Thoracic organ transplantation: Laboratory methods

Methods in Molecular Biology

Volumn 1034, Issue , 2013, Pages 127-143

  Patel, Jignesh K ^a   Kobashigawa, Jon A ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Allomap; Biomarkers; Calculated panel reactive antibodies; Circulating antibodies; Complement fixing antibodies; Immune monitoring; Laboratory techniques; Virtual crossmatch

Indexed keywords

ANTIBODY; IMMUNOSUPPRESSIVE AGENT;

ACUTE GRAFT REJECTION; ANTIBODY BLOOD LEVEL; ARTICLE; CELLULAR IMMUNITY; CHRONIC GRAFT REJECTION; DESENSITIZATION; GENE EXPRESSION PROFILING; GRAFT RECIPIENT; HEART TRANSPLANTATION; HISTOCOMPATIBILITY TEST; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; LABORATORY TEST; LUNG TRANSPLANTATION; MICROCHIMERISM; PATIENT MONITORING; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SURGICAL RISK; T LYMPHOCYTE; THORAX SURGERY;

EID: 84883225201     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-493-7_7     Document Type: Article

References (62)

1. Billingham RE, Brent L, Medawar PB (1953) Actively acquired tolerance of foreign cells. Nature 172(4379):603-606
2. Kobashigawa J, Mehra M, West L, Kerman R, George J, Rose M et al (2009) Report from a consensus conference on the sensitized patient awaiting heart transplantation. J Heart Lung Transplant 28(3):213-225. doi: S1053-2498(08)01785-3 [pii] 10.1016/j. healun.2008.12.017
3. Oyer PE, Stinson EB, Jamieson SW (1983) Cyclosporine in cardiac transplantation: A 21/2 year follow-up. Transplant Proc 15(Suppl 1): 2546
4. Armitage JM, Kormos RL, Griffi th BP, Hardesty RL, Fricker FJ, Stuart RS et al (1991) A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation. Transplant Proc 23(1 Pt 2):1149-1152
5. Cheung A, Menkis AH (1998) Cyclosporine heart transplantation. Transplant Proc 30(5): 1881-1884
6. Stehlik J, Edwards LB, Kucheryavaya AY, Benden C, Christie JD, Dobbels F et al (2011) The Registry of the International Society for Heart and Lung Transplantation: Twentyeighth Adult Heart Transplant Report -2011. J Heart Lung Transplant 30(10):1078-1094. doi: S1053-2498(11)01086-2 [pii] 10.1016/j. healun.2011.08.003
7. Michaels PJ, Espejo ML, Kobashigawa J, Alejos JC, Burch C, Takemoto S et al (2003) Humoral rejection in cardiac transplantation: Risk factors, hemodynamic consequences and relationship to transplant coronary artery disease. J Heart Lung Transplant 22(1):58-69
8. Itescu S, Tung TC, Burke EM, Weinberg AD, Mancini D, Michler RE et al (1998) An immunological algorithm to predict risk of highgrade rejection in cardiac transplant recipients. Lancet 352(9124):263-270
9. Nwakanma LU, Williams JA, Weiss ES, Russell SD, Baumgartner WA, Conte JV (2007) Infl uence of pretransplant panel-reactive antibody on outcomes in 8,160 heart transplant recipients in recent era. Ann Thorac Surg 84(5):1556-1562. doi: S0003-4975(07)01217-9 [pii] 10.1016/j.athoracsur.2007.05.095 ; discussion 1562-1553
10. Tinckam KJ, Chandraker A (2006) Mechanisms and role of HLA and non-HLA alloantibodies. Clin J Am Soc Nephrol 1(3):404-414. doi: CJN.00270106 [pii]2215/CJN.00270106
