High analgesic and anti-inflammatory in vivo activities of six new hybrids NSAIAs tetrahydropyran derivatives

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 19, 2013, Pages 6003-6010

  Capim, Saulo L ^a   Gonçalves, Gabriela M ^b   Dos Santos, Gabriela C M ^b   Marinho, Bruno G ^b   Vasconcellos, Mário L A A ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^b FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Antinociceptive; Hybridization; In vivo; NSAIAs; Tetrahydropyran

Indexed keywords

ACETIC ACID; ACETYLSALICYLIC ACID; BENORILATE; DICLOFENAC; IBUPROFEN; INDOMETACIN; KETOPROFEN; NAPROXEN; TETRAHYDROPYRAN DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG INTOXICATION; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; LD 50; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; OPEN FIELD TEST; WRITHING TEST;

MUS;

ANTINOCICEPTIVE; HYBRIDIZATION; IN VIVO; NSAIAS; TETRAHYDROPYRAN;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PYRANS;

EID: 84883445023     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.07.041     Document Type: Article

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