Rutin exerts antitumor effects on nude mice bearing SW480 tumor

Archives of Medical Research

Volumn 44, Issue 5, 2013, Pages 346-351

  Alonso Castro, Angel Josabad ^a,b   Domínguez, Fabiola ^c   García Carrancá, Alejandro ^a,b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Angiogenesis; Antitumor; Colon cancer; Cytotoxic; Rutin; VEGF

Indexed keywords

RUTOSIDE; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIFESPAN; MOUSE; NONHUMAN; ORGAN WEIGHT; PROTEIN BLOOD LEVEL; SURVIVAL TIME; TUMOR VOLUME; ANALYSIS OF VARIANCE; ANIMAL; COLONIC NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; IC50; NUDE MOUSE; PATHOLOGY; TUMOR CELL CULTURE;

ANALYSIS OF VARIANCE; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, NUDE; RUTIN; TUMOR BURDEN; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84883348491     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2013.06.002     Document Type: Article

References (26)

1. World Heatlh Organization. 2012. Available at http://www.who.int/mediacentre/factsheets/fs297/en/index.html.
2. Vainio H., Weiderpass E. Fruit and vegetables in cancer prevention. Nutr Cancer 2006, 54:111-142.
3. Bingham S. Diet and colorectal cancer prevention. Biochem Soc Trans 2000, 28:12-16.
4. Ren W., Qiao Z., Wang H., et al. Flavonoids: promising anticancer agents. Med Res Rev 2003, 23:519-534.
5. Scalbert A., Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000, 130:2073S-2085S.
6. Knekt P., Jarvinen R., Seppanen R., et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997, 146:223-230.
7. Molnár J., Béládi I., Domonkos K., et al. Antitumor activity of flavonoids on NK/Ly ascites tumor cells. Neoplasma 1981, 28:11-18.
8. Menon L.G., Kuttan R., Kuttan G. Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer Lett 1995, 95:221-225.
9. Kuntz S., Wenzel U., Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr 1999, 38:133-142.
10. Chidambara Murthy K.N., Kim J., Vikram J., et al. Differential inhibition of human colon cancer cells by structurally similar flavonoids of citrus. Food Chem 2012, 132:27-34.
11. Yang M.Y., Chang Y.C., Chan K.C., et al. Flavonoid-enriched extracts from Nelumbo nucifera leaves inhibits proliferation of breast cancer invitro and invivo. Eur J Integr Med 2011, 3:153-163.
12. Alonso-Castro A.J., Ortiz-Sanchez E., Dominguez F., et al. Antitumor effect of Croton lechleri Mull. Arg. (Euphorbiaceae). J Ethnopharmacol 2012, 140:438-442.
13. Alonso-Castro A.J., Juárez-Vázquez MdC., González-Sánchez I., et al. The antitumoral effect of the American mistletoe Phoradendron serotinum (Raf.) M. C. Johnst. (Viscaceae) is associated with the release of immunity-related cytokines. J Ethnopharmacol 2012, 142:857-864.
14. Martínez Conesa C., Vicente Ortega V., Yáñez Gascón M.J., et al. Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin. J Agric Food Chem 2005, 53:6791-6797.
15. Deschner E.E., Ruperto J.F., Wong G.Y., et al. The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet. Nutr Cancer 1993, 20:199-204.
16. Mahmoud N.N., Carothers A.M., Grunberger D., et al. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis 2000, 21:921-927.
17. Looney W.B., Mayo A.A., Janners M.Y., et al. Cell proliferation andtumor growth in hepatomas 3924A. Cancer Res 1971, 31:821-825.
18. Patil S.L., Somashekarappa H.M., Rajashekhar K.P. Evaluation of the radioprotective action of rutin in mice exposed to gamma-radiation. Int J Biol Pharm Res 2012, 3:12-18.
19. Marcarini J.C., Ferreira Tsuboy M.S., Cabral Luiz R., et al. Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells. Exp Toxicol Pathol 2011, 63:459-465.
20. Bjeldanes L.F., Chang G.W. Mutagenic activity of quercetin and related compounds. Science 1977, 197:577-578.
21. Hirono I., Ueno I., Hosaka S., et al. Carcinogenicity examination of quercetin and rutin in ACI rats. Cancer Lett 1988, 13:15-21.
22. Parabathina R.K., Muralinath E., Lakshmana S.P., et al. Effects ofvitamin-E, morin, rutin, quercetin against doxorubicin in rabbits: a hematological study. Res J Pharm Biol Chem Sci 2011, 2:74-84.
23. Shahi J., Singh A. Effect of bioactive compounds extracted from Euphorbious plants on hematological and biochemical parameters ofChanna punctatus. Rev Inst Med Trop Sao Paulo 2011, 53:259-263.
24. Oberling C., Guerin M. The role of viruses in the production of cancer. Adv Cancer Res 1954, 2:353-423.
25. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
26. Schindler R., Mentlein R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J Nutr 2006, 136:1477-1482.