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Volumn 33, Issue 3, 2014, Pages 336-346

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

Author keywords

Gas6 Axl; merlin; NFkB; proliferation adhesion survival; schwannoma

Indexed keywords

AXL PROTEIN; BETA1 INTEGRIN; CYCLIN D1; FOCAL ADHESION KINASE; GROWTH ARREST SPECIFIC PROTEIN 6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MERLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN TYROSINE KINASE; SOMATOMEDIN C; SURVIVIN; UNCLASSIFIED DRUG;

EID: 84883034231     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.587     Document Type: Article
Times cited : (73)

References (54)
  • 1
    • 0032543712 scopus 로고    scopus 로고
    • Determinants for transformation induced by the Axl receptor tyrosine kinase
    • Burchert A, Attar EC, McCloskey P, Fridell YW, Liu ET. Determinants for transformation induced by the Axl receptor tyrosine kinase. Oncogene 1998; 16: 3177-3187.
    • (1998) Oncogene , vol.16 , pp. 3177-3187
    • Burchert, A.1    Attar, E.C.2    McCloskey, P.3    Fridell, Y.W.4    Liu, E.T.5
  • 2
    • 0029612297 scopus 로고
    • Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation
    • Taylor IC, Roy S, Varmus HE. Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation. Oncogene 1995; 11: 2619-2626.
    • (1995) Oncogene , vol.11 , pp. 2619-2626
    • Taylor, I.C.1    Roy, S.2    Varmus, H.E.3
  • 3
    • 33745814436 scopus 로고    scopus 로고
    • Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases
    • Hafizi S, Dahlback B. Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases. Cytokine Growth Factor Rev 2006; 17: 295-304.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 295-304
    • Hafizi, S.1    Dahlback, B.2
  • 4
    • 20444495979 scopus 로고    scopus 로고
    • Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation
    • Valverde P. Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation. Biochem Biophys Res Commun 2005; 333: 180-185.
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 180-185
    • Valverde, P.1
  • 5
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
    • Linger RM, Keating AK, Earp HS, Graham DK. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res 2008; 100: 35-83.
    • (2008) Adv Cancer Res , vol.100 , pp. 35-83
    • Linger, R.M.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 7
    • 84860188906 scopus 로고    scopus 로고
    • Differential expression of Axl and correlation with invasion and multidrug resistance in cancer cells
    • Zhao Y, Sun X, Jiang L, Yang F, Zhang Z, Jia L. Differential expression of Axl and correlation with invasion and multidrug resistance in cancer cells. Cancer Invest 2012; 30: 287-294.
    • (2012) Cancer Invest , vol.30 , pp. 287-294
    • Zhao, Y.1    Sun, X.2    Jiang, L.3    Yang, F.4    Zhang, Z.5    Jia, L.6
  • 8
    • 84858794811 scopus 로고    scopus 로고
    • Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL
    • Sayan AE, Stanford R, Vickery R, Grigorenko E, Diesch J, Kulbicki K et al. Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL. Oncogene 2012; 31: 1493-1503.
    • (2012) Oncogene , vol.31 , pp. 1493-1503
    • Sayan, A.E.1    Stanford, R.2    Vickery, R.3    Grigorenko, E.4    Diesch, J.5    Kulbicki, K.6
  • 10
    • 48549095272 scopus 로고    scopus 로고
    • Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma
    • Ammoun S, Flaiz C, Ristic N, Schuldt J, Hanemann CO. Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma. Cancer Res 2008; 68: 5236-5245.
    • (2008) Cancer Res , vol.68 , pp. 5236-5245
    • Ammoun, S.1    Flaiz, C.2    Ristic, N.3    Schuldt, J.4    Hanemann, C.O.5
  • 11
    • 78149474027 scopus 로고    scopus 로고
    • ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma
    • Ammoun S, Cunliffe CH, Allen JC, Chiriboga L, Giancotti FG, Zagzag D et al. ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma. Neuro Oncol 2010; 12: 834-843.
    • (2010) Neuro Oncol , vol.12 , pp. 834-843
    • Ammoun, S.1    Cunliffe, C.H.2    Allen, J.C.3    Chiriboga, L.4    Giancotti, F.G.5    Zagzag, D.6
  • 12
    • 84859420929 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival
    • Ammoun S, Schmid MC, Zhou L, Ristic N, Ercolano E, Hilton DA et al. Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival. Oncogene 2011; 31: 1710-1722.
