Amlodipine reduces cardiac iron overload in patients with thalassemia major: A pilot trial

American Journal of Medicine

Volumn 126, Issue 9, 2013, Pages 834-837

  Fernandes, Juliano Lara ^a   Sampaio, Erika Fontana ^a   Fertrin, Kleber ^a   Coelho, Otavio Rizzi ^a   Loggetto, Sandra ^b   Piga, Antonio ^c   Verissimo, Monica ^d   Saad, Sara T ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Centro de Otorrinolaringologia de São Paulo Complexo Hospitalar Edmundo Vasconcelos   (Brazil)

^c UNIVERSITY OF TURIN   (Italy)

^d CENTRO INFANTIL BOLDRINI   (Brazil)

Author keywords

Iron overload; Magnetic resonance imaging; Thalassemia

Indexed keywords

AMLODIPINE; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN; HEMOGLOBIN; IRON;

ADULT; ARTICLE; BLOOD PRESSURE; CHELATION THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FERRITIN BLOOD LEVEL; HEART; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON CHELATION; IRON OVERLOAD; LEG EDEMA; LIVER LEVEL; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; THALASSEMIA MAJOR; TISSUE LEVEL;

IRON OVERLOAD; MAGNETIC RESONANCE IMAGING; THALASSEMIA;

ADOLESCENT; ADULT; AMLODIPINE; ANALYSIS OF VARIANCE; BETA-THALASSEMIA; CALCIUM CHANNEL BLOCKERS; CHELATION THERAPY; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; IRON OVERLOAD; MAGNETIC RESONANCE IMAGING; MALE; MYOCARDIUM; PILOT PROJECTS; TREATMENT OUTCOME;

EID: 84883235451     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2013.05.002     Document Type: Article

References (16)

1. C. Borgna-Pignatti, and M.R. Gamberini Complications of thalassemia major and their treatment Expert Rev Hematol 4 3 2011 353 366
2. G.J. Kontoghiorghes Introduction of higher doses of deferasirox: better efficacy but not effective iron removal from the heart and increased risks of serious toxicities Expert Opin Drug Saf 9 4 2010 633 641
3. G.Y. Oudit, H. Sun, and M.G. Trivieri L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy Nat Med 9 9 2003 1187 1194
4. G.Y. Oudit, M.G. Trivieri, and N. Khaper Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy J Mol Med (Berl) 84 5 2006 349 364
5. R.G. Tsushima, A.D. Wickenden, and R.A. Bouchard Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload Circ Res 84 11 1999 1302 1309
6. T. He, P.D. Gatehouse, and G.C. Smith Myocardial T2* measurements in iron-overloaded thalassemia: an in vivo study to investigate optimal methods of quantification Magn Reson Med 60 5 2008 1082 1089
7. J.C. Wood, C. Enriquez, and N. Ghugre MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients Blood 106 4 2005 1460 1465
8. M.A. Tanner, R. Galanello, and C. Dessi Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction J Cardiovasc Magn Reson 10 2008 12
9. M.A. Tanner, R. Galanello, and C. Dessi A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance Circulation 115 14 2007 1876 1884
10. D.J. Pennell, V. Berdoukas, and M. Karagiorga Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis Blood 107 9 2006 3738 3744
11. D.J. Pennell, J.B. Porter, and M.D. Cappellini Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia Blood 115 12 2010 2364 2371
12. B.P. Esposito, W. Breuer, and P. Sirankapracha Labile plasma iron in iron overload: redox activity and susceptibility to chelation Blood 102 7 2003 2670 2677
13. S. Ludwiczek, I. Theurl, and M.U. Muckenthaler Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 Nat Med 13 4 2007 448 454
14. J.T. Flynn Efficacy and safety of prolonged amlodipine treatment in hypertensive children Pediatr Nephrol 20 5 2005 631 635
15. D.R. Abernethy, and J.B. Schwartz Calcium-antagonist drugs N Engl J Med 341 19 1999 1447 1457
16. H.T. Dougall, and J. McLay A comparative review of the adverse effects of calcium antagonists Drug Saf 15 2 1996 91 106