Expression of N-Acetylglucosaminyltransferase V Is Associated with Prognosis and Histology in Non-Small Cell Lung Cancers

Clinical Cancer Research

Volumn 10, Issue 5, 2004, Pages 1773-1779

  Dosaka Akita, Hirotoshi ^a   Miyoshi, Eiji ^b   Suzuki, Osamu ^c   Itoh, Tomoo ^d   Katoh, Hiroyuki ^a   Taniguchi, Naoyuki ^b  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^d HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1,3(6) MANNOSYLGLYCOPROTEIN BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; ASPARAGINE LINKED OLIGOSACCHARIDE; KI 67 ANTIGEN; LEUKOAGGLUTINATING PHYTOHEMAGGLUTININ; N ACETYLGLUCOSAMINYLTRANSFERASE; PHYTOHEMAGGLUTININ; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BIOLOGY; CANCER INVASION; CANCER STAGING; CARBOHYDRATE SYNTHESIS; CLINICAL FEATURE; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; LABELING INDEX; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; METASTASIS; PATHOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; SURVIVAL TIME;

AGED; BRONCHI; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEOPLASM METASTASIS; NEOPLASM STAGING; ODDS RATIO; PHYTOHEMAGGLUTININS; PROGNOSIS; REFERENCE VALUES; RESPIRATORY MUCOSA; RISK FACTORS; SMOKING; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 1842583688     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-1047-3     Document Type: Article

References (40)