    • (2011) Oncogene , vol.31 , pp. 1710-1722
    • Ammoun, S.1    Schmid, M.C.2    Zhou, L.3    Ristic, N.4    Ercolano, E.5    Hilton, D.A.6
  • 13
    • 84855434528 scopus 로고    scopus 로고
    • Merlindeficient human tumors show loss of contact inhibition and activation of Wnt/beta-catenin signaling linked to the PDGFR/Src and Rac/PAK pathways
    • Zhou L, Ercolano E, Ammoun S, Schmid MC, Barczyk MA, Hanemann CO. Merlindeficient human tumors show loss of contact inhibition and activation of Wnt/beta-catenin signaling linked to the PDGFR/Src and Rac/PAK pathways. Neoplasia 2011; 13: 1101-1112.
    • (2011) Neoplasia , vol.13 , pp. 1101-1112
    • Zhou, L.1    Ercolano, E.2    Ammoun, S.3    Schmid, M.C.4    Barczyk, M.A.5    Hanemann, C.O.6
  • 15
    • 0033826595 scopus 로고    scopus 로고
    • Enhanced proliferation and potassium conductance of Schwann cells isolated from NF2 schwannomas can be reduced by quinidine
    • Rosenbaum C, Kamleiter M, Grafe P, Kluwe L, Mautner V, Muller HW et al. Enhanced proliferation and potassium conductance of Schwann cells isolated from NF2 schwannomas can be reduced by quinidine. Neurobiol Dis 2000; 7: 483-491.
    • (2000) Neurobiol Dis , vol.7 , pp. 483-491
    • Rosenbaum, C.1    Kamleiter, M.2    Grafe, P.3    Kluwe, L.4    Mautner, V.5    Muller, H.W.6
  • 16
    • 84865860585 scopus 로고    scopus 로고
    • The role of insulin-like growth factors signaling in merlin-deficient human schwannomas
    • Ammoun S, Schmid MC, Ristic N, Zhou L, Hilton D, Ercolano E et al. The role of insulin-like growth factors signaling in merlin-deficient human schwannomas. Glia 2012; 60: 1721-1733.
    • (2012) Glia , vol.60 , pp. 1721-1733
    • Ammoun, S.1    Schmid, M.C.2    Ristic, N.3    Zhou, L.4    Hilton, D.5    Ercolano, E.6
  • 17
    • 0042627886 scopus 로고    scopus 로고
    • Pathological adhesion of primary human schwannoma cells is dependent on altered expression of integrins
    • Utermark T, Kaempchen K, Hanemann CO. Pathological adhesion of primary human schwannoma cells is dependent on altered expression of integrins. Brain Pathol 2003; 13: 352-363.
    • (2003) Brain Pathol , vol.13 , pp. 352-363
    • Utermark, T.1    Kaempchen, K.2    Hanemann, C.O.3
  • 18
    • 36049021784 scopus 로고    scopus 로고
    • Expression of ErbB-1 and 2 in vestibular schwannomas
    • Wickremesekera A, Hovens CM, Kaye AH. Expression of ErbB-1 and 2 in vestibular schwannomas. J Clin Neurosci 2007; 14: 1199-1206.
    • (2007) J Clin Neurosci , vol.14 , pp. 1199-1206
    • Wickremesekera, A.1    Hovens, C.M.2    Kaye, A.H.3
  • 19
    • 76749108011 scopus 로고    scopus 로고
    • Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
    • Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L et al. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 2010; 140: 477-490.
    • (2010) Cell , vol.140 , pp. 477-490
    • Li, W.1    You, L.2    Cooper, J.3    Schiavon, G.4    Pepe-Caprio, A.5    Zhou, L.6
  • 20
    • 77955909174 scopus 로고    scopus 로고
    • Merlin in organ size control and tumorigenesis: Hippo versus EGFR?
    • Yi C, Kissil JL. Merlin in organ size control and tumorigenesis: Hippo versus EGFR? Genes Dev 2010; 24: 1673-1679.
    • (2010) Genes Dev , vol.24 , pp. 1673-1679
    • Yi, C.1    Kissil, J.L.2
  • 21
    • 9344261751 scopus 로고    scopus 로고
    • Identification of Gas6 as a growth factor for human Schwann cells
    • Li R, Chen J, Hammonds G, Phillips H, Armanini M, Wood P et al. Identification of Gas6 as a growth factor for human Schwann cells. J Neurosci 1996; 16: 2012-2019.
