Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways

G3: Genes, Genomes, Genetics

Volumn 3, Issue 2, 2013, Pages 305-313

  Shtessel, Ludmila ^a,b   Lowden, Mia Rochelle ^a,c   Cheng, Chen ^a,d   Simon, Matt ^a,b   Wang, Kyle ^a   Ahmed, Shawn ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Department of Curriculum in Genetics and Molecular Biology ^*  (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; PROTECTION OF TELOMERE 1 PROTEIN; PROTECTION OF TELOMERE 2 PROTEIN; PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE REVERSE TRANSCRIPTASE 1; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; PHOTOPROTEIN; POT 2 PROTEIN, C ELEGANS; POT-2 PROTEIN, C ELEGANS; RED FLUORESCENT PROTEIN; TELOMERASE; TELOMERE BINDING PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE REPRESSION; IN VIVO STUDY; MUTANT; MUTATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; SENESCENCE; SIGNAL TRANSDUCTION; SURVIVAL; TELOMERE HOMEOSTASIS; AGING; ANIMAL; BIOSYNTHESIS; GENETICS; METABOLISM; TELOMERE;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA; NEMATODA;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; LUMINESCENT PROTEINS; MUTATION; RECOMBINANT FUSION PROTEINS; TELOMERASE; TELOMERE; TELOMERE-BINDING PROTEINS;

EID: 84883187057     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.112.004440     Document Type: Article

References (46)

