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Volumn 35, Issue 2, 2012, Pages 359-366

The influence of stabilizer and bioadhesive polymer on the permeation-enhancing effect of AT1002 in the nasal delivery of a paracellular marker

Author keywords

AT1002; Bioadhesive polymer; Carrageenan; Mannitol; Permeation enhancer; Stability

Indexed keywords

AMINO ACID; ARGININE; AT 1002; CARRAGEENAN; CYSTEINE; GLUCOSE; GLYCINE; MANNITOL; POLYMER; TOXIN; UNCLASSIFIED DRUG; AT1002; EXCIPIENT; OLIGOPEPTIDE; TISSUE ADHESIVE;

EID: 84862698123     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0217-5     Document Type: Article
Times cited : (14)

References (26)
  • 1
    • 28444463645 scopus 로고    scopus 로고
    • In situ gelling, bioadhesive nasal inserts for extended drug delivery: In vitro characterization of a new nasal dosage form
    • Bertram, U. and Bodmeier, R., In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. Eur. J. Pharm. Sci., 27, 62-71 (2006).
    • (2006) Eur. J. Pharm. Sci. , vol.27 , pp. 62-71
    • Bertram, U.1    Bodmeier, R.2
  • 2
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factorand factor X-dependent activation of protease-activated receptor 2 by factor VIIa
    • Camerer, E., Huang, W., and Coughlin, S. R., Tissue factorand factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc. Natl. Acad. Sci. U. S. A., 97, 5255-5260 (2000).
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 4
    • 0034880291 scopus 로고    scopus 로고
    • Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin
    • Cox, D. S., Gao, H., Raje, S., Scott, K. R., and Eddington, N. D., Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin. Eur. J. Pharm. Biopharm., 52, 145-150 (2001).
    • (2001) Eur. J. Pharm. Biopharm. , vol.52 , pp. 145-150
    • Cox, D.S.1    Gao, H.2    Raje, S.3    Scott, K.R.4    Eddington, N.D.5
  • 5
    • 0036846813 scopus 로고    scopus 로고
    • Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin
    • Cox, D. S., Raje, S., Gao, H., Salama, N. N., and Eddington, N. D., Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin. Pharm. Res., 19, 1680-1688 (2002).
    • (2002) Pharm. Res. , vol.19 , pp. 1680-1688
    • Cox, D.S.1    Raje, S.2    Gao, H.3    Salama, N.N.4    Eddington, N.D.5
  • 6
    • 0028131270 scopus 로고
    • Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system
    • Critchley, H., Davis, S. S., Farraj, N. F., and Illum, L., Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system, J. Pharm. Pharmacol., 46, 651-656 (1994).
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 651-656
    • Critchley, H.1    Davis, S.S.2    Farraj, N.F.3    Illum, L.4
  • 7
    • 0035374570 scopus 로고    scopus 로고
    • Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    • Di Pierro, M., Lu, R., Uzzau, S., Wang, W., Margaretten, K., Pazzani, C., Maimone, F., and Fasano, A., Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J. Biol. Chem., 276, 19160-19165 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 19160-19165
    • Di Pierro, M.1    Lu, R.2    Uzzau, S.3    Wang, W.4    Margaretten, K.5    Pazzani, C.6    Maimone, F.7    Fasano, A.8
  • 8
    • 77956682296 scopus 로고    scopus 로고
    • Efficacy and safety of an antiviral iota-carrageenan nasal spray: A randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold
    • Eccles, R., Meier, C., Jawad, M., Weinmüllner, R., Grassauer, A., and Prieschl-Grassauer, E., Efficacy and safety of an antiviral iota-carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. Respir. Res., 11, 108 (2010).
    • (2010) Respir. Res. , vol.11 , pp. 108
    • Eccles, R.1    Meier, C.2    Jawad, M.3    Weinmüllner, R.4    Grassauer, A.5    Prieschl-Grassauer, E.6
  • 11
    • 0030938926 scopus 로고    scopus 로고
    • Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
    • Fasano, A. and Uzzau, S., Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J. Clin. Invest., 99, 1158-1164 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 1158-1164
    • Fasano, A.1    Uzzau, S.2
  • 12
    • 0031051849 scopus 로고    scopus 로고
