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Volumn 7, Issue 3, 2013, Pages 224-234

Update on antifungal resistance and its clinical impact

Author keywords

1,3 D glucan synthase inhibition; Antifungal drug resistance; Antifungal treatment; Aspergillus species; Azoles; Bloodstream infection; Breakthrough infection; Candida species; Clinical outcome; Echinocandins; Efflux pump gene overexpression; Fungemia; Invasive fungal infection; Lanosterol 14 demethylase gene mutation; Multidrug resistance

Indexed keywords

ABC TRANSPORTER; AMPHOTERICIN B LIPID COMPLEX; ANIDULAFUNGIN; CASPOFUNGIN; ECHINOCANDIN; EFUNGUMAB; FLUCONAZOLE; ITRACONAZOLE; MICAFUNGIN; MK 3118; POSACONAZOLE; PYRROLE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VORICONAZOLE;

EID: 84883460526     PISSN: 19363761     EISSN: 1936377X     Source Type: Journal    
DOI: 10.1007/s12281-013-0143-0     Document Type: Article
Times cited : (5)

References (106)
  • 1
    • 67649998723 scopus 로고    scopus 로고
    • Antibiotic resistance: The perfect storm
    • 19596110 1:CAS:528:DC%2BD1MXosVWls7s%3D 10.1016/S0924-8579(09)70549-7
    • Gould IM. Antibiotic resistance: the perfect storm. Int J Antimicrob Agents. 2009;34 Suppl 3:S2-5.
    • (2009) Int J Antimicrob Agents , vol.34 , Issue.SUPPL. 3 , pp. 2-5
    • Gould, I.M.1
  • 2
    • 84055199809 scopus 로고    scopus 로고
    • Antifungal drug resistance: Mechanisms, epidemiology, and consequences for treatment
    • 22196207 1:CAS:528:DC%2BC3MXhs12hsbnM 10.1016/j.amjmed.2011.11.001 A comprehensive review highlighting the essential role of antifungal susceptibility testing in patient management and resistance surveillance
    • •• Pfaller MA. Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment. Am J Med. 2012;125 Suppl 1:S3-13. A comprehensive review highlighting the essential role of antifungal susceptibility testing in patient management and resistance surveillance.
    • (2012) Am J Med , vol.125 , Issue.SUPPL. 1 , pp. 3-13
    • Pfaller, M.A.1
  • 3
    • 74949107171 scopus 로고    scopus 로고
    • Epidemiology of invasive mycoses in North America
    • 20088682 10.3109/10408410903241444
    • Pfaller MA, Diekema DJ. Epidemiology of invasive mycoses in North America. Crit Rev Microbiol. 2010;36:1-53.
    • (2010) Crit Rev Microbiol , vol.36 , pp. 1-53
    • Pfaller, M.A.1    Diekema, D.J.2
  • 4
    • 78449308457 scopus 로고    scopus 로고
    • Epidemiology of invasive candidiasis
    • 20711075 10.1097/MCC.0b013e32833e84d2 An in-depth focus on the incidence, pathogen's antifungal susceptibility, host groups, risk factors, and outcome of this life-threatening fungal infection
    • •• Arendrup MC. Epidemiology of invasive candidiasis. Curr Opin Crit Care. 2010;16:445-52. An in-depth focus on the incidence, pathogen's antifungal susceptibility, host groups, risk factors, and outcome of this life-threatening fungal infection.
    • (2010) Curr Opin Crit Care , vol.16 , pp. 445-452
    • Arendrup, M.C.1
  • 5
    • 78751683832 scopus 로고    scopus 로고
    • Emerging opportunistic yeast infections
    • 21272794 10.1016/S1473-3099(10)70218-8 A special emphasis on epidemiological, diagnostic, and therapeutic aspects of infections due to non-albicans Candida species and other uncommon yeasts that are emerging as key opportunistic pathogens
    • •• Miceli MH, Díaz JA, Lee SA. Emerging opportunistic yeast infections. Lancet Infect Dis. 2011;11:142-51. A special emphasis on epidemiological, diagnostic, and therapeutic aspects of infections due to non-albicans Candida species and other uncommon yeasts that are emerging as key opportunistic pathogens.
    • (2011) Lancet Infect Dis , vol.11 , pp. 142-151
    • Miceli, M.H.1    Díaz, J.A.2    Lee, S.A.3
  • 6
    • 80053981736 scopus 로고    scopus 로고
    • Emerging moulds: Epidemiological trends and antifungal resistance
    • 21672045 10.1111/j.1439-0507.2011.02032.x
    • Miceli MH, Lee SA. Emerging moulds: epidemiological trends and antifungal resistance. Mycoses. 2011;54:e666-78.
    • (2011) Mycoses , vol.54 , pp. 666-678
    • Miceli, M.H.1    Lee, S.A.2
  • 7
    • 63849233258 scopus 로고    scopus 로고
    • The changing face of epidemiology of invasive fungal disease in Europe
    • 19391253 10.1111/j.1439-0507.2009.01691.x An interesting view on how current treatment strategies and antifungal prophylaxis use have contributed to substantial changes in the European epidemiology of invasive mycoses
    • • Lass-Flörl C. The changing face of epidemiology of invasive fungal disease in Europe. Mycoses. 2009;52:197-205. An interesting view on how current treatment strategies and antifungal prophylaxis use have contributed to substantial changes in the European epidemiology of invasive mycoses.
    • (2009) Mycoses , vol.52 , pp. 197-205
    • Lass-Flörl, C.1
  • 8
    • 80053222265 scopus 로고    scopus 로고
    • Evaluating the role of prophylaxis in the management of invasive fungal infections in patients with hematologic malignancy
    • 21752098 1:CAS:528:DC%2BC3MXhtlGisbbF 10.1111/j.1600-0609.2011.01682.x
    • Cornely OA, Aversa F, Cook P, et al. Evaluating the role of prophylaxis in the management of invasive fungal infections in patients with hematologic malignancy. Eur J Haematol. 2011;87:289-301.
    • (2011) Eur J Haematol , vol.87 , pp. 289-301
    • Cornely, O.A.1    Aversa, F.2    Cook, P.3
  • 9
    • 64049088064 scopus 로고    scopus 로고
    • Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: An update
    • 19254165 1:CAS:528:DC%2BD1MXislWrsrg%3D 10.1586/14787210.7.2.165
    • Smith WJ, Drew RH, Perfect JR. Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update. Expert Rev Anti Infect Ther. 2009;7:165-81.
    • (2009) Expert Rev Anti Infect Ther , vol.7 , pp. 165-181
    • Smith, W.J.1    Drew, R.H.2    Perfect, J.R.3
  • 10
    • 84865372882 scopus 로고    scopus 로고
    • Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: Real-life data from a single-centre institutional retrospective observational study
    • 22653819 1:CAS:528:DC%2BC38Xht1egt7rM 10.1093/jac/dks189
    • Auberger J, Lass-Flörl C, Aigner M, et al. Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: real-life data from a single-centre institutional retrospective observational study. J Antimicrob Chemother. 2012;67:2268-73.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 2268-2273
    • Auberger, J.1    Lass-Flörl, C.2    Aigner, M.3
  • 11
    • 70350593957 scopus 로고    scopus 로고
    • New triazoles and echinocandins: Mode of action, in vitro activity and mechanisms of resistance
    • 19803707 1:CAS:528:DC%2BD1MXht1Wru7bP 10.1586/eri.09.67
    • Fera MT, La Camera E, De Sarro A. New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance. Expert Rev Anti Infect Ther. 2009;7:981-98.
