Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation

Food and Chemical Toxicology

Volumn 60, Issue , 2013, Pages 431-438

  Jackson, Steven J T ^a   Murphy, Laura L ^b   Venema, Richard C ^c   Singletary, Keith W ^d   Young, Andrew J ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cell cycle; Curcumin; Endothelial; Tubulin

Indexed keywords

CURCUMIN; HEME OXYGENASE 1; TUBULIN;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER MODEL; CELL CYCLE ARREST; CELL PROLIFERATION; CELLULAR PARAMETERS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SEGREGATION; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; KARYORRHEXIS; MICRONUCLEATION; MICROTUBULE; MITOSIS; NONHUMAN; UPREGULATION;

BAE; BOVINE AORTIC ENDOTHELIAL; CELL CYCLE; CMN; CURCUMIN; ENDOTHELIAL; HEMEOXYGENASE-1; HO-1; TUBULIN;

ANIMALS; ANTIOXIDANTS; CATTLE; CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL LINE; CELL PROLIFERATION; CURCUMIN; ENDOTHELIAL CELLS; HEME OXYGENASE-1; MICROTUBULES; MITOSIS; TUBULIN;

EID: 84883232795     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.008     Document Type: Article

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