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Volumn 1019, Issue , 2013, Pages 37-98

Designing a GWAS: Power, sample size, and data structure

Author keywords

Bayes factors; Bayesian power calculations; Bayesian statistics; BIC criterion; Candidate gene association studies; Case control studies; Experimental design; Family based association studies; Frequentist statistics; Genome scans; Genome wide association studies (GWAS); ldDesign R package; Linkage; Linkage disequilibrium; Posterior probabilities; Power calculations; Prior elicitation; Quantitative trait loci (QTL); Quantitative traits; Replication and validation; Robust detection of effects; S TDT test; SDT test; TDT test

Indexed keywords

ARTICLE; CALCULATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC DATABASE; GENOTYPE; POPULATION GENETICS; PRIORITY JOURNAL; SAMPLE SIZE; SYSTEM ANALYSIS;

EID: 84883151673     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-447-0_3     Document Type: Article
Times cited : (23)

References (85)
  • 2
    • 0032403973 scopus 로고    scopus 로고
    • Linkage disequilibriummapping of complex disease: Fantasy or reality?
    • Terwilliger JD, Weiss KM (1998) Linkage disequilibriummapping of complex disease: Fantasy or reality? Curr Opin Biotechnol 9:578-594
    • (1998) Curr Opin Biotechnol , vol.9 , pp. 578-594
    • Terwilliger, J.D.1    Weiss, K.M.2
  • 3
    • 0035399728 scopus 로고    scopus 로고
    • SNP association studies in Alzheimer's disease highlight problems for complex disease analysis
    • Emahazion T, Feuk L, Jobs M, Sawyer SL, Fredman D et al (2001) SNP association studies in Alzheimer's disease highlight problems for complex disease analysis. Trends Genet 17: 407-413
    • (2001) Trends Genet , vol.17 , pp. 407-413
    • Emahazion, T.1    Feuk, L.2    Jobs, M.3    Sawyer, S.L.4    Fredman, D.5
  • 4
    • 3042745450 scopus 로고    scopus 로고
    • Association genetics of complex traits in conifers
    • Neale DB, Savolainen O (2004) Association genetics of complex traits in conifers. Trends Plant Sci 9:325-330
    • (2004) Trends Plant Sci , vol.9 , pp. 325-330
    • Neale, D.B.1    Savolainen, O.2
  • 5
    • 0035958676 scopus 로고    scopus 로고
    • Can SNPs deliver on susceptibility genes?
    • Gura T (2000) Can SNPs deliver on susceptibility genes?. Science 293:593-595
    • (2000) Science , vol.293 , pp. 593-595
    • Gura, T.1
  • 6
    • 32744457394 scopus 로고    scopus 로고
    • Focus September 29, 2000. Harvard University, Cambridge
    • Hampton T (2000) Research brief, Focus September 29, 2000. Harvard University, Cambridge
    • (2000) Research brief
    • Hampton, T.1
  • 7
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • TheWellcome Trust Case Control Consortium.
    • TheWellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678
    • (2007) Nature , vol.447 , pp. 661-678
  • 8
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University and Novartis Institutes for Biomedical Research.