    • (2009) Expert Rev Anti Infect Ther , vol.7 , pp. 981-998
    • Fera, M.T.1    La Camera, E.2    De Sarro, A.3
  • 12
    • 79952983544 scopus 로고    scopus 로고
    • Newer antifungal agents
    • 21417872 10.1586/eri.10.163 1:CAS:528:DC%2BC3MXjsFCqsr8%3D
    • Türel O. Newer antifungal agents. Expert Rev Anti Infect Ther. 2011;9:325-38.
    • (2011) Expert Rev Anti Infect Ther , vol.9 , pp. 325-338
    • Türel, O.1
  • 13
    • 70349754592 scopus 로고    scopus 로고
    • Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients
    • 19767376 10.2146/ajhp080325
    • Menzin J, Meyers JL, Friedman M, et al. Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients. Am J Health Syst Pharm. 2009;66:1711-7.
    • (2009) Am J Health Syst Pharm , vol.66 , pp. 1711-1717
    • Menzin, J.1    Meyers, J.L.2    Friedman, M.3
  • 14
    • 58749083534 scopus 로고    scopus 로고
    • Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: Analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry
    • Neofytos D, Horn D, Anaissie E, et al. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry. Clin Infect Dis. 2009;48:2651-73.
    • (2009) Clin Infect Dis , vol.48 , pp. 2651-2673
    • Neofytos, D.1    Horn, D.2    Anaissie, E.3
  • 15
    • 84875240701 scopus 로고    scopus 로고
    • Mortality in patients with early- or late-onset candidaemia
    • 23236102 10.1093/jac/dks480 1:CAS:528:DC%2BC3sXjslGnur0%3D
    • De Rosa FG, Trecarichi EM, Montrucchio C, et al. Mortality in patients with early- or late-onset candidaemia. J Antimicrob Chemother. 2013;68:927-35.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 927-935
    • De Rosa, F.G.1    Trecarichi, E.M.2    Montrucchio, C.3
  • 16
    • 84878643045 scopus 로고    scopus 로고
    • Epidemiology, outcomes, and mortality predictors of invasive mold infections among transplant recipients: A 10-year, single-center experience
    • [Epub ahead of print]
    • Neofytos D, Treadway S, Ostrander D, et al. Epidemiology, outcomes, and mortality predictors of invasive mold infections among transplant recipients: a 10-year, single-center experience. Transpl Infect Dis. 2013 [Epub ahead of print]
    • (2013) Transpl Infect Dis.
    • Neofytos, D.1    Treadway, S.2    Ostrander, D.3
  • 17
    • 79952190110 scopus 로고    scopus 로고
    • Use of antifungal combination therapy: Agents, order, and timing
    • 20574543 10.1007/s12281-010-0018-6
    • Johnson MD, Perfect JR. Use of antifungal combination therapy: agents, order, and timing. Curr Fungal Infect Rep. 2010;4:87-95.
    • (2010) Curr Fungal Infect Rep , vol.4 , pp. 87-95
    • Johnson, M.D.1    Perfect, J.R.2
  • 18
    • 79952645830 scopus 로고    scopus 로고
    • Newer combination antifungal therapies for invasive aspergillosis
    • 20608784 10.3109/13693786.2010.499374
    • Steinbach WJ, Juvvadi PR, Fortwendel JR, Rogg LE. Newer combination antifungal therapies for invasive aspergillosis. Med Mycol. 2011;49 Suppl 1:S77-81.
    • (2011) Med Mycol , vol.49 , Issue.SUPPL. 1 , pp. 77-81
    • Steinbach, W.J.1    Juvvadi, P.R.2    Fortwendel, J.R.3    Rogg, L.E.4
  • 19
    • 79951539030 scopus 로고    scopus 로고
    • Management of invasive fungal infections: A role for polyenes
    • 21172787 1:CAS:528:DC%2BC3MXitVWiur0%3D 10.1093/jac/dkq479 A review on the actual usefulness of the oldest antifungal agents, polyenes, in the treatment of invasive fungal infections, to consideration by clinicians
    • • Chandrasekar P. Management of invasive fungal infections: a role for polyenes. J Antimicrob Chemother. 2011;66:457-65. A review on the actual usefulness of the oldest antifungal agents, polyenes, in the treatment of invasive fungal infections, to consideration by clinicians.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 457-465
    • Chandrasekar, P.1
  • 20
    • 62149098304 scopus 로고    scopus 로고
    • Liposomal amphotericin B: A review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections
    • 19275278 1:CAS:528:DC%2BD1MXls1yls7w%3D 10.2165/00003495-200969030-00010
    • Moen MD, Lyseng-Williamson KA, Scott LJ. Liposomal amphotericin B: a review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections. Drugs. 2009;69:361-92.
    • (2009) Drugs , vol.69 , pp. 361-392
    • Moen, M.D.1    Lyseng-Williamson, K.A.2    Scott, L.J.3
  • 21
    • 84863745855 scopus 로고    scopus 로고
    • The PATH (Prospective Antifungal Therapy) Alliance® registry and invasive fungal infections: Update 2012
    • 22789847 10.1016/j.diagmicrobio.2012.06.012 An updated overview on the epidemiology, diagnostic tests, treatments, and outcomes of vastly various and large numbers of IFIs from selected tertiary care medical centers in North America
    • •• Azie N, Neofytos D, Pfaller M, et al. The PATH (Prospective Antifungal Therapy) Alliance® registry and invasive fungal infections: update 2012. Diagn Microbiol Infect Dis. 2012;73:293-300. An updated overview on the epidemiology, diagnostic tests, treatments, and outcomes of vastly various and large numbers of IFIs from selected tertiary care medical centers in North America.
    • (2012) Diagn Microbiol Infect Dis , vol.73 , pp. 293-300
    • Azie, N.1    Neofytos, D.2    Pfaller, M.3
  • 22
    • 84869083702 scopus 로고    scopus 로고
    • Epidemiology and outcomes of candidemia in 3648 patients: Data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004-2008
    • 23102556 10.1016/j.diagmicrobio.2012.10.003
    • Pfaller M, Neofytos D, Diekema D, et al. Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004-2008. Diagn Microbiol Infect Dis. 2012;74:323-31.
    • (2012) Diagn Microbiol Infect Dis , vol.74 , pp. 323-331
    • Pfaller, M.1    Neofytos, D.2    Diekema, D.3
  • 23
    • 84859613323 scopus 로고    scopus 로고
    • Epidemiology, species distribution and in vitro antifungal susceptibility of fungaemia in a Spanish multicentre prospective survey
    • 22351683 10.1093/jac/dks019 1:CAS:528:DC%2BC38Xlt1Gntrs%3D
    • Pemán J, Cantón E, Quindós G, et al. Epidemiology, species distribution and in vitro antifungal susceptibility of fungaemia in a Spanish multicentre prospective survey. J Antimicrob Chemother. 2012;67:1181-7.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 1181-1187
    • Pemán, J.1    Cantón, E.2    Quindós, G.3
  • 24
    • 65249158433 scopus 로고    scopus 로고
    • Identification of Candida nivariensis and Candida bracarensis in a large global collection of Candida glabrata isolates: Comparison to the literature
    • 19193845 1:CAS:528:DC%2BD1MXlvVamtLg%3D 10.1128/JCM.02315-08
    • Lockhart SR, Messer SA, Gherna M, et al. Identification of Candida nivariensis and Candida bracarensis in a large global collection of Candida glabrata isolates: comparison to the literature. J Clin Microbiol. 2009;47:1216-7.
