Physicochemical and immunological studies on mitochondrial DNA modified by peroxynitrite: Implications of neo-epitopes of mitochondrial DNA in the etiopathogenesis of systemic lupus erythematosus

Lupus

Volumn 22, Issue 10, 2013, Pages 1024-1037

  Al Shobaili, H A ^a   Rasheed, Z ^a  

^a QASSIM UNIVERSITY   (Saudi Arabia)

Author keywords

Mitochondrial DNA; ONOO mtDNA; peroxynitrite; SLE; SLE IgG

Indexed keywords

3 NITROTYROSINE; AUTOANTIBODY; EPITOPE; IMMUNOGLOBULIN G; MITOCHONDRIAL DNA; NEO EPITOPE; NITRIC OXIDE; NUCLEASE S1; PEROXYNITRITE; SUPEROXIDE; UNCLASSIFIED DRUG;

ADULT; AGAR GEL ELECTROPHORESIS; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; ETIOLOGY; FEMALE; GEL; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOLOGICAL TECHNIQUE; MALE; NITROSATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; ULTRAVIOLET RADIATION;

MITOCHONDRIAL DNA; ONOO--MTDNA; PEROXYNITRITE; SLE; SLE IGG;

ADOLESCENT; ADULT; AUTOANTIBODIES; DNA, MITOCHONDRIAL; EPITOPES; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PEROXYNITROUS ACID; SEVERITY OF ILLNESS INDEX;

EID: 84883008218     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203313498803     Document Type: Article

References (57)