1. Ginsberg, R. J., Vokes, E. E., and Rosenzweig, K. Non-small cell lung cancer. In: V. T. DeVita, S. Hellma, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, 6th ed., pp. 925-982. Philadelphia: Lippincott-Raven Publishers, 2001.
2. Carney, D. N. Lung cancer: time to move on from chemotherapy. N. Engl. J. Med., 346: 126-128, 2002.
3. Sekido, Y., Fong, K. M., and Minna, J. D. Molecular genetics of lung cancer. In: C. T. Caskey, C. Austin, and J. Hoxie (eds.), Annual Review of Medicine, Vol, 54, pp. 73-87. Palo Alto: Annual Reviews, 2003.
4. Hanahan, D., and Weinberg, R. A. The hallmarks of cancer. Cell, 100: 57-70, 2000.
5. Strauss, G. M., Kwiatkowski, D. J., Harpole, D. H., Lynch, T. J., Skarin, A. T., and Sugarbaker, D. J. Molecular and pathologic markers in stage I non-small cell carcinoma of the lung. J. Clin. Oncol., 13: 1265-1279, 1995.
6. Harpole, D. H., Jr., Herndon, J. E., II, Wolfe, W. G., Iglehart, J. D., and Marks, J. R. A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression. Cancer Res., 55: 51-56, 1995.
7. Kwiatkowski, D. J., Harpole, D. H., Jr., Goleski, J., Herndon, J. E. II, Dar-Bin, S., Richards, W., Blanco, R., Xu, H., Strauss, G. M., and Sugarbaker, D. J. Molecular pathologic substaging in 244 stage I non small-cell lung cancer patients: clinical implications. J. Clin. Oncol., 16. 2468-2477, 1998.
8. 1 cyclins in cell proliferation and prognosis. Cancer Res., 61: 2500-2504, 2001.
9. Gibbs, J. B. Mechanism-based target identification and drug discovery in cancer research. Science (Wash. DC), 287: 1969-1973, 2000.
10. Hakomori, S. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv. Cancer Res., 52: 257-331, 1989.
11. Varki, A. Biological roles of oligosaccharides: all of the theories are correct. Glycobiology, 3: 97-130, 1993.
12. Fernandes, B., Sagman, U., Auger, M., Demetriou, M., and Dennis, J. W. β1-6 Branched oligosaccharides as a marker of tumor progression in human breast and colon neoplasia. Cancer Res., 51: 718-723, 1991.
13. Seelentag, W. K., Li, W. P., Schmitz, S. F., Metzger, U., Aeberhard, P., Heitz, P. U., and Roth, J. Prognostic value of β1,6-branched oligosaccharides in human colorectal carcinoma. Cancer Res., 58: 5559-5564, 1998.
14. Murata, K., Miyoshi, E., Kameyama, M., Ishikawa, O., Kabuto, T., Sasaki, Y., Hiratsuka, M., Ohigashi, H., Ishiguro, S., Ito, S., Honda, H., Takemura, F., Taniguchi, N., and Imaoka, S. Expression of N-acetyl-glucosaminyltransferase V in colorectal cancer correlates with metastasis and poor prognosis. Clin. Cancer Res., 6: 1772-1777, 2000.
15. Li, W. P., and Roth, J. Expression of β1,6 branched asparagine-linked oligosaccharides in non-mitotic and non-migratory cells of normal human and rat tissues. Int. J. Cancer, 71: 483-490, 1997.
16. Perng, G. S., Shoreibah, M., Margitich, I., Pierce, M., and Fregien, N. Expression of N-acetylglucosaminyltransferase V mRNA in mammalian tissues and cell lines. Glycobiology, 4: 867-871, 1994.
17. WHO. Histological typing of lung tumors, 2nd ed. Am. J. Clin. Pathol., 77: 123-136, 1982.
18. American Joint Committee on Cancer. Lung. In: O. H. Beahrs, D. E. Henson, R. V. P. Hutter, and B. J. Kennedy (eds.), Manual for Staging of Cancer, 4th ed., pp. 15-122. Philadelphia: J. B. Lippincott Co., 1992.
19. KIP1 protein and Ki-67 growth fraction in non-small cell lung cancers. Clin. Cancer Res., 6: 4073-4081, 2000.
20. Mishina, T., Dosaka-Akita, H., Hommura, F., Nishi, M., Kojima, T., Ogura, S., Shimizu, M., Katoh, H., and Kawakami, Y. Cyclin E expression, a potential prognostic marker for non-small cell lung cancers. Clin. Cancer Res., 6: 11-16, 2000.
21. Dosaka-Akita, H., Kinoshita, I., Yamazaki, K., Izumi, H., Itoh, T., Katoh, H., Nishimura, M., Matsuo, K., Yamada, Y., and Kohno, K. N-Acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers. Br. J. Cancer, 87: 751-755, 2002.
22. Suzuki, O., Nozawa, Y., Kawaguchi, T., and Abe, M. Phaseolus vulgaris leukoagglutinating lectin-binding reactivity in human diffuse large B cell lymphoma and its relevance to the patient's clinical outcome: lectin histochemistry and lectin blot analysis. Pathol. Int., 49: 874-880, 1999.
23. Cox, D., and Snell, E. Analysis of Binary Data, 2nd ed. London: Chapman and Hall, 1989.
24. Cummings, R. D., and Kornfeld, S. Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins. J. Biol. Chem., 257: 11230-11234, 1982.
25. Li, W. P., Zuber, C., Heitz, P. U., and Roth, J. Cytochemical staining for β1,6 branching of asparagine-linked oligosaccharides in variants of metastatic human colon carcinoma cells. Am. J. Pathol., 145: 470-480, 1994.
26. Saito, T., Miyoshi, E., Sasai, K., Nakano, N., Eguchi, H., Honke, K., and Taniguchi, N. A secreted type of β1,6-N-acetylglucosaminyl-transferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity. J. Biol. Chem., 277: 17002-17008, 2002.
27. Shimosato, Y., Kodama, T., and Kameya, T. Morphogenesis of peripheral type adenocarcinoma of the lung. In: Y. Shimosato, M. R. Melamed, and P. Nettesheim (eds.), Morphogenesis of Lung Cancer, Vol. 1, pp. 65-89. Boca Raton, FL: CRC Press, 1982.
28. Konishi, T., Lin, Z., Fujino, S., Kato, H., and Mori, A. Association of p53 protein expression in stage I lung adenocarcinoma with reference to cytological subtypes. Hum. Pathol., 28: 544-548, 1997.
29. Maeshima, A., Miyagi, A., Hirai, T., and Nakajima, T. Mucin-producing adenocarcinoma of the lung, with special reference to goblet cell type adenocarcinoma: immunohistochemical observation and Ki-ras gene mutation. Pathol. Int., 47: 454-460, 1997.
30. Ito, Y., Miyoshi, E., Sakon, M., Takeda, T., Noda, K., Tsujimoto, M., Ito, S., Honda, H., Takemura, F., Wakasa, K., Monden, M., Matsuura, N., and Taniguchi, N. Elevated expression of UDP-N-acetylglucosamine:α-mannoside β1,6 N-acetylglucosaminyltransferase is an early event in hepatocarcinogenesis. Int. J. Cancer, 91: 631-637, 2001.
31. Dennis, J. W., and Laferte, S. Oncodevelopmental expression of -GlcNAc β1-6Man α1-6Man β1-branched asparagine-linked oligosaccharides in murine tissues and human breast carcinomas. Cancer Res., 49: 945-950, 1989.
32. Buckhaults, P., Chen, L., Fregien, N., and Pierce, M. Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene. J. Biol. Chem., 272: 19575-19581, 1997.
33. Chen, L., Zhang, W., Fregien, N., and Pierce, M. The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase V and expression of its cell surface oligosaccharide products. Oncogene, 17: 2087-2093, 1998.
34. Demetriou, M., Nabi, I. R., Coppolino, M., Dedhar, S., and Dennis, J. W. Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. J. Cell Biol., 130: 383-392, 1995.
35. Dennis, J. W., Laferte, S., Waghorne, C., Breitman, M. L., and Kerbel, R. S. β1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science (Wash. DC), 236: 582-585, 1987.
36. Saitoh, O., Wang, W. C., Lotan, R., and Fukuda, M. Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials. J. Biol. Chem., 267: 5700-5711, 1992.
37. Takano, R., Nose, M., Nishihira, T., and Kyogoku, M. Increase of β1-6-branched oligosaccharides in human esophageal carcinomas invasive against surrounding tissue in vivo and in vitro. Am. J. Pathol., 137: 1007-1011, 1990.
38. Granovsky, M., Fata, J., Pawling, J., Muller, W. J., Khokha, R., and Dennis, J. W. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat. Med., 6: 306-312, 2000.
39. 1 integrin clustering and stimulates cell migration. Cancer Res., 62: 6837-6845, 2002.
40. Ihara, S., Miyoshi, E., Ko, J. H., Murata, K., Nakahara, S., Honke, K., Dickson, R. B., Lin, C. Y., and Taniguchi, N. Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding β1-6 GlcNAc branching. J. Biol. Chem., 277: 16960-16967, 2002.