A risk-stratification model of non-small cell lung cancers using cyclin E, KI-67, and ras p21: Different roles of G1 cyclins in cell proliferation and prognosis

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2500-2504

  Dosaka Akita, H ^a   Hommura, F ^a   Mishina, T ^a   Ogura, S ^a   Shimizu, M ^a   Katoh, H ^a   Kawakami, Y ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN E; CYCLINE; KI 67 ANTIGEN; PROTEIN P21;

ARTICLE; CANCER MORTALITY; CELL PROLIFERATION; DISEASE ASSOCIATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LABELING INDEX; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL RATE;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIVISION; COHORT STUDIES; CYCLIN D1; CYCLIN E; FEMALE; G1 PHASE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS P21(RAS); RISK FACTORS; SURVIVAL RATE;

EID: 0035866753     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Non-small cell lung cancer
2. Molecular biology of lung cancer
3. The hallmarks of cancer
4. Molecular and pathologic markers in stage I non-small cell carcinoma of the lung
5. A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopatholoy, and oncoprotein expression
6. Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: Clinical implications
7. Mechanism-based target identification and drug discovery in cancer research
8. Anticancer drug targets: Cell cycle and checkpoint control
9. Preclinical and clinical development of cyclin-dependent kinase modulators
10. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
11. Cancer cell cycle
12. Principles of CDK regulation
13. 1 phase progression: Cycling on cue
14. Inhibitors of mammalian G1 cyclin-dependent kinases
15. G1 control in mammalian cells
16. CDK6 (PLSTIRE) and CDK4 (PSK- J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1
17. PSK-J3/cdk4) for mammalian D type G1 cyclins
18. D-type cyclin-dependent kinase activity in mammalian cells
19. Identification of G1 kinase activity for cdk6, a novel cyclin D partner
20. 1 progression
21. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
22. 1-S phase protein kinase
23. 1 phase of the human cell cycle
24. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma
25. Determination of the prognostic value of cyclin D1 overexpression in breast cancer
26. Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer
27. Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression
28. Cyclin E, a potential prognostic marker for breast cancer
29. Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status
30. KIPI and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
31. Prognostic significance of p53 and ras p21 expression in non-small cell lung cancer
32. INK4A and retinoblastoma protein status in non-small cell lung cancer: Potential synergistic effect with altered p53 protein on proliferative activity
33. Altered retinoblastoma protein expression in non-small cell lung cancer: Its synergistic effects with altered ras and p53 protein status on prognosis
34. INK4A, retino-blastoma and p53 proteins for the prognosis of non-small-cell lung cancers
35. KIPI and Ki-67 growth fraction in non-small cell lung cancers
36. Cyclin D1 expression in non-small cell lung cancers: Its association with altered p53 expression, cell proliferation and clinical outcome
37. Cyclin E expression, a potential prognostic marker for non-small cell lung cancers
38. Lung
39. Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer
40. Bcl-2 expression in non-small cell lung cancers: Higher frequency of expression in squamous cell carcinomas with earlier pT status
41. Frequent loss of gelsolin expression in non-small cell lung cancer of heavy smokers
42. Deregulated cyclin E induces chromosome instability
43. Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E
44. Cyclin D1 and p21/wafl are involved in p53 growth suppression