Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa

G3: Genes, Genomes, Genetics

Volumn 3, Issue 6, 2013, Pages 971-977

  Moumad, Khalid ^a,b,c   Lascorz, Jesus ^a   Bevier, Melanie ^a   Khyatti, Meriem ^b   Ennaji, Moulay Mustapha ^c   Benider, Abdellatif ^d   Huhn, Stefanie ^a   Lu, Shun ^a   Chouchane, Lotfi ^e   Corbex, Marilys ^f   Hemminki, Kari ^a,g   Försti, Asta ^a,f  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Institut Pasteur du Maroc   (Morocco)

^c HASSAN II UNIVERSITY OF CASABLANCA   (Morocco)

^d IBN ROCHD UNIVERSITY HOSPITAL   (Morocco)

^e WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^f INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^g LUND UNIVERSITY   (Sweden)

Author keywords

Epstein barr virus; Host innate immune sensors; Nasopharyngeal carcinoma; North Africa; SNPs

Indexed keywords

C TYPE LECTIN RECEPTOR; CD209 ANTIGEN; LECTIN RECEPTOR; MANNOSE BINDING LECTIN 2; RETINOIC ACID; RETINOIC ACID INDUCIBLE GENE I LIKE RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AFRICA; AGED; ALLELE; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CHILD; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOST; HOST INNATE IMMUNE SENSORS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NASOPHARYNX CARCINOMA; NASOPHARYNX TUMOR; NORTH AFRICA; PATTERN RECOGNITION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SNPS; VERY ELDERLY; YOUNG ADULT;

HUMAN HERPESVIRUS 4;

EID: 84883207452     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.112.005371     Document Type: Article

References (46)

