-
2
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G and Thompson CB: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20, 2008.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
Deberardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
3
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P and Hall MN: Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol cell 10: 457-468, 2002.
-
(2002)
Mol Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
4
-
-
0037507252
-
The mammalian target of rapamycin (mTOR) partner, RAPTOR, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
-
Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J and Yonezawa K: The mammalian target of rapamycin (mTOR) partner, RAPTOR, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem 278: 15461-15464, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 15461-15464
-
-
Nojima, H.1
Tokunaga, C.2
Eguchi, S.3
Oshiro, N.4
Hidayat, S.5
Yoshino, K.6
Hara, K.7
Tanaka, N.8
Avruch, J.9
Yonezawa, K.10
-
5
-
-
62749096589
-
Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
-
Dunlop EA and Tee AR: Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cell Signall 21: 827-835, 2009.
-
(2009)
Cell Signall
, vol.21
, pp. 827-835
-
-
Dunlop, E.A.1
Tee, A.R.2
-
6
-
-
0025277750
-
Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway
-
Kaiser CA and Schekman R: Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. Cell 61: 723-733, 1990.
-
(1990)
Cell
, vol.61
, pp. 723-733
-
-
Kaiser, C.A.1
Schekman, R.2
-
7
-
-
7944235758
-
Mammalian TOR complex controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A and Hall MN: Mammalian TOR complex controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biology 6: 1122-1128, 2004.
-
(2004)
Nat Cell Biology
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
8
-
-
0026323221
-
Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control
-
Levy S, Avni D, Hariharan N, Perry RP and Meyuhas O: Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control. Proc Nati Acad Sci list 88: 3319-3323, 1991.
-
(1991)
Proc Nati Acad Sci List
, vol.88
, pp. 3319-3323
-
-
Levy, S.1
Avni, D.2
Hariharan, N.3
Perry, R.P.4
Meyuhas, O.5
-
9
-
-
65549167833
-
Targeting the mTOR signaling network for cancer therapy
-
Meric-Bernstam F and Gonzalez-Angulo AM: Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 27: 2278-2287, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2278-2287
-
-
Meric-Bernstam, F.1
Gonzalez-Angulo, A.M.2
-
10
-
-
0028126506
-
PHAS-I as a link between mitogenactivated protein kinase and translation initiation
-
Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N and Lawrence JC Jr.: PHAS-I as a link between mitogenactivated protein kinase and translation initiation. Science 266: 653-656, 1994.
-
(1994)
Science
, vol.266
, pp. 653-656
-
-
Lin, T.A.1
Kong, X.2
Haystead, T.A.3
Pause, A.4
Belsham, G.5
Sonenberg, N.6
Lawrence Jr., J.C.7
-
11
-
-
0035032444
-
The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure
-
Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ and Sonenberg N: The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA 7: 382-394, 2001.
-
(2001)
RNA
, vol.7
, pp. 382-394
-
-
Svitkin, Y.V.1
Pause, A.2
Haghighat, A.3
Pyronnet, S.4
Witherell, G.5
Belsham, G.J.6
Sonenberg, N.7
-
12
-
-
12344281782
-
The implications of structured 5' untranslated regions on translation and disease
-
Pickering BM and Willis AE: The implications of structured 5' untranslated regions on translation and disease. Semi Cell Develop Biol 16: 39-47, 2005.
-
(2005)
Semi Cell Develop Biol
, vol.16
, pp. 39-47
-
-
Pickering, B.M.1
Willis, A.E.2
-
13
-
-
3242786475
-
The prevalence of pituitary adenomas: A systematic review
-
Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML and McCutcheon IE: The prevalence of pituitary adenomas: A systematic review. Cancer 101: 613-619, 2004.
-
(2004)
Cancer
, vol.101
, pp. 613-619
-
-
Ezzat, S.1
Asa, S.L.2
Couldwell, W.T.3
Barr, C.E.4
Dodge, W.E.5
Vance, M.L.6
McCutcheon, I.E.7
-
14
-
-
84874630091
-
Inhibition of PI3K/AKT/mTOR pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude mice
-
Dai C, Zhang B, Liu X, Ma S, Yang Y, Yao Y, Feng M, Bao X, Li G, Wang J, Guo K, Ma W, Xing B, Lian W, Xiao J, Cai F, Zhang H and Wang R: Inhibition of PI3K/AKT/mTOR pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude mice. Endocrinology 154: 1247-1259, 2013.