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University and Novartis Institutes for Biomedical Research (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1345
    • (2007) Science , vol.316 , pp. 1331-1345
  • 9
    • 42249087793 scopus 로고    scopus 로고
    • Estimation of significance thresholds for genome-wide association scans
    • Dudbridge F, Gusnato A (2008) Estimation of significance thresholds for genome-wide association scans. Genet Epidemiol 32:227-234
    • (2008) Genet Epidemiol , vol.32 , pp. 227-234
    • Dudbridge, F.1    Gusnato, A.2
  • 10
    • 84936527430 scopus 로고
    • Statistical analysis and the illusion of objectivity
    • Berger J, BerryD(1988) Statistical analysis and the illusion of objectivity. Am Sci 76:159-165
    • (1988) Am Sci , vol.76 , pp. 159-165
    • Berger, J.1    Berry, D.2
  • 11
    • 26444433586 scopus 로고
    • Bayesian statistical inference for psychological research
    • Edwards W, Lindman H, Savage LJ (1963) Bayesian statistical inference for psychological research. Psychol Rev 70:193-242
    • (1963) Psychol Rev , vol.70 , pp. 193-242
    • Edwards, W.1    Lindman, H.2    Savage, L.J.3
  • 12
    • 84950900304 scopus 로고
    • Testing a point null hypo thesis: The irreconcilability of P-values and evidence (with discussion)
    • Berger JO, Sellke T (1987) Testing a point null hypothesis: The irreconcilability of P-values and evidence (with discussion). J Am Stat Assoc 82:112-139
    • (1987) J Am Stat Assoc , vol.82 , pp. 112-139
    • Berger, J.O.1    Sellke, T.2
  • 13
    • 0035671699 scopus 로고    scopus 로고
    • Bayesian methods for quantitative trait loci mapping based on model selection: Approximate analysis using the Bayesian Information Criterion
    • Accessed 29 May 2012
    • Ball RD (2001) Bayesian methods for quantitative trait loci mapping based on model selection: Approximate analysis using the Bayesian Information Criterion. Genetics 159: 1351-1364. http://www.genetics.org/cgi/content/ abstract/159/3/1351. Accessed 29 May 2012
    • (2001) Genetics , vol.159 , pp. 1351-1364
    • Ball, R.D.1
  • 14
    • 22144499636 scopus 로고    scopus 로고
    • Experimental designs for reliable detection of linkage disequilibrium in unstructured random population association studies
    • Accessed 29 May 2012
    • Ball RD (2005) Experimental designs for reliable detection of linkage disequilibrium in unstructured random population association studies. Genetics 170:859-873. http://www. genetics.org/cgi/content/abstract/170/2/859. Accessed 29 May 2012
    • (2005) Genetics , vol.170 , pp. 859-873
    • Ball, R.D.1
  • 15
    • 37249043646 scopus 로고    scopus 로고
    • Quantifying evidence for candidate gene polymorphisms: Bayesian analysis combining sequence-specific and quantitative trait loci colocation information
    • Accessed 29 May 2012
    • Ball RD (2007) Quantifying evidence for candidate gene polymorphisms: Bayesian analysis combining sequence-specific and quantitative trait loci colocation information. Genetics 177:2399-2416. http://www.genetics.org/cgi/ content/abstract/177/4/2399. Accessed 29 May 2012
    • (2007) Genetics , vol.177 , pp. 2399-2416
    • Ball, R.D.1
  • 16
    • 83655182972 scopus 로고    scopus 로고
    • Experimental designs for robust detection of effects in genome-wide case-control studies
    • Accessed 29May 2012
    • Ball RD (2011) Experimental designs for robust detection of effects in genome-wide case-control studies. Genetics 189:1497-1514. http://www. genetics.org/cgi/content/abstract/189/4/1497. Accessed 29May 2012
    • (2011) Genetics , vol.189 , pp. 1497-1514