    • (2009) J Clin Microbiol , vol.47 , pp. 1216-1217
    • Lockhart, S.R.1    Messer, S.A.2    Gherna, M.3
  • 25
    • 40749127196 scopus 로고    scopus 로고
    • Candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents
    • 18199788 1:CAS:528:DC%2BD1cXksVeiurc%3D 10.1128/JCM.02116-07
    • Borman AM, Petch R, Linton CJ, et al. Candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents. J Clin Microbiol. 2008;46:933-8.
    • (2008) J Clin Microbiol , vol.46 , pp. 933-938
    • Borman, A.M.1    Petch, R.2    Linton, C.J.3
  • 26
    • 77954203947 scopus 로고    scopus 로고
    • Candidaemia associated with decreased in vitro fluconazole susceptibility: Is Candida speciation predictive of the susceptibility pattern?
    • 20430790 1:CAS:528:DC%2BC3cXnsVOqu7g%3D 10.1093/jac/dkq136
    • Oxman DA, Chow JK, Frendl G, et al. Candidaemia associated with decreased in vitro fluconazole susceptibility: is Candida speciation predictive of the susceptibility pattern? J Antimicrob Chemother. 2010;65:1460-5.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1460-1465
    • Oxman, D.A.1    Chow, J.K.2    Frendl, G.3
  • 27
    • 78751679139 scopus 로고    scopus 로고
    • Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: A prospective multicenter study involving 2,441 patients
    • 21078946 1:CAS:528:DC%2BC3MXisVyjs7c%3D 10.1128/AAC.01128-10
    • Lortholary O, Desnos-Ollivier M, Sitbon K, et al. Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patients. Antimicrob Agents Chemother. 2011;55:532-8.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 532-538
    • Lortholary, O.1    Desnos-Ollivier, M.2    Sitbon, K.3
  • 28
    • 70349635812 scopus 로고    scopus 로고
    • Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007
    • 19656983 1:CAS:528:DC%2BD1MXhsVerurfF 10.1128/JCM.00946-09
    • Pfaller MA, Messer SA, Hollis RJ, et al. Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007. J Clin Microbiol. 2009;47:3185-90.
    • (2009) J Clin Microbiol , vol.47 , pp. 3185-3190
    • Pfaller, M.A.1    Messer, S.A.2    Hollis, R.J.3
  • 29
    • 79955538785 scopus 로고    scopus 로고
    • Clinical breakpoints for the echinocandins and Candida revisited: Integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria
    • 21353623 1:CAS:528:DC%2BC3MXntlGktL8%3D 10.1016/j.drup.2011.01.004
    • Pfaller MA, Diekema DJ, Andes D, et al. Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria. Drug Resist Updat. 2011;14:164-76.
    • (2011) Drug Resist Updat , vol.14 , pp. 164-176
    • Pfaller, M.A.1    Diekema, D.J.2    Andes, D.3
  • 30
    • 78649936372 scopus 로고    scopus 로고
    • Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: Application of new CLSI clinical breakpoints and epidemiologic cutoff values to characterize resistance in the SENTRY Antimicrobial Surveillance Program (2009)
    • 21146713 1:CAS:528:DC%2BC3cXhsFCru7jL 10.1016/j.diagmicrobio.2010.08.013
    • Pfaller MA, Castanheira M, Messer SA, et al. Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: application of new CLSI clinical breakpoints and epidemiologic cutoff values to characterize resistance in the SENTRY Antimicrobial Surveillance Program (2009). Diagn Microbiol Infect Dis. 2011;69:45-50.
    • (2011) Diagn Microbiol Infect Dis , vol.69 , pp. 45-50
    • Pfaller, M.A.1    Castanheira, M.2    Messer, S.A.3
  • 31
    • 78650924029 scopus 로고    scopus 로고
    • Geographic variations in species distribution and echinocandin and azole antifungal resistance rates among Candida bloodstream infection isolates: Report from the SENTRY Antimicrobial Surveillance Program (2008 to 2009)
    • 21068282 10.1128/JCM.01398-10
    • Pfaller MA, Moet GJ, Messer SA, et al. Geographic variations in species distribution and echinocandin and azole antifungal resistance rates among Candida bloodstream infection isolates: report from the SENTRY Antimicrobial Surveillance Program (2008 to 2009). J Clin Microbiol. 2011;49:396-9.
    • (2011) J Clin Microbiol , vol.49 , pp. 396-399
    • Pfaller, M.A.1    Moet, G.J.2    Messer, S.A.3
  • 32
    • 77149169382 scopus 로고    scopus 로고
    • Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient
    • 20038613 1:CAS:528:DC%2BC3cXjtFWqtL4%3D 10.1128/AAC.01138-09
    • Chapeland-Leclerc F, Hennequin C, Papon N, et al. Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. Antimicrob Agents Chemother. 2010;54:1360-2.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1360-1362
    • Chapeland-Leclerc, F.1    Hennequin, C.2    Papon, N.3
  • 33
    • 84863337736 scopus 로고    scopus 로고
    • Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata
    • 22278842 1:CAS:528:DC%2BC38Xmt1yktbw%3D 10.1128/JCM.06112-11 The first documented evidence, to the authors' knowledge, attesting the emergence of co-resistance over time to both azoles and echinocandins in clinical isolates of C. glabrata
    • •• Pfaller MA, Castanheira M, Lockhart SR, et al. Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata. J Clin Microbiol. 2012;50:1199-203. The first documented evidence, to the authors' knowledge, attesting the emergence of co-resistance over time to both azoles and echinocandins in clinical isolates of C. glabrata.
    • (2012) J Clin Microbiol , vol.50 , pp. 1199-1203
    • Pfaller, M.A.1    Castanheira, M.2    Lockhart, S.R.3
  • 34
    • 77950240283 scopus 로고    scopus 로고
    • Caspofungin-non-susceptible Candida isolates in cancer patients
    • 20016020 1:CAS:528:DC%2BC3cXhtVSru7g%3D 10.1093/jac/dkp444
    • Kofteridis DP, Lewis RE, Kontoyiannis DP. Caspofungin-non-susceptible Candida isolates in cancer patients. J Antimicrob Chemother. 2010;65:293-5.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 293-295
    • Kofteridis, D.P.1    Lewis, R.E.2    Kontoyiannis, D.P.3
  • 35
    • 77954444121 scopus 로고    scopus 로고
    • Breakthrough invasive candidiasis on micafungin
    • 20421445 1:CAS:528:DC%2BC3cXhtVaktb7L 10.1128/JCM.02390-09
    • Pfeiffer CD, Garcia-Effron G, Zaas AK, et al. Breakthrough invasive candidiasis on micafungin. J Clin Microbiol. 2010;48:2373-80.