1. Gomez-Cabrera MC, Sanchis-Gomar F, Garcia-Valles R, et al. Mitochondria as sources and targets of damage in cellular aging. Clin Chem Lab Med. 2012 ; 50: 1287-1295
2. Kirkinezos IG, Moraes CT. Reactive oxygen species and mitochondrial diseases. Semin Cell Dev Biol. 2001 ; 12: 449-457
3. Giulivi C. Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism. Biochem J. 1998 ; 332: 673-679
4. Giulivi C, Poderoso JJ, Boveris A. Production of nitric oxide by mitochondria. J Biol Chem. 1998 ; 273: 11038-11043
5. Nakamoto H, Kaneko T, Tahara S, et al. Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats. Exp Gerontol. 2007 ; 42: 287-295
6. de Souza-Pinto NC, Hogue BA, Bohr VA. DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. Free Radic Biol Med. 2001 ; 30: 916-923
7. Hiona A, Leeuwenburgh C. The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging. Exp Gerontology. 2008 ; 43: 24-33
8. Kim G, Sikder H, Singh KK. A colony color method identifies the vulnerability of mitochondria to oxidative damage. Mutagenesis. 2002 ; 17: 375-381
9. Reimer G, Rubin RL, Kotzin BL, Tan EM. Anti-native DNA antibodies from autoimmune sera also bind to DNA in mitochondria. J Immunol. 1984 ; 133: 2532-2536
10. Gurevitz SL, Snyder JA, Wessel EK, Frey J, Williamson BA. Systemic lupus erythematosus: A review of the disease and treatment options. Consult Pharm. 2013 ; 28: 110-121
11. Choi J, Kim ST, Craft J. The pathogenesis of systemic lupus erythematosus - an update. Curr Opin Immunol. 2012 ; 24: 651-657
12. Radic M, Herrmann M, van der Vlag J, Rekvig OP. Regulatory and pathogenetic mechanisms of autoantibodies in SLE. Autoimmunity. 2011 ; 44: 349-356
13. Gergely P, Grossman C, Niland B, et al. Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arthritis Rheum. 2002 ; 46: 175-190
14. Askanase A, Shum K, Mitnick H. Systemic lupus erythematosus: An overview. Soc Work Health Care. 2012 ; 51: 576-586
15. Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008 ; 7: 567-573
16. Ahmad R, Ahsan H. Role of peroxynitrite-modified biomolecules in the etiopathogenesis of systemic lupus erythematosus. Clin Exp Med. Epub ahead of print 23 November 2012.
17. Cai P, König R, Khan MF, Qiu S, Kaphalia BS, Ansari GA. Autoimmune response in MRL+/+ mice following treatment with dichloroacetylchloride or dichloroacetic anhydride. Toxicol Appl Pharmacol. 2006 ; 216: 248-255
18. Pisetsky DS, Grudier JP, Gilkeson GS. A role for the immunogenic DNA in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. 1990 ; 33: 159-164
19. Munns TW, Liszewski MK, Hahn BH. Antibody-nucleic acid complexes. Conformational and base specificities associated with spontaneously occurring poly- and monoclonal anti-DNA antibodies from autoimmune mice. Biochemistry. 1984 ; 23: 2964-2970
20. Al-Shobaili HA, Al Robaee A, Alzolibani AA, Rasheed Z. Antibodies against 4-hydroxy-2-nonenal modified epitopes recognized chromatin and its oxidized forms: Role of chromatin, oxidized forms of chromatin and 4-hydroxy-2-nonenal modified epitopes in the etiopathogenesis of SLE. Dis Markers. 2012 ; 33: 19-34
21. Calcerrada P, Peluffo G, Radi R. Nitric oxide-derived oxidants with a focus on peroxynitrite: Molecular targets, cellular responses and therapeutic implications. Curr Pharm Des. 2011 ; 17: 3905-3932
22. Ahmad R, Rasheed Z, Ahsan H. Biochemical and cellular toxicology of peroxynitrite: Implications in cell death and autoimmune phenomenon. Immunopharmacol Immunotoxicol. 2009 ; 31: 388-396
23. Chen W, Li Y, Li J, Han Q, Ye L, Li A. Myricetin affords protection against peroxynitrite-mediated DNA damage and hydroxyl radical formation. Food Chem Toxicol. 2011 ; 49: 2439-2444
24. Cantoni O, Guidarelli A. Indirect mechanisms of DNA strand scission by peroxynitrite. Methods Enzymol. 2008 ; 440: 111-120
25. Mazzon E, De Sarro A, Caputi AP, Cuzzocrea S. Role of tight junction derangement in the endothelial dysfunction elicited by exogenous and endogenous peroxynitrite and poly(ADP-ribose) synthetase. Shock. 2002 ; 18: 434-439
26. Witt A, Ahr HJ, Brendler-Schwaab S, Enzmann H, Steinke W. Carcinogen-induced mitochondrial DNA damage in the ovo model. Toxicol In Vitro. 1998 ; 12: 329-333
27. Alam K, Moinuddin, Jabeen S. Immunogenicity of mitochondrial DNA modified by hydroxyl radical. Cell Immunol. 2007 ; 247: 12-17