    • Ball, R.D.1
  • 17
    • 0001185873 scopus 로고
    • An essay towards solving a problem in the doctrine of chances
    • Bayes T (1763) An essay towards solving a problem in the doctrine of chances. Phil Trans Roy Soc 53:370-418
    • (1763) Phil Trans Roy Soc , vol.53 , pp. 370-418
    • Bayes, T.1
  • 22
    • 84892625671 scopus 로고    scopus 로고
    • What is Bayesian statistics an why everything else is wrong
    • Lavine M (1999) What is Bayesian statistics an why everything else is wrong. J Undergraduate Math Appl 20:165-174
    • (1999) J Undergraduate Math Appl , vol.20 , pp. 165-174
    • Lavine, M.1
  • 24
    • 84921386393 scopus 로고
    • Reconciling Bayesian and frequentist evidence in the onesided testing problem
    • Casella G, Berger RL (1987) Reconciling Bayesian and frequentist evidence in the onesided testing problem. J. Am. Stat. Assoc. 82:106-111
    • (1987) J. Am. Stat. Assoc. , vol.82 , pp. 106-111
    • Casella, G.1    Berger, R.L.2
  • 25
    • 0000458172 scopus 로고
    • Bayes factors for linear and log-linear models with vague prior information
    • Spiegelhalter D, Smith AFM (1982) Bayes factors for linear and log-linear models with vague prior information. J R Stat Soc B 44:377-387
    • (1982) J R Stat Soc B , vol.44 , pp. 377-387
    • Spiegelhalter, D.1    Smith, A.F.M.2
  • 26
    • 0001755446 scopus 로고
    • On the foundations of statistical inference (with discussion)
    • Birnbaum A (1962) On the foundations of statistical inference (with discussion). J Am Stat Assoc 57:269-306
    • (1962) J Am Stat Assoc , vol.57 , pp. 269-306
    • Birnbaum, A.1
  • 27
    • 0016823140 scopus 로고
    • Sufficiency and conditionality (with discussion)
    • Kalbfleisch JD (1975) Sufficiency and conditionality (with discussion). Biometrika 62:251-268
    • (1975) Biometrika , vol.62 , pp. 251-268
    • Kalbfleisch, J.D.1
  • 28
    • 0005131998 scopus 로고    scopus 로고
    • Biometrika centenary: Theory and general methodology
    • Davison AC (2001) Biometrika centenary: Theory and general methodology. Biometrika 88:13-52
    • (2001) Biometrika , vol.88 , pp. 13-52
    • Davison, A.C.1
  • 29
    • 32444449699 scopus 로고
    • Dependence of the fiducial argument on the sampling rule
    • Anscombe FJ (1957) Dependence of the fiducial argument on the sampling rule. Biometrika 44:464-469
    • (1957) Biometrika , vol.44 , pp. 464-469
    • Anscombe, F.J.1
  • 30
    • 0009234989 scopus 로고
    • Fiducial distributions and Bayes' theorem
    • Lindley DV (1958) Fiducial distributions and Bayes' theorem. J R Stat Soc B 20:102-107
    • (1958) J R Stat Soc B , vol.20 , pp. 102-107
    • Lindley, D.V.1
  • 31
    • 33746331616 scopus 로고
    • Fiducial inference for location and scale parameters
    • Fraser DAS (1964) Fiducial inference for location and scale parameters. Biometrika 51:17-24
    • (1964) Biometrika , vol.51 , pp. 17-24
    • Fraser, D.A.S.1
  • 34
    • 0035630521 scopus 로고    scopus 로고
    • Calibration of P-values for testing precise null hypotheses
    • Sellke T, Bayarri MJ, Berger J (2001) Calibration of P-values for testing precise null hypotheses. Am Stat 55:62-71
    • (2001) Am Stat , vol.55 , pp. 62-71
    • Sellke, T.1    Bayarri, M.J.2    Berger, J.3
  • 36
    • 0001677717 scopus 로고
    • Controlling the false discovery rate a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate a practical and powerful approach to multiple testing. J R Stat Soc B 57:289-300
    • (1995) J R Stat Soc B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 37
    • 0034370950 scopus 로고    scopus 로고
