Alkalinization of urinary pH accelerates renal excretion of ochratoxin A in pigs

Journal of Nutrition

Volumn 134, Issue 9, 2004, Pages 2355-2358

  Blank, Ralf ^a   Wolffram, Siegfried ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Bioavailability; Excretion; Mycotoxins; Ochratoxin A; Ochratoxin B

Indexed keywords

BICARBONATE; HYDROGEN; OCHRATOXIN;

ALKALINIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; CALCULATION; CONFERENCE PAPER; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; DIFFUSION; DRUG EFFECT; DRUG MECHANISM; KIDNEY DISEASE; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; SWINE; URINARY EXCRETION; URINE PH; URINE VOLUME;

ANIMALIA; SUS SCROFA;

EID: 4444366657     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.9.2355     Document Type: Conference Paper

References (29)

1. Kuiper-Goodman, T. & Scott, P. M. (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed. Environ. Sci. 2: 179-248.
2. Studer-Rohr, I., Dietrich, D. R., Schlatter, J. & Schlatter, C. (1995) The occurrence of ochratoxin A in coffee. Food Chem. Toxicol. 33: 341-355.
3. MacDonald, S., Wilson, P., Barnes, K., Damant, A., Massey, R., Mortby, E. & Shepherd, M. J. (1999) Ochratoxin A in dried vine fruit: method development and survey. Food Addit. Contam. 16: 253-260.
4. Gareis, M. & Scheuer, R. (2000) Ochratoxin A in meat and meat products. Arch. Lebensmittelhyg. 51: 102-104.
5. Breitholtz-Emanuelsson, A., Olsen, M., Oskarsson, A., Palminger, I. & Hult, K. (1993) Ochratoxin A in cow's milk and in human milk with corresponding human blood samples. J. Assoc. Off. Anal. Chem. Int. 76: 842-846.
6. Skaug, M. A. 1999 Analysis of Norwegian milk and infant formulas for ochratoxin A. Food Addit. Contam. 26: 75-78.
7. Blank, R. (2002) Contribution of animal products to human dietary mycotoxin intake. Z. Umweltchem. Ökotox. 14:104-109.
8. Krogh, P. (1992) Role of ochratoxin A in disease causation. Food. Chem. Toxicol. 30: 213-224.
9. Tatu, C. A., Orem, W. H., Finkelman, R. B. & Feder, G. L. (1998) The etiology of Balkan Endemic Nephropathy: still more questions than answers. Environ. Health Perspect. 106: 689-700.
10. IARC (1993) IARC Monographs on evaluation of carcinogenic risks to humans. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. Vol. 56: 489-521.
11. Zingerle, M., Silbemagl, S. & Gekle, M. (1997) Reabsorption of the nephrotoxin ochratoxin A along the rat nephron in vivo. J. Pharmacol. Exp. Ther. 280:220-224.
12. Dahlmann, A., Dantzler, W. H., Silbernagl, S. & Gekle, M. (1998) Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: the nephrotoxin can be reabsorbed in all nephron segments by different mechanisms. J. Pharmacol. Exp. Ther. 286: 157-162.
13. Xiao, H., Marquardt, R. R., Frohlich, A. A. & Ling, Y. Z. (1995) Synthesis and structural elucidation of analogs of ochratoxin A. J. Agric. Food Chem. 43: 524-530.
14. Xiao, H., Marquardt, R. R., Abramson, D. & Frohlich, A. A. (1996) Metabolites of ochratoxins in rat urine and in a culture of Aspergillus ochraceus. Appl. Environm. Microbiol. 62: 648-655.
15. Tapia, M. O. & Seawright, A. A. (1984) Experimental ochratoxicosis A in pigs. Austr. Vet. J. 61: 219-222.
16. Patience, J. F., Austic, R. E. & Boyd, R. D. (1986) The effect of sodium bicarbonate on acid-base status and protein and energy digestibility in swine. Nutr. Res. 6: 263-273.
17. Blank, R., Rolfs, J.-P., Südekum, K.-H., Frohlich, A. A., Marquardt, R. R. & Wolffram, S. (2003) Effects of chronic ingestion of ochratoxin A on blood levels and excretion of the mycotoxin in sheep. J. Agric. Food Chem. 51: 6899-6905.
18. Kumagai, S. (1988) Effects of plasma ochratoxin A and luminal pH on the jejunal absorption of ochratoxin A in rats. Food Chem. Toxicol. 26: 753-758.
19. Kumagai, S. & Aibara, K. (1982) Intestinal absorption and secretion of ochratoxin A in the rat. Toxicol. Appl. Pharmacol. 64: 94-102.
20. Hagelberg, S., Hult, K. & Fuchs, R. (1989) Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J. Appl. Toxicol. 9: 91-96.
21. Roth, A., Chakor, K., Creppy, E. E., Kane, A., Röschenthaler, R. & Dirhelmer, G. (1988) Evidence for an enterohepatic circulation of ochratoxin A in mice. Toxicology 48: 293-308.
22. Rang, H. P., Dale, M. M., Ritter, J. M. & Moore, P. K. (2003) Pharmacology, 5th ed. Churchill Livingstone, Edinburgh, UK.
23. Madhyastha, M. S., Marquardt, R. R. & Frohlich, A. A. (1992) Hydrolysis of ochratoxin A by the microbial activity of digesta in the gastrointestinal tract of rats. Arch. Environ. Contam. Toxicol. 23: 468-472.
24. Galtier, P. (1991) Pharmacokinetics of ochratoxin A in animals. In: Mycotoxins, Endemic Nephropathy and Urinary Tract Tumors (Castegnaro, M., Pleština, R., Dirheimer, G., Chernozemsky, I. N. & Bartsch, H., eds.), pp. 187-200. International Agency for Research on Cancer, Lyon, France.
25. Li, S., Marquardt, R. R., Frohlich, A. A., Vitti, T. G. & Crow, G. (1997) Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicol. Appl. Pharmacol. 145: 82-90.
26. Gekle, M. & Silbernagl, S. (1994) The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: toxodynamic and toxokinetic aspects. Renal Physiol. Biochem. 17: 40-49.
27. Yong, S., Albassam, M. & Prior, M. (1987) Protective effects of sodium bicarbonate on murine ochratoxicosis. J. Environ. Sci. Health B 22: 455-470.
28. Patience, J. F. (1990) A review of the role of acid-base balance in amino acid nutrition. J. Anim. Sci. 68: 398-408.
29. Schwerdt, G., Freudinger, R., Schuster, C., Silbernagl, S. & Gekle, M. (2003) Inhibition of mitochondria and extracellular acidification enhance ochratoxin A-induced apoptosis in renal collecting duct-derived MDCK-C7 cells. Cell. Physiol. Biochem. 14: 47-56.