Mechanistic basis for unexpected bioavailability enhancement of polyelectrolyte complexes incorporating BCS class III drugs and carrageenans

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 1, 2013, Pages 26-33

  Heinen, C ^a   Reuss, S ^a   Saaler Reinhardt, S ^b   Langguth, P ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KHS Pharma Holding GmbH   (Germany)

Author keywords

Intestinal loop; Mucoadhesion; Permeation; Polyelectrolyte complexes; Trospium chloride; Ussing chamber

Indexed keywords

ATENOLOL; CARRAGEENAN; POLYELECTROLYTE; SCOPOLAMINE BUTYL BROMIDE; TROSPIUM CHLORIDE;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG PENETRATION; DRUG STRUCTURE; ELECTRIC RESISTANCE; FEEDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE LOOP; JEJUNUM; MALE; NONHUMAN; PEYER PATCH; PH; RAT; TANDEM MASS SPECTROMETRY; TIGHT JUNCTION; ULTRAVIOLET SPECTROPHOTOMETRY;

ACTIVE PHARMACEUTICAL INGREDIENT; API; INTESTINAL LOOP; KBR; KREBS-RINGER-BICARBONATE-BUFFER. PH 7.4; MUCOADHESION; P-GLYCOPROTEIN; PD; PECS; PERMEATION; PGP; POLYELECTROLYTE COMPLEXES; POTENTIAL DIFFERENCE; R; SDS; SODIUM DODECYL SULFATE; TEER; TIGHT JUNCTIONS; TJS; TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; TPGS; TRANSEPITHELIAL ELECTRICAL RESISTANCE; TRANSSEGMENTAL ELECTRICAL RESISTANCE; TROSPIUM CHLORIDE; USSING CHAMBER;

ANIMALS; BENZILATES; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CARRAGEENAN; CELL MEMBRANE PERMEABILITY; DRUG CARRIERS; ELECTROLYTES; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; JEJUNUM; MALE; MUCUS; MUSCARINIC ANTAGONISTS; NORTROPANES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SOLUBILITY; TIGHT JUNCTIONS;

EID: 84883002237     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.03.010     Document Type: Article

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