11. Schlaf G, Pollok-Kopp B, Manzke T, Schurat O, Altermann W (2010) Novel solid phase-based ELISA assays contribute to an improved detection of anti-HLA antibodies and to an increased reliability of pre-and post-transplant crossmatching. NDT Plus 3(6):527-538
12. Altermann WW, Seliger B, Sel S, Wendt D, Schlaf G (2006) Comparison of the established standard complement-dependent cytotoxicity and fl ow cytometric crossmatch assays with a novel ELISA-based HLA crossmatch procedure. Histol Histopathol 21(10): 1115-1124
13. Smith JD, Hamour IM, Banner NR, Rose ML (2007) C4d fi xing, luminex binding antibodies -a new tool for prediction of graft failure after heart transplantation. Am J Transplant 7(12):2809-2815. doi: AJT1991 [pii] .1111/j.1600-6143.2007.01991.x
14. Won DI, Jung HD, Jung OJ, Huh S, Suh JS (2007) Flow cytometry PRA using lymphocyte pools from random donors. Cytometry B Clin Cytom 72(4):256-264. doi: 10.1002/ cyto.b.20175
15. El-Awar N, Lee J, Terasaki PI (2005) HLA antibody identification with single antigen beads compared to conventional methods. Hum Immunol 66(9):989-997. doi: S0198-8859(05)00138-2 [pii] 10.1016/j. humimm.2005.07.005
16. Reinsmoen NL, Lai CH, Vo A, Cao K, Ong G, Naim M et al (2008) Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy. Transplantation 86(6):820-825. doi: 10.1097/TP.0b013e318 1856f98 00007890-200809270-00012 [pii]
17. Stehlik J, Islam N, Hurst D, Kfoury AG, Movsesian MA, Fuller A et al (2009) Utility of virtual crossmatch in sensitized patients awaiting heart transplantation. J Heart Lung Transplant 28(11):1129-1134
18. Yanagida R, Czer LS, Reinsmoen NL, Cao K, Rafi ei M, De Robertis MA et al (2011) Impact of virtual cross match on waiting times for heart transplantation. Ann Thorac Surg 92(6): 2104-2110. doi: S0003-4975(11)01910-2 [pii] 10.1016/j.athoracsur.2011.07.082 ; discussion 2111
19. Zangwill S, Ellis T, Stendahl G, Zahn A, Berger S, Tweddell J (2007) Practical application of the virtual crossmatch. Pediatr Transplant 11(6):650-654. doi: PTR746 [pii] .1111/j.1399-3046.2007.00746.x
20. Vaidya S, Hilson B, Sheldon S, Cano P, Fernandez-Vina M (2007) DP reactive antibody in a zero mismatch renal transplant pair. Hum Immunol 68(12):947-949. doi: S0198-8859(07)00465-X [pii] 10.1016/j. humimm.2007.10.013
21. Kobashigawa JA, Patel JK, Kittleson MM, Kawano MA, Kiyosaki KK, Davis SN et al (2010) The long-term outcome of treated sensitized patients who undergo heart transplantation. Clin Transplant 25(1):E61-E67. doi: 10.1111/j.1399-0012. 2010.01334.x
22. Patel J, Everly M, Chang D, Kittleson M, Reed E, Kobashigawa J (2011) Reduction of alloantibodies via proteosome inhibition in cardiac transplantation. J Heart Lung Transplant 30(12):1320-1326. doi: S1053-2498(11) 01110-7 [pii] 10.1016/j.healun.2011.08.009
23. Kauke T, Kaczmarek I, Dick A, Schmoeckel M, Deutsch MA, Beiras-Fernandez A et al (2009) Anti-MICA antibodies are related to adverse outcome in heart transplant recipients. J Heart Lung Transplant 28(4):305-311. doi: S1053-2498(09)00024-2 [pii] 10.1016/j. healun.2009.01.003
24. Angaswamy N, Saini D, Ramachandran S, Nath DS, Phelan D, Hachem R et al (2010) Development of antibodies to human leukocyte antigen precedes development of antibodies to major histocompatibility class I-related chain A and are significantly associated with development of chronic rejection after human lung transplantation. Hum Immunol 71(6):560-565. doi: S0198-8859(10)00064-9 [pii] 10.1016/j.humimm.2010.02.021
