Role of organic cation transporters in the ocular disposition of its intravenously injected substrate in rabbits: Implications for ocular drug therapy

Experimental Eye Research

Volumn 116, Issue , 2013, Pages 27-35

  Nirmal, Jayabalan ^a   Sirohiwal, Anju ^a   Singh, Sundararajan Baskar ^b   Biswas, Nihar Ranjan ^b   Thavaraj, Vasantha ^c   Azad, Raj Vardhan ^a   Velpandian, Thirumurthy ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c Indian Council for Medical Research   (India)

Author keywords

Blood to vitreous transport; Intravenous; Ocular; Organic cation transporters; Pharmacokinetics; Rabbits

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 1; ORGANIC CATION TRANSPORTER; QUINIDINE; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; BLOOD EYE BARRIER; BRAIN; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; FEMALE; GENE EXPRESSION; HEART; INTRAOCULAR DRUG ADMINISTRATION; IRIS; KIDNEY; LENS; LIVER; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCLERA;

BLOOD-TO-VITREOUS TRANSPORT; INTRAVENOUS; OCULAR; ORGANIC CATION TRANSPORTERS; PHARMACOKINETICS; RABBITS;

ANIMALS; AQUEOUS HUMOR; BIOLOGICAL TRANSPORT; BLOOD-RETINAL BARRIER; CATION TRANSPORT PROTEINS; CHROMATOGRAPHY, LIQUID; DISEASE MODELS, ANIMAL; EYE DISEASES; GENE EXPRESSION REGULATION; INJECTIONS, INTRAVENOUS; POTASSIUM CHANNEL BLOCKERS; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TETRAETHYLAMMONIUM; TISSUE DISTRIBUTION; VITREOUS BODY;

EID: 84883312121     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.07.004     Document Type: Article

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