    • (1996) J Neurosci , vol.16 , pp. 2012-2019
    • Li, R.1    Chen, J.2    Hammonds, G.3    Phillips, H.4    Armanini, M.5    Wood, P.6
  • 23
    • 0038344831 scopus 로고    scopus 로고
    • Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells
    • Kaempchen K, Mielke K, Utermark T, Langmesser S, Hanemann CO. Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells. Hum Mol Genet 2003; 12: 1211-1221.
    • (2003) Hum Mol Genet , vol.12 , pp. 1211-1221
    • Kaempchen, K.1    Mielke, K.2    Utermark, T.3    Langmesser, S.4    Hanemann, C.O.5
  • 24
    • 70849088929 scopus 로고    scopus 로고
    • Activation of ERK AKT and JNK signalling pathways in human schwannomas in situ
    • Hilton DA, Ristic N, Hanemann CO. Activation of ERK, AKT and JNK signalling pathways in human schwannomas in situ. Histopathology 2009; 55: 744-749.
    • (2009) Histopathology , vol.55 , pp. 744-749
    • Hilton, D.A.1    Ristic, N.2    Hanemann, C.O.3
  • 25
    • 70449533744 scopus 로고    scopus 로고
    • Targeting ERK1/2 activation and proliferation in human primary schwannoma cells with MEK1/2 inhibitor AZD6244
    • Ammoun S, Ristic N, Matthies C, Hilton DA, Hanemann CO. Targeting ERK1/2 activation and proliferation in human primary schwannoma cells with MEK1/2 inhibitor AZD6244. Neurobiol Dis 2010; 37: 141-146.
    • (2010) Neurobiol Dis , vol.37 , pp. 141-146
    • Ammoun, S.1    Ristic, N.2    Matthies, C.3    Hilton, D.A.4    Hanemann, C.O.5
  • 26
    • 79960107083 scopus 로고    scopus 로고
    • Emerging therapeutic targets in schwannomas and other merlin-deficient tumors
    • Ammoun S, Hanemann CO. Emerging therapeutic targets in schwannomas and other merlin-deficient tumors. Nat Rev Neurol 2011; 7: 392-399.
    • (2011) Nat Rev Neurol , vol.7 , pp. 392-399
    • Ammoun, S.1    Hanemann, C.O.2
  • 27
    • 80052726645 scopus 로고    scopus 로고
    • Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2
    • Ammoun S, Schmid MC, Triner J, Manley P, Hanemann CO. Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2. Neuro Oncol 2011; 13: 759-766.
    • (2011) Neuro Oncol , vol.13 , pp. 759-766
    • Ammoun, S.1    Schmid, M.C.2    Triner, J.3    Manley, P.4    Hanemann, C.O.5
  • 30
    • 26944502352 scopus 로고    scopus 로고
    • TNFalpha mediates Schwann cell death by upregulating p75NTR expression without sustained activation of NFkappaB
    • Boyle K, Azari MF, Cheema SS, Petratos S. TNFalpha mediates Schwann cell death by upregulating p75NTR expression without sustained activation of NFkappaB. Neurobiol Dis 2005; 20: 412-427.
    • (2005) Neurobiol Dis , vol.20 , pp. 412-427
    • Boyle, K.1    Azari, M.F.2    Cheema, S.S.3    Petratos, S.4
  • 31
    • 34248203559 scopus 로고    scopus 로고
    • NFkappaB-independent signaling to the cyclin D1 gene by Rac
    • Klein EA, Yang C, Kazanietz MG, Assoian RK. NFkappaB-independent signaling to the cyclin D1 gene by Rac. Cell Cycle 2007; 6: 1115-1121.
    • (2007) Cell Cycle , vol.6 , pp. 1115-1121
    • Klein, E.A.1    Yang, C.2    Kazanietz, M.G.3    Assoian, R.K.4
  • 32
    • 80052300279 scopus 로고    scopus 로고
    • Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression
    • PART 6
    • Cooper J, Li W, You L, Schiavon G, Pepe-Caprio A, Zhou L et al. Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression. Sci Signal 2011; 4: pt6.
