Reduced levels of both circulating CD4+CD25+CD127low/neg and CD4+CD8neg invariant natural killer regulatory T cells in stable heart transplant recipients

Clinical and Experimental Immunology

Volumn 163, Issue 1, 2011, Pages 104-112

  Chen, M ^a   Mohtize, M ^a   Mattei M F ^a   Villemot, J P ^a   Kohler, C ^a   Faure, G C ^a   Bene M C ^a   De Carvalho Bittencourt, M ^a  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

Author keywords

Cardiac transplantation; Immunomonitoring; Invariant NK T cells; Regulatory T cells

Indexed keywords

CD4 ANTIBODY; INTERLEUKIN 7 RECEPTOR;

ADULT; AGED; ALLOGRAFT; ARTICLE; BLOOD SAMPLING; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD4+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLOW CYTOMETRY; GRAFT RECIPIENT; GRAFT REJECTION; HEART GRAFT; HEART TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER T CELL; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD4; ANTIGENS, CD8; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; MONITORING, IMMUNOLOGIC; NATURAL KILLER T-CELLS; PROSPECTIVE STUDIES; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 78649751636     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04281.x     Document Type: Article

References (33)

1. Ducloux D, Carron PL, Rebibou JM et al. CD4 lymphocytopenia as a risk factor for skin cancers in renal transplant recipients. Transplantation 1998; 65:1270-2.
2. Lechler R, Chai JG, Marelli-Berg F, Lombardi G. The contributions of T-cell anergy to peripheral T-cell tolerance. Immunology 2001; 103:262-9.
3. Lechler RI, Garden OA, Turka LA. The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol 2003; 3:147-58.
4. Walsh PT, Taylor DK, Turka LA. Tregs and transplantation tolerance. J Clin Invest 2004; 114:1398-403.
5. Dijke IE, Weimar W, Baan CC. Regulatory T cells after organ transplantation: where does their action take place? Hum Immunol 2008; 69:389-98.
6. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 2001; 167:1245-53.
7. Liu W, Putnam AL, Xu-yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells. J Exp Med 2006; 203:1701-11.
8. Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-700.
9. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007; 319:41-52.
10. Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 2004; 114:1379-88.
11. Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Kaer LV. NKT cells: what's in a name? Nat Rev Immunol 2004; 4:231-7.
12. Seino KI, Fukao K, Muramoto K et al. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc Natl Acad Sci USA 2001; 98:2577-81.
13. Jiang S, Game DS, Davies D, Lombardi G, Lechler RI. Activated CD1d-restricted natural killer T cells secrete IL-2: innate help for CD4+CD25+ regulatory T cells? Eur J Immunol 2005; 35:1193-200.
14. Cava AL, Kaer LV, Fu DS. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol 2006; 27:322-7.
15. Jiang X, Kojo S, Harada M, Ohkohchi N, Taniguchi M, Seino KI. Mechanism of NKT cell-mediated transplant tolerance. Am J Transplant 2007; 7:1482-90.
16. Pillai AB, George TI, Dutt S, Strober S. Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease. Blood 2009; 113:4458-67.
17. Gao SZ, Alderman EL, Schroeder JS, Silverman JF, Hunt SA. Accelerated coronary vascular disease in the heart transplant patient: coronary arteriographic findings. J Am Coll Cardiol 1988; 12:334-40.
18. Sakaguchi S, Ono M, Setoguchi R et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006; 212:8-27.
19. Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007; 110:2983-90.
20. Roncarolo MG, Gregori S. Is FOXP3 a bona fide marker for human regulatory T cells? Eur J Immunol 2008; 38:925-7.
21. Codarri L, Vallotton L, Ciuffreda D et al. Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7R{alpha}high cell population in solid organ transplant recipients. J Exp Med 2007; 204:1533-41.
22. Battaglia M. Potential T regulatory cell therapy in transplantation: how far have we come and how far can we go? Transplant Int 2010; 23:761-70.
23. Schmidt-Lucke C, Aicher A, Romagnani P et al. Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients. Am J Physiol Heart Circ Physiol 2007; 292:H2425-H2431.
24. Lanio N, Sarmiento E, Gallego A et al. The potential role of T-cell memory distribution as predisposing factor for rejection in heart transplant recipients. Transplant Proc 2009; 41:2480-4.
25. Graca L, Cobbold SP, Waldmann H. Identification of regulatory T Cells in tolerated allografts. J Exp Med 2002; 195:1641-6.
26. Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and Type 1 diabetic patients. J Immunol 2006; 177:8338-47.
27. Zeiser R, Nguyen VH, Beilhack A et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006; 108:390-9.
28. Nakai Y, Iwabuchi K, Fujii S et al. Natural killer T cells accelerate atherogenesis in mice. Blood 2004; 104:2051-9.
29. Toyofuku A, Yasunami Y, Nabeyama K et al. Natural killer T-cells participate in rejection of islet allografts in the liver of mice. Diabetes 2006; 55:34-9.
30. Galante NZ, Ozaki KS, Cenedeze MA et al. Frequency of Valpha24+Vbeta11+ NKT cells in peripheral blood of human kidney transplantation recipients. Int Immunopharmacol 2005; 5:53-8.
31. Wang S, Jiang J, Guan Q et al. Reduction of Foxp3-expressing regulatory T cell infiltrates during the progression of renal allograft rejection in a mouse model. Transplant Immunol 2008; 19:93-102.
32. Ashton-Chess J, Dugast E, Colvin RB et al. Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients. J Am Soc Nephrol 2009; 20:1113-22.
33. Yapici Ü, Bemelman FJ, Scheepstra CG et al. Intragraft FOXP3 protein or mRNA during acute renal allograft rejection correlates with inflammation, fibrosis, and poor renal outcome. Transplantation 2009; 87:1377-80.