-
1
-
-
43749103335
-
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
Adjei A.A., Cohen R.B., Franklin W., Morris C., Wilson D., Molina J.R., Hanson L.J., Gore L., Chow L., Leong S., Maloney L., Gordon G., Simmons H., Marlow A., Litwiler K., Brown S., Poch G., Kane K., Haney J., and Eckhardt S.G. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J. Clin. Oncol. 26 (2008) 2139-2146
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
Morris, C.4
Wilson, D.5
Molina, J.R.6
Hanson, L.J.7
Gore, L.8
Chow, L.9
Leong, S.10
Maloney, L.11
Gordon, G.12
Simmons, H.13
Marlow, A.14
Litwiler, K.15
Brown, S.16
Poch, G.17
Kane, K.18
Haney, J.19
Eckhardt, S.G.20
more..
-
2
-
-
48549095272
-
Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma
-
Ammoun S., Flaiz C., Ristic N., Schuldt J., and Hanemann C.O. Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma. Cancer Res. 68 (2008) 5236-5245
-
(2008)
Cancer Res.
, vol.68
, pp. 5236-5245
-
-
Ammoun, S.1
Flaiz, C.2
Ristic, N.3
Schuldt, J.4
Hanemann, C.O.5
-
3
-
-
39649101914
-
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4)
-
Atanasoski S., Boentert M., De V.L., Pohl H., Baranek C., Beier K., Young P., Barbacid M., and Suter U. Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4). Mol. Cell. Neurosci. 37 (2008) 519-527
-
(2008)
Mol. Cell. Neurosci.
, vol.37
, pp. 519-527
-
-
Atanasoski, S.1
Boentert, M.2
De, V.L.3
Pohl, H.4
Baranek, C.5
Beier, K.6
Young, P.7
Barbacid, M.8
Suter, U.9
-
5
-
-
46749098413
-
Increase of MCP-1 (CCL2) in myelin mutant Schwann cells is mediated by MEK-ERK signaling pathway
-
Fischer S., Weishaupt A., Troppmair J., and Martini R. Increase of MCP-1 (CCL2) in myelin mutant Schwann cells is mediated by MEK-ERK signaling pathway. GLIA 56 (2008) 836-843
-
(2008)
GLIA
, vol.56
, pp. 836-843
-
-
Fischer, S.1
Weishaupt, A.2
Troppmair, J.3
Martini, R.4
-
6
-
-
44949117867
-
Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells
-
Flaiz C., Utermark T., Parkinson D.B., Poetsch A., and Hanemann C.O. Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells. GLIA 56 (2008) 506-515
-
(2008)
GLIA
, vol.56
, pp. 506-515
-
-
Flaiz, C.1
Utermark, T.2
Parkinson, D.B.3
Poetsch, A.4
Hanemann, C.O.5
-
7
-
-
51049113834
-
BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins
-
Friday B.B., Yu C., Dy G.K., Smith P.D., Wang L., Thibodeau S.N., and Adjei A.A. BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. Cancer Res. 68 (2008) 6145-6153
-
(2008)
Cancer Res.
, vol.68
, pp. 6145-6153
-
-
Friday, B.B.1
Yu, C.2
Dy, G.K.3
Smith, P.D.4
Wang, L.5
Thibodeau, S.N.6
Adjei, A.A.7
-
8
-
-
51349098887
-
Cotargeting survival signaling pathways in cancer
-
Grant S. Cotargeting survival signaling pathways in cancer. J. Clin. Invest. 118 (2008) 3003-3006
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3003-3006
-
-
Grant, S.1
-
9
-
-
33750595624
-
Differential gene expression between human schwannoma and control Schwann cells
-
Hanemann C.O., Bartelt-Kirbach B., Diebold R., Kampchen K., Langmesser S., and Utermark T. Differential gene expression between human schwannoma and control Schwann cells. Neuropathol. Appl. Neurobiol. 32 (2006) 605-614
-
(2006)
Neuropathol. Appl. Neurobiol.
