-
1
-
-
70449091904
-
The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway
-
Gordon I, Paoloni M, Mazcko C, Khanna C, (2009) The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway. PLoS Med. 6(10): e1000161.
-
(2009)
PLoS Med
, vol.6
, Issue.10
-
-
Gordon, I.1
Paoloni, M.2
Mazcko, C.3
Khanna, C.4
-
2
-
-
77949290207
-
Methods and mortality results of a health survey of purebred dogs in the UK
-
Adams VJ, Evans KM, Sampson J, Wood JL, (2010) Methods and mortality results of a health survey of purebred dogs in the UK. J Small Anim Pract. 51(10): 512-24.
-
(2010)
J Small Anim Pract
, vol.51
, Issue.10
, pp. 512-524
-
-
Adams, V.J.1
Evans, K.M.2
Sampson, J.3
Wood, J.L.4
-
3
-
-
77649224964
-
Leading the way: canine models of genomics and disease
-
Shearin AL, Ostrander EA, (2010) Leading the way: canine models of genomics and disease. Disease models & mechanisms. 3(1-2): 27-34.
-
(2010)
Disease models & mechanisms
, vol.3
, Issue.1-2
, pp. 27-34
-
-
Shearin, A.L.1
Ostrander, E.A.2
-
4
-
-
38549112058
-
Translation of new cancer treatments from pet dogs to humans
-
Paoloni M, Khanna C, (2008) Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer. 8(2): 147-56.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.2
, pp. 147-156
-
-
Paoloni, M.1
Khanna, C.2
-
5
-
-
65249091846
-
Comparative expression pathway analysis of human and canine mammary tumors
-
Uva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, et al. (2009) Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics. 10: 135.
-
(2009)
BMC Genomics
, vol.10
, pp. 135
-
-
Uva, P.1
Aurisicchio, L.2
Watters, J.3
Loboda, A.4
Kulkarni, A.5
-
6
-
-
84883370178
-
-
Cancer statistics registrations, Available at: (Accessed August 2013)
-
Cancer statistics registrations (2010) Available at: http://www.ons.gov.uk/ons/rel/vsob1/cancer-registrations-in-england/2010/2010-cancer-registrations-in-england-statistical-bulletin-2.html (Accessed August 2013).
-
(2010)
-
-
-
7
-
-
84883329065
-
-
Cancer Incidence in Wales 2003-2007, Available at: (Accessed August 2013)
-
Cancer Incidence in Wales 2003-2007 (2009) Available at: http://www.wales.nhs.uk/sites3/Documents/242/Cancer%20Incidence%20in%20Wales%202003-2007.pdf (Accessed August 2013).
-
(2009)
-
-
-
8
-
-
84883444406
-
-
Cancer incidence in Scotland, Available at: (Accessed August 2013)
-
Cancer incidence in Scotland (2013) Available at: http://www.isdscotland.org/Health-Topics/Cancer/ (Accessed August 2013).
-
(2013)
-
-
-
9
-
-
37349034010
-
Canine Lymphoma and Lymphoid Leukemia
-
Withrow SJ, Vail DM, (ed) 4ed. London/GB: Elsevier Health Sciences; 2007
-
Vail DM, Young KM (2007) Canine Lymphoma and Lymphoid Leukemia. In:. Withrow and MacEwen's small animal clinical oncology, Withrow SJ, Vail DM, (ed) 4ed. London/GB: Elsevier Health Sciences; 2007. p. 699-700.
-
(2007)
Withrow and MacEwen's small animal clinical oncology
, pp. 699-700
-
-
Vail, D.M.1
Young, K.M.2
-
10
-
-
77956933850
-
Pathogenesis of diffuse large B cell lymphoma
-
Chan WJ, (2010) Pathogenesis of diffuse large B cell lymphoma. Int J Hematol. 92(2): 219-30.
