Power calculations for a general class of family-based association tests: Dichotomous traits

American Journal of Human Genetics

Volumn 71, Issue 3, 2002, Pages 575-584

  Lange, Christoph ^a   Laird, Nan M ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; FAMILY STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC MODEL; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; PARENT; PHENOTYPE; PRIORITY JOURNAL; SIBLING;

EID: 0036724540     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/342406     Document Type: Article

References (19)

1. Genetic association mapping based on discordant sib pairs: The discordant-alleles test
2. Genomewide transmission/disequilibrium testing - Consideration of the genotypic relative risks at disease loci
3. A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genes
4. A discordant-sibship test for disequilibrium and linkage: No need for parental data
5. The family based association test method: Strategies for studying general genotype-phenotype associations
6. A note on power approximations for the transmission/disequilibrium test
7. Using exact P values to compare the power between the reconstruction-combined transmission/disequilibrium test and the sib transmission/disequilibrium test
8. Implementing a unified approach to family based tests of association
9. On a general class of conditional tests for family-based association studies in genetics: The asymptotic distribution, the conditional power and optimality considerations
10. A multivariate transmission disequilibrium test: FBAT-GEE
11. Statistical properties of the haplotype relative risk
12. Searching for genetic determinants in the new millennium
13. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information
14. The future of genetic studies of complex human diseases
15. A sibship test for linkage in the presence of association
16. Genetic association mapping at the crossroads: Which test and why? Overview and practical guidelines
17. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
18. Power comparisons of the transmission/disequilibrium test and sib-transmission/disequilibrium-test statistics
19. Family-based association studies