Alterations to the circuitry of the frontal cortex following exposure to the polybrominated diphenyl ether mixture, DE-71

Toxicology

Volumn 312, Issue 1, 2013, Pages 48-55

  Bradner, Joshua M ^a,b   Suragh, Tiffany A ^a   Caudle, W Michael ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cognition; DE 71; Frontal cortex; GABA; Glutamate; Polybrominated diphenyl ethers

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; GLUTAMATE DECARBOXYLASE 67; GLUTAMIC ACID; POLYBROMINATED DIPHENYL ETHER; VESICULAR GLUTAMATE TRANSPORTER; VESICULAR INHIBITORY AMINO ACID TRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; IN VIVO STUDY; MALE; MOUSE; NERVE FIBER GROWTH; NEUROPATHOLOGY; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL;

COGNITION; DE-71; FRONTAL CORTEX; GABA; GLUTAMATE; POLYBROMINATED DIPHENYL ETHERS;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAME RETARDANTS; FRONTAL LOBE; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HALOGENATED DIPHENYL ETHERS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA;

EID: 84883037377     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.07.015     Document Type: Article

References (42)

1. Alm H., Kultima K., Scholz B., Nilsson A., Andren P.E., Fex-Svenningsen A., Dencker L., Stigson M. Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex. Neurotoxicology 2008, 29:628-637.
2. Alm H., Scholz B., Fischer C., Kultima K., Viberg H., Eriksson P., Dencker L., Stigson M. Proteomic evaluation of neonatal exposure to 2,2,4,4,5-pentabromodiphenyl ether. Environ. Health Perspect. 2006, 114:254-259.
3. Bradner J.M., Suragh T.A., Wilson W.W., Lazo C.R., Stout K.A., Kim H.M., Wang M.Z., Walker D.I., Pennell K.D., Richardson J.R., Miller G.W., Caudle W.M. Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity. Exp. Neurol. 2013, 241:138-147.
4. Caudle W.M., Richardson J.R., Delea K.C., Guillot T.S., Wang M., Pennell K.D., Miller G.W. Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity. Toxicol. Sci. 2006, 92:490-499.
5. Chao H.R., Tsou T.C., Huang H.L., Chang-Chien G.P. Levels of breast milk PBDEs from southern Taiwan and their potential impact on neurodevelopment. Pediatr. Res. 2011, 70:596-600.
6. Courchesne E., Pierce K. Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Curr. Opin. Neurobiol. 2005, 15:225-230.
7. Darnerud P.O. Toxic effects of brominated flame retardants in man and in wildlife. Environ. Int. 2003, 29:841-853.
8. Darnerud P.O., Eriksen G.S., Johannesson T., Larsen P.B., Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ. Health Perspect. 2001, 109(Suppl. 1):49-68.
9. Davies M. The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J. Psychiatry Neurosci. 2003, 28:263-274.
10. de Wit C.A. An overview of brominated flame retardants in the environment. Chemosphere 2002, 46:583-624.
11. DeLorey T.M., Sahbaie P., Hashemi E., Homanics G.E., Clark J.D. Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behav. Brain Res. 2008, 187:207-220.
12. Dingemans M.M., Ramakers G.M., Gardoni F., van Kleef R.G., Bergman A., Di Luca M., van den Berg M., Westerink R.H., Vijverberg H.P. Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus. Environ. Health Perspect. 2007, 115:865-870.
13. Driscoll L.L., Gibson A.M., Hieb A. Chronic postnatal DE-71 exposure: effects on learning, attention and thyroxine levels. Neurotoxicol. Teratol. 2009, 31:76-84.
14. Dufault C., Poles G., Driscoll L.L. Brief postnatal PBDE exposure alters learning and the cholinergic modulation of attention in rats. Toxicol. Sci. 2005, 88:172-180.
15. Eskenazi B., Chevrier J., Rauch S.A., Kogut K., Harley K.G., Johnson C., Trujillo C., Sjodin A., Bradman A. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environ. Health Perspect. 2013, 121:257-262.
16. Fatemi S.H., Reutiman T.J., Folsom T.D., Rooney R.J., Patel D.H., Thuras P.D. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. J. Autism Dev. Disord. 2010, 40:743-750.
17. Fitzgerald E.F., Shrestha S., Gomez M.I., McCaffrey R.J., Zimmerman E.A., Kannan K., Hwang S.A. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and neuropsychological status among older adults in New York. Neurotoxicology 2012, 33:8-15.