-
(2010)
Int J Hematol
, vol.92
, Issue.2
, pp. 219-230
-
-
Chan, W.J.1
-
11
-
-
67650724069
-
Regulation and function of NF-kappaB transcription factors in the immune system
-
Vallabhapurapu S, Karin M, (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27: 693-733.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
12
-
-
0034598746
-
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
-
Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 403(6769): 503-11.
-
(2000)
Nature
, vol.403
, Issue.6769
, pp. 503-511
-
-
Alizadeh, A.A.1
Eisen, M.B.2
Davis, R.E.3
Ma, C.4
Lossos, I.S.5
-
13
-
-
23944468557
-
Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma
-
Tagawa H, Suguro M, Tsuzuki S, Matsuo K, Karnan S, et al. (2005) Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma. Blood. 106(5): 1770-7.
-
(2005)
Blood
, vol.106
, Issue.5
, pp. 1770-1777
-
-
Tagawa, H.1
Suguro, M.2
Tsuzuki, S.3
Matsuo, K.4
Karnan, S.5
-
14
-
-
0043192901
-
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
-
Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, et al. (2003) A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci U S A 100(17): 9991-6.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.17
, pp. 9991-9996
-
-
Wright, G.1
Tan, B.2
Rosenwald, A.3
Hurt, E.H.4
Wiestner, A.5
-
15
-
-
0037142053
-
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
-
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, et al. (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 346(25): 1937-47.
-
(2002)
N Engl J Med
, vol.346
, Issue.25
, pp. 1937-1947
-
-
Rosenwald, A.1
Wright, G.2
Chan, W.C.3
Connors, J.M.4
Campo, E.5
-
16
-
-
77951010885
-
Mechanisms of Disease: Aggressive lymphomas
-
Lenz G, Staudt LM, (2010) Mechanisms of Disease: Aggressive lymphomas. N Engl J Med. 362(15): 1417-29.
-
(2010)
N Engl J Med
, vol.362
, Issue.15
, pp. 1417-1429
-
-
Lenz, G.1
Staudt, L.M.2
-
17
-
-
77952959216
-
Establishment and characterization of a novel canine B-cell line derived from a spontaneously occurring diffuse large cell lymphoma
-
Rutgen BC, Hammer SE, Gerner W, Christian M, de Arespacochaga AG, et al. (2010) Establishment and characterization of a novel canine B-cell line derived from a spontaneously occurring diffuse large cell lymphoma. Leuk Res. 34(7): 932-8.
-
(2010)
Leuk Res
, vol.34
, Issue.7
, pp. 932-938
-
-
Rutgen, B.C.1
Hammer, S.E.2
Gerner, W.3
Christian, M.4
de Arespacochaga, A.G.5
-
18
-
-
66649127621
-
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
-
Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, et al. (2009) Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature. 459(7247): 717-21.
-
(2009)
Nature
, vol.459
, Issue.7247
, pp. 717-721
-
-
Compagno, M.1
Lim, W.K.2
Grunn, A.3
Nandula, S.V.4
Brahmachary, M.5
-
19
-
-
84883320792
-
-
Available from: (cited and accessed 20 October 2010)
-
Gatto L, Yaqcaffy (2010) Available from: http://bioconductor.org/packages/release/bioc/html/yaqcaffy.html (cited and accessed 20 October 2010).
-
(2010)
-
-
Gatto, L.1
Yaqcaffy2
-
20
-
-
84883400792
-
-
affyQCReport, Available from: (cited and accesses 20 October 2010)
-
Parman C, Halling C, Gentleman R, affyQCReport (2010) Available from: http://www.bioconductor.org/packages/release/bioc/html/affyQCReport.html (cited and accesses 20 October 2010).
-
(2010)
-
-
Parman, C.1
Halling, C.2
Gentleman, R.3
-
21
-
-
28744458859
-
Bioconductor: open software development for computational biology and bioinformatics
-
Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5(10): R80.