-
(2013)
Endocrinology
, vol.154
, pp. 1247-1259
-
-
Dai, C.1
Zhang, B.2
Liu, X.3
Ma, S.4
Yang, Y.5
Yao, Y.6
Feng, M.7
Bao, X.8
Li, G.9
Wang, J.10
Guo, K.11
Ma, W.12
Xing, B.13
Lian, W.14
Xiao, J.15
Cai, F.16
Zhang, H.17
Wang, R.18
-
15
-
-
68549139637
-
Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors
-
Dworakowska D, Wlodek E, Leontiou CA, Igreja S, Cakir M, Teng M, Prodromou N, Goth MI, Grozinsky-Glasberg S, Gueorguiev M, Kola B, Korbonits M and Grossman AB: Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors. Endocrine-related Cancer 16: 1329-1338, 2009.
-
(2009)
Endocrine-related Cancer
, vol.16
, pp. 1329-1338
-
-
Dworakowska, D.1
Wlodek, E.2
Leontiou, C.A.3
Igreja, S.4
Cakir, M.5
Teng, M.6
Prodromou, N.7
Goth, M.I.8
Grozinsky-Glasberg, S.9
Gueorguiev, M.10
Kola, B.11
Korbonits, M.12
Grossman, A.B.13
-
16
-
-
84867396558
-
PI3K/AKT/mTOR and RAF/MEK/ERK signaling pathways perturbations in nonfunctioning pituitary adenomas
-
Rubinfeld H and Shimon I: PI3K/AKT/mTOR and RAF/MEK/ERK signaling pathways perturbations in nonfunctioning pituitary adenomas. Endocrine 42: 285-291, 2012.
-
(2012)
Endocrine
, vol.42
, pp. 285-291
-
-
Rubinfeld, H.1
Shimon, I.2
-
17
-
-
84875243104
-
MTOR is frequently active in GH-secreting pituitary adenomas without influencing their morphopathological features
-
Sajjad EA, Zielinski G, Maksymowicz M, Hutnik L, Bednarczuk T and Wlodarski P: mTOR is frequently active in GH-secreting pituitary adenomas without influencing their morphopathological features. Endocrin Pathol 24: 11-19, 2013.
-
(2013)
Endocrin Pathol
, vol.24
, pp. 11-19
-
-
Sajjad, E.A.1
Zielinski, G.2
Maksymowicz, M.3
Hutnik, L.4
Bednarczuk, T.5
Wlodarski, P.6
-
18
-
-
72749102942
-
Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce antiproliferative effects in GHsecreting pituitary tumor cells in vitro
-
Gorshtein A, Rubinfeld H, Kendler E, Theodoropoulou M, Cerovac V, Stalla GK, Cohen ZR, Hadani M, and Shimon I: Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce antiproliferative effects in GHsecreting pituitary tumor cells in vitro. Endocrine-related Cancer 16: 1017-1027, 2009.
-
(2009)
Endocrine-related Cancer
, vol.16
, pp. 1017-1027
-
-
Gorshtein, A.1
Rubinfeld, H.2
Kendler, E.3
Theodoropoulou, M.4
Cerovac, V.5
Stalla, G.K.6
Cohen, Z.R.7
Hadani, M.8
Shimon, I.9
-
19
-
-
79952998207
-
MTOR inhibition reduces cellular proliferation and sensitizes pituitary adenoma cells to ionizing radiation
-
Sukumari-Ramesh S, Singh N, Dhandapani KM and Vender JR: mTOR inhibition reduces cellular proliferation and sensitizes pituitary adenoma cells to ionizing radiation. Surg Neurol Int 2: 22, 2011.
-
(2011)
Surg Neurol Int
, vol.2
, pp. 22
-
-
Sukumari-Ramesh, S.1
Singh, N.2
Dhandapani, K.M.3
Vender, J.R.4
-
20
-
-
84876231995
-
Prognostic and therapeutic implications of mTORC1 and RICTOR expression in human breast cancer
-
Wazir U, Newbold RF, Jiang WG, Sharma AK and Mokbel K: Prognostic and therapeutic implications of mTORC1 and RICTOR expression in human breast cancer. Oncol Rep 29: 1969-74, 2013.
-
(2013)
Oncol Rep
, vol.29
, pp. 1969-1974
-
-
Wazir, U.1
Newbold, R.F.2
Jiang, W.G.3
Sharma, A.K.4
Mokbel, K.5
-
21
-
-
0027450982
-
Pituitary adenomas with invasion of the cavernous sinus space: A magnetic resonance imaging classification compared with surgical findings
-
discussion 617-618
-
Knosp E, Steiner E, Kitz K and Matula C: Pituitary adenomas with invasion of the cavernous sinus space: A magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33: 610-617; discussion 617-618, 1993.
