A novel concept for detoxification: Complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang')

Journal of Ethnopharmacology

Volumn 149, Issue 2, 2013, Pages 562-569

  Peter, Karoline ^a   Schinnerl, Johann ^b   Felsinger, Susanne ^b   Brecker, Lothar ^b   Bauer, Rudolf ^c   Breiteneder, Heimo ^a   Xu, Riurong ^d   Ma, Yan ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF GRAZ   (Austria)

^d AFFILIATED HOSPITAL OF SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Aconitine; Complex formation; Decoction; Herbal interaction; Liquiritin; Sini Tang

Indexed keywords

ACONITINE; ACONITUM EXTRACT; CHINESE DRUG; CINNAMOMUM CASSIA EXTRACT; GINGER EXTRACT; GLYCYRRHIZA URALENSIS EXTRACT; LIQUIRITIN; METHANOL; SINI TANG; UNCLASSIFIED DRUG;

ACONITUM CARMICHAELII; AQUEOUS SOLUTION; ARTICLE; CHINESE HERB; CHINESE MEDICINE; CINNAMOMUM CASSIA; COMPLEX FORMATION; DETOXIFICATION; DRUG ISOLATION; GINGER; GLYCYRRHIZA URALENSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; PYROLYSIS; STOICHIOMETRY; ULTRAVIOLET SPECTROSCOPY;

ACONITUM CARMICHAELII; CINNAMOMUM AROMATICUM; GLYCYRRHIZA URALENSIS; ZINGIBER OFFICINALE;

ACONITINE; COMPLEX FORMATION; DECOCTION; HERBAL INTERACTION; LIQUIRITIN; SINI TANG;

ACONITINE; ACONITUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMOMUM AROMATICUM; DRUGS, CHINESE HERBAL; FLAVANONES; GINGER; GLUCOSIDES; GLYCYRRHIZA URALENSIS; PLANT EXTRACTS;

EID: 84883175363     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.07.022     Document Type: Article

References (34)