    • On the adaptive control of the false discovery rate in multiple testing with independent statistics
    • Benjamini Y, Hochberg Y (2000) On the adaptive control of the false discovery rate in multiple testing with independent statistics. J Educ Behav Stat 25:60-83
    • (2000) J Educ Behav Stat , vol.25 , pp. 60-83
    • Benjamini, Y.1    Hochberg, Y.2
  • 38
    • 0035733108 scopus 로고    scopus 로고
    • The control of the false discovery rate in multiple testing under dependency
    • Benjamini Y, Yekutieli D (2001) The control of the false discovery rate in multiple testing under dependency. Ann Stat 29:1165-1188
    • (2001) Ann Stat , vol.29 , pp. 1165-1188
    • Benjamini, Y.1    Yekutieli, D.2
  • 39
    • 0345822598 scopus 로고    scopus 로고
    • The positive false discovery rate: A Bayesian interpretation and the q-value
    • Storey JD (2003) The positive false discovery rate: A Bayesian interpretation and the q-value. Ann Stat 31:2013-2035
    • (2003) Ann Stat , vol.31 , pp. 2013-2035
    • Storey, J.D.1
  • 40
    • 0001017827 scopus 로고
    • Complex experiments
    • Yates F (1935) Complex experiments. J R Stat Soc Suppl 2:181-247
    • (1935) J R Stat Soc Suppl , vol.2 , pp. 181-247
    • Yates, F.1
  • 42
    • 37249042403 scopus 로고    scopus 로고
    • Oraguzie NC et al (eds Association mapping in plants. Springer 69 ISBN 0387358447 Chater 8
    • Ball RD (2007) Statistical analysis and experimental design. In: Oraguzie NC et al (eds) Association mapping in plants. Springer, 69 pp. ISBN 0387358447 (Chapter 8)
    • (2007) Statistical analysis and experimental design
    • Ball, R.D.1
  • 43
    • 0002467247 scopus 로고
    • The weighted likelihood ratio, linear hypothesis on normal location parameters
    • Dickey JM (1971) The weighted likelihood ratio, linear hypothesis on normal location parameters. Ann Math Stat 42:204-223
    • (1971) Ann Math Stat , vol.42 , pp. 204-223
    • Dickey, J.M.1
  • 44
    • 34547782270 scopus 로고    scopus 로고
    • A Bayesian measure of the probability of false discovery in genetic epidemiology studies
    • Wakefield J (2007) A Bayesian measure of the probability of false discovery in genetic epidemiology studies. Am J Hum Genet 81: 208-227
    • (2007) Am J Hum Genet , vol.81 , pp. 208-227
    • Wakefield, J.1
  • 45
    • 28044457646 scopus 로고    scopus 로고
    • Bayes factors based on test statistics
    • Johnson VE (2005) Bayes factors based on test statistics. J R Stat Soc B 67:689-701
    • (2005) J R Stat Soc B , vol.67 , pp. 689-701
    • Johnson, V.E.1
  • 46
    • 43749095435 scopus 로고    scopus 로고
    • Properties of Bayes factors based on test statistics
    • Johnson VE (2008) Properties of Bayes factors based on test statistics. Scand J Stat 35: 354-368
    • (2008) Scand J Stat , vol.35 , pp. 354-368
    • Johnson, V.E.1
  • 47
    • 0000120766 scopus 로고
    • Estimating the dimension of a model
    • Schwarz G (1978) Estimating the dimension of a model. Ann Stat 6:461-464
    • (1978) Ann Stat , vol.6 , pp. 461-464
    • Schwarz, G.1
  • 48
    • 0001201909 scopus 로고
    • Bayesian model selection in social research (with discussion)
    • Marsden PV (ed. Blackwells, Cambridge
    • Raftery AE (1995) Bayesian model selection in social research (with discussion). In: Marsden PV (ed) Sociological methodology. Blackwells, Cambridge, pp 111-196
    • (1995) Sociological methodology , pp. 111-196
    • Raftery, A.E.1
  • 49
    • 3142698408 scopus 로고    scopus 로고
    • Modifying the Schwarz Bayesian information criterion to locate multiple interacting quantitative trait loci
