Efficacy and safety of prolonged amlodipine treatment in hypertensive children

Pediatric Nephrology

Volumn 20, Issue 5, 2005, Pages 631-635

  Flynn, Joseph T ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Adolescents; Amlodipine; Calcium channel blockers; Children; Clinical trial; Drug safety

Indexed keywords

AMLODIPINE; CYCLOSPORIN; CALCIUM CHANNEL BLOCKING AGENT;

ADOLESCENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; DIZZINESS; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FATIGUE; FEMALE; FLUSHING; GINGIVA HYPERPLASIA; HUMAN; HYPERTENSION; LONG TERM CARE; MALE; MONOTHERAPY; PRIORITY JOURNAL; SIDE EFFECT; BLOOD PRESSURE; DRUG EFFECT; HEART RATE; INFANT; NEWBORN; PRESCHOOL CHILD; RENOVASCULAR HYPERTENSION; TREATMENT OUTCOME;

ADOLESCENT; AMLODIPINE; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CHILD; CHILD, PRESCHOOL; FEMALE; HEART RATE; HUMANS; HYPERTENSION, RENAL; INFANT; INFANT, NEWBORN; MALE; TREATMENT OUTCOME;

EID: 21244483979     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-004-1781-9     Document Type: Article

References (25)

1. Murdoch D, Heel RC (1991) Amlodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular disease. Drugs 41:478-505
2. Flynn JT, Pasko DA (2000) Calcium channel blockers: Pharmacology and place in therapy of pediatric hypertension. Pediatr Nephrol 15:302-316
3. Khattak S, Rogan JW, Saunder EF, Theis JG, Arbus GS, Koren G (1998) Efficacy of amlodipine in pediatric bone marrow transplant patients. Clin Pediatr (Phila)37:31-35
4. Pfammatter, JF, Clericetti-Affolter C, Trittmann AC, Busch K, Laux-End R, Bianchetti MG (1998) Amlodipine once-daily in systemic hypertension. Eur J Pediatr 157:618-621
5. Tallian KB, Nahata MC, Turman MA, Mahan JD, Hayes JR, Mentser MI (1999) Efficacy of amlodipine in pediatric patients with hypertension. Pediatr Nephrol 13:304-310
6. Rogan JW, Lyszkiewicz DA, Blowey D, Khattak S, Arbus GS, Koren G (2000) A randomized prospective crossover trial of amlodipine in pediatric hypertension. Pediatr Nephrol 14:1083-1087
7. Flynn JT, Smoyer WE, Bunchman TE (2000) Treatment of hypertensive children with amlodipine. Am J Hypertens 13:1061-1066
8. Vigier RO von, Franscini LMD, Bianda NDF, Pfister R, Casaulta-Aebischer C, Bianchetti MG (2001) Antihypertensive efficacy of amlodipine in children with chronic kidney diseases. J Hum Hypertens 15:387-391
9. Parker ML, Robinson RF, Nahata MC (2002) Amlodipine therapy in pediatric patients with hypertension. J Am Pharm Assoc 42:114-117
10. Gartenmann AC, Fossali E, von Vigier RO, Simonetti GD, Schmidtko J, Edefonti A, Bianchetti MG (2003) Better renoprotective effect of angiotensin II antagonist compared to dihydropyridine calcium channel blocker in childhood. Kidney Int 64:1450-1454
11. Flynn JT, Warnick SJ (2002) Isradipine treatment of hypertension in children: A single-center experience. Pediatr Nephrol 17:748-753
12. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents (1996) Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: A working group report from the National High Blood Pressure Education Program. Pediatrics 98:649-658 8885941
13. Nahata MC, Morosco RS, Hipple TF (1999) Stability of amlodipine besylate in two liquid dosage forms. J Am Pharm Assoc 39:375-377
14. Shirkey H (1968) Therapeutic orphans. J Pediatr 72:119-120
15. Schreiner MS (1998) Safety and effectiveness data: Will children gain access? Am Heart J 136:4-5
16. Flynn JT. Pediatric use of antihypertensive medications: Much more to learn (2001) Curr Ther Res Clin Exp 62:314-328
17. Blowey D (2002) Safety of the newer antihypertensive agents in children. Expert Opin Drug Saf 1:39-43
18. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Drug therapy: Developmental pharmacology - drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157-1167
19. Wells TG (1999) Trials of antihypertensive therapies in children. Blood Press Monit 4:189-192
20. Flynn JT (2003) Successes and shortcomings of the FDA Modernization Act. Am J Hypertens 16:889-891
21. Trachtman H, Frank R, Mahan JD, Portman R, Restaino I, Matoo TK, Tou C, Klibaner M (2003) Clinical trial of extended-release felodipine in pediatric essential hypertension. Pediatr Nephrol 18:548-553
22. Flynn JT, Newburger JW, Daniels SR, Sanders SP, Portman RJ, Hogg RJ (2004) A randomized, placebo-controlled trial of amlodipine in children with hypertension. J Pediatr 145:353-359
23. Flynn, JT, Mottes TA, Brophy PB, Kershaw DB, Smoyer WE, Bunchman TE (2001) Intravenous nicardipine for treatment of severe hypertension in children. J Pediatr 139:38-43
24. Flynn JT, Ludden T, Mahan Jr JD, Nahata MC, Robinson R, Arbus GS, Portman RJ, Greenleaf PA, Cropp AB (2002) Population pharmacokinetics of amlodipine in children with hypertension (abstract). Am J Hypertens 15 (4, Part 2): 206A
25. Andrawis NS, Abernathy DR (1992) Verapamil blocks basal and angiotensin II-induced RNA synthesis of rat aortic vascular smooth muscle. Biochem Biophys Res Commun 183:767-773