Evidencing the modulation of P-glycoprotein at blood-ocular barriers using gamma scintigraphy

Current Eye Research

Volumn 34, Issue 1, 2009, Pages 73-77

  Senthilkumari, Srinivasan ^a   Velpandian, Thirumurthy ^a   Biswas, Nihar Ranjan ^b   Bhatnagar, Assem ^c   Mittal, Gaurav ^c   Ghose, Supriyo ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Blood ocular barriers; Gamma scintigraphy; P gp; Rabbits

Indexed keywords

GLYCOPROTEIN P; OFLOXACIN; TECHNETIUM 99M; VERAPAMIL; ANTIINFECTIVE AGENT; DIAGNOSTIC AGENT; TECHNETIUM; VASODILATOR AGENT;

ARTICLE; BLOOD EYE BARRIER; CONTROLLED STUDY; GAMMA SCINTIGRAPHY; IMAGING; ISOTOPE LABELING; MALE; MODULATION; NEW ZEALAND; NONHUMAN; PRIORITY JOURNAL; RABBIT; RADIOCHEMISTRY; ANIMAL; BLOOD RETINA BARRIER; METABOLISM; PHYSIOLOGY; SCINTILLATION CAMERA; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VITREOUS BODY;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD-AQUEOUS BARRIER; BLOOD-RETINAL BARRIER; GAMMA CAMERAS; MALE; OFLOXACIN; P-GLYCOPROTEIN; RABBITS; TECHNETIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VASODILATOR AGENTS; VERAPAMIL; VITREOUS BODY;

EID: 59449094029     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680802563430     Document Type: Article

References (9)

1. Cunha-Vaz J. The blood-ocular barriers. Surv Ophthalmol. 1979;23:279-286.
2. Duvvuri S, Majumdar S, Mitra AK. Drug delivery to the retina: Challenges and opportunities. Expert Opin Biol Ther. 2003;3:45-56.
3. Senthilkumari S, Velpandian T, Biswas NR, Sonali N, Ghose S. Evaluation of the impact of P-glycoprotein (P-gp) drug efflux transporter blockade on the systemic and ocular disposition of P-gp substrate. J Ocul Pharmacol Ther. 2007;24:290-300.
4. Senthilkumari S, Velpandian T, Biswas NR, Saxena R, Ghose S.Evaluation of the modulation of P-glycoprotein (P-gp) on the intraocular disposition of its substrate in rabbits. Curr Eye Res. 2008;33:333-343.
5. Piwnica-Worms D, ChiAML, Budding M, Kronauge JF, Kramer RA, Croop JM. Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Rev. 1993;53:1-8.
6. Ballinger J, Hua H, Berry B. Firby P. Boxen 1. Technetium-99m-sestamibi as an agent for imaging P-glycoprotein-mediated multidrug resistance: In vitro and in vivo studies in a rat breast tumor cell line and its doxorubicin-resistant variant. Nucl Med Commun. 1995:16:253-257.
7. Ambudkar SV, Dey S, Hryeyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol. 1999;39:361-398.
8. Wackers FJ, Berman D, Maddahi J, Waston DD, Beller GA, Strauss HW, et al. Technetium-99m-hexakis 2-methoxy isobutlisonitrile: Human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med. 1989;30:301-309.
9. Bambeke FV, Michot JM, Tulkens PM. Antibiotic efflux pumps in eukaryotic cells: Occurrence and impact on antibiotic cellular pharmacokinetics, pharmaodynamics, and toxicodynamics. J Antimicro Chemo. 2003;51:1067-1077.