1. Ahmed, S., and J. Hodgkin, 2000 MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Nature 403: 159-164.
2. Armbruster, B. N., C. M. Linardic, T. Veldman, N. P. Bansal, D. L. Downie et al., 2004 Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. Mol. Cell. Biol. 24: 3552-3561.
3. Bass, H. W., W. F. Marshall, J. W. Sedat, D. A. Agard, and W. Z. Cande, 1997 Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J. Cell Biol. 137: 5-18.
4. Baumann, P., and T. R. Cech, 2001 Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292: 1171-1175.
5. Boerckel, J., D. Walker, and S. Ahmed, 2007 The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication. Genetics 176: 703-709.
6. Cheng, C., L. Shtessel, M. M. Brady, and S. Ahmed, 2012 Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths. Proc. Natl. Acad. Sci. USA 109: 7805-7810.
7. Cinquin, O., S. L. Crittenden, D. E. Morgan, and J. Kimble, 2010 Progression from a stem cell-like state to early differentiation in the C. elegans germ line. Proc. Natl. Acad. Sci. USA 107: 2048-2053.
8. Colgin, L. M., K. Baran, P. Baumann, T. R. Cech, and R. R. Reddel, 2003 Human POT1 facilitates telomere elongation by telomerase. Curr. Biol. 13: 942-946.
9. Cooper, J. P., Y. Watanabe, and P. Nurse, 1998 Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature 392: 828-831.
10. Dernburg, A. F., K. McDonald, G. Moulder, R. Barstead, M. Dresser et al., 1998 Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis. Cell 94: 387-398.
11. Desai, A., S. Rybina, T. Muller-Reichert, A. Shevchenko, A. Hyman et al., 2003 KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 17: 2421-2435.
12. Diotti, R., and D. Loayza, 2011 Shelterin complex and associated factors at human telomeres. Nucleus 2: 119-135.
13. Frokjaer-Jensen, C., M. W. Davis, C. E. Hopkins, B. J. Newman, J. M. Thummel et al., 2008 Single-copy insertion of transgenes in Caenorhabditis elegans. Nat. Genet. 40: 1375-1383.
14. Greider, C. W., and E. H. Blackburn, 1989 A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331-337.
15. Harley, C. B., A. B. Futcher, and C. W. Greider, 1990 Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460.
16. He, H., A. S. Multani, W. Cosme-Blanco, H. Tahara, J. Ma et al., 2006 POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J. 25: 5180-5190.
17. He, H., Y. Wang, X. Guo, S. Ramchandani, J. Ma et al., 2009 Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol. Cell. Biol. 29: 229-240.
18. Henson, J. D., Y. Cao, L. I. Huschtscha, A. C. Chang, A. Y. Au et al., 2009 DNA C-circles are specific and quantifiable markers of alternativelengthening- of-telomeres activity. Nat. Biotechnol. 27: 1181-1185.
19. Hockemeyer, D., A. J. Sfeir, J. W. Shay, W. E. Wright, and T. de Lange, 2005 POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24: 2667-2678.
20. Hockemeyer, D., J. P. Daniels, H. Takai, and T. de Lange, 2006 Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126: 63-77.
21. Hockemeyer, D., W. Palm, R. C. Wang, S. S. Couto, and T. de Lange, 2008 Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 22: 1773-1785.
22. Kelleher, C., I. Kurth, and J. Lingner, 2005 Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol. 25: 808-818.
23. Kendellen, M. F., K. S. Barrientos, and C. M. Counter, 2009 POT1 association with TRF2 regulates telomere length. Mol. Cell. Biol. 29: 5611-5619.
24. Kim, N. W., M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West et al., 1994 Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
25. Kim, S. H., P. Kaminker, and J. Campisi, 1999 TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23: 405-412.
26. Lackner, D. H., M. Raices, H. Maruyama, C. Haggblom, and J. Karlseder, 2012 Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. EMBO J. 31: 2024-2033.
27. Liu, D., A. Safari, M. S. O'Connor, D. W. Chan, A. Laegeler, et al., 2004 PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol. 6: 673-680.
28. Loayza, D., and T. De Lange, 2003 POT1 as a terminal transducer of TRF1 telomere length control. Nature 423: 1013-1018.
29. Lowden, M. R., B. Meier, T. W. Lee, J. Hall, and S. Ahmed, 2008 End joining at Caenorhabditis elegans telomeres. Genetics 180: 741-754.
30. Lowden, M. R., S. Flibotte, D. G. Moerman, and S. Ahmed, 2011 DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions. Science 332: 468-471.
31. Meier, B., I. Clejan, Y. Liu, M. Lowden, A. Gartner, et al., 2006 trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. PLoS Genet. 2: e18.
32. Meier, B., L. J. Barber, Y. Liu, L. Shtessel, S. J. Boulton, et al., 2009 The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans. EMBO J. 28: 3549-3563.
33. Raices, M., R. E. Verdun, S. A. Compton, C. I. Haggblom, J. D. Griffith, et al., 2008 C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell 132: 745-757.
34. Scherthan, H., S. Weich, H. Schwegler, C. Heyting, M. Harle, et al., 1996 Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J. Cell Biol. 134: 1109-1125.
35. Shakirov, E. V., Y. V. Surovtseva, N. Osbun, and D. E. Shippen, 2005 The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection. Mol. Cell. Biol. 25: 7725-7733.
36. Shakirov, E. V., P. F. Perroud, A. D. Nelson, M. E. Cannell, R. S. Quatrano, et al., 2010 Protection of Telomeres 1 is required for telomere integrity in the moss Physcomitrella patens. Plant Cell 22: 1838-1848.
37. Sharma, H. W., J. A. Sokoloski, J. R. Perez, J. Y. Maltese, A. C. Sartorelli, et al., 1995 Differentiation of immortal cells inhibits telomerase activity. Proc. Natl. Acad. Sci. USA 92: 12343-12346.
38. Smogorzewska, A., B. van Steensel, A. Bianchi, S. Oelmann, M. R. Schaefer, et al., 2000 Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20: 1659-1668.
39. Surovtseva, Y. V., E. V. Shakirov, L. Vespa, N. Osbun, X. Song, et al., 2007 Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. EMBO J. 26: 3653-3661.
40. van Steensel, B., and T. de Lange, 1997 Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-743.
41. Veldman, T., K. T. Etheridge, and C. M. Counter, 2004 Loss of hPot1 function leads to telomere instability and a cut-like phenotype. Curr. Biol. 14: 2264-2270.
42. Wang, F., E. R. Podell, A. J. Zaug, Y. Yang, P. Baciu, et al., 2007 The POT1- TPP1 telomere complex is a telomerase processivity factor. Nature 445: 506-510.
43. Wu, L., A. S. Multani, H. He, W. Cosme-Blanco, Y. Deng, et al., 2006 Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126: 49-62.
44. Yamamoto, A., and Y. Hiraoka, 2001 How do meiotic chromosomes meet their homologous partners?: lessons from fission yeast. Bioessays 23: 526-533.
45. Ye, J. Z., and T. de Lange, 2004 TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36: 618-623.
46. Ye, J. Z., D. Hockemeyer, A. N. Krutchinsky, D. Loayza, S. M. Hooper, et al., 2004 POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev. 18: 1649-1654.