25. Reinsmoen NL, Lai C-H, Mirocha J, Cao K, Ong GD, Naim M et al (2013) Increased negative impact of anti-angiotensin type-1 receptor antibodies together with de novo donor HLA specific antibodies on graft outcome in heart transplant recipients. J Heart Lung Transplant 32(4S):S113
26. Hiemann NE, Meyer R, Wellnhofer E, Schoenemann C, Heidecke H, Lachmann N, Hetzer R et al. (2012) Dragun Non-HLA antibodies targeting vascular receptors enhance alloimmune response and microvasculopathy after heart transplantation. Transplantation. Nov 15;94(9):919-24
27. Faulk WP, Rose M, Meroni PL, Del Papa N, Torry RJ, Labarrere CA et al (1999) Antibodies to endothelial cells identify myocardial damage and predict development of coronary artery disease in patients with transplanted hearts. Hum Immunol 60(9):826-832
28. Jurcevic S, Ainsworth ME, Pomerance A, Smith JD, Robinson DR, Dunn MJ et al (2001) Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation. Transplantation 71(7):886-892
29. Goers TA, Ramachandran S, Aloush A, Trulock E, Patterson GA, Mohanakumar T (2008) De novo production of K-alpha1 tubulin-specific antibodies: Role in chronic lung allograft rejection. J Immunol 180(7):4487-4494. doi: 180/7/4487 [pii]
30. Iwata T, Philipovskiy A, Fisher AJ, Presson RG Jr, Chiyo M, Lee J et al (2008) Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. J Immunol 181(8):5738-5747. doi: 181/8/5738 [pii]
31. Zhang Q, Cecka JM, Gjertson DW, Ge P, Rose ML, Patel JK, Ardehali A et al (2011) HLA and MICA: Targets of antibody-mediated rejection in heart transplantation. Transplantation 91(10):1153-1158. doi: 10.1097/TP. 0b013e3182157d60 00007890-201105270-00015 [pii]
32. Mahesh B, Leong HS, McCormack A, Sarathchandra P, Holder A, Rose ML (2007) Autoantibodies to vimentin cause accelerated rejection of cardiac allografts. Am J Pathol 170(4):1415-1427. doi: S0002-9440(10) 61355-7 [pii] 10.2353/ajpath.2007. 060728
33. Chin C, Chen G, Sequeria F, Berry G, Siehr S, Bernstein D et al (2010) Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fi xing complement in sensitized pediatric heart transplant patients. J Heart Lung Transplant 30(2):158-163. doi: S1053-2498(10)00508-5 [pii] 10.1016/j. healun.2010.08.020
34. Chen G, Sequeira F, Tyan DB (2011) Novel C1q assay reveals a clinically relevant subset of human leukocyte antigen antibodies independent of immunoglobulin G strength on single antigen beads. Hum Immunol 72(10):849-doi: S0198-8859(11)00171-6 [pii] 10.1016/j.humimm.2011.07.001
35. Kobashigawa J, Crespo-Leiro MG, Ensminger SM, Reichenspurner H, Angelini A, Berry G et al (2011) Report from a consensus conference on antibody-mediated rejection in heart transplantation. J Heart Lung Transplant 30(3):252-269. doi: S1053-2498(10)00731-X [pii] 10.1016/j.healun.2010.11.003
36. Mehra MR, Parameshwar J (2010) Gene expression profiling and cardiac allograft rejection monitoring: Is IMAGE just a mirage? J Heart Lung Transplant 29(6):599-602