-
(2004)
Genome Biol
, vol.5
, Issue.10
-
-
Gentleman, R.C.1
Carey, V.J.2
Bates, D.M.3
Bolstad, B.4
Dettling, M.5
-
22
-
-
84883418204
-
-
The R Project for Statistical Computing, Available from: [cited and accessed 20 October 2010]
-
The R Project for Statistical Computing (2010) Available from: http://www.r-project.org [cited and accessed 20 October 2010].
-
(2010)
-
-
-
23
-
-
0142121516
-
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
-
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4(2): 249-64.
-
(2003)
Biostatistics
, vol.4
, Issue.2
, pp. 249-264
-
-
Irizarry, R.A.1
Hobbs, B.2
Collin, F.3
Beazer-Barclay, Y.D.4
Antonellis, K.J.5
-
24
-
-
12344280017
-
Summaries of Affymetrix GeneChip probe level data
-
Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, et al. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31(4): e15.
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.4
-
-
Irizarry, R.A.1
Bolstad, B.M.2
Collin, F.3
Cope, L.M.4
Hobbs, B.5
-
25
-
-
84883408068
-
-
NetAffx Analysis Center, Available from: [cited 2010 and Accessed August 2010)
-
NetAffx Analysis Center (2010) Available from: http://www.affymetrix.com/analysis/index.affx [cited 2010 and Accessed August 2010).
-
(2010)
-
-
-
26
-
-
84883385491
-
-
Partek, 6.5 ed. St. Louis: Partek Inc
-
Partek (2010) Partek® Genomics SuiteTM Revision 6.5 ed. St. Louis: Partek Inc.
-
(2010)
Partek® Genomics SuiteTM Revision
-
-
-
27
-
-
61449172037
-
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
-
Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4(1): 44-57.
-
(2009)
Nat Protoc
, vol.4
, Issue.1
, pp. 44-57
-
-
da Huang, W.1
Sherman, B.T.2
Lempicki, R.A.3
-
28
-
-
84883381332
-
-
1.22.1 ed:; (Accessed October 2010)
-
Bolstad B affy (2009) 1.22.1 ed: http://bioconductor.org; (Accessed October 2010).
-
(2009)
-
-
Bolstad, B.1
-
29
-
-
38449101120
-
Integration of biological networks and gene expression data using Cytoscape
-
Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, et al. (2007) Integration of biological networks and gene expression data using Cytoscape. Nat Protoc. 2(10): 2366-82.
-
(2007)
Nat Protoc
, vol.2
, Issue.10
, pp. 2366-2382
-
-
Cline, M.S.1
Smoot, M.2
Cerami, E.3
Kuchinsky, A.4
Landys, N.5
-
30
-
-
2942552459
-
An automated method for finding molecular complexes in large protein interaction networks
-
Bader GD, Hogue CW, (2003) An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4: 2.
-
(2003)
BMC Bioinformatics
, vol.4
, pp. 2
-
-
Bader, G.D.1
Hogue, C.W.2
-
31
-
-
84883351978
-
-
Ingenuity, 8.7 ed. Redwood City, CA Ingenuity Systems Inc
-
Ingenuity (2010) Ingenuity Pathways Analysis. 8.7 ed. Redwood City, CA Ingenuity Systems Inc.
-
(2010)
Ingenuity Pathways Analysis
-
-
-
32
-
-
76549129820
-
Drug combination studies and their synergy quantification using the Chou-Talalay method
-
Jan 15
-
Chou TC, (2010) Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010 Jan 15 70(2): 440-6.
-
(2010)
Cancer Res 2010
, vol.70
, Issue.2
, pp. 440-446
-
-
Chou, T.C.1
-
33
-
-
33947586159
-
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications
-
Jost PJ, Ruland J, (2007) Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 109(7): 2700-7.
-
(2007)
Blood
, vol.109
, Issue.7
, pp. 2700-2707
-
-
Jost, P.J.1
Ruland, J.2
-
34
-
-
33846570444
-
The transcription factor nuclear factor-kappa B and cancer
-
Escarcega RO, Fuentes-Alexandro S, Garcia-Carrasco M, Gatica A, Zamora A, (2007) The transcription factor nuclear factor-kappa B and cancer. Clin Oncol (R Coll Radiol). 19(2): 154-61.