    • (2010) J Clin Microbiol , vol.48 , pp. 2373-2380
    • Pfeiffer, C.D.1    Garcia-Effron, G.2    Zaas, A.K.3
  • 36
    • 78649671319 scopus 로고    scopus 로고
    • FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from U.S. population-based surveillance
    • 20837754 1:CAS:528:DC%2BC3cXhsF2nu7nN 10.1128/AAC.00836-10
    • Zimbeck AJ, Iqbal N, Ahlquist AM, et al. FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from U.S. population-based surveillance. Antimicrob Agents Chemother. 2010;54:5042-7.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 5042-5047
    • Zimbeck, A.J.1    Iqbal, N.2    Ahlquist, A.M.3
  • 37
    • 79956031869 scopus 로고    scopus 로고
    • Antifungal use in hospitalized adults in U.S. academic health centers
    • 21330683 10.2146/ajhp100423
    • Pakyz AL, Gurgle HE, Oinonen MJ. Antifungal use in hospitalized adults in U.S. academic health centers. Am J Health Syst Pharm. 2011;68:415-8.
    • (2011) Am J Health Syst Pharm , vol.68 , pp. 415-418
    • Pakyz, A.L.1    Gurgle, H.E.2    Oinonen, M.J.3
  • 38
    • 84860723063 scopus 로고    scopus 로고
    • The changing epidemiology of healthcare-associated candidemia over three decades
    • 22578938 10.1016/j.diagmicrobio.2012.02.001
    • Diekema D, Arbefeville S, Boyken L, et al. The changing epidemiology of healthcare-associated candidemia over three decades. Diagn Microbiol Infect Dis. 2012;73:45-8.
    • (2012) Diagn Microbiol Infect Dis , vol.73 , pp. 45-48
    • Diekema, D.1    Arbefeville, S.2    Boyken, L.3
  • 39
    • 80054709630 scopus 로고    scopus 로고
    • Prior caspofungin exposure in patients with hematological malignancies is a risk factor for subsequent fungemia due to decreased susceptibility in Candida spp.: A case-control study in Paris, France
    • 21859944 1:CAS:528:DC%2BC3MXhsVSqsr7O 10.1128/AAC.00690-11
    • Blanchard E, Lortholary O, Boukris-Sitbon K, et al. Prior caspofungin exposure in patients with hematological malignancies is a risk factor for subsequent fungemia due to decreased susceptibility in Candida spp.: a case-control study in Paris, France. Antimicrob Agents Chemother. 2011;55:5358-61.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5358-5361
    • Blanchard, E.1    Lortholary, O.2    Boukris-Sitbon, K.3
  • 40
    • 77955472795 scopus 로고    scopus 로고
    • Risk factors for fluconazole resistance in patients with Candida glabrata bloodstream infection: Potential impact of control group selection on characterizing the association between previous fluconazole use and fluconazole resistance
    • 20371135 1:CAS:528:DC%2BC3cXhtFyqtbrF 10.1016/j.ajic.2009.12.011
    • Lee I, Zaoutis TE, Fishman NO, et al. Risk factors for fluconazole resistance in patients with Candida glabrata bloodstream infection: potential impact of control group selection on characterizing the association between previous fluconazole use and fluconazole resistance. Am J Infect Control. 2010;38:456-60.
    • (2010) Am J Infect Control , vol.38 , pp. 456-460
    • Lee, I.1    Zaoutis, T.E.2    Fishman, N.O.3
  • 41
    • 68249158188 scopus 로고    scopus 로고
    • Trends in invasive fungal infections, with emphasis on invasive aspergillosis
    • 19673973 1:CAS:528:DC%2BD1MXhtFWit7nL 10.1111/j.1469-0691.2009.02929.x
    • Erjavec Z, Kluin-Nelemans H, Verweij PE. Trends in invasive fungal infections, with emphasis on invasive aspergillosis. Clin Microbiol Infect. 2009;15:625-33.
    • (2009) Clin Microbiol Infect , vol.15 , pp. 625-633
    • Erjavec, Z.1    Kluin-Nelemans, H.2    Verweij, P.E.3
  • 42
    • 79952654257 scopus 로고    scopus 로고
    • Aspergillus species intrinsically resistant to antifungal agents
    • 10.3109/13693786.2010.499916
    • Van Der Linden JWM, Warris A, Verweij PE. Aspergillus species intrinsically resistant to antifungal agents. Med Mycol. 2011;49 Suppl 1:S82-9.
    • (2011) Med Mycol , vol.49 , Issue.SUPPL. 1 , pp. 82-89
    • Van Der Linden, J.W.M.1    Warris, A.2    Verweij, P.E.3
  • 43
    • 79952645511 scopus 로고    scopus 로고
    • Acquired antifungal drug resistance in Aspergillus fumigatus: Epidemiology and detection
    • 20795765 1:CAS:528:DC%2BC3MXjtVCrur0%3D 10.3109/13693786.2010.508469
    • Howard SJ, Arendrup MC. Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection. Med Mycol. 2011;49 Suppl 1:S90-5.
    • (2011) Med Mycol , vol.49 , Issue.SUPPL. 1 , pp. 90-95
    • Howard, S.J.1    Arendrup, M.C.2
  • 44
    • 81155153709 scopus 로고    scopus 로고
    • Azole antifungal resistance today: Focus on Aspergillus
    • 21931980 10.1007/s11908-011-0218-4
    • Bowyer P, Moore CB, Rautemaa R, et al. Azole antifungal resistance today: focus on Aspergillus. Curr Infect Dis Rep. 2011;13:485-91.
    • (2011) Curr Infect Dis Rep , vol.13 , pp. 485-491
    • Bowyer, P.1    Moore, C.B.2    Rautemaa, R.3
  • 45
    • 70749088981 scopus 로고    scopus 로고
    • Azole-resistance in Aspergillus: Proposed nomenclature and breakpoints
    • 19879181 1:CAS:528:DC%2BD1MXhsFagtLrF 10.1016/j.drup.2009.09.002
    • Verweij PE, Howard SJ, Melchers WJ, Denning DW. Azole-resistance in Aspergillus: proposed nomenclature and breakpoints. Drug Resist Updat. 2009;12:141-7.
    • (2009) Drug Resist Updat , vol.12 , pp. 141-147
    • Verweij, P.E.1    Howard, S.J.2    Melchers, W.J.3    Denning, D.W.4
  • 46
    • 56749159784 scopus 로고    scopus 로고
    • Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism
    • 18998768 10.1371/journal.pmed.0050219 1:CAS:528:DC%2BD1MXhtVKgsb0%3D
    • Snelders E, van der Lee HA, Kuijpers J, et al. Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med. 2008;5:e219.
    • (2008) PLoS Med. , vol.5 , pp. 219
    • Snelders, E.1    Van Der Lee, H.A.2    Kuijpers, J.3
  • 47
    • 67650657544 scopus 로고    scopus 로고
    • Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure
    • 19624922 1:CAS:528:DC%2BD1MXptFGhs7w%3D 10.3201/eid1507.090043
    • Howard SJ, Cerar D, Anderson MJ, et al. Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis. 2009;15:1068-76.
    • (2009) Emerg Infect Dis , vol.15 , pp. 1068-1076
    • Howard, S.J.1    Cerar, D.2    Anderson, M.J.3
  • 48
    • 71549143158 scopus 로고    scopus 로고
    • Azole resistance in Aspergillus fumigatus: A side-effect of environmental fungicide use?
    • 19926038 1:CAS:528:DC%2BC3cXhtFyisbfF 10.1016/S1473-3099(09)70265-8
    • Verweij PE, Snelders E, Kema GH, Mellado E, Melchers WJ. Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use? Lancet Infect Dis. 2009;9:789-95.