28. Rasheed Z, Al-Shobaili HA, Al Robaee AA, et al. Preferential recognition of peroxynitrite damaged thymidine-monophosphate by anti-DNA autoantibodies in systemic lupus erythematosus. Nucleosides Nucleotides Nucleic Acids. 2012 ; 31: 736-751
29. Ashraf JM, Arif B, Dixit K, Moinuddin, Alam K. Physicochemical analysis of structural changes in DNA modified with glucose. Int J Biol Macromol. 2012 ; 51: 604-611
30. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997 ; 40: 1725-1725
31. The American College of Rheumatology response criteria for systemic lupus erythematosus clinical trials: Measures of overall disease activity. Arthritis Rheum. 2004 ; 50: 3418-3426
32. Rasheed Z, Al-Shobaili HA, Alzolibani AA, et al. Immunological functions of oxidized human immunoglobulin G in type 1 diabetes mellitus: Its potential role in diabetic smokers as a biomarker of elevated oxidative stress. Dis Markers. 2011 ; 31: 47-54
33. Al-Shobaili HA, Al Robaee AA, Alzolibani A, Khan MI, Rasheed Z. Hydroxyl radical modification of immunoglobulin g generated cross-reactive antibodies: Its potential role in systemic lupus erythematosus. Clin Med Insights Arthritis Musculoskelet Disord. 2011 ; 23: 11-19
34. Goding JW. Use of staphylococcal protein-A as an immunological reagent. Immuol Methods. 1976 ; 20: 241-253
35. Rasheed Z. Hydroxyl radical damaged immunoglobulin G in patients with rheumatoid arthritis: Biochemical and immunological studies. Clin Biochem. 2008 ; 41: 663-669
36. Rasheed Z, Ali R. Reactive oxygen species damaged human serum albumin in patients with type 1 diabetes mellitus: Biochemical and immunological studies. Life Sci. 2006 ; 79: 2320-2328
37. Hokland P, Heron I. Analysis of the lymphocyte distribution during Isopaque-Ficoll isolation of mononuclear cells from human peripheral blood. J Immunol Methods. 1980 ; 32: 31-39
38. Wang G, Cai P, Ansari GA, Khan MF. Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response. Toxicology. 2007 ; 229: 186-193
39. Kang D, Hamasaki N. Mitochondrial oxidative stress and mitochondrial DNA. Clin Chem Lab Med. 2003 ; 41: 1281-1288
40. Wardell TM, Ferguson E, Chinnery PF, et al. Changes in the human mitochondrial genome after treatment of malignant disease. Mutat Res. 2003 ; 525: 19-27
41. Takai D, Park SH, Takada Y, Ichinose S, Kitagawa M, Akashi M. UV-irradiation induces oxidative damage to mitochondrial DNA primarily through hydrogen peroxide: Analysis of 8-oxodGuo by HPLC. Free Radic Res. 2006 ; 40: 1138-1148
42. Richter C. Reactive oxygen and DNA damage in mitochondria. Mutat Res. 1992 ; 275: 249-255
43. Vallance P, Moncada S. Nitric oxide - from mediator to medicines. J R Coll Physicians Lond. 1994 ; 28: 209-219
44. MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol. 1997 ; 15: 323-350
45. Brown GC. Nitric oxide and mitochondrial respiration. Biochim Biophys Acta. 1999 ; 1411: 351-369
46. Nisoli E, Clementi E, Paolucci C, et al. Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide. Science. 2003 ; 299: 896-899
47. Brown GC, Foxwell N, Moncada S. Transcellular regulation of cell respiration by nitric oxide generated by activated macrophages. FEBS Lett. 1998 ; 439: 321-324
48. Pryor WA, Squadrito G. Chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Phys. 1995 ; 268 (5 Pt 1). L699 - L722
49. Beckman JS, Beckman TW, Chen J, Marshall BA, Frecman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990 ; 87: 1620-1624
50. Murphy MP. Nitric oxide and cell death. Biochim Biophys Acta. 1999 ; 1411: 401-414
51. Szabo C, Ohshima H. DNA damage induced by peroxynitrite: Subsequent biological effects. Nitric Oxide. 1997 ; 1: 373-385
52. Sherer Y, Gorstein A, Fritzler MJ, Shoenfeld Y. Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients. Semin Arthritis Rheum. 2004 ; 34: 501-537
53. Ahsan H, Ali A, Ali R. Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol. 2003 ; 131: 398-404
54. Perl A, Hanczko R, Doherty E. Assessment of mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus. Methods Mol Biol. 2012 ; 900: 61-89
55. Nagy G, Barcza M, Gonchoroff N, Phillips PE, Perl A. Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells. J Immunol. 2004 ; 173: 3676-3683
56. Nemirovskiy OV, Radabaugh MR, Aggarwal P, et al. Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS' role in disease. Nitric Oxide. 2009 ; 20: 150-156
57. Khan F, Ali R. Antibodies against nitric oxide damaged poly L-tyrosine and 3-nitrotyrosine levels in systemic lupus erythematosus. J Biochem Mol Biol. 2006 ; 39: 189-196