37. McWilliams TJ, Williams TJ, Whitford HM, Snell GI (2008) Surveillance bronchoscopy in lung transplant recipients: Risk versus benefi t. J Heart Lung Transplant 27(11):1203-1209. doi: S1053-2498(08)00581-0 [pii] 10.1016/j. healun.2008.08.004
38. Deng MC, Eisen HJ, Mehra MR, Billingham M, Marboe CC, Berry G et al (2006) Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant 6(1):150-160
39. Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, Deng MC, Cappola TP et al (2010) Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med 362(20):1890-1900
40. Kowalski RJ, Post DR, Mannon RB, Sebastian A, Wright HI, Sigle G et al (2006) Assessing relative risks of infection and rejection: A meta-analysis using an immune function assay. Transplantation 82(5):663-668. doi: 10.1097/01.tp.0000234837.02126.70 00007890-200609150-00011 [pii]
41. Kobashigawa JA, Kiyosaki KK, Patel JK, Kittleson MM, Kubak BM, Davis SN et al (2010) Benefi t of immune monitoring in heart transplant patients using ATP production in activated lymphocytes. J Heart Lung Transplant 29(5):504-508. doi: S1053-2498(09)01536-8 [pii] 10.1016/j.healun.2009.12.015
42. Rossano JW, Denfi eld SW, Kim JJ, Price JF, Jefferies JL, Decker JA et al (2009) Assessment of the Cylex ImmuKnow cell function assay in pediatric heart transplant patients. J Heart Lung Transplant 28(1):26-31. doi: S1053-2498(08)00734-1 [pii] 10.1016/j. healun.2008.10.001
43. Bhorade SM, Janata K, Vigneswaran WT, Alex CG, Garrity ER (2008) Cylex ImmuKnow assay levels are lower in lung transplant recipients with infection. J Heart Lung Transplant 27(9):990-994. doi: S1053-2498(08)00477-4 [pii] 10.1016/j.healun.2008.06.005
44. Husain S, Raza K, Pilewski JM, Zaldonis D, Crespo M, Toyoda Y et al (2009) Experience with immune monitoring in lung transplant recipients: Correlation of low immune function with infection. Transplantation 87(12):1852-1857. doi: 10.1097/TP.0b013e3181a75ad2 00007890-200906270-00015 [pii]
45. Gautam A, Morrissey PE, Brem AS, Fischer SA, Gohh RY, Yango AF et al (2006) Use of an immune function assay to monitor immunosuppression for treatment of post-transplant lymphoproliferative disorder. Pediatr Transplant 10(5):613-616. doi: PTR510 [pii] 10.1111/j.1399-3046.2006.00510.x
46. Masters RG, Davies RA, Veinot JP, Hendry PJ, Smith SJ, de Bold AJ (1999) Discoordinate modulation of natriuretic peptides during acute cardiac allograft rejection in humans. Circulation 100(3):287-291
47. O'Neill JO, McRae AT 3rd, Troughton RW, Ng K, Taylor DO, Yamani MH et al (2005) Brain natriuretic peptide levels do not correlate with acute cellular rejection in De Novo orthotopic heart transplant recipients. J Heart Lung Transplant 24(4):416-420. doi: S105324980400035X [pii] 10.1016/j. healun.2003.12.006
48. Kittleson MM, Skojec DV, Wittstein IS, Champion HC, Judge DP, Barouch LA et al (2009) The change in B-type natriuretic peptide levels over time predicts significant rejection in cardiac transplant recipients. J Heart Lung Transplant 28(7):704-709. doi: S1053-2498(09)00241-1 [pii] 10.1016/j. healun.2009.04.019 Jignesh K. Patel and Jon A. Kobashigawa 143
49. Claudius I, Lan YT, Chang RK, Wetzel GT, Alejos J (2003) Usefulness of B-type natriuretic peptide as a noninvasive screening tool for cardiac allograft pathology in pediatric heart transplant recipients. Am J Cardiol 92(11):1368-1370. doi: S0002914903012049 [pii]