    • (2009) Lancet Infect Dis , vol.9 , pp. 789-795
    • Verweij, P.E.1    Snelders, E.2    Kema, G.H.3    Mellado, E.4    Melchers, W.J.5
  • 49
    • 77957241722 scopus 로고    scopus 로고
    • Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009
    • 20729241 1:CAS:528:DC%2BC3cXhtFylsb3J 10.1093/jac/dkq279
    • Bueid A, Howard SJ, Moore CB, et al. Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009. J Antimicrob Chemother. 2010;65:2116-8.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 2116-2118
    • Bueid, A.1    Howard, S.J.2    Moore, C.B.3
  • 50
    • 80051827318 scopus 로고    scopus 로고
    • Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene
    • 21690285 1:CAS:528:DC%2BC3MXhtFaitr3I 10.1128/AAC.00185-11
    • Lockhart SR, Frade JP, Etienne KA, et al. Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene. Antimicrob Agents Chemother. 2011;55:4465-8.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4465-4468
    • Lockhart, S.R.1    Frade, J.P.2    Etienne, K.A.3
  • 51
    • 79951496607 scopus 로고    scopus 로고
    • Use of epidemiological cutoff values to examine 9-year trends in susceptibility of Aspergillus species to the triazoles
    • 21123534 1:CAS:528:DC%2BC3MXjtFSnsL4%3D 10.1128/JCM.02136-10
    • Pfaller M, Boyken L, Hollis R, et al. Use of epidemiological cutoff values to examine 9-year trends in susceptibility of Aspergillus species to the triazoles. J Clin Microbiol. 2011;49:586-90.
    • (2011) J Clin Microbiol , vol.49 , pp. 586-590
    • Pfaller, M.1    Boyken, L.2    Hollis, R.3
  • 52
    • 78651507737 scopus 로고    scopus 로고
    • Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies
    • 21131690 1:CAS:528:DC%2BC3MXnsFahsQ%3D%3D 10.1093/jac/dkq450
    • Alanio A, Sitterlé E, Liance M, et al. Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies. J Antimicrob Chemother. 2011;66:371-4.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 371-374
    • Alanio, A.1    Sitterlé, E.2    Liance, M.3
  • 53
    • 77952355177 scopus 로고    scopus 로고
    • In vitro susceptibility testing in Aspergillus species: An update
    • 20441550 10.2217/fmb.10.34
    • Lass-Flörl C. In vitro susceptibility testing in Aspergillus species: an update. Future Microbiol. 2010;5:789-99.
    • (2010) Future Microbiol , vol.5 , pp. 789-799
    • Lass-Flörl, C.1
  • 54
    • 35748956729 scopus 로고    scopus 로고
    • Breakthrough invasive aspergillosis in allogeneic haematopoietic stem cell transplant recipients treated with caspofungin
    • 18029149 1:CAS:528:DC%2BD2sXht12itr7M 10.1016/j.ijantimicag.2007.07.026
    • Madureira A, Bergeron A, Lacroix C, et al. Breakthrough invasive aspergillosis in allogeneic haematopoietic stem cell transplant recipients treated with caspofungin. Int J Antimicrob Agents. 2007;30:551-4.
    • (2007) Int J Antimicrob Agents , vol.30 , pp. 551-554
    • Madureira, A.1    Bergeron, A.2    Lacroix, C.3
  • 55
    • 62949220164 scopus 로고    scopus 로고
    • Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: Laboratory characteristics and implication for susceptibility testing
    • 19104024 1:CAS:528:DC%2BD1MXivF2ksrc%3D 10.1128/AAC.01292-08
    • Arendrup MC, Garcia-Effron G, Buzina W, et al. Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. Antimicrob Agents Chemother. 2009;53:1185-93.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1185-1193
    • Arendrup, M.C.1    Garcia-Effron, G.2    Buzina, W.3
  • 56
    • 84858441721 scopus 로고    scopus 로고
    • Breakthrough invasive mould infections in patients treated with caspofungin
    • 22227384 10.1016/j.jinf.2011.12.015
    • Pang KA, Godet C, Fekkar A, et al. Breakthrough invasive mould infections in patients treated with caspofungin. J Infect. 2012;64:424-9.
    • (2012) J Infect , vol.64 , pp. 424-429
    • Pang, K.A.1    Godet, C.2    Fekkar, A.3
  • 57
    • 79956307891 scopus 로고    scopus 로고
    • Wild-type MIC distributions and epidemiological cutoff values for caspofungin and Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document)
    • 21422219 1:CAS:528:DC%2BC3MXnt1Kiu70%3D 10.1128/AAC.01730-10
    • Espinel-Ingroff A, Fothergill A, Fuller J, et al. Wild-type MIC distributions and epidemiological cutoff values for caspofungin and Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document). Antimicrob Agents Chemother. 2011;55:2855-9.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2855-2859
    • Espinel-Ingroff, A.1    Fothergill, A.2    Fuller, J.3
  • 58
    • 47049090269 scopus 로고    scopus 로고
    • Stress, drugs, and evolution: The role of cellular signaling in fungal drug resistance
    • 18375617 1:CAS:528:DC%2BD1cXmvVSrsro%3D 10.1128/EC.00041-08
    • Cowen LE, Steinbach WJ. Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot Cell. 2008;7:747-64.
    • (2008) Eukaryot Cell , vol.7 , pp. 747-764
    • Cowen, L.E.1    Steinbach, W.J.2
  • 59
    • 39149087719 scopus 로고    scopus 로고
    • The evolution of fungal drug resistance: Modulating the trajectory from genotype to phenotype
    • 18246082 1:CAS:528:DC%2BD1cXhvFCgt7k%3D 10.1038/nrmicro1835
    • Cowen LE. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nat Rev Microbiol. 2008;6:187-98.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 187-198
    • Cowen, L.E.1
  • 60
    • 84930481483 scopus 로고    scopus 로고
    • Clinical implications of azole resistance in Aspergillus fumigatus, the Netherlands, 2007-2009
    • 22000354 10.3201/eid1710.110226 1:CAS:528:DC%2BC3MXhtlOmsr3E
    • van der Linden JW, Snelders E, Kampinga GA, et al. Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009. Emerg Infect Dis. 2011;17:1846-54.
    • (2011) Emerg Infect Dis , vol.17 , pp. 1846-1854
    • Van Der Linden, J.W.1    Snelders, E.2    Kampinga, G.A.3
  • 61
    • 70350026151 scopus 로고    scopus 로고
    • Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation
    • 19799636 1:CAS:528:DC%2BD1MXhtlOis7bL 10.1111/j.1567-1364.2009.00578.x An exhaustive summary of the transcriptional regulation of drug resistance genes, a crucial mechanism that can be 'ad hoc' modified by the fungal pathogen
    • •• Sanglard D, Coste A, Ferrari S. Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation. FEMS Yeast Res. 2009;9:1029-50. An exhaustive summary of the transcriptional regulation of drug resistance genes, a crucial mechanism that can be 'ad hoc' modified by the fungal pathogen.
    • (2009) FEMS Yeast Res , vol.9 , pp. 1029-1050
    • Sanglard, D.1    Coste, A.2    Ferrari, S.3
  • 62
    • 84877642562 scopus 로고    scopus 로고
    • Erg 11 mutations associated with azole resistance in clinical isolates of Candida albicans
    • [Epub ahead of print]
    • Xiang MJ Liu JY, Ni PH, et al. Erg 11 mutations associated with azole resistance in clinical isolates of Candida albicans. FEMS Yeast Res. 2013 [Epub ahead of print].
