RG, Veldhuijzen JP, &, Van Loon JJ, (2003) Microgravity and bone cell mechanosensitivity. Adv Space Res 32, 1551-1559.
5. Kher N, &, Marsh JD, (2004) Pathobiology of atherosclerosis-a brief review. Semin Thromb Hemost 30, 665-672.
6. Marshall KL, &, Lumpkin EA, (2012) The molecular basis of mechanosensory transduction. Adv Exp Med Biol 739, 142-155.
7. Sato M, &, Ohashi T, (2005) Biorheological views of endothelial cell responses to mechanical stimuli. Biorheology 42, 421-441.
8. Chen CS, Mrksich M, Huang S, Whitesides GM, &, Ingber DE, (1997) Geometric control of cell life and death. Science 276, 1425-1428.
9. Huang S, Chen CS, &, Ingber DE, (1998) Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell 9, 3179-3193.
10. Huang S, &, Ingber DE, (2000) Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp Cell Res 261, 91-103.
11. Ingber DE, Prusty D, Sun Z, Betensky H, &, Wang N, (1995) Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis. J Biomech 28, 1471-1484.
12. de Juan-Pardo EM, Hoang MB, &, Conboy IM, (2006) Geometric control of myogenic cell fate. Int J Nanomedicine 1, 203-212.
13. Lei Y, Zouani OF, Remy M, Ayela C, &, Durrieu MC, (2012) Geometrical microfeature cues for directing tubulogenesis of endothelial cells. PLoS ONE 7, e41163.
14. Kilian KA, Bugarija B, Lahn BT, &, Mrksich M, (2010) Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci USA 107, 4872-4877.
15. Song W, Lu H, Kawazoe N, &, Chen G, (2011) Adipogenic differentiation of individual mesenchymal stem cell on different geometric micropatterns. Langmuir 27, 6155-6162.
16. Montalvo J, Spencer C, Hackathorn A, Masterjohn K, Perkins A, Doty C, Arumugam A, Ongusaha PP, Lakshmanaswamy R, Liao JK, et al,. (2013) ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression. Curr Mol Med 13, 205-219.
17. Sims JR, Karp S, &, Ingber DE, (1992) Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape. J Cell Sci 103, 1215-1222.
18. Jean RP, Gray DS, Spector AA, &, Chen CS, (2004) Characterization of the nuclear deformation caused by changes in endothelial cell shape. J Biomech Eng 126, 552-558.
19. Martins RP, Finan JD, Guilak F, &, Lee DA, (2012) Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng 14, 431-455.
20. Thomas CH, Collier JH, Sfeir CS, &, Healy KE, (2002) Engineering gene expression and protein synthesis by modulation of nuclear shape. Proc Natl Acad Sci USA 99, 1972-1977.
21. Lanctot C, Cheutin T, Cremer M, Cavalli G, &, Cremer T, (2007) Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nat Rev Genet 8, 104-115.
22. Misteli T, (2007) Beyond the sequence: cellular organization of genome function. Cell 128, 787-800.
23. Maniotis AJ, Chen CS, &, Ingber DE, (1997) Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci USA 94, 849-854.
24. Le Beyec J, Xu R, Lee SY, Nelson CM, Rizki A, Alcaraz J, &, Bissell MJ, (2007) Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res 313, 3066-3075.
25. Versaevel M, Grevesse T, &, Gabriele S, (2012) Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat Commun 3, 671.
26. Gupta S, Marcel N, Sarin A, &, Shivashankar GV, (2012) Role of actin dependent nuclear deformation in regulating early gene expression. PLoS ONE 7, e53031.
27. Matonoha P, &, Zechmeister A, (1978) Scanning electron microscopic observation of intimal surface of normal and atherosclerotic arteries. Acta Morphol Acad Sci Hung 26, 173-184.
28. Levesque MJ, Liepsch D, Moravec S, &, Nerem RM, (1986) Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta. Arteriosclerosis 6, 220-229.
29. Lichtenstein N, Geiger B, &, Kam Z, (2003) Quantitative analysis of cytoskeletal organization by digital fluorescent microscopy. Cytometry A 54, 8-18.
30. Massey F, (1957) The kolmogorov-smirnov test for goodness of fit. J Am Stat Assoc 46, 68-78.
31. Toma I, &, McCaffrey TA, (2012) Transforming growth factor-beta and atherosclerosis: interwoven atherogenic and atheroprotective aspects. Cell Tissue Res 347, 155-175.
32. Woods RGR, (2002) Digital Image Processing, Vol. 2. Prentice Hall, Upper Saddle River, NJ.