50. Rossano JW, Denfi eld SW, Kim JJ, Price JF, Jefferies JL, Decker JA et al (2008) B-type natriuretic peptide is a sensitive screening test for acute rejection in pediatric heart transplant patients. J Heart Lung Transplant 27(6):649-654. doi: S1053-2498(08)00248-9 [pii] 10.1016/j.healun.2008.03.008
51. Mehra MR, Uber PA, Walther D, Vesely M, Wohlgemuth JG, Prentice J et al (2006) Gene expression profiles and B-type natriuretic peptide elevation in heart transplantation: More than a hemodynamic marker. Circulation 114(1 Suppl): I21-I26. doi: 114/1-suppl/I-21 [pii] 10.1161/ CIRCULATIONAHA.105.000513
52. Martinez-Dolz L, Almenar L, Reganon E, Vila V, Sanchez-Soriano R, Martinez-Sales V et al (2009) What is the best biomarker for diagnosis of rejection in heart transplantation? Clin Transplant 23(5):672-680. doi: CTR1074 [pii] 10.1111/j.1399-0012.2009.01074
53. Balduini A, Campana C, Ceresa M, Arbustini E, Bosoni T, Serio A et al (2003) Utility of biochemical markers in the follow-up of heart transplant recipients. Transplant Proc 35(8):3075-3078. doi: S0041134503011394 [pii]
54. Labarrere CA, Lee JB, Nelson DR, Al-Hassani M, Miller SJ, Pitts DE (2002) C-reactive protein, arterial endothelial activation, and development of transplant coronary artery disease: A prospective study. Lancet 360(9344):1462-1467. doi: S0140-6736(02)11473-5 [pii] 10.1016/S0140-6736(02) 11473-5
55. Raichlin ER, McConnell JP, Lerman A, Kremers WK, Edwards BS, Kushwaha SS et al (2007) Systemic infl ammation and metabolic syndrome in cardiac allograft vasculopathy. J Heart Lung Transplant 26(8):826-833. doi: S1053-2498(07)00400-7 [pii] 10.1016/j. healun.2007.05.008
56. Hognestad A, Endresen K, Wergeland R, Stokke O, Geiran O, Holm T et al (2003) Plasma C-reactive protein as a marker of cardiac allograft vasculopathy in heart transplant recipients. J Am Coll Cardiol 42(3):477-482. doi: S0735109703006454 [pii]
57. Sahota A, Gao S, Hayes J, Jindal RM (2000) Microchimerism and rejection: A meta-analysis. Clin Transplant 14(4 Pt 1):345-350
58. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B et al (2002) Chimerism of the transplanted heart. N Engl J Med 346(1):5-15. doi: 10.1056/ NEJMoa012081346/1/5 [pii]
59. Pujal JM, Gallardo D (2008) PCR-based methodology for molecular microchimerism detection and quantification. Exp Biol Med (Maywood) 233(9):1161-1170. doi: 0802-RM-35 [pii] 10.3181/0802-RM-35
60. Schmidt-Lucke C, Aicher A, Romagnani P, Gareis B, Romagnani S, Zeiher AM et al (2007) Specific recruitment of CD4 + CD25++ regulatory T cells into the allograft in heart transplant recipients. Am J Physiol Heart Circ Physiol 292(5):H2425-H2431. doi: 01197.2006 [pii] 10.1152/ajpheart.01197.2006
61. Chen M, Mohtize M, Mattei MF, Villemot JP, Kohler C, Faure GC et al (2010) Reduced levels of both circulating CD4+ CD25+ CD127(low/ neg) and CD4+ CD8(neg) invariant natural killer regulatory T cells in stable heart transplant recipients. Clin Exp Immunol 163(1):104-112. doi: 10.1111/j.1365-2249.2010. 04281.x
62. http://optn.transplant.hrsa.gov/resources/ allocationcalculators.asp? index=78 Accessed on 1st May 2013