    • (2013) FEMS Yeast Res.
    • Xiang, M.J.1    Liu, J.Y.2    Ni, P.H.3
  • 63
    • 0346784897 scopus 로고    scopus 로고
    • Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding
    • 14742211 1:CAS:528:DC%2BD2cXhtFGltr4%3D 10.1128/AAC.48.2.568-574.2004
    • Xiao L, Madison V, Chau AS, Loebenberg D, Palermo RE, McNicholas PM. Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding. Antimicrob Agents Chemother. 2004;48:568-74.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 568-574
    • Xiao, L.1    Madison, V.2    Chau, A.S.3    Loebenberg, D.4    Palermo, R.E.5    McNicholas, P.M.6
  • 64
    • 84870590660 scopus 로고    scopus 로고
    • Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing
    • 23226235 1:CAS:528:DC%2BC38XhvVKqsbnP 10.1371/journal.pone.0050034
    • Camps SM, Dutilh BE, Arendrup MC, Rijs AJ, Snelders E, Huynen MA, et al. Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing. PLoS One. 2012;7:e50034.
    • (2012) PLoS One , vol.7 , pp. 50034
    • Camps, S.M.1    Dutilh, B.E.2    Arendrup, M.C.3    Rijs, A.J.4    Snelders, E.5    Huynen, M.A.6
  • 65
    • 67149128129 scopus 로고    scopus 로고
    • Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles
    • 19376899 1:CAS:528:DC%2BD1MXotFalsLw%3D 10.1128/AEM.00231-09
    • Snelders E, Veld RA H i 't, Rijs AJ, Kema GH, Melchers WJ, Verweij PE. Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles. Appl Environ Microbiol. 2009;75:4053-7.
    • (2009) Appl Environ Microbiol , vol.75 , pp. 4053-4057
    • Snelders, E.1    Veld Ra, H.I.'.2    Rijs, A.J.3    Kema, G.H.4    Melchers, W.J.5    Verweij, P.E.6
  • 66
    • 78049318458 scopus 로고    scopus 로고
    • Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain
    • 20805399 1:CAS:528:DC%2BC3cXhsVCitr7F 10.1128/AAC.00692-10
    • Mortensen KL, Mellado E, Lass-Flörl C, et al. Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain. Antimicrob Agents Chemother. 2010;54:4545-9.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 4545-4549
    • Mortensen, K.L.1    Mellado, E.2    Lass-Flörl, C.3
  • 67
    • 34250223076 scopus 로고    scopus 로고
    • A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations
    • 17371828 1:CAS:528:DC%2BD2sXmtlKku7s%3D 10.1128/AAC.01092-06
    • Mellado E, Garcia-Effron G, Alcázar-Fuoli L, et al. A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrob Agents Chemother. 2007;51:1897-904.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1897-1904
    • Mellado, E.1    Garcia-Effron, G.2    Alcázar-Fuoli, L.3
  • 68
    • 35348903338 scopus 로고    scopus 로고
    • Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates
    • 17693596 1:CAS:528:DC%2BD2sXht1Smu7vN 10.1128/EC.00151-07
    • Coste A, Selmecki A, Forche A, et al. Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates. Eukaryot Cell. 2007;6:1889-904.
    • (2007) Eukaryot Cell , vol.6 , pp. 1889-1904
    • Coste, A.1    Selmecki, A.2    Forche, A.3
  • 69
    • 41749113291 scopus 로고    scopus 로고
    • An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
    • 18363649 1:CAS:528:DC%2BD1cXlsVOitL4%3D 10.1111/j.1365-2958.2008.06176.x
    • Selmecki A, Gerami-Nejad M, Paulson C, et al. An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. Mol Microbiol. 2008;68:624-41.
    • (2008) Mol Microbiol , vol.68 , pp. 624-641
    • Selmecki, A.1    Gerami-Nejad, M.2    Paulson, C.3
  • 70
    • 0032734512 scopus 로고    scopus 로고
    • The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents
    • 10543759 1:CAS:528:DyaK1MXnt1Wrtbw%3D
    • Sanglard D, Ischer F, Calabrese D, et al. The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents. Antimicrob Agents Chemother. 1999;43:2753-65.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2753-2765
    • Sanglard, D.1    Ischer, F.2    Calabrese, D.3
  • 71
    • 12944263708 scopus 로고    scopus 로고
    • Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance
    • 15673750 1:CAS:528:DC%2BD2MXht12ntLg%3D 10.1128/AAC.49.2.668-679.2005
    • Sanguinetti M, Posteraro B, Fiori B, et al. Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance. Antimicrob Agents Chemother. 2005;49:668-79.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 668-679
    • Sanguinetti, M.1    Posteraro, B.2    Fiori, B.3
  • 72
    • 40549126935 scopus 로고    scopus 로고
    • The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata
    • 18312269 1:CAS:528:DC%2BD1cXksVKjsL4%3D 10.1111/j.1365-2958.2008.06143.x
    • Torelli R, Posteraro B, Ferrari S, et al. The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata. Mol Microbiol. 2008;68:186-201.
    • (2008) Mol Microbiol , vol.68 , pp. 186-201
    • Torelli, R.1    Posteraro, B.2    Ferrari, S.3
  • 73
    • 77950180902 scopus 로고    scopus 로고
    • Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection
    • 20086148 1:CAS:528:DC%2BC3cXksFOisLw%3D 10.1128/AAC.01645-09
    • MacCallum DM, Coste A, Ischer F, et al. Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. Antimicrob Agents Chemother. 2010;54:1476-83.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1476-1483
    • Maccallum, D.M.1    Coste, A.2    Ischer, F.3
  • 74
    • 79955625171 scopus 로고    scopus 로고
    • Current perspectives on echinocandin class drugs
    • 21526945 1:CAS:528:DC%2BC3MXltlegs7w%3D 10.2217/fmb.11.19
    • Perlin DS. Current perspectives on echinocandin class drugs. Future Microbiol. 2011;6:441-57.
    • (2011) Future Microbiol , vol.6 , pp. 441-457
    • Perlin, D.S.1
  • 75
    • 77958184622 scopus 로고    scopus 로고
    • Echinocandin antifungal drug resistance in Candida species: A cause for concern?
    • 21308552 10.1007/s11908-010-0131-2
    • Sanguinetti M, Posteraro P, Posteraro B. Echinocandin antifungal drug resistance in Candida species: a cause for concern? Curr Infect Dis Rep. 2010;12:437-43.
    • (2010) Curr Infect Dis Rep , vol.12 , pp. 437-443
    • Sanguinetti, M.1    Posteraro, P.2    Posteraro, B.3
  • 76
    • 33748049789 scopus 로고    scopus 로고
    • Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes
    • 16757500 1:CAS:528:DC%2BD28Xotl2ltrw%3D 10.1093/jac/dkl237
    • Posteraro B, Sanguinetti M, Fiori B, et al. Caspofungin activity against clinical isolates of azole cross-resistant Candida glabrata overexpressing efflux pump genes. J Antimicrob Chemother. 2006;58:458-61.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 458-461
    • Posteraro, B.1    Sanguinetti, M.2    Fiori, B.3
  • 77
    • 84872031378 scopus 로고    scopus 로고
    • Elevated chitin content reduces the susceptibility of Candida species to caspofungin
    • 23089748 1:CAS:528:DC%2BC3sXlt1Srs7c%3D 10.1128/AAC.01486-12
    • Walker LA, Gow NA, Munro CA. Elevated chitin content reduces the susceptibility of Candida species to caspofungin. Antimicrob Agents Chemother. 2013;57:146-54.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 146-154
    • Walker, L.A.1    Gow, N.A.2    Munro, C.A.3
  • 78
    • 78650808399 scopus 로고    scopus 로고
    • Echinocandin antifungal drugs in fungal infections: A comparison
    • 21175238 1:CAS:528:DC%2BC3MXitlegtLo%3D 10.2165/11585270-000000000-00000
    • Chen SC, Slavin MA, Sorrell TC. Echinocandin antifungal drugs in fungal infections: a comparison. Drugs. 2011;71:11-41.