    • (2011) Sci Signal , pp. 4
    • Cooper, J.1    Li, W.2    You, L.3    Schiavon, G.4    Pepe-Caprio, A.5    Zhou, L.6
  • 33
    • 76749109371 scopus 로고    scopus 로고
    • GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche
    • Shiozawa Y, Pedersen EA, Patel LR, Ziegler AM, Havens AM, Jung Y et al. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia 2010; 12: 116-127.
    • (2010) Neoplasia , vol.12 , pp. 116-127
    • Shiozawa, Y.1    Pedersen, E.A.2    Patel, L.R.3    Ziegler, A.M.4    Havens, A.M.5    Jung, Y.6
  • 34
    • 18744428417 scopus 로고    scopus 로고
    • Inhibition of ras-mediated activator protein 1 activity and cell growth by merlin
    • Kim H, Lim JY, Kim YH, Park SH, Lee KH, Han H et al. Inhibition of ras-mediated activator protein 1 activity and cell growth by merlin. Mol Cells 2002; 14: 108-114.
    • (2002) Mol Cells , vol.14 , pp. 108-114
    • Kim, H.1    Lim, J.Y.2    Kim, Y.H.3    Park, S.H.4    Lee, K.H.5    Han, H.6
  • 35
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
    • Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet Jr RJ, Sledge Jr GW. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 1997; 17: 3629-3639.
    • (1997) Mol Cell Biol , vol.17 , pp. 3629-3639
    • Nakshatri, H.1    Bhat-Nakshatri, P.2    Martin, D.A.3    Goulet Jr., R.J.4    Sledge Jr., G.W.5
  • 37
    • 0033535058 scopus 로고    scopus 로고
    • Delta-catenin, an adhesive junction-associated protein which promotes cell scattering
    • Lu Q, Paredes M, Medina M, Zhou J, Cavallo R, Peifer M et al. delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J Cell Biol 1999; 144: 519-532.
    • (1999) J Cell Biol , vol.144 , pp. 519-532
    • Lu, Q.1    Paredes, M.2    Medina, M.3    Zhou, J.4    Cavallo, R.5    Peifer, M.6
  • 38
    • 0029768923 scopus 로고    scopus 로고
    • Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vitro and in vivo
    • Costa M, Bellosta P, Basilico C. Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vitro and in vivo. J Cell Physiol 1996; 168: 737-744.
    • (1996) J Cell Physiol , vol.168 , pp. 737-744
    • Costa, M.1    Bellosta, P.2    Basilico, C.3
  • 39
    • 33846872571 scopus 로고    scopus 로고
    • A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
    • Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM et al. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Blood 2007; 109: 1026-1033.
    • (2007) Blood , vol.109 , pp. 1026-1033
    • Sather, S.1    Kenyon, K.D.2    Lefkowitz, J.B.3    Liang, X.4    Varnum, B.C.5    Henson, P.M.6
  • 40
    • 34249985524 scopus 로고    scopus 로고
    • A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors
    • Mahadevan D, Cooke L, Riley C, Swart R, Simons B, Della Croce K et al. A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors. Oncogene 2007; 26: 3909-3919.
    • (2007) Oncogene , vol.26 , pp. 3909-3919
    • Mahadevan, D.1    Cooke, L.2    Riley, C.3    Swart, R.4    Simons, B.5    Della Croce, K.6
  • 41
    • 78651260241 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling
    • Du J, Sun C, Hu Z, Yang Y, Zhu Y, Zheng D et al. Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling. PloS one 2010; 5: e15940.
    • (2010) PloS One , vol.5
    • Du, J.1    Sun, C.2    Hu, Z.3    Yang, Y.4    Zhu, Y.5    Zheng, D.6
  • 42
    • 33751534730 scopus 로고    scopus 로고
    • The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression
    • Georgakis GV, Li Y, Rassidakis GZ, Medeiros LJ, Younes A. The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression. Exp Hematol 2006; 34: 1670-1679.
    • (2006) Exp Hematol , vol.34 , pp. 1670-1679
    • Georgakis, G.V.1    Li, Y.2    Rassidakis, G.Z.3    Medeiros, L.J.4    Younes, A.5
  • 43
    • 67349256384 scopus 로고    scopus 로고
    • PAK kinase regulates Rac GTPase and is a potential target in human schwannomas
    • Flaiz C, Chernoff J, Ammoun S, Peterson JR, Hanemann CO. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol 2009; 218: 137-144.
