Mechanism of activation of elongation factor Tu by ribosome: Catalytic histidine activates GTP by protonation

RNA

Volumn 19, Issue 9, 2013, Pages 1218-1225

  Aleksandrov, Alexey ^a   Field, Martin ^b  

^a LABORATOIRE DE BIOCHIMIE   (France)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Elongation factor Tu; Free energy calculation; GTP hydrolysis; Molecular dynamics simulation; Quantum chemical molecular mechanical simulation; Ribosome

Indexed keywords

ELONGATION FACTOR TU; GLUTAMINE; GUANOSINE TRIPHOSPHATE; HISTIDINE; HYDROXYL GROUP; MUTANT PROTEIN; PROTON; RNA; RNA 23S;

ALTERNATIVE HYPOTHESIS; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; GENE MUTATION; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTON TRANSPORT; QUANTUM CHEMISTRY; REACTION ANALYSIS; REGULATORY MECHANISM; RIBOSOME; WILD TYPE;

ELONGATION FACTOR TU; FREE ENERGY CALCULATION; GTP HYDROLYSIS; MOLECULAR DYNAMICS SIMULATION; QUANTUM CHEMICAL/MOLECULAR MECHANICAL SIMULATION; RIBOSOME;

CATALYSIS; GUANOSINE TRIPHOSPHATE; HISTIDINE; HYDROLYSIS; KINETICS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PEPTIDE ELONGATION FACTOR TU; QUANTUM THEORY; RIBOSOMES; RNA, TRANSFER; THERMODYNAMICS;

EID: 84883188970     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.040097.113     Document Type: Article

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