    • (2011) Drugs , vol.71 , pp. 11-41
    • Chen, S.C.1    Slavin, M.A.2    Sorrell, T.C.3
  • 79
    • 73749084743 scopus 로고    scopus 로고
    • Fungal echinocandin resistance
    • 19770064 1:CAS:528:DC%2BC3cXnsFWqtw%3D%3D 10.1016/j.fgb.2009.09.003
    • Walker LA, Gow NA, Munro CA. Fungal echinocandin resistance. Fungal Genet Biol. 2010;47:117-26.
    • (2010) Fungal Genet Biol , vol.47 , pp. 117-126
    • Walker, L.A.1    Gow, N.A.2    Munro, C.A.3
  • 80
    • 84869203438 scopus 로고    scopus 로고
    • Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: Implications for echinocandin resistance
    • 23027185 1:CAS:528:DC%2BC38XhslKls77N 10.1128/AAC.00813-12
    • Katiyar SK, Alastruey-Izquierdo A, Healey KR, et al. Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance. Antimicrob Agents Chemother. 2012;56:6304-9.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 6304-6309
    • Katiyar, S.K.1    Alastruey-Izquierdo, A.2    Healey, K.R.3
  • 81
    • 35848964834 scopus 로고    scopus 로고
    • A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus
    • 17724146 1:CAS:528:DC%2BD2sXht1ygtLvO 10.1128/AAC.00917-07
    • Rocha EM, Garcia-Effron G, Park S, Perlin DS. A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Antimicrob Agents Chemother. 2007;51:4174-6.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 4174-4176
    • Rocha, E.M.1    Garcia-Effron, G.2    Park, S.3    Perlin, D.S.4
  • 82
    • 54049095946 scopus 로고    scopus 로고
    • Establishing in vitro-in vivo correlations for Aspergillus fumigatus: The challenge of azoles versus echinocandins
    • 18644959 1:CAS:528:DC%2BD1cXht1SrtbjJ 10.1128/AAC.00190-08
    • Arendrup MC, Perkhofer S, Howard SJ, et al. Establishing in vitro-in vivo correlations for Aspergillus fumigatus: the challenge of azoles versus echinocandins. Antimicrob Agents Chemother. 2008;52:3504-11.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3504-3511
    • Arendrup, M.C.1    Perkhofer, S.2    Howard, S.J.3
  • 83
    • 39349086422 scopus 로고    scopus 로고
    • Antimicrobial resistance: Resistance to antifungal agents: Mechanisms and clinical impact
    • 18171227 10.1086/524071
    • Kanafani ZA, Perfect JR. Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact. Clin Infect Dis. 2008;46:120-8.
    • (2008) Clin Infect Dis , vol.46 , pp. 120-128
    • Kanafani, Z.A.1    Perfect, J.R.2
  • 85
    • 60549098868 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America
    • 19191635 1:CAS:528:DC%2BD1MXjslantLY%3D 10.1086/596757
    • Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503-35.
    • (2009) Clin Infect Dis , vol.48 , pp. 503-535
    • Pappas, P.G.1    Kauffman, C.A.2    Andes, D.3
  • 86
    • 63649151310 scopus 로고    scopus 로고
    • Azole-resistant central nervous system aspergillosis
    • 19272019 10.1086/597465
    • van der Linden JW, Jansen RR, Bresters D, et al. Azole-resistant central nervous system aspergillosis. Clin Infect Dis. 2009;48:1111-3.
    • (2009) Clin Infect Dis , vol.48 , pp. 1111-1113
    • Van Der Linden, J.W.1    Jansen, R.R.2    Bresters, D.3
  • 87
    • 39449095735 scopus 로고    scopus 로고
    • Treatment of aspergillosis: Clinical practice guidelines of the Infectious Diseases Society of America
    • 18177225 1:CAS:528:DC%2BD1cXitlKqt7c%3D 10.1086/525258
    • Walsh TJ, Anaissie EJ, Denning DW, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:327-60.
    • (2008) Clin Infect Dis , vol.46 , pp. 327-360
    • Walsh, T.J.1    Anaissie, E.J.2    Denning, D.W.3
  • 88
    • 79960884598 scopus 로고    scopus 로고
    • Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance
    • 21791665 1:CAS:528:DC%2BC3MXps1OnsL8%3D 10.1093/infdis/jir351
    • Ben-Ami R, Garcia-Effron G, Lewis RE, et al. Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance. J Infect Dis. 2011;204:626-35.
    • (2011) J Infect Dis , vol.204 , pp. 626-635
    • Ben-Ami, R.1    Garcia-Effron, G.2    Lewis, R.E.3
  • 89
    • 84455161690 scopus 로고    scopus 로고
    • Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo
    • 21986821 1:CAS:528:DC%2BC38Xjt1GrsQ%3D%3D 10.1128/AAC.00683-11
    • Lee KK, MacCallum DM, Jacobsen MD, et al. Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo. Antimicrob Agents Chemother. 2012;56:208-17.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 208-217
    • Lee, K.K.1    Maccallum, D.M.2    Jacobsen, M.D.3
  • 90
    • 70049109583 scopus 로고    scopus 로고
    • Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin
    • 19649312 10.1371/journal.ppat.1000532 1:CAS:528:DC%2BD1MXhtVShtLnK
    • Singh SD, Robbins N, Zaas AK, et al. Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. PLoS Pathog. 2009;5:e1000532.
    • (2009) PLoS Pathog , vol.5 , pp. 1000532
    • Singh, S.D.1    Robbins, N.2    Zaas, A.K.3
  • 91
    • 84868014787 scopus 로고    scopus 로고
    • Optimizing echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations
    • 22948870 1:CAS:528:DC%2BC38XhsF2iurfE 10.1128/AAC.01102-12
    • Lepak A, Castanheira M, Diekema D, et al. Optimizing echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations. Antimicrob Agents Chemother. 2012;56:5875-82.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 5875-5882
    • Lepak, A.1    Castanheira, M.2    Diekema, D.3
  • 92
    • 84878342622 scopus 로고    scopus 로고
    • Increasing echinocandin resistance in Candida glabrata: Clinical failure correlates with presence of FKS mutations and elevated MIC
    • [Epub ahead of print]
    • Alexander BD, Johnson MD, Pfeiffer CD, et al. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated MIC. Clin Infect Dis. 2013 [Epub ahead of print].
    • (2013) Clin Infect Dis.
    • Alexander, B.D.1    Johnson, M.D.2    Pfeiffer, C.D.3
  • 93
    • 77956343542 scopus 로고    scopus 로고
    • An insight into the antifungal pipeline: Selected new molecules and beyond
    • 20725094 1:CAS:528:DC%2BC3cXhtVCmurvK 10.1038/nrd3074
    • Ostrosky-Zeichner L, Casadevall A, Galgiani JN, et al. An insight into the antifungal pipeline: selected new molecules and beyond. Nat Rev Drug Discov. 2010;9:719-27.