, vol.32
, pp. 605-614
-
-
Hanemann, C.O.1
Bartelt-Kirbach, B.2
Diebold, R.3
Kampchen, K.4
Langmesser, S.5
Utermark, T.6
-
10
-
-
33645984545
-
Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation
-
Hansen M.R., Roehm P.C., Chatterjee P., and Green S.H. Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation. GLIA 53 (2006) 593-600
-
(2006)
GLIA
, vol.53
, pp. 593-600
-
-
Hansen, M.R.1
Roehm, P.C.2
Chatterjee, P.3
Green, S.H.4
-
11
-
-
4143146568
-
The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation
-
Harrisingh M.C., Perez-Nadales E., Parkinson D.B., Malcolm D.S., Mudge A.W., and Lloyd A.C. The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation. EMBO J. 23 (2004) 3061-3071
-
(2004)
EMBO J.
, vol.23
, pp. 3061-3071
-
-
Harrisingh, M.C.1
Perez-Nadales, E.2
Parkinson, D.B.3
Malcolm, D.S.4
Mudge, A.W.5
Lloyd, A.C.6
-
12
-
-
34748917797
-
AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma
-
Huynh H., Chow P.K., and Soo K.C. AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma. Mol. Cancer Ther. 6 (2007) 2468-2476
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2468-2476
-
-
Huynh, H.1
Chow, P.K.2
Soo, K.C.3
-
13
-
-
61549142162
-
Negative regulation of myelination: relevance for development, injury, and demyelinating disease
-
Jessen K.R., and Mirsky R. Negative regulation of myelination: relevance for development, injury, and demyelinating disease. GLIA 56 (2008) 1552-1565
-
(2008)
GLIA
, vol.56
, pp. 1552-1565
-
-
Jessen, K.R.1
Mirsky, R.2
-
14
-
-
0038344831
-
Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells
-
Kaempchen K., Mielke K., Utermark T., Langmesser S., and Hanemann C.O. Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells. Hum. Mol. Genet. 12 (2003) 1211-1221
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1211-1221
-
-
Kaempchen, K.1
Mielke, K.2
Utermark, T.3
Langmesser, S.4
Hanemann, C.O.5
-
15
-
-
25844447107
-
Membrane organization and tumorigenesis-the NF2 tumor suppressor
-
McClatchey A.I., and Giovannini M. Membrane organization and tumorigenesis-the NF2 tumor suppressor. Merlin Genes Dev. 19 (2005) 2265-2277
-
(2005)
Merlin Genes Dev.
, vol.19
, pp. 2265-2277
-
-
McClatchey, A.I.1
Giovannini, M.2
-
16
-
-
44649089666
-
Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors
-
McCubrey J.A., Milella M., Tafuri A., Martelli A.M., Lunghi P., Bonati A., Cervello M., Lee J.T., and Steelman L.S. Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors. Curr. Opin. Investig. Drugs 9 (2008) 614-630
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, pp. 614-630
-
-
McCubrey, J.A.1
Milella, M.2
Tafuri, A.3
Martelli, A.M.4
Lunghi, P.5
Bonati, A.6
Cervello, M.7
Lee, J.T.8
Steelman, L.S.9
-
17
-
-
34547209343
-
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
-
McCubrey J.A., Steelman L.S., Chappell W.H., Abrams S.L., Wong E.W., Chang F., Lehmann B., Terrian D.M., Milella M., Tafuri A., Stivala F., Libra M., Basecke J., Evangelisti C., Martelli A.M., and Franklin R.A. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim. Biophys. Acta 1773 (2007) 1263-1284
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1263-1284
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Wong, E.W.5
Chang, F.6
Lehmann, B.7
Terrian, D.M.8
Milella, M.9
Tafuri, A.10
Stivala, F.11
Libra, M.12
Basecke, J.13
Evangelisti, C.14
Martelli, A.M.15
Franklin, R.A.16
-
19
-
-
33846702026
-
Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
-
Morrison H., Sperka T., Manent J., Giovannini M., Ponta H., and Herrlich P. Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res. 67 (2007) 520-527
-
(2007)
Cancer Res.