    • Bogdan M, Ghosh JK, Doerge RW (2004) Modifying the Schwarz Bayesian information criterion to locate multiple interacting quantitative trait loci. Genetics 167:989-999
    • (2004) Genetics , vol.167 , pp. 989-999
    • Bogdan, M.1    Ghosh, J.K.2    Doerge, R.W.3
  • 50
    • 0001588455 scopus 로고
    • Comments on model selection criteria of Akaike and Schwarz
    • Stone M (1979) Comments on model selection criteria of Akaike and Schwarz. J R Stat Soc Ser B 41:276-278
    • (1979) J R Stat Soc Ser B , vol.41 , pp. 276-278
    • Stone, M.1
  • 51
    • 0037336255 scopus 로고    scopus 로고
    • Approximations and consistency of Bayes factors as model dimension grows
    • Berger JO, Ghosh JK, Mukhopadhyay N (2003) Approximations and consistency of Bayes factors as model dimension grows. J Stat Plann Inference 112:241-258
    • (2003) J Stat Plann Inference , vol.112 , pp. 241-258
    • Berger, J.O.1    Ghosh, J.K.2    Mukhopadhyay, N.3
  • 52
    • 0035612908 scopus 로고    scopus 로고
    • Stratified exponential families: Graphical models and model selection
    • Geiger D, Heckerman D, King H, Meek C (2001) Stratified exponential families: Graphical models and model selection. Ann Stat 29:505-529
    • (2001) Ann Stat , vol.29 , pp. 505-529
    • Geiger, D.1    Heckerman, D.2    King, H.3    Meek, C.4
  • 53
    • 27944462549 scopus 로고
    • A reference Bayesian test for nested hypothesis and its relationship to the Schwarz criterion
    • Kass RE, Wasserman L (1995) A reference Bayesian test for nested hypothesis and its relationship to the Schwarz criterion. J Am Stat Assoc 90:928-934
    • (1995) J Am Stat Assoc , vol.90 , pp. 928-934
    • Kass, R.E.1    Wasserman, L.2
  • 54
    • 0002648792 scopus 로고    scopus 로고
    • The Schwarz criterion and related methods for normal linear methods
    • Pauler D (1998) The Schwarz criterion and related methods for normal linear methods. Biometrika 85:13-27
    • (1998) Biometrika , vol.85 , pp. 13-27
    • Pauler, D.1
  • 55
    • 0003722668 scopus 로고    scopus 로고
    • PhD dissertation, Department of Statistics, University of California, Berkeley. Accessed 29 May 2012
    • Broman KW (1997) Identifying quantitative trait loci in experimental crosses. PhD dissertation, Department of Statistics, University of California, Berkeley. http://www.biostat.wisc. edu/~kbroman/publications/thesis.pdf. Accessed 29 May 2012
    • (1997) Identifying quantitative trait loci in experimental crosses
    • Broman, K.W.1
  • 56
    • 0036433546 scopus 로고    scopus 로고
    • A model selection approach for the identification of quantitative trait loci in experimental crosses (with discussion)
    • 641 656
    • Broman KW, Speed TP (2002) A model selection approach for the identification of quantitative trait loci in experimental crosses (with discussion). J R Stat Soc B 64:641-656, 731-775
    • (2002) J R Stat Soc B , vol.64 , pp. 731-775
    • Broman, K.W.1    Speed, T.P.2
  • 57
    • 84892626287 scopus 로고    scopus 로고
    • Discussion of: Broman K. W. and Speed T. P. 2002: A model selection approach for the identification of quantitative trait loci in experimental crosses (with discussion)
    • Ball RD (2002) Discussion of: Broman K. W. and Speed T. P. 2002: A model selection approach for the identification of quantitative trait loci in experimental crosses (with discussion). J R Stat Soc B 64:749-750
    • (2002) J R Stat Soc B , vol.64 , pp. 749-750
    • Ball, R.D.1
  • 58
    • 0032006925 scopus 로고    scopus 로고
    • Detecting linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations
    • Luo ZW (1998) Detecting linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations. Heredity 80:198-208
    • (1998) Heredity , vol.80 , pp. 198-208
    • Luo, Z.W.1
  • 61
    • 44149127481 scopus 로고    scopus 로고
    • PGA: Power calculator for case-control genetic association analyses
    • doi:10.1186/1471-2156-9-3608
    • Menashe I, Rosenberg PS, Chen BE (2008) PGA: Power calculator for case-control genetic association analyses. BMC Genet 9:36. doi:10.1186/1471- 2156-9-3608
    • (2008) BMC Genet , vol.9 , pp. 36
    • Menashe, I.1    Rosenberg, P.S.2    Chen, B.E.3
  • 63
    • 0032470875 scopus 로고    scopus 로고
    • A discordantsibship test for disequilibrium and linkage: No need for parental data
    • Horvath S, Laird NM (1998) A discordantsibship test for disequilibrium and linkage: No need for parental data. Am J Hum Genet 63:1886-1897
    • (1998) Am J Hum Genet , vol.63 , pp. 1886-1897
    • Horvath, S.1    Laird, N.M.2
  • 64
    • 0031912715 scopus 로고    scopus 로고
    • A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test
    • Spielman RS, Ewens WJ (1998) A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test. Am J Hum Genet 62:450-458
    • (1998) Am J Hum Genet , vol.62 , pp. 450-458
    • Spielman, R.S.1    Ewens, W.J.2
  • 65
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
    • (1993) Am J Hum Genet , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 66
    • 0000596361 scopus 로고
    • Note on the sampling error of the difference between correlated proportions or percentages
    • McNemar Q (1947) Note on the sampling error of the difference between correlated proportions or percentages. Psychometrika 12:153-157
    • (1947) Psychometrika , vol.12 , pp. 153-157
    • McNemar, Q.1
  • 67
    • 0026494911 scopus 로고
    • A haplotype based haplotype relative risk approach to detecting allelic associations
    • Terwilliger JD, Ott J (1992) A haplotype based haplotype relative risk approach to detecting allelic associations. Hum Hered 42:337-346
    • (1992) Hum Hered , vol.42 , pp. 337-346
    • Terwilliger, J.D.1    Ott, J.2
  • 69
    • 0032231362 scopus 로고    scopus 로고
    • A comparative study of sibship tests of linkage and/or association
    • Monks AA, Kaplan NL, Weir BS (1998) A comparative study of sibship tests of linkage and/or association. Am J Hum Genet 63:1507-1516
    • (1998) Am J Hum Genet , vol.63 , pp. 1507-1516
    • Monks, A.A.1    Kaplan, N.L.2    Weir, B.S.3
  • 70
    • 0031028361 scopus 로고    scopus 로고
    • Transmissiondisequilibrium tests for quantitative traits
    • Allison DB (1997) Transmissiondisequilibrium tests for quantitative traits. Am J Hum Genet 60:676-690
    • (1997) Am J Hum Genet , vol.60 , pp. 676-690
    • Allison, D.B.1
  • 71
    • 0033358532 scopus 로고    scopus 로고
    • Sibling-based tests of linkage and association for quantitative traits
    • Allison DB, Heo M, Kaplan N, Martin ER (1999) Sibling-based tests of linkage and association for quantitative traits. Am J Hum Genet 64:1754-1763
    • (1999) Am J Hum Genet , vol.64 , pp. 1754-1763
    • Allison, D.B.1    Heo, M.2    Kaplan, N.3    Martin, E.R.4
  • 72
    • 0033366671 scopus 로고    scopus 로고
    • Combined linkage and association sibpair analysis for quantitative traits
    • Fulker DW, Cherny SS, Sham PC, Hewitt JK (1999) Combined linkage and association sibpair analysis for quantitative traits. Am J Hum Genet 64:259-267
    • (1999) Am J Hum Genet , vol.64 , pp. 259-267
    • Fulker, D.W.1    Cherny, S.S.2    Sham, P.C.3    Hewitt, J.K.4
  • 73
    • 0033909546 scopus 로고    scopus 로고
    • A general test of association for quantitative traits in nuclear families
