Expression of HAb18G in non-small lung cancer and characterization of activation, migration, proliferation, and apoptosis in A549 cells following siRNA-induced downregulation of HAb18G

Molecular and Cellular Biochemistry

Volumn 383, Issue 1-2, 2013, Pages 1-11

  Xu, Xiaoyan ^a   Liu, Shuguang ^a   Lei, Bin ^a   Li, Wenxia ^a   Lin, Ni ^a   Sheng, Wenjie ^a   Huang, Aili ^a   Shen, Hong ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

HAb18G; MMPs; Non small cell lung cancer; Prognosis; Small interfering RNA; VEGF

Indexed keywords

CD147 ANTIGEN; COMPLEMENTARY DNA; FLUORESCEIN ISOTHIOCYANATE; HEPATOMA ASSOCIATED ANTIGEN; LIPOCORTIN 5; PROPIDIUM IODIDE; SMALL INTERFERING RNA; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CANCER CELL; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING; WOUND HEALING;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD147; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COCULTURE TECHNIQUES; DOWN-REGULATION; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RNA, MESSENGER; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84883453979     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1722-7     Document Type: Article

References (32)

1. Carney DN (2002) Lung cancer-time to move on from chemotherapy. N Engl J Med 346:126-128. doi: 10.1056/NEJM200201103460211
2. Dosaka-Akita H, Hommura F, Mishina T, Ogura S, Shimizu M, Katoh H, Kawakami Y (2001) A risk-stratification model of non-small cell lung cancers using cyclin E, Ki-67, and ras p21: different roles of G1 cyclins in cell proliferation and prognosis. Cancer Res 61:2500-2504
3. Dosaka-Akita H, Miyoshi E, Suzuki O, Itoh T, Katoh H, Taniguchi N (2004) Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers. Clin Cancer Res 10:1773-1779
4. Jiang JL, Zhou Q, Yu MK, Ho LS, Chen ZN, Chan HC (2001) The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells. J Biol Chem 276:46870-46877. doi: 10.1074/jbc.M108291200
5. Li Y, Xu J, Chen L, Zhong WD, Zhang Z, Mi L, Zhang Y, Liao CG, Bian HJ, Jiang JL, Yang XM, Li XY, Fan CM, Zhu P, Fu L, Chen ZN (2009) HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology 54:677-687. doi: 10.1111/j.1365-2559.2009.03280.x
6. Liu F, Cui L, Zhang Y, Chen L, Wang Y, Fan Y, Lei T, Gu F, Lang R, Pringle GA, Zhang X, Chen Z, Fu L (2010) Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma. Breast Cancer Res Treat 124:677-688. doi: 10.1007/s10549-010-0790-6
7. Zhong WD, Liang YX, Lin SX, Li L, He HC, Bi XC, Han ZD, Dai QS, Ye YK, Chen QB, Wang YS, Zeng GH, Zhu G, Zhang Z, Chen ZN, Wu CL (2012) Expression of CD147 is associated with prostate cancer progression. Int J Cancer 130:300-308. doi: 10.1002/ijc.25982
8. Zhu S, Li Y, Mi L, Zhang Y, Zhang L, Gong L, Han X, Yao L, Lan M, Chen Z, Zhang W (2011) Clinical impact of HAb18G/CD147 expression in esophageal squamous cell carcinoma. Dig Dis Sci 56:3569-3576. doi: 10.1007/s10620-011-1812- x
9. Biswas C, Zhang Y, DeCastro R, Guo H, Nakamura T, Kataoka H, Nabeshima K (1995) The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res 55:434-439
10. Kanekura T, Chen X, Kanzaki T (2002) Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer 99:520-528. doi: 10.1002/ijc.10390
11. Marieb EA, Zoltan-Jones A, Li R, Misra S, Ghatak S, Cao J, Zucker S, Toole BP (2004) Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res 64:1229-1232
12. Tang Y, Nakada MT, Kesavan P, McCabe F, Millar H, Rafferty P, Bugelski P, Yan L (2005) Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res 65:3193-3199. doi: 10.1158/0008-5472.CAN-04-3605
13. Detterbeck FC, Boffa DJ, Tanoue LT (2009) The new lung cancer staging system. Chest 136:260-271. doi: 10.1378/chest.08-0978