-
(2007)
Clin Oncol (R Coll Radiol)
, vol.19
, Issue.2
, pp. 154-161
-
-
Escarcega, R.O.1
Fuentes-Alexandro, S.2
Garcia-Carrasco, M.3
Gatica, A.4
Zamora, A.5
-
35
-
-
33745298519
-
Nuclear factor-kappaB in cancer development and progression
-
Karin M, (2006) Nuclear factor-kappaB in cancer development and progression. Nature. 441(7092): 431-6.
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 431-436
-
-
Karin, M.1
-
36
-
-
40249109853
-
The IkappaB kinase - a bridge between inflammation and cancer
-
Karin M, (2008) The IkappaB kinase - a bridge between inflammation and cancer. Cell Res. 18(3): 334-42.
-
(2008)
Cell Res
, vol.18
, Issue.3
, pp. 334-342
-
-
Karin, M.1
-
37
-
-
2442612540
-
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
-
Thome M, (2004) CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol. 4(5): 348-59.
-
(2004)
Nat Rev Immunol
, vol.4
, Issue.5
, pp. 348-359
-
-
Thome, M.1
-
38
-
-
0035139943
-
Hostile takeovers: viral appropriation of the NF-kappaB pathway
-
Hiscott J, Kwon H, Genin P, (2001) Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest. 107(2): 143-51.
-
(2001)
J Clin Invest
, vol.107
, Issue.2
, pp. 143-151
-
-
Hiscott, J.1
Kwon, H.2
Genin, P.3
-
39
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, et al. (2010) Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 463(7277): 88-92.
-
(2010)
Nature
, vol.463
, Issue.7277
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
Tolar, P.4
Young, R.M.5
-
40
-
-
34548161868
-
Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis
-
Brien G, Trescol-Biemont MC, Bonnefoy-Berard N, (2007) Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis. Oncogene. 26(39): 5828-32.
-
(2007)
Oncogene
, vol.26
, Issue.39
, pp. 5828-5832
-
-
Brien, G.1
Trescol-Biemont, M.C.2
Bonnefoy-Berard, N.3
-
41
-
-
33645745347
-
Constitutive activation of extracellular signal-regulated kinase predisposes diffuse large B-cell lymphoma cell lines to CD40-mediated cell death
-
Hollmann CA, Owens T, Nalbantoglu J, Hudson TJ, Sladek R, (2006) Constitutive activation of extracellular signal-regulated kinase predisposes diffuse large B-cell lymphoma cell lines to CD40-mediated cell death. Cancer Res 66(7): 3550-7.
-
(2006)
Cancer Res
, vol.66
, Issue.7
, pp. 3550-3557
-
-
Hollmann, C.A.1
Owens, T.2
Nalbantoglu, J.3
Hudson, T.J.4
Sladek, R.5
-
42
-
-
33745749038
-
The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas
-
Paterson JC, Tedoldi S, Craxton A, Jones M, Hansmann ML, et al. (2006) The differential expression of LCK and BAFF-receptor and their role in apoptosis in human lymphomas. Haematologica. 91(6): 772-80.
-
(2006)
Haematologica
, vol.91
, Issue.6
, pp. 772-780
-
-
Paterson, J.C.1
Tedoldi, S.2
Craxton, A.3
Jones, M.4
Hansmann, M.L.5
-
43
-
-
0033621619
-
NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase
-
Zamanian-Daryoush M, Mogensen TH, DiDonato JA, Williams BR, (2000) NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol Cell Biol. 20(4): 1278-90.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.4
, pp. 1278-1290
-
-
Zamanian-Daryoush, M.1
Mogensen, T.H.2
DiDonato, J.A.3
Williams, B.R.4
-
44
-
-
79551686422
-
Oncogenically active MYD88 mutations in human lymphoma
-
Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, et al. (2011) Oncogenically active MYD88 mutations in human lymphoma. Nature. 470(7332): 115-9.