, vol.67
, pp. 520-527
-
-
Morrison, H.1
Sperka, T.2
Manent, J.3
Giovannini, M.4
Ponta, H.5
Herrlich, P.6
-
20
-
-
0032127257
-
Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients
-
Rosenbaum C., Kluwe L., Mautner V.F., Friedrich R.E., Mueller H.W., and Hanemann C.O. Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients. Neurobiol. Dis. 5 (1998) 55-64
-
(1998)
Neurobiol. Dis.
, vol.5
, pp. 55-64
-
-
Rosenbaum, C.1
Kluwe, L.2
Mautner, V.F.3
Friedrich, R.E.4
Mueller, H.W.5
Hanemann, C.O.6
-
22
-
-
17444397758
-
Rearrangements of the intermediate filament GFAP in primary human schwannoma cells
-
Utermark T., Schubert S.J., and Hanemann C.O. Rearrangements of the intermediate filament GFAP in primary human schwannoma cells. Neurobiol. Dis. 19 (2005) 1-9
-
(2005)
Neurobiol. Dis.
, vol.19
, pp. 1-9
-
-
Utermark, T.1
Schubert, S.J.2
Hanemann, C.O.3
-
23
-
-
0025138525
-
Cell-specific cyclic AMP-mediated induction of the PDGF receptor
-
Weinmaster G., and Lemke G. Cell-specific cyclic AMP-mediated induction of the PDGF receptor. EMBO J. 9 (1990) 915-920
-
(1990)
EMBO J.
, vol.9
, pp. 915-920
-
-
Weinmaster, G.1
Lemke, G.2
-
24
-
-
38949115895
-
Integrin-mediated signalling through the MAP-kinase pathway
-
Yee K.L., Weaver V.M., and Hammer D.A. Integrin-mediated signalling through the MAP-kinase pathway. IET Syst. Biol. 2 (2008) 8-15
-
(2008)
IET Syst. Biol.
, vol.2
, pp. 8-15
-
-
Yee, K.L.1
Weaver, V.M.2
Hammer, D.A.3
-
25
-
-
33947401129
-
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
-
Yeh T.C., Marsh V., Bernat B.A., Ballard J., Colwell H., Evans R.J., Parry J., Smith D., Brandhuber B.J., Gross S., Marlow A., Hurley B., Lyssikatos J., Lee P.A., Winkler J.D., Koch K., and Wallace E. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin. Cancer Res. 13 (2007) 1576-1583
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 1576-1583
-
-
Yeh, T.C.1
Marsh, V.2
Bernat, B.A.3
Ballard, J.4
Colwell, H.5
Evans, R.J.6
Parry, J.7
Smith, D.8
Brandhuber, B.J.9
Gross, S.10
Marlow, A.11
Hurley, B.12
Lyssikatos, J.13
Lee, P.A.14
Winkler, J.D.15
Koch, K.16
Wallace, E.17
-
26
-
-
0034038538
-
Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging
-
Zhu X.P., Li K.L., Kamaly-Asl I.D., Checkley D.R., Tessier J.J., Waterton J.C., and Jackson A. Quantification of endothelial permeability, leakage space, and blood volume in brain tumors using combined T1 and T2* contrast-enhanced dynamic MR imaging. J. Magn. Reson. Imaging 11 (2000) 575-585
-
(2000)
J. Magn. Reson. Imaging
, vol.11
, pp. 575-585
-
-
Zhu, X.P.1
Li, K.L.2
Kamaly-Asl, I.D.3
Checkley, D.R.4
Tessier, J.J.5
Waterton, J.C.6
Jackson, A.7
|