    • Abecasis GR, Cardon LR, Cookson WOC (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292
    • (2000) Am J Hum Genet , vol.66 , pp. 279-292
    • Abecasis, G.R.1    Cardon, L.R.2    Cookson, W.O.C.3
  • 74
    • 0034987323 scopus 로고    scopus 로고
    • The power to detect linkage disequilibrium with quantitative traits in selected samples
    • Abecasis GR, Cookson WOC, Cardon LR (2001) The power to detect linkage disequilibrium with quantitative traits in selected samples. Am J Hum Genet 68:1463-1474
    • (2001) Am J Hum Genet , vol.68 , pp. 1463-1474
    • Abecasis, G.R.1    Cookson, W.O.C.2    Cardon, L.R.3
  • 75
    • 0036908726 scopus 로고    scopus 로고
    • Power and design considerations for a general class of family-based association tests: Quantitative traits
    • Lange C, DeMeo DL, LairdNM(2002) Power and design considerations for a general class of family-based association tests: Quantitative traits. Am J Hum Genet 71:1330-1341
    • (2002) Am J Hum Genet , vol.71 , pp. 1330-1341
    • Lange, C.1    DeMeo, D.L.2    Laird, N.M.3
  • 76
    • 0036724540 scopus 로고    scopus 로고
    • Analytical sample size and power calculations for a general class of family-based association tests: Dichotomous traits
    • Lange C, Laird NM (2002) Analytical sample size and power calculations for a general class of family-based association tests: Dichotomous traits. Am J Hum Genet 71:575-584
    • (2002) Am J Hum Genet , vol.71 , pp. 575-584
    • Lange, C.1    Laird, N.M.2
  • 77
    • 0029956803 scopus 로고    scopus 로고
    • General score tests for associations of genetic markers with disease using cases and their parents
    • Schaid DJ (1996) General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449
    • (1996) Genet Epidemiol , vol.13 , pp. 423-449
    • Schaid, D.J.1
  • 78
    • 0030827556 scopus 로고    scopus 로고
    • A transmission disequilibrium test for quantitative trait loci
    • Rabinowitz D (1997) A transmission disequilibrium test for quantitative trait loci. Hum Hered 47:342-350
    • (1997) Hum Hered , vol.47 , pp. 342-350
    • Rabinowitz, D.1
  • 79
    • 0033927575 scopus 로고    scopus 로고
    • Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus
    • Monks SA, Kaplan NL (2000) Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. Am J Hum Genet 66:576-592
    • (2000) Am J Hum Genet , vol.66 , pp. 576-592
    • Monks, S.A.1    Kaplan, N.L.2
  • 81
    • 42649123990 scopus 로고    scopus 로고
    • Sizing up human height variation
    • Visscher PM (2008) Sizing up human height variation. Nat Genet 40:489-490
    • (2008) Nat Genet , vol.40 , pp. 489-490
    • Visscher, P.M.1
  • 82
    • 42649118126 scopus 로고    scopus 로고
    • Many sequence variants affecting diversity of adult human height
    • Gudbjartsson DF et al (2008) Many sequence variants affecting diversity of adult human height. Nat Genet 40:609-615
    • (2008) Nat Genet , vol.40 , pp. 609-615
    • Gudbjartsson, D.F.1
  • 83
    • 42649092874 scopus 로고    scopus 로고
    • Identification of ten loci associated with height highlights new biological pathways in human growth
    • Lettre G et al (2008) Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 40:584-590
    • (2008) Nat Genet , vol.40 , pp. 584-590
    • Lettre, G.1
  • 85
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • Lango Allen H, Estrada K, Lettre G et al (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832-838
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1    Estrada, K.2    Lettre, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.