Structural basis for the functional roles of critical residues in human cytochrome P450 aromatase

Biochemistry

Volumn 52, Issue 34, 2013, Pages 5821-5829

  Lo, Jessica ^a   Di Nardo, Giovanna ^b   Griswold, Jennifer ^c   Egbuta, Chinaza ^a   Jiang, Wenhua ^a   Gilardi, Gianfranco ^b   Ghosh, Debashis ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; ANALYTICAL ULTRACENTRIFUGATION; CATALYTIC RESIDUE; INTERMOLECULAR INTERACTIONS; INTERMOLECULAR INTERFACES; NATIVE GEL ELECTROPHORESIS; QUATERNARY STRUCTURE; STRUCTURE-FUNCTION RELATIONSHIP;

AMINO ACIDS; BIOCHEMISTRY; ELECTROPHORESIS; PORPHYRINS; RECOMBINANT PROTEINS; SIZE EXCLUSION CHROMATOGRAPHY;

ENZYME ACTIVITY;

AROMATASE; RECOMBINANT ENZYME;

AMINO ACID SEQUENCE; ARTICLE; CATALYST; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; GENE DELETION; HUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; ULTRACENTRIFUGATION;

AMINO ACID SEQUENCE; AROMATASE; AROMATASE INHIBITORS; CATALYTIC DOMAIN; CRYSTALLIZATION; FEMALE; HUMANS; KINETICS; PLACENTA; PREGNANCY; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; X-RAY DIFFRACTION;

EID: 84883210549     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400669h     Document Type: Article

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