14. Xue YJ, Lu Q, Sun ZX (2011) CD147 overexpression is a prognostic factor and a potential therapeutic target in bladder cancer. Med Oncol 28:1363-1372. doi: 10.1007/s12032-010-9582-4
15. Dai JY, Dou KF, Wang CH, Zhao P, Lau WB, Tao L, Wu YM, Tang J, Jiang JL, Chen ZN (2009) The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC cancer 9:337. doi: 10.1186/1471-2407-9-337
16. Rucci N, Millimaggi D, Mari M, Del Fattore A, Bologna M, Teti A, Angelucci A, Dolo V (2010) Receptor activator of NF-kappaB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147. Cancer Res 70:6150-6160. doi: 10.1158/0008-5472.CAN-09-2758
17. Hakuma N, Betsuyaku T, Kinoshita I, Itoh T, Kaga K, Kondo S, Nishimura M, Dosaka-Akita H (2007) High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological parameters. Oncology 72:197-204. doi: 10.1159/000112826
18. Sienel W, Polzer B, Elshawi K, Lindner M, Morresi-Hauf A, Vay C, Eder F, Passlick B, Klein CA (2008) Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9. Mod Pathol 21:1130-1138. doi: 10.1038/modpathol.2008.102
19. Liu Q, Yang H, Zhang SF (2010) Expression and significance of MIF and CD147 in non-small cell lung cancer. Sichuan da xue xue bao Yi xue ban 41:85-90
20. Xu HY, Qian AR, Shang P, Xu J, Kong LM, Bian HJ, Chen ZN (2007) siRNA targeted against HAb18G/CD147 inhibits MMP-2 secretion, actin and FAK expression in hepatocellular carcinoma cell line via ERK1/2 pathway. Cancer Lett 247:336-344. doi: 10.1016/j.canlet.2006.05.017
21. Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-174. doi: 10.1038/nrc745
22. Hicklin DJ, Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011-1027. doi: 10.1200/JCO.2005.06.081
23. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2:737-744. doi: 10.1038/35036374
24. Fang J, Shing Y, Wiederschain D, Yan L, Butterfield C, Jackson G, Harper J, Tamvakopoulos G, Moses MA (2000) Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. Proc Natl Acad Sci USA 97:3884-3889
25. Belotti D, Calcagno C, Garofalo A, Caronia D, Riccardi E, Giavazzi R, Taraboletti G (2008) Vascular endothelial growth factor stimulates organ-specific host matrix metalloproteinase-9 expression and ovarian cancer invasion. Mol Cancer Res 6:525-534. doi: 10.1158/1541-7786.MCR-07-0366
26. Chen X, Lin J, Kanekura T, Su J, Lin W, Xie H, Wu Y, Li J, Chen M, Chang J (2006) A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res 66(23):11323-11330. doi: 10.1158/0008-5472.CAN-06-1536
27. Jiang JL, Chan HC, Zhou Q, Yu MK, Yao XY, Lam SY, Zhu H, Ho LS, Leung KM, Chen ZN (2004) HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains. Cell Mol Life Sci 61:2083-2091. doi: 10.1007/s00018-004-4146-4+
28. Xu J, Xu HY, Zhang Q, Song F, Jiang JL, Yang XM, Mi L, Wen N, Tian R, Wang L, Yao H, Feng Q, Zhang Y, Xing JL, Zhu P, Chen ZN (2007) HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res 5:605-614. doi: 10.1158/1541-7786.MCR-06-0286
29. Zucker S, Hymowitz M, Rollo EE, Mann R, Conner CE, Cao J, Foda HD, Tompkins DC, Toole BP (2001) Tumorigenic potential of extracellular matrix metalloproteinase inducer. Am J Pathol 158:1921-1928. doi: 10.1016/S0002- 9440(10)64660-3
30. Yang JM, O'Neill P, Jin W, Foty R, Medina DJ, Xu Z, Lomas M, Arndt GM, Tang Y, Nakada M, Yan L, Hait WN (2006) Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem 281:9719-9727. doi: 10.1074/jbc.M508421200
31. Zhou X, Lv JY, Gong BL (2010) Down-regutation of CD147 expression induces SiHa cell apoptosis through the Bcl-2 pathway. Nan fang yi ke da xue xue bao 30:1695-1698
32. Baba M, Inoue M, Itoh K, Nishizawa Y (2008) Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem Biophys Res Commun 374:111-116. doi: 10.1016/j.bbrc.2008.06.122