-
(2011)
Nature
, vol.470
, Issue.7332
, pp. 115-119
-
-
Ngo, V.N.1
Young, R.M.2
Schmitz, R.3
Jhavar, S.4
Xiao, W.5
-
45
-
-
79960394765
-
NEMO-Binding Domain Peptide Inhibits Constitutive NF-kappa B Activity and Reduces Tumor Burden in a Canine Model of Relapsed
-
Gaurnier-Hausser A, Patel R, Baldwin AS, May MJ, Mason NJ, (2011) NEMO-Binding Domain Peptide Inhibits Constitutive NF-kappa B Activity and Reduces Tumor Burden in a Canine Model of Relapsed, Refractory Diffuse Large B-Cell Lymphoma Clinical Cancer Research: 17. 14: 4661-4671.
-
(2011)
Refractory Diffuse Large B-Cell Lymphoma Clinical Cancer Research
, vol.17
, Issue.14
, pp. 4661-4671
-
-
Gaurnier-Hausser, A.1
Patel, R.2
Baldwin, A.S.3
May, M.J.4
Mason, N.J.5
-
46
-
-
0028909195
-
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia
-
Matherly LH, Taub JW, Ravindranath Y, Proefke SA, Wong SC, et al. (1995) Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia. Blood. 85(2): 500-9.
-
(1995)
Blood
, vol.85
, Issue.2
, pp. 500-509
-
-
Matherly, L.H.1
Taub, J.W.2
Ravindranath, Y.3
Proefke, S.A.4
Wong, S.C.5
-
47
-
-
46749119475
-
Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies
-
Molina JR, (2008) Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies. IDrugs. 11(7): 508-21.
-
(2008)
IDrugs
, vol.11
, Issue.7
, pp. 508-521
-
-
Molina, J.R.1
-
48
-
-
77954702943
-
Predictive factors for anthracycline-based chemotherapy for human breast cancer
-
Miyoshi Y, Kurosumi M, Kurebayashi J, Matsuura N, Takahashi M, et al. (2010) Predictive factors for anthracycline-based chemotherapy for human breast cancer. Breast Cancer. 17(2): 103-9.
-
(2010)
Breast Cancer
, vol.17
, Issue.2
, pp. 103-109
-
-
Miyoshi, Y.1
Kurosumi, M.2
Kurebayashi, J.3
Matsuura, N.4
Takahashi, M.5
-
49
-
-
70449589073
-
MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy
-
Savage KJ, Johnson NA, Ben-Neriah S, Connors JM, Sehn LH, et al. (2009) MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood. 114(17): 3533-7.
-
(2009)
Blood
, vol.114
, Issue.17
, pp. 3533-3537
-
-
Savage, K.J.1
Johnson, N.A.2
Ben-Neriah, S.3
Connors, J.M.4
Sehn, L.H.5
-
50
-
-
77956949925
-
A systematic review and meta-analysis of rituximab-based immunochemotherapy for subtypes of diffuse large B cell lymphoma
-
Fang C, Xu W, Li JY, (2010) A systematic review and meta-analysis of rituximab-based immunochemotherapy for subtypes of diffuse large B cell lymphoma. Ann Hematol. 89(11): 1107-13.
-
(2010)
Ann Hematol
, vol.89
, Issue.11
, pp. 1107-1113
-
-
Fang, C.1
Xu, W.2
Li, J.Y.3
-
51
-
-
84883094328
-
Molecular Profiling Reveals Prognostically Significant Subtypes of Canine
-
Frantz AM, Sarver AL, Ito D, Phang TL, Karimpour-Fard A, et al. (2013) Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma Vet Pathol, vol. 50 no. 4 693-703.
-
(2013)
Lymphoma Vet Pathol
, vol.50
, Issue.4
, pp. 693-703
-
-
Frantz, A.M.1
Sarver, A.L.2
Ito, D.3
Phang, T.L.4
Karimpour-Fard, A.5
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