Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: Role of dopamine handling in neurotoxicity

Experimental Neurology

Volumn 241, Issue 1, 2013, Pages 138-147

  Bradner, Joshua M ^a,b   Suragh, Tiffany A ^a   Wilson, W Wyatt ^a   Lazo, Carlos R ^a,b   Stout, Kristen A ^a,b   Kim, Hye Mi ^a   Wang, Min Z ^a,b   Walker, Douglas I ^c   Pennell, Kurt D ^c   Richardson, Jason R ^d   Miller, Gary W ^a,b   Caudle, W Michael ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Tufts University   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

DE 71; Dopamine; Parkinson's disease; Polybrominated diphenyl ethers; Striatum; Vesicular monoamine transporter 2

Indexed keywords

DE 71; DOPAMINE; DOPAMINE TRANSPORTER; POLYBROMINATED DIPHENYL ETHER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL ISOLATION; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINE METABOLISM; DOPAMINERGIC SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; SUBSTANTIA NIGRA PARS COMPACTA;

3,4-DIHYDROXYPHENYLACETIC ACID; ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; CELLS, CULTURED; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOGENATED DIPHENYL ETHERS; HOMOVANILLIC ACID; HUMANS; MESENCEPHALON; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; NEURONS; NEUROTOXICITY SYNDROMES; TRANSFECTION; TYROSINE 3-MONOOXYGENASE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 84872865127     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.12.013     Document Type: Article

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