1. Acioli-Santos, B., L. Segat, R. Dhalia, C. A. A. Brito, U. M. Braga-Neto et al., 2008 MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype. Hum. Immunol. 69: 122-128.
2. Bell, J. K., I. Botos, P. R. Hall, J. Askins, J. Shiloach et al., 2005 The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc. Natl. Acad. Sci. USA 102: 10976-10980.
3. Bosch, E., F. Calafell, D. Comas, P. J. Oefner, P. A. Underhill et al., 2001 High-resolution analysis of human y-chromosome variation shows a sharp discontinuity and limited gene flow between Northwestern Africa and the Iberian Peninsula. Am. J. Hum. Genet. 68: 1019-1029.
4. Busson, P., C. Keryer, T. Ooka, and M. Corbex, 2004 EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies. Trends Microbiol. 12: 356-360.
5. Chang, E. T., and H. O. Adami, 2006 The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol. Biomarkers Prev. 15: 1765- 1777.
6. Clingan, J. M., K. Ostrow, K. A. Hosiawa, Z. J. Chen, and M. Matloubian, 2012 Differential roles for RIG-I2like receptors and nucleic acidsensing TLR pathways in controlling a chronic viral Infection. J. Immunol. 188: 4432-4440.
7. Dhiman, N., I. G. Ovsyannikova, R. A. Vierkant, J. E. Ryan, V. Shane Pankratz et al., 2008 Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. Vaccine 26: 1731-1736.
8. El-Omar, E. M., M. T. Ng, and G. L. Hold, 2008 Polymorphisms in Toll-like receptor genes and risk of cancer. Oncogene 27: 244-252.
9. Faure, M., and C. Rabourdin-Combe, 2011 Innate immunity modulation in virus entry. Curr Opin Virol 1: 6-12.
10. Feng, B. J., M. Jalbout, W. B. Ayoub, M. Khyatti, S. Dahmoul et al., 2007 Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries. Int. J. Cancer 121: 1550-1555.
11. Feng, B. J., M. Khyatti, W. Ben-Ayoub, S. Dahmoul, M. Ayad et al., 2009 Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa. Br. J. Cancer 101: 1207-1212.
12. Frakking, F. N., J. Israels, L. C. Kremer, T. W. Kuijpers, H. N. Caron et al., 2011 Mannose-binding lectin (MBL) and the risk for febrile neutropenia and infection in pediatric oncology patients with chemotherapy. Pediatr. Blood Cancer 57: 89-96.
13. Gabriel, S. B., S. F. Schaffner, H. Nguyen, J. M. Moore, J. Roy et al., 2002 The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
14. Gonzalez-Reyes, S., L. Marin, L. Gonzalez, L. O. Gonzalez, J. M. del Casar et al., 2010 Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer 10: 665.
15. Gorbea, C., K. A. Makar, M. Pauschinger, G. Pratt, J. L. Bersola et al., 2010 A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J. Biol. Chem. 285: 23208-23223.
16. Hajjej, A., H. Kaabi, M. H. Sellami, A. Dridi, A. Jeridi et al., 2006 The contribution of HLA class I and II alleles and haplotypes to the investigation of the evolutionary history of Tunisians. Tissue Antigens 68: 153- 162.
17. Haralambieva, I. H., I. G. Ovsyannikova, B. J. Umlauf, R. A. Vierkant, V. Shane Pankratz et al., 2011 Genetic polymorphisms in host antiviral genes: associations with humoral and cellular immunity to measles vaccine. Vaccine 29: 8988-8997.
18. He, J. F., W. H. Jia, Q. Fan, X. X. Zhou, H. D. Qin et al., 2007 Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population. BMC Cancer 7: 194.
19. Hu, J., E. Nistal-Villan, A. Voho, A. Ganee, M. Kumar et al., 2010 A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells. J. Immunol. 185: 424-432.
20. Iwakiri, D., L. Zhou, M. Samanta, M. Matsumoto, T. Ebihara et al., 2009 Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3. J. Exp. Med. 206: 2091-2099.
21. Jia, W. H., and H. D. Qin, 2012 Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review. Semin. Cancer Biol. 22: 117-126.
22. Kawai, T., and S. Akira, 2006 Innate immune recognition of viral infection. Nat. Immunol. 7: 131-137.
23. Koizumi, Y., S. Kageyama, Y. Fujiyama, M. Miyashita, R. Lwembe et al., 2007 RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs. AIDS Res. Hum. Retroviruses 23: 713-719.
24. Koutsounaki, E., G. Goulielmos, M. Koulentaki, C. Choulaki, E. Kouroumalis et al., 2008 Mannose-binding bectin MBL2 gene polymorphisms and
25. Laplanche, A., L. Alzieu, T. Delozier, J. Berlie, C. Veyret et al., 2000 Polyadenylic-polyuridylic acid plus locoregional radiotherapy vs. chemotherapy with CMF in operable breast cancer: a 14 year follow-up analysis of a randomized trial of the Federation Nationale des Centres de Lutte contre le Cancer (FNCLCC). Breast Cancer Res. Treat. 64: 189-191.
26. Li, L., D. Liu, L. Hutt-Fletcher, A. Morgan, M. G. Masucci et al., 2002 Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4. Blood 99: 3725-3734.
27. Mezger, M., M. Steffens, C. Semmler, E. M. Arlt, M. Zimmer et al., 2008 Investigation of promoter variations in dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN) (CD209) and their relevance for human cytomegalovirus reactivation and disease after allogeneic stem-cell transplantation. Clin. Microbiol. Infect. 14: 228-234.
28. Nakhaei, P., P. Genin, A. Civas, and J. Hiscott, 2009 RIG-I-like receptors: sensing and responding to RNA virus infection. Semin. Immunol. 21: 215-222.
29. Oshiumi, H., M. Matsumoto, K. Funami, T. Akazawa, and T. Seya, 2003 TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol. 4: 161-167.
30. Pine, S. O., M. J. McElrath, and P.-Y. Bochud, 2009 Polymorphisms in tolllike receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-12infected individuals. AIDS 23: 2387-2395.
31. Ranjith-Kumar, C. T., W. Miller, J. Sun, J. Xiong, J. Santos et al., 2007 Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J. Biol. Chem. 282: 17696-17705.
32. Ritchie, M. D., L. W. Hahn, N. Roodi, L. R. Bailey, W. D. Dupont et al., 2001 Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am. J. Hum. Genet. 69: 138-147.
33. Ryan, E. J., M. Dring, C. M. Ryan, C. McNulty, N. J. Stevenson et al., 2010 Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection. Hum. Immunol. 71: 829- 832.
34. Sakuntabhai, A., C. Turbpaiboon, I. Casademont, A. Chuansumrit, T. Lowhnoo et al., 2005 A variant in the CD209 promoter is associated with severity of dengue disease. Nat. Genet. 37: 507-513.
35. Salaun, B., I. Coste, M.-C. Rissoan, S. J. Lebecque, and T. Renno, 2006 TLR3 can directly trigger apoptosis in human cancer cells. J. Immunol. 176: 4894-4901.
36. Salaun, B., S. Lebecque, S. Matikainen, D. Rimoldi, and P. Romero, 2007 Toll-like receptor 3 expressed by melanoma cells as a target for therapy? Clin. Cancer Res. 13: 4565-4574.
37. Samanta, M., D. Iwakiri, T. Kanda, T. Imaizumi, and K. Takada, 2006 EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN. EMBO J. 25: 4207-4214.
38. Severa, M., E. Giacomini, V. Gafa, E. Anastasiadou, F. Rizzo et al., 2013 EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: Implications for viral immune escape. Eur. J. Immunol. 43: 147-158.
39. Sun, J., K. E. Duffy, C. T. Ranjith-Kumar, J. Xiong, R. J. Lamb et al., 2006 Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation. J. Biol. Chem. 281: 11144-11151.
40. Thompson, J. M., and A. Iwasaki, 2008 Toll-like receptors regulation of viral infection and disease. Adv. Drug Deliv. Rev. 60: 786-794.
41. Vannberg, F. O., S. J. Chapman, C. C. Khor, K. Tosh, S. Floyd et al., 2008 CD209 genetic polymorphism and tuberculosis disease. PLoS ONE 3: e1388.
42. Velez, D., C. Wejse, M. Stryjewski, E. Abbate, W. Hulme et al., 2010 Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum. Genet. 127: 65-73.
43. Wang, L., R.-F. Chen, J.-W. Liu, I.-K. Lee, C.-P. Lee et al., 2011 Promoter 2336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation. PLoS Negl. Trop. Dis. 5: e934.
44. Xu, Y.-F., W.-L. Liu, J.-Q. Dong, W.-S. Liu, Q.-S. Feng et al., 2010 Sequencing of DC-SIGN promoter indicates an association between promoter variation and risk of nasopharyngeal carcinoma in cantonese. BMC Med. Genet. 11: 161.
45. Yang, C.-A., M. J. Raftery, L. Hamann, M. Guerreiro, G. Grütz et al., 2012 Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis. Hum Immunol. 73: 844-851.
46. Zhou, T., Y. Chen, L. Hao, and Y. Zhang, 2006 DC-SIGN and immunoregulation. Cell. Mol. Immunol. 3: 279-283.