18. Gascon M., Fort M., Martinez D., Carsin A.E., Forns J., Grimalt J.O., Santa Marina L., Lertxundi N., Sunyer J., Vrijheid M. Polybrominated diphenyl ethers (PBDEs) in breast milk and neuropsychological development in infants. Environ. Health Perspect. 2012, 120:1760-1765.
19. Gaspar P.A., Bustamante M.L., Silva H., Aboitiz F. Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications. J. Neurochem. 2009, 111:891-900.
20. Gee J.R., Moser V.C., McDanie K.L., Herr D.W. Neurochemical changes following a single dose of polybrominated diphenyl ether 47 in mice. Drug Chem. Toxicol. 2011, 34:213-219.
21. Giordano G., Kavanagh T.J., Costa L.G. Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol. Appl. Pharmacol. 2008, 232:161-168.
22. Hallgren S., Darnerud P.O. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology 2002, 177:227-243.
23. Hallgren S., Sinjari T., Hakansson H., Darnerud P.O. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. 2001, 75:200-208.
24. Hendriks H.S., Antunes Fernandes E.C., Bergman A., van den Berg M., Westerink R.H. PCB-47, PBDE-47, and 6-OH-PBDE-47 differentially modulate human GABAA and alpha4beta2 nicotinic acetylcholine receptors. Toxicol. Sci. 2010, 118:635-642.
25. Herbstman J.B., Sjodin A., Kurzon M., Lederman S.A., Jones R.S., Rauh V., Needham L.L., Tang D., Niedzwiecki M., Wang R.Y., Perera F. Prenatal exposure to PBDEs and neurodevelopment. Environ. Health Perspect. 2010, 118:712-719.
26. Koenig C.M., Lango J., Pessah I.N., Berman R.F. Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Neurotoxicol. Teratol. 2012, 34:571-580.
27. Lewis D.A., Hashimoto T., Volk D.W. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 2005, 6:312-324.
28. Lewis D.A., Sweet R.A. Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies. J. Clin. Invest. 2009, 119:706-716.
29. Llansola M., Erceg S., Monfort P., Montoliu C., Felipo V. Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons. Eur. J. Neurosci. 2007, 25:373-379.
30. Llansola M., Hernandez-Viadel M., Erceg S., Montoliu C., Felipo V. Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task. J. Neurosci. Res. 2009, 87:2351-2355.
31. Mohler H. Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors. J. Neurochem. 2007, 102:1-12.
32. Monaghan D.T., Bridges R.J., Cotman C.W. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 1989, 29:365-402.
33. Norstrom R.J., Simon M., Moisey J., Wakeford B., Weseloh D.V. Geographical distribution (2000) and temporal trends (1981-2000) of brominated diphenyl ethers in Great Lakes hewing gull eggs. Environ. Sci. Technol. 2002, 36:4783-4789.
34. Roze E., Meijer L., Bakker A., Van Braeckel K.N., Sauer P.J., Bos A.F. Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age. Environ. Health Perspect. 2009, 117:1953-1958.
35. Rubenstein J.L., Merzenich M.M. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav. 2003, 2:255-267.
36. Rushworth M.F., Buckley M.J., Behrens T.E., Walton M.E., Bannerman D.M. Functional organization of the medial frontal cortex. Curr. Opin. Neurobiol. 2007, 17:220-227.
37. Schoch P., Richards J.G., Haring P., Takacs B., Stahli C., Staehelin T., Haefely W., Mohler H. Co-localization of GABA receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies. Nature 1985, 314:168-171.
38. Suvorov A., Takser L. Delayed response in the rat frontal lobe transcriptome to perinatal exposure to the flame retardant BDE-47. J. Appl. Toxicol. 2011, 31:477-483.
39. Viberg H., Fredriksson A., Eriksson P. Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Toxicol. Appl. Pharmacol. 2003, 192:95-106.
40. Viberg H., Johansson N., Fredriksson A., Eriksson J., Marsh G., Eriksson P. Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice. Toxicol. Sci. 2006, 92:211-218.
41. Yan T., Xiang L., Xuejun J., Chengzhi C., Youbin Q., Xuelan Y., Yang L., Changyan P., Hui C. Spatial learning and memory deficit of low level polybrominated diphenyl ethers-47 in male adult rat is modulated by intracellular glutamate receptors. J. Toxicol. Sci. 2012, 37:223-233.
42. Zahr N.M., Mayer D., Pfefferbaum A., Sullivan E.V. Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy. Cereb. Cortex 2008, 18:2241-2250.