    • The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway
    • Fasano, A., Uzzau, S., Fiore, C., and Margaretten, K., The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology, 112, 839-846 (1997).
    • (1997) Gastroenterology , vol.112 , pp. 839-846
    • Fasano, A.1    Uzzau, S.2    Fiore, C.3    Margaretten, K.4
  • 14
    • 12244281485 scopus 로고    scopus 로고
    • Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells
    • Karyekar, C. S., Fasano, A., Raje, S., Lu, R., Dowling, T. C., and Eddington, N. D., Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells. J. Pharm. Sci., 92, 414-423 (2003).
    • (2003) J. Pharm. Sci. , vol.92 , pp. 414-423
    • Karyekar, C.S.1    Fasano, A.2    Raje, S.3    Lu, R.4    Dowling, T.C.5    Eddington, N.D.6
  • 16
    • 0029689063 scopus 로고    scopus 로고
    • Changes in nasal cavity volume and target area of exposure to nasal drops with age in rats
    • Kuboyama, Y., Mori, K., Suzuki, K., Ishii, A., and Shuto, K., Changes in nasal cavity volume and target area of exposure to nasal drops with age in rats. Exp. Anim., 45, 15-22 (1996).
    • (1996) Exp. Anim. , vol.45 , pp. 15-22
    • Kuboyama, Y.1    Mori, K.2    Suzuki, K.3    Ishii, A.4    Shuto, K.5
  • 17
    • 0032472335 scopus 로고    scopus 로고
    • A rheological examination of the mucoadhesive/mucus interaction: The effect of mucoadhesive type and concentration
    • Madsen, F., Eberth, K., and Smart, J. D., A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration. J. Control. Release, 50, 167-178 (1998).
    • (1998) J. Control. Release , vol.50 , pp. 167-178
    • Madsen, F.1    Eberth, K.2    Smart, J.D.3
  • 19
    • 12244273009 scopus 로고    scopus 로고
    • Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol
    • Salama, N. N., Fasano, A., Lu, R., and Eddington, N. D., Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol. Int. J. Pharm., 251, 113-121 (2003).
    • (2003) Int. J. Pharm. , vol.251 , pp. 113-121
    • Salama, N.N.1    Fasano, A.2    Lu, R.3    Eddington, N.D.4
  • 20
    • 1942466467 scopus 로고    scopus 로고
    • The effect of delta G on the transport and oral absorption of macromolecules
    • Salama, N. N., Fasano, A., Thakar, M., and Eddington, N. D., The effect of delta G on the transport and oral absorption of macromolecules. J. Pharm. Sci., 93, 1310-1319 (2004).
    • (2004) J. Pharm. Sci. , vol.93 , pp. 1310-1319
    • Salama, N.N.1    Fasano, A.2    Thakar, M.3    Eddington, N.D.4
  • 21
    • 11844272009 scopus 로고    scopus 로고
    • The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents
    • Salama, N. N., Fasano, A., Thakar, M., and Eddington, N. D., The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents. J. Pharmacol. Exp. Ther., 312, 199-205 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 199-205
    • Salama, N.N.1    Fasano, A.2    Thakar, M.3    Eddington, N.D.4
  • 22
    • 0025851808 scopus 로고
    • The nasal mucociliary clearance: Relevance to nasal drug delivery
    • Schipper, N. G., Verhoef, J. C., and Merkus, F. W., The nasal mucociliary clearance: relevance to nasal drug delivery. Pharm. Res., 8, 807-814 (1991).
    • (1991) Pharm. Res. , vol.8 , pp. 807-814
    • Schipper, N.G.1    Verhoef, J.C.2    Merkus, F.W.3
  • 24
    • 38849207768 scopus 로고    scopus 로고
    • Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A
    • Song, K.-H., Fasano, A., and Eddington, N. D., Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A. Int. J. Pharm., 351, 8-14 (2008a).
    • (2008) Int. J. Pharm. , vol.351 , pp. 8-14
    • Song, K.-H.1    Fasano, A.2    Eddington, N.D.3
  • 25
    • 41549090387 scopus 로고    scopus 로고
    • Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator
    • Song, K.-H., Fasano, A., and Eddington, N. D., Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator. Eur. J. Pharm. Biopharm., 69, 231-237 (2008b).
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 231-237
    • Song, K.-H.1    Fasano, A.2    Eddington, N.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.