    • (2010) Nat Rev Drug Discov. , vol.9 , pp. 719-727
    • Ostrosky-Zeichner, L.1    Casadevall, A.2    Galgiani, J.N.3
  • 94
    • 79551652182 scopus 로고    scopus 로고
    • Heat shock protein inhibitors for the treatment of fungal infections
    • 21192778 1:CAS:528:DC%2BC3MXkslSmsbw%3D 10.2174/157489111794407840
    • Wirk B. Heat shock protein inhibitors for the treatment of fungal infections. Recent Pat Antiinfect Drug Discov. 2011;6:38-44.
    • (2011) Recent Pat Antiinfect Drug Discov. , vol.6 , pp. 38-44
    • Wirk, B.1
  • 95
    • 84872011467 scopus 로고    scopus 로고
    • Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis
    • 23129729 1:CAS:528:DC%2BC3sXntVektg%3D%3D 10.1093/jac/dks402
    • Seyedmousavi S, Brüggemann RJ, Melchers WJ, et al. Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis. J Antimicrob Chemother. 2013;68:385-93.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 385-393
    • Seyedmousavi, S.1    Brüggemann, R.J.2    Melchers, W.J.3
  • 96
    • 84872866366 scopus 로고    scopus 로고
    • In vitro interaction of voriconazole and anidulafungin against triazole-resistant Aspergillus fumigatus
    • 23183435 1:CAS:528:DC%2BC3sXntVCrtLY%3D 10.1128/AAC.00980-12
    • Seyedmousavi S, Meletiadis J, Melchers WJ, et al. In vitro interaction of voriconazole and anidulafungin against triazole-resistant Aspergillus fumigatus. Antimicrob Agents Chemother. 2013;57:796-803.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 796-803
    • Seyedmousavi, S.1    Meletiadis, J.2    Melchers, W.J.3
  • 97
    • 84875134112 scopus 로고    scopus 로고
    • Pharmacodynamics and dose-response relationships of liposomal amphotericin B against different azole-resistant Aspergillus fumigatus isolates in a murine model of disseminated aspergillosis
    • 23380732 1:CAS:528:DC%2BC3sXltVKrsbg%3D 10.1128/AAC.02226-12
    • Seyedmousavi S, Melchers WJ, Mouton JW, Verweij PE. Pharmacodynamics and dose-response relationships of liposomal amphotericin B against different azole-resistant Aspergillus fumigatus isolates in a murine model of disseminated aspergillosis. Antimicrob Agents Chemother. 2013;57:1866-71.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 1866-1871
    • Seyedmousavi, S.1    Melchers, W.J.2    Mouton, J.W.3    Verweij, P.E.4
  • 98
    • 62449104891 scopus 로고    scopus 로고
    • Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
    • 19196973 1:CAS:528:DC%2BD1MXislaht7s%3D 10.1073/pnas.0813394106
    • Cowen LE, Singh SD, Köhler JR, et al. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci USA. 2009;106:2818-23.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2818-2823
    • Cowen, L.E.1    Singh, S.D.2    Köhler, J.R.3
  • 99
    • 70449717496 scopus 로고    scopus 로고
    • Efungumab: A novel agent in the treatment of invasive candidiasis
    • 19773528 1:CAS:528:DC%2BC3cXmtlWns7Y%3D 10.1345/aph.1M218
    • Karwa R, Wargo KA. Efungumab: a novel agent in the treatment of invasive candidiasis. Ann Pharmacother. 2009;43:1818-23.
    • (2009) Ann Pharmacother , vol.43 , pp. 1818-1823
    • Karwa, R.1    Wargo, K.A.2
  • 100
    • 80054701122 scopus 로고    scopus 로고
    • Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors
    • 21844320 1:CAS:528:DC%2BC3MXhsVSru7jK 10.1128/AAC.00432-11
    • Walker SS, Xu Y, Triantafyllou I, et al. Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors. Antimicrob Agents Chemother. 2011;55:5099-106.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5099-5106
    • Walker, S.S.1    Xu, Y.2    Triantafyllou, I.3
  • 101
    • 84875265220 scopus 로고    scopus 로고
    • Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST)
    • 23190764 1:CAS:528:DC%2BC3sXjslGntb4%3D 10.1093/jac/dks466
    • Pfaller MA, Messer SA, Motyl MR, et al. Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST). J Antimicrob Chemother. 2013;68:858-63.
    • (2013) J Antimicrob Chemother , vol.68 , pp. 858-863
    • Pfaller, M.A.1    Messer, S.A.2    Motyl, M.R.3
  • 102
    • 84872854619 scopus 로고    scopus 로고
    • In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods
    • 23229479 1:CAS:528:DC%2BC3sXntVCqsrg%3D 10.1128/AAC.01588-12
    • Pfaller MA, Messer SA, Motyl MR, et al. In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods. Antimicrob Agents Chemother. 2013;57:1065-8.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 1065-1068
    • Pfaller, M.A.1    Messer, S.A.2    Motyl, M.R.3
  • 103
    • 72349094324 scopus 로고    scopus 로고
    • In vitro susceptibility testing in fungi: A global perspective on a variety of methods
    • 20078786 10.1111/j.1439-0507.2009.01813.x
    • Lass-Flörl C, Perkhofer S, Mayr A. In vitro susceptibility testing in fungi: a global perspective on a variety of methods. Mycoses. 2010;53:1-11.
    • (2010) Mycoses , vol.53 , pp. 1-11
    • Lass-Flörl, C.1    Perkhofer, S.2    Mayr, A.3
  • 104
    • 70350536660 scopus 로고    scopus 로고
    • Antifungal drug resistance: Do molecular methods provide a way forward?
    • 19741524 1:CAS:528:DC%2BD1MXhtlensrvN 10.1097/QCO.0b013e3283321ce5
    • Perlin DS. Antifungal drug resistance: do molecular methods provide a way forward? Curr Opin Infect Dis. 2009;22:568-73.
    • (2009) Curr Opin Infect Dis , vol.22 , pp. 568-573
    • Perlin, D.S.1
  • 105
    • 79953869925 scopus 로고    scopus 로고
    • High-frequency triazole resistance found in nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease
    • 21467016 1:CAS:528:DC%2BC3MXksFGktbw%3D 10.1093/cid/cir179
    • Denning DW, Park S, Lass-Florl C, et al. High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease. Clin Infect Dis. 2011;52:1123-9.
    • (2011) Clin Infect Dis , vol.52 , pp. 1123-1129
    • Denning, D.W.1    Park, S.2    Lass-Florl, C.3
  • 106
    • 84879479980 scopus 로고    scopus 로고
    • Azole resistance in Aspergillus fumigatus from bronchoalveolar lavage fluid samples of patients with chronic diseases
    • [Epub ahead of print]
    • Zhao Y, Stensvold CR, Perlin DS, Arendrup MC. Azole resistance in Aspergillus fumigatus from bronchoalveolar lavage fluid samples of patients with chronic diseases. J Antimicrob Chemother. 2013 [Epub ahead of print]
    • (2013) J Antimicrob Chemother.
    • Zhao, Y.1    Stensvold, C.R.2    Perlin, D.S.3    Arendrup, M.C.4


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