Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury

Biomaterials

Volumn 34, Issue 35, 2013, Pages 8949-8959

  An, Sai ^a   Kuang, Yuyang ^a   Shen, Teng ^a   Li, Jianfeng ^a   Ma, Haojun ^a   Guo, Yubo ^a   He, Xi ^a   Jiang, Chen ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Ask1; Brain targeting nanoparticles; Dermorphin; Ischemia reperfusion injury; RNAi

Indexed keywords

APOPTOTIC CELL DEATH; ASK1; CEREBRAL ISCHEMIA-REPERFUSION; DERMORPHIN; ISCHEMIA/REPERFUSION; RNAI; SHORT HAIRPIN RNA (SHRNA); TRANSFECTION EFFICIENCY;

CELL DEATH; GENE THERAPY; GENE TRANSFER; MOLECULAR BIOLOGY; NANOPARTICLES; RNA;

BRAIN;

APOPTOSIS SIGNAL REGULATING KINASE 1; BRAIN TARGETING NANOPARTICLE; DENDRIGRAFT POLYLYSINE; DENDRIMER; DERMORPHIN; MACROGOL; MESSENGER RNA; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NANOPARTICLE; PLASMID DNA; POLYLYSINE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN CAPILLARY; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN SLICE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; ENDOTHELIUM CELL; FLUORESCENCE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULARLY TARGETED THERAPY; MOUSE; NEUROPROTECTION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITATIVE RESEARCH; QUANTITATIVE STUDY; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY;

ASK1; BRAIN-TARGETING NANOPARTICLES; DERMORPHIN; ISCHEMIA/REPERFUSION INJURY; RNAI;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE, TUMOR; CEREBRAL INFARCTION; ENDOTHELIAL CELLS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HUMANS; MALE; MICE; MICE, INBRED ICR; MICE, NUDE; NANOPARTICLES; PLASMIDS; POLYETHYLENE GLYCOLS; POLYLYSINE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84883246296     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.07.060     Document Type: Article

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