    • (2009) Exp Neurol , vol.218 , pp. 137-144
    • Flaiz, C.1    Chernoff, J.2    Ammoun, S.3    Peterson, J.R.4    Hanemann, C.O.5
  • 45
    • 77952985477 scopus 로고    scopus 로고
    • PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport
    • Rexhepaj R, Rotte A, Pasham V, Gu S, Kempe DS, Lang F. PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport. Cell Physiol Biochem 2010; 25: 715-722.
    • (2010) Cell Physiol Biochem , vol.25 , pp. 715-722
    • Rexhepaj, R.1    Rotte, A.2    Pasham, V.3    Gu, S.4    Kempe, D.S.5    Lang, F.6
  • 46
    • 78049483946 scopus 로고    scopus 로고
    • Involvement of Src family kinase activation in angiotensin II-induced hyperresponsiveness of rat bronchial smooth muscle
    • Sakai H, Nishimura A, Watanabe Y, Nishizawa Y, Hashimoto Y, Chiba Y et al. Involvement of Src family kinase activation in angiotensin II-induced hyperresponsiveness of rat bronchial smooth muscle. Peptides 2010; 31: 2216-2221.
    • (2010) Peptides , vol.31 , pp. 2216-2221
    • Sakai, H.1    Nishimura, A.2    Watanabe, Y.3    Nishizawa, Y.4    Hashimoto, Y.5    Chiba, Y.6
  • 47
    • 0025942516 scopus 로고
    • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
    • Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 1991; 266: 15771-15781.
    • (1991) J Biol Chem , vol.266 , pp. 15771-15781
    • Toullec, D.1    Pianetti, P.2    Coste, H.3    Bellevergue, P.4    Grand-Perret, T.5    Ajakane, M.6
  • 48
    • 72949106003 scopus 로고    scopus 로고
    • Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer
    • Kim RJ, Kim SR, Roh KJ, Park SB, Park JR, Kang KS et al. Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer. Cancer Lett 2010; 287: 172-181.
    • (2010) Cancer Lett , vol.287 , pp. 172-181
    • Kim, R.J.1    Kim, S.R.2    Roh, K.J.3    Park, S.B.4    Park, J.R.5    Kang, K.S.6
  • 49
    • 0028973293 scopus 로고
    • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
    • Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J et al. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem 1995; 270: 26802-26806.
    • (1995) J Biol Chem , vol.270 , pp. 26802-26806
    • Lerner, E.C.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Vogt, A.5    Sun, J.6
  • 50
    • 14844355090 scopus 로고    scopus 로고
    • The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
    • Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG et al. The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol 2005; 25: 2384-2394.
    • (2005) Mol Cell Biol , vol.25 , pp. 2384-2394
    • Xiao, G.H.1    Gallagher, R.2    Shetler, J.3    Skele, K.4    Altomare, D.A.5    Pestell, R.G.6
  • 51
    • 33947249662 scopus 로고    scopus 로고
    • Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    • Lee H, Kim D, Dan HC, Wu EL, Gritsko TM, Cao C et al. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol Cell Biol 2007; 27: 2103-2119.
    • (2007) Mol Cell Biol , vol.27 , pp. 2103-2119
    • Lee, H.1    Kim, D.2    Dan, H.C.3    Wu, E.L.4    Gritsko, T.M.5    Cao, C.6
  • 53
    • 1842412458 scopus 로고    scopus 로고
    • Schwann cell differentiation in Charcot-Marie-Tooth disease type 1A (CMT1A): Normal number of myelinating Schwann cells in young CMT1A patients and neural cell adhesion molecule expression in onion bulbs
    • Hanemann CO, Gabreels-Festen AA, Stoll G, Mueller HW. Schwann cell differentiation in Charcot-Marie-Tooth disease type 1A (CMT1A): normal number of myelinating Schwann cells in young CMT1A patients and neural cell adhesion molecule expression in onion bulbs. Acta Neuropathol 1997; 94: 310-315.
    • (1997) Acta Neuropathol , vol.94 , pp. 310-315
    • Hanemann, C.O.1    Gabreels-Festen, A.A.2    Stoll, G.3    Mueller, H.W.4
  • 54
    • 2942566011 scopus 로고    scopus 로고
    • Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts
    • Stenhoff J, Dahlback B, Hafizi S. Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts. Biochem Biophys Res Commun 2004; 319: 871-878.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 871-878
    • Stenhoff, J.1    Dahlback, B.2    Hafizi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.