Ethanol extract of Cnidium officinale exhibits anti-inflammatory effects in BV2 microglial cells by suppressing NF-κB nuclear translocation and the activation of the PI3K/Akt signaling pathway

International Journal of Molecular Medicine

Volumn 32, Issue 4, 2013, Pages 876-882

  Lee, Shin Hwa ^a   Lee, Jun Hyuk ^b   Oh, Eun Young ^c   Kim, Gi Young ^d   Choi, Byung Tae ^c   Kim, Cheolmin ^c,e   Choi, Yung Hyun ^f,g  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Intellectual Property Office   (South Korea)

^c Pusan National University   (South Korea)

^d Jeju National University   (South Korea)

^e Pusan National University School of Medicine   (South Korea)

^f Dong Eui University   (South Korea)

^g Dong Eui University   (South Korea)

Author keywords

Anti inflammation; Cnidium officinale Makino; Microglia; Nuclear factor B; Phosphoinositide 3 kinase Akt

Indexed keywords

ANTIINFLAMMATORY AGENT; CNIDIUM OFFICINALE EXTRACT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROSTAGLANDIN E2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELLULAR DISTRIBUTION; CNIDIUM; CNIDIUM OFFICINALE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOFLUORESCENCE; MEDICINAL PLANT; MICROGLIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CNIDIUM; CYCLOOXYGENASE 2; ETHANOL; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84883350978     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1447     Document Type: Article

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