1. A. Ameri Structure-dependent inhibitory action of the aconitum alkaloids 14-benzoyltalitasamine and talitasamine in rat hippocampal slices Naunyn Schmiedeberg′s Archives of Pharmacology 357 1998 585 592
2. T.Y. Chan Causes and prevention of herb-induced aconite poisonings in Asia Human & Experimental Toxicology 30 2011 2023 2026
3. J.K. Chen, T.T. Chen, and L. Crampton Chinese Medical Herbology and Pharmacology 2004 Art of Medicine Press, Inc. City of Industry, CA
4. Z. Chen, D. Lu, and S.G. Weber High-throughput phase-distribution method to determine drug-cyclodextrin binding constants Journal of Pharmaceutical Sciences 98 2009 229 238
5. China Pharmacopoeia Committee Pharmacopoeia of the People′s Republic of China 36 2010 177 220
6. D.Y. Choi, Y.H. Beak, J.E. Huh, J.M. Ko, H. Woo, J.D. Lee, and D.S. Park Stimulatory effect of Cinnamomum cassia and cinnamic acid on angiogenesis through up-regulation of VEGF and Flk-1/KDR expression International Immunopharmacology 9 2009 959 967
7. D. Csupor, E.M. Wenzig, I. Zupko, K. Wolkart, J. Hohmann, and R. Bauer Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots Journal of Chromatography A 1216 2009 2079 2086
8. H. Ehmke, K. von Borstel, and T. Hartmann Alkaloid N-oxides as transport and vacuolar storage compounds of pyrrolizidine alkaloids in Senecio vulgaris L Planta 176 1988 83 90
9. Y.F. Fan, Y. Xie, L. Liu, H.M. Ho, Y.F. Wong, Z.Q. Liu, and H. Zhou Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine Journal of Ethnopharmacology 141 2012 701 708
10. P. Feldsine, C. Abeyta, and W.H. Andrews AOAC International methods committee guidelines for validation of qualitative and quantitative food microbiological official methods of analysis Journal of the Association of Official Analytical Chemists International 85 2002 1187 1200
11. a) from solution NMR data Tetrahedron 56 2000 6151 6170
12. Y. Fujita, K. Terui, M. Fujita, A. Kakizaki, N. Sato, K. Oikawa, H. Aoki, K. Takahashi, and S. Endo Five cases of aconite poisoning: toxicokinetics of aconitines Journal of analytical toxicology 31 2007 132 137
13. Q.A. Huang, Y.M. Zhang, Y. He, J. Lu, and R.C. Lin Studies on hydrolysis of aconitine Zhongguo Zhong Yao Za Zhi 32 2007 2143 2145
14. A. Huang Research of the change of aconitine with compatibility of Radix aconiti carmichaeli, Rhizoma zingiberis and liquorice Guangming Journal of Chinese Medicine 8 2011 119
15. Z.H. Jiang, Y. Xie, H. Zhou, J.R. Wang, Z.Q. Liu, Y.F. Wong, X. Cai, H.X. Xu, and L. Liu Quantification of Aconitum alkaloids in aconite roots by a modified RP-HPLC method Phytochemical Analysis 16 2005 415 421
16. P. Job Formation and stability of inorganic complexes in solution Annali di Chimica Applicata 9 1928 113 203
17. N. Li, R. Tsao, Z. Sui, J. Ma, and Z. Liu Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model Planta Medica 78 2012 692 697
18. Q. Liu, L. Zhuo, L. Liu, S. Zhu, A. Sunnassee, M. Liang, L. Zhou, and Y. Liu Seven cases of fatal aconite poisoning: forensic experience in China Forensic Science International 212 2011 e5 e9
19. G. Lu, Z. Dong, Q. Wang, G. Qian, W. Huang, Z. Jiang, K.S. Leung, and Z. Zhao Toxicity assessment of nine types of decoction pieces from the daughter root of Aconitum carmichaelii (Fuzi) based on the chemical analysis of their diester diterpenoid alkaloids Planta Medica 76 2010 825 830
20. H. Lyu, H. Kwak, D. Lee, K. Kim, S. Kim, and N. Baek Isolation of flavonoids from processed aconiti tuber Journal of Applied Biological Chemistry 51 2008 165 168
21. M. Mizugaki, K. Ito, Y. Ohyama, Y. Konishi, S. Tanaka, and K. Kurasawa Quantitative analysis of Aconitum alkaloids in the urine and serum of a male attempting suicide by oral intake of aconite extract Journal of Analytical Toxicology 22 1998 336 340
22. H. Ohta, Y. Seto, N. Tsunoda, Y. Takahashi, K. Matsuura, and K. Ogasawara Determination of Aconitum alkaloids in blood and urine samples. II. Capillary liquid chromatographic-frit fast atom bombardment mass spectrometric analysis Journal of Chromatography B 714 1998 215 221
23. M. Pei, X. Duan, and X. Pei Compatability chemistry of acid-alkaline pair medicine of Fuzi and Gancao in Sini decoction Zhongguo Zhong Yao Za Zhi 34 2009 2047 2050
24. X. Qiu, and J. He Effect on the contens of ester-type alkaloids in Radix aconiti Lateralis Preparata by different decocting time and compatibility dosage of Radix glycyrrhizae Lishizhen Medicine and Materia Medica Research 18 2007 3015 3017
25. D. Salvatierra, C. Diez, and C. Jaime Host/guest interactions and NMR spectroscopy. a computer program for association constant determination Journal of Inclusion Phenomena and Molecular Recognition in Chemistry 27 1997 215 231
26. S. Shen, Y. Zhang, J. Yang, and G. Sun Determination of liquiritin in licorice by HPLC and its change before and after compatibility of licorice with aconite Lishizhen Medicine and Materia Medica Research 20 2009 846 847
27. S.H. Shim, S.Y. Lee, J.S. Kim, K.H. Son, and S.S. Kang Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaelii Archives of Pharmacal Research 28 2005 1239 1243
28. J. Singhuber, M. Zhu, S. Prinz, and B. Kopp Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? Journal of Ethnopharmacology 126 2009 18 30
29. Z. Sui, M. Chen, Z. Liu, Z.F. Pi, and Z. Liu Changes in contents of Aconitum alkaloids of Fuzi during processes of decocting and co-decocting with other herbs Journal of Jilin University 2009
30. H. Sun, B. Ni, A. Zhang, M. Wang, H. Dong, and X. Wang Metabolomics study on Fuzi and its processed products using ultra-performance liquid- chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis The Analyst 137 2012 170 185
31. L. Tang, Y. Gong, C. Lv, L. Ye, L. Liu, and Z. Liu Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaelii) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS Journal of Ethnopharmacology 141 2012 736 741
32. Y. Xie, Z.H. Jiang, H. Zhou, H.X. Xu, and L. Liu Simultaneous determination of six Aconitum alkaloids in proprietary Chinese medicines by high-performance liquid chromatography Journal of Chromatography A 1093 2005 195 203
33. S. Xu, C. Chen, and J. Gao Attenuated effect of active components of Radix glycyrrhizae on Radix aconiti Lateralis and the related mechanisms Chinese Traditional Patent Medicine 2006 28
34. H. Yue, Z.F. Pi, H.L. Li, F.R. Song, Z.Q. Liu, and S.Y. Liu Studies on the stability of diester-diterpenoid alkaloids from the genus Aconitum L. by high performance liquid chromatography combined with electrospray ionisation tandem mass spectrometry (HPLC/ESI/MSn) Phytochemical Analysis 19 2008 141 147