Role of Actin Dependent Nuclear Deformation in Regulating Early Gene Expression

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Gupta, Soumya ^a,c   Marcel, Nimi ^a,b   Sarin, Apurva ^a   Shivashankar, G V ^a,c  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b MANIPAL UNIVERSITY   (India)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CD69 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TENASCIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CELL ELONGATION; CELL NUCLEUS; CELL SHAPE; CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; DOWN REGULATION; FIBROBLAST; GENE EXPRESSION; IMMOBILIZED CELL; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; POLARIZATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ACTINS; ANIMALS; CELL NUCLEUS; CELL NUCLEUS SHAPE; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NIH 3T3 CELLS; STRESS, MECHANICAL; T-LYMPHOCYTES; TIME FACTORS;

EID: 84871672523     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053031     Document Type: Article

References (26)

1. Dahl KN, Ribeiro AJ, Lammerding J, (2008) Nuclear shape, mechanics, and mechanotransduction. Circ Res 102: 1307-1318.
2. Brandt A, Papagiannouli F, Wagner N, Wilsch-Brauninger M, Braun M, et al. (2006) Developmental control of nuclear size and shape by Kugelkern and Kurzkern. Current biology: CB 16: 543-552.
3. Olins AL, Olins DE, (2004) Cytoskeletal influences on nuclear shape in granulocytic HL-60 cells. BMC cell biology 5: 30.
4. Versaevel M, Grevesse T, Gabriele S, (2012) Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nature communications 3: 671.
5. Khatau SB, Hale CM, Stewart-Hutchinson PJ, Patel MS, Stewart CL, et al. (2009) A perinuclear actin cap regulates nuclear shape. Proc Natl Acad Sci U S A 106: 19017-19022.
6. Li Y, Chu JS, Kurpinski K, Li X, Bautista DM, et al. (2011) Biophysical regulation of histone acetylation in mesenchymal stem cells. Biophysical journal 100: 1902-1909.
7. Roca-Cusachs P, Alcaraz J, Sunyer R, Samitier J, Farre R, et al. (2008) Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation. Biophys J 94: 4984-4995.
8. Thomas CH, Collier JH, Sfeir CS, Healy KE, (2002) Engineering gene expression and protein synthesis by modulation of nuclear shape. Proceedings of the National Academy of Sciences of the United States of America 99: 1972-1977.
9. Wang N, Tytell JD, Ingber DE, (2009) Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nature reviews Molecular cell biology 10: 75-82.
10. Mazumder A, Shivashankar GV, (2010) Emergence of a prestressed eukaryotic nucleus during cellular differentiation and development. J R Soc Interface 7Suppl 3: S321-330.
11. Lammerding J, Schulze PC, Takahashi T, Kozlov S, Sullivan T, et al. (2004) Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. The Journal of clinical investigation 113: 370-378.
12. Lammerding J, Hsiao J, Schulze PC, Kozlov S, Stewart CL, et al. (2005) Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. The Journal of cell biology 170: 781-791.
13. Billadeau DD, Nolz JC, Gomez TS, (2007) Regulation of T-cell activation by the cytoskeleton. Nature reviews Immunology 7: 131-143.
14. Palacios EH, Weiss A, (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23: 7990-8000.
15. Krummel MF, Macara I, (2006) Maintenance and modulation of T cell polarity. Nature immunology 7: 1143-1149.
16. Shen K, Thomas VK, Dustin ML, Kam LC, (2008) Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proceedings of the National Academy of Sciences of the United States of America 105: 7791-7796.
17. Testi R, Phillips JH, Lanier LL, (1989) Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C. J Immunol 142: 1854-1860.
18. Sancho D, Gomez M, Sanchez-Madrid F, (2005) CD69 is an immunoregulatory molecule induced following activation. Trends Immunol 26: 136-140.
19. Schuh K, Twardzik T, Kneitz B, Heyer J, Schimpl A, et al. (1998) The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells. J Exp Med 188: 1369-1373.
20. Shivashankar GV, (2011) Mechanosignaling to the cell nucleus and gene regulation. Annual review of biophysics 40: 361-378.
21. Lopez-Cabrera M, Munoz E, Blazquez MV, Ursa MA, Santis AG, et al. (1995) Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. The Journal of biological chemistry 270: 21545-21551.
22. Sawada Y, Tamada M, Dubin-Thaler BJ, Cherniavskaya O, Sakai R, et al. (2006) Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 127: 1015-1026.
23. Maier S, Lutz R, Gelman L, Sarasa-Renedo A, Schenk S, et al. (2008) Tenascin-C induction by cyclic strain requires integrin-linked kinase. Biochim Biophys Acta 1783: 1150-1162.
24. Maschler S, Grunert S, Danielopol A, Beug H, Wirl G, (2004) Enhanced tenascin-C expression and matrix deposition during Ras/TGF-beta-induced progression of mammary tumor cells. Oncogene 23: 3622-3633.
25. Babich A, Li S, O'Connor RS, Milone MC, Freedman BD, et al. (2012) F-actin polymerization and retrograde flow drive sustained PLCgamma1 signaling during T cell activation. The Journal of cell biology 197: 775-787.
26. Judokusumo E, Tabdanov E, Kumari S, Dustin ML, Kam LC, (2012) Mechanosensing in T lymphocyte activation. Biophysical journal 102: L5-7.