Reduction of alloantibodies via proteosome inhibition in cardiac transplantation

Journal of Heart and Lung Transplantation

Volumn 30, Issue 12, 2011, Pages 1320-1326

  Patel, Jignesh ^a   Everly, Matthew ^b   Chang, David ^a   Kittleson, Michelle ^a   Reed, Elaine ^c   Kobashigawa, Jon ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b Paul I Teraski Foundation Laboratory   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

alloantibodies; bortezomib; calculated panel reactive antibodies; heart transplantation; HLA; plasmapheresis; proteosome inhibitor

Indexed keywords

ALLOANTIBODY; BORTEZOMIB; HLA ANTIBODY; IMMUNOGLOBULIN; PANEL REACTIVE ANTIBODY; RITUXIMAB;

ADULT; AMYLOIDOSIS; ARTICLE; CLINICAL ARTICLE; DESENSITIZATION; GRAFT DYSFUNCTION; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; PLASMA CELL; PLASMAPHERESIS; PRIORITY JOURNAL; SEPSIS;

ADULT; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; BORONIC ACIDS; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFECTION; ISOANTIBODIES; MALE; MIDDLE AGED; PILOT PROJECTS; PLASMAPHERESIS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TREATMENT OUTCOME;

EID: 80655148955     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2011.08.009     Document Type: Article

References (34)

1. J. Kobashigawa, M. Mehra, and L. West Report from a consensus conference on the sensitized patient awaiting heart transplantation J Heart Lung Transplant 28 2009 213 225
2. D.K. Hooper, J.A. Hawkins, and T.C. Fuller Panel-reactive antibodies late after allograft implantation in children Ann Thorac Surg 79 2005 641 644 (Pubitemid 40186574)
3. E.F. Reed, A.J. Demetris, and E. Hammond Acute antibody-mediated rejection of cardiac transplants J Heart Lung Transplant 25 2006 153 159 (Pubitemid 43156365)
4. P.J. Michaels, M.L. Espejo, and J. Kobashigawa Humoral rejection in cardiac transplantation: risk factors, hemodynamic consequences and relationship to transplant coronary artery disease J Heart Lung Transplant 22 2003 58 69 (Pubitemid 36071418)
5. S. Zangwill, T. Ellis, and G. Stendahl Practical application of the virtual crossmatch Pediatr Transplant 11 2007 650 654 (Pubitemid 47174397)
6. R. Pei, J.H. Lee, N.J. Shih, and M. Chen Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities Transplantation 75 2003 43 49 (Pubitemid 36139693)
7. R.A. Bray, J.D. Nolen, and C. Larsen Transplanting the highly sensitized patient: the Emory algorithm Am J Transplant 6 2006 2307 2315 (Pubitemid 44359415)
8. B.A. Pisani, G.M. Mullen, and K. Malinowska Plasmapheresis with intravenous immunoglobulin G is effective in patients with elevated panel reactive antibody prior to cardiac transplantation J Heart Lung Transplant 18 1999 701 706 (Pubitemid 29363032)
9. R. John, K. Lietz, and E. Burke Intravenous immunoglobulin reduces anti-HLA alloreactivity and shortens waiting time to cardiac transplantation in highly sensitized left ventricular assist device recipients Circulation 100 1999 II-229 35
10. A.A. Vo, M. Lukovsky, and M. Toyoda Rituximab and intravenous immune globulin for desensitization during renal transplantation N Engl J Med 359 2008 242 251 (Pubitemid 352008439)
11. M.P. Curran, and K. McKeage Bortezomib: a review of its use in patients with multiple myeloma Drugs 69 2009 859 888
12. A. Idica, H. Kaneku, and M.J. Everly Elimination of post-transplant donor-specific HLA antibodies with bortezomib Clin Transplant 2008 229 239
13. M.J. Everly, J.J. Everly, and B. Susskind Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection Transplantation 86 2008 1754 1761
14. H.L. Trivedi, P.I. Terasaki, and A. Feroz Abrogation of anti-HLA antibodies via proteasome inhibition Transplantation 87 2009 1555 1561
15. R. Sberro-Soussan, J. Zuber, and C. Suberbielle-Boissel Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies Am J Transplant 10 2010 681 686
16. R.C. Walsh, J.J. Everly, and P. Brailey Proteasome inhibitor-based primary therapy for antibody-mediated renal allograft rejection Transplantation 89 2010 277 284
17. M. Wahrmann, M. Haidinger, and G.F. Kormoczi Effect of the proteasome inhibitor bortezomib on humoral immunity in two presensitized renal transplant candidates Transplantation 89 2010 1385 1390
18. UNOS calculated panel reactive antibody calculator http://optn. transplant.hrsa.gov/resources/allocationcalculators.asp?index=78
19. M.R. Garovoy, M.A. Rheinschmidt, and M. Biggs Flow cytometery analysis; a high technology crossmatch technique facilitating transplantation Transplant Proc 15 1983 1939
20. A.M. Hahn, G.A. Land, and R.M. Strothman American Society for Histocompatibility and Immunogenetics: laboratory manual 4th edition 2000 ASHI Lenexa, KS 1 13
21. M. Billingham, and J.A. Kobashigawa The revised ISHLT heart biopsy grading scale J Heart Lung Transplant 24 2005 1709 (Pubitemid 41641840)
22. J.A. Kobashigawa, J.K. Patel, and M.M. Kittleson The long-term outcome of treated sensitized patients who undergo heart transplantation Clin Transpl 2011 E61 E67
23. D.K. Perry, J.M. Burns, and H.S. Pollinger Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production Am J Transplant 9 2009 201 209
24. M.J. Everly, P.I. Terasaki, and J. Hopfield Protective immunity remains intact after antibody removal by means of proteasome inhibition Transplantation 90 2010 1493 1498
25. M.J. Everly A summary of bortezomib use in transplantation across 29 centers Clin Transpl 2009 323 337
26. J. Neumann, S. Schio, and H. Tarrasconi Bortezomib in lung transplantation: a promising start Clin Transpl 2009 421 424
27. A. Govil, R.C. Walsh, and A. Tevar Bortezomib-based treatment of antibody mediated rejection in pancreas allograft recipients Clin Transpl 2009 443 453
28. P.M. Eckman, M. Thorsgard, and D. Maurer Bortezomib for refractory antibody-mediated cardiac allograft rejection Clin Transpl 2009 475 478
29. E.R. Island, I.M. Gonzalez-Pinto, and H.L. Tsai Successful treatment with bortezomib of a refractory humoral rejection of the intestine after multivisceral transplantation Clin Transpl 2009 465 469
30. S.R. Raghavaiah, T.S. Diwan, and J.M. Burns Depletion of alloantibody-secreting plasma cells by proteasome inhibition improves desensitization Am J Transplant 10 2010 44
31. K.M. Coggeshall Inhibitory signaling by B cell Fc gamma RIIb Curr Opin Immunol 10 1998 306 312 (Pubitemid 28286957)
32. G.R. Ehrhardt, R.S. Davis, and J.T. Hsu The inhibitory potential of Fc receptor homolog 4 on memory B cells Proc Natl Acad Sci USA 100 2003 13489 13494 (Pubitemid 37444769)
33. Z. Xiang, A.J. Cutler, and R.J. Brownlie FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis Nat Immunol 8 2007 419 429 (Pubitemid 46745417)
34. P. Moreau, H. Pylypenko, and S. Grosicki Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study Lancet Oncol 12 2011 431 440