-
(1993)
Neurosurgery
, vol.33
, pp. 610-617
-
-
Knosp, E.1
Steiner, E.2
Kitz, K.3
Matula, C.4
-
22
-
-
0002759359
-
Transsphenoidal surgery of hypersecreting pituitary tumors
-
Kohler PO and Ross GT (eds.). Amsterdam, Exerpta Medica
-
Hardy J: Transsphenoidal surgery of hypersecreting pituitary tumors. In: Diagnosis and Treatment of Pituitary Tumors, Kohler PO and Ross GT (eds.). Amsterdam, Exerpta Medica, pp: 179-198, 1973.
-
(1973)
Diagnosis and Treatment of Pituitary Tumors
, pp. 179-198
-
-
Hardy, J.1
-
23
-
-
70350418625
-
MTOR signaling at a glance
-
Laplante M and Sabatini DM: mTOR signaling at a glance. J Cell Sci 122: 3589-3594, 2009.
-
(2009)
J Cell Sci
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
24
-
-
80051598688
-
Levels of p27 sensitize to dual PI3K/mTOR inhibition
-
Lee M, Theodoropoulou M, Graw J, Roncaroli F, Zatelli MC and Pellegata NS: Levels of p27 sensitize to dual PI3K/mTOR inhibition. Mole Cancer Ther 10: 1450-1459, 2011.
-
(2011)
Mole Cancer Ther
, vol.10
, pp. 1450-1459
-
-
Lee, M.1
Theodoropoulou, M.2
Graw, J.3
Roncaroli, F.4
Zatelli, M.C.5
Pellegata, N.S.6
-
25
-
-
46349095103
-
Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors
-
Lu C, Willingham MC, Furuya F and Cheng SY: Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors. Endocrinology 149: 3339-3345, 2008.
-
(2008)
Endocrinology
, vol.149
, pp. 3339-3345
-
-
Lu, C.1
Willingham, M.C.2
Furuya, F.3
Cheng, S.Y.4
-
26
-
-
75349087887
-
Dissecting the role of mTOR: Lessons from mTOR inhibitors
-
Dowling RJ, Topisirovic I, Fonseca BD, and Sonenberg N: Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta 1804: 433-439, 2010.
-
(2010)
Biochim Biophys Acta
, vol.1804
, pp. 433-439
-
-
Dowling, R.J.1
Topisirovic, I.2
Fonseca, B.D.3
Sonenberg, N.4
-
27
-
-
84858160987
-
New targeted therapies in pituitary carcinoma resistant to temozolomide
-
Jouanneau E, Wierinckx A, Ducray F, Favrel V, Borson-Chazot F, Honnorat J, Trouillas J, and Raverot G: New targeted therapies in pituitary carcinoma resistant to temozolomide. Pituitary 15: 37-43, 2012.
-
(2012)
Pituitary
, vol.15
, pp. 37-43
-
-
Jouanneau, E.1
Wierinckx, A.2
Ducray, F.3
Favrel, V.4
Borson-Chazot, F.5
Honnorat, J.6
Trouillas, J.7
Raverot, G.8
-
28
-
-
80053391859
-
Nelfinavir induces radiation sensitization in pituitary adenoma cells
-
Zeng J, See AP, Aziz K, Thiyagarajan S, Salih T, Gajula RP, Armour M, Phallen J, Terezakis S, Kleinberg L, Redmond K, Hales RK, Salvatori R, Quinones-Hinojosa A, Tran PT and Lim M: Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 12: 657-663, 2011.
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 657-663
-
-
Zeng, J.1
See, A.P.2
Aziz, K.3
Thiyagarajan, S.4
Salih, T.5
Gajula, R.P.6
Armour, M.7
Phallen, J.8
Terezakis, S.9
Kleinberg, L.10
Redmond, K.11
Hales, R.K.12
Salvatori, R.13
Quinones-Hinojosa, A.14
Tran, P.T.15
Lim, M.16
-
29
-
-
79960897419
-
Hypoxiainducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation
-
Zhang H, Zhang G, Gonzalez FJ, Park SM and Cai D: Hypoxiainducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol 9: e1001112, 2011.
-
(2011)
PLoS Biol
, vol.9
-
-
Zhang, H.1
Zhang, G.2
Gonzalez, F.J.3
Park, S.M.4
Cai, D.5
-
30
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A and Sabatini DM: mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Revi Mol Cell Biol 12: 21-35, 2011.